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The structure of psychological processes in relation to cerebral organization.

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Визуальное расстройство при множественном склерозе, связанном с постгенифицированной серой и белой материей: выше и выше.

Визуальное расстройство является одним из наиболее распространенных и нетрудоспособных проявлений множественного склероза (МС). Несмотря на то, что зрительная дисфункция, связанная с оптическим невритом и участием в работе мозговой системы, хорошо известна, зрительные нарушения, связанные с постгенетическими визуальными путями, включая оптические излучение и зрительные коры коры, относительно недостаточно изучены и недостаточно признаны в клинической практике. Увеличение числа свидетельств, полученных в результате продвинутого нейроимации, оптической томографии и нейропсихологического тестиров

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… In 1987, Day et al. reported a 34-year-old woman with relapsing remitting MS (RRMS) who presented with alexia with agraphia and Gerstmann's syndrome as her third clinical event of MS. … Alexia with agraphia in MS. J Neurol Sci. (1987) 78:343–8. doi: 10.1016/0022-510X(87)90047-5 35. Mao-Draayer Y, Panitch H. Alexia without agraphia in MS. Mult Scler. (2004) 10:705–7. doi: 10.1191/1352458504ms1075cr 36. Poser CM, Brinar VV. Epilepsy and MS. …

Limb-kinetic apraxia.

Five cases of limb-kinetic apraxia following primary degenerative cerebral pathology are reported. Apraxia appeared as the main symptom and was not concomitant to aphasia or to widespread cognitive impairments. Apraxia was not a consequence of elementary motor or sensory deficits, lack of coordination, or the result of the presence of rigid-akinetic symptoms. The apraxia was usually unilateral, being present in both routine activities and testing sessions and consisting of the coarse, unilateral, awkward execution of correctly planned movements. Conceptual knowledge of the movements and their

Neuropsychological evidence for a spatial bias in visual short-term memory after left posterior ventral damage.

For the first time, we report a spatial bias in visual short-term memory (VSTM) after left medial and inferior occipito-temporal damage. Our patient D.M. showed a spatial bias in report from VSTM, being more accurate at reporting stimuli presented in her left than her right visual field (Experiment 1). This spatial bias could not be attributed to a visual field deficit (Experiment 2) and was based on the relative rather than the absolute locations of the stimuli (Experiment 3). It was reduced when the transfer of items to VSTM was facilitated-for example, by grouping stimuli (Experiment 4) or

Leukoencephalopathy During Daratumumab-Based Therapy: A Case Series of Two Patients with Multiple Myeloma.

Leukoencephalopathy in the setting of multiple myeloma (MM) is a rare demyelinating condition, with few reported cases in literature. Daratumumab is a CD38 targeted monoclonal antibody that has been widely used for the management of MM. In the absence of central nervous system (CNS) disease, many medication-induced leukoencephalopathy cases reported with MM, including daratumumab-induced, are associated with progressive multifocal leukoencephalopathy (PML) and John Cunningham (JC) virus. Currently, there are no reported cases of daratumumab-induced leukoencephalopathy among patients without CN

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… She also had acalculia, agraphia, and apraxia. She had right hemibody neglect and left upper extremity dysmetria, with symmetric hyperreflexia in all upper and lower extremities. A repeat LP on May 28, 2020 was still negative for malignancy and showed a continued elevated MBP level of 13.7 ng/mL. … after initiation of daratumumab | 6 months after initiation of daratumumab Clinical features | Cognitive changes, word finding difficulties; dysphagia; diffuse pathological reflexes; pseudobulbar affect; right facial droop; right upper extremity weakness; right hemi-body neglect; apraxia; acalculia; agraphia …

[A case of progressive multifocal leukoencephalopathy presenting white matter MRI lesions extending over the cerebral cortex and a marked decrease in cerebral blood flow on SPECT, and associated with HTLV-I infection].

We report a 47-year-old woman with progressive multifocal leukoencephalopathy (PML). She was a carrier of HTLV-I virus, and developed subacu … t hemiplegia, mild right hemihypesthesia, limb-kinetic apraxia in the left hand, idiomotor apraxia, agraphia, perseveration, marked spasticity and brisk tendon reflex in four extremities, and positive bilateral pathological reflexes. MRI showed multifocal T2-high lesions mainly in the cerebral white matter, predominantly in the left hemisphere, and partly …

Presenile dementia diagnosed as posterior cortical atrophy.

Posterior cortical atrophy (PCA) was originally proposed in 1988 based on five cases of dementia presenting characteristic clinical symptoms. The concept of PCA is still not generally accepted. Herein, we present a case of a presenile female with PCA. A 57-year-old woman was brought to the hospital by her older sister. The patient's chief complaints were that she could not drive a car safely and had caused numerous traffic accidents. Construction apraxia and unilateral spatial agnosia were detected by neuropsychological tests. The patient could not write a coherent the letter even though she w

Tactile agnosia and tactile aphasia: symptomatological and anatomical differences.

Two patients with tactile naming disorders are reported. Case 1 (right hand tactile agnosia due to bilateral cerebral infarction) differentiated tactile qualities of objects normally, but could neither name nor categorize the objects. Case 2 (bilateral tactile aphasia after operation of an epidural left parietal haematoma) had as severe a tactile naming disturbance as Case 1, but could categorize objects normally, demonstrating that tactile recognition was preserved. Case 1 may be the first case of tactile agnosia clearly differentiated from tactile aphasia. CT scans of Case 1 revealed lesions

Training a new generation of speech-language pathologists with competences in the management of literacy disorders and learning disabilities in Hong Kong.

One of the recent developments in the education of speech-language pathology is to include literacy disorders and learning disabilities as key training components in the training curriculum. Disorders in reading and writing are interwoven with disorders in speaking and listening, which should be managed holistically, particularly in children and adolescents. With extensive training in clinical linguistics, language disorders, and other theoretical knowledge and clinical skills, speech-language pathologists (SLPs) are the best equipped and most competent professionals to screen, identify, diagn

The impact of periventricular brain injury on reading and spelling abilities in the late elementary and adolescent years.

The present study was designed: (1) to investigate the long-term consequences of both the presence and the severity of periventricular brain injury (PVBI) on intellectual, academic, and cognitive outcome in extremely-low-birthweight (ELBW: < 1,000 grams) children at a mean age of 11 years; and (2) to determine the nature of the underlying difficulties associated with academic problems in these children. The results indicated that ELBW children without PVBI performed as well as full-term children on intelligence, academic, and cognitive ability tests. In contrast, ELBW children with mild and se

Transient headache and neurological deficits with cerebrospinal fluid lymphocytosis syndrome: A comprehensive systematic review of 93 patients from 57 studies.

BACKGROUND: Headache with neurologic deficits and cerebrospinal fluid lymphocytosis, previously also termed pseudomigraine with temporary ne … uded sensory deficit (60%) and motor deficits (54.8%). The least common symptoms were nystagmus and agraphia, which were reported in one patient each. Antiviral agents were a common treatment option in the acute phase (n  =  23 patients [23.6%]), while Flunarizine was the most commonly used agent in the chronic setting (n = 3 patients [3.2%]). While most o …

Parkinsonism following bilateral lesions of the globus pallidus: performance on a variety of motor tasks shows similarities with Parkinson's disease.

OBJECTIVES: The authors report the results of detailed investigations into the motor function of a patient who, after a heavy drinking binge and subsequent unconsciousness, respiratory acidosis, and initial recovery, developed parkinsonism characterised by hypophonic speech and palilalia, "fast micrographia", impaired postural reflexes, and brady/akinesia in proximal (but not distal) alternating upper limb movements. METHODS: In addition to brain magnetic resonance imaging (MRI), different aspects of motor function were investigated using reaction time (RT) tasks, pegboard and finger tapping

[Dynamics of neurological symptoms in patients with brain tumors during combined therapy (operation plus betatron electromagnetic radiation)].

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Проблема в том, что диагноз мозга бабочек.

Каллосум с корпусом может раскрыть "бутерфляж" изображения в различных условиях, включая глиобластому, первичную центральную нервную лимфому, тумефактивный множественный склероз и токсоплазмоз. Раннее различие между этими условиями имеет решающее значение для того, чтобы избежать агрессивного лечения. В одном случае 70-летняя женщина с многократным склерозом пережила неврологический спад. В то время как снимки указывают на высокий уровень глиомы, биопсия в конечном счете подтвердила диагноз тумефактивного множественного склероза. Пациент показал, что стероидная терапия улучшается. Важно провод

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… Butterfly gliomas cause symptoms related to disconnection syndromes, including alexia, agraphia, and apraxia, while sensomotoric deficits are more atypical [ 6 ]. …

Cancer-related cognitive impairment in patients with hematologic malignancies after CAR T cell therapy: a systematic review and meta-analysis of prevalence.

PURPOSE: Cancer-related cognitive impairment is one of the symptoms of neurotoxicity among patients receiving chimeric antigen receptor (CAR) T cell therapy. Evidence of the overall estimated prevalence of cancer-related cognitive impairment following CAR T-cell therapy among patients with hematologic malignancies at short-term and long-term follow-ups is lacking. This review aimed to summarize the cognitive functioning status and estimate the prevalence of cancer-related cognitive impairment at follow-up within 1 month, 1 to 12 months, and > 12 months after CAR T cell therapy. METHODS: PubMe

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… = .03, d = .17) - Divided attention ( p = .001, d = .28) Belin, [ 23 ], France 84 Relapsing BCL (76 DLBCL, 6 tFL, 2 FL) Axicabtasene ciloleucel, Tisagenlecleucel 59 (median) 69 CTCAE, ASTCT grading scale, and clinical notes assessed by neurologists Frequencies: 10 aphasia, 7 executive disorders, 5 agraphia … .17) - Divided attention ( p = .001, d = .28) Belin, [ 23 ], France | 84 | Relapsing BCL (76 DLBCL, 6 tFL, 2 FL) | Axicabtasene ciloleucel, Tisagenlecleucel | 59 (median) | 69 | CTCAE, ASTCT grading scale, and clinical notes assessed by neurologists | Frequencies: 10 aphasia, 7 executive disorders, 5 agraphia …

A clinicopathologic study of malignancy in VCP-associated multisystem proteinopathy.

BACKGROUND: Valosin containing protein (VCP) is an important protein with many vital functions mostly related to the ubiquitin-proteasome system that provides protein quality control. VCP-associated inclusion body myopathy with Paget disease of bone and frontotemporal dementia, also termed VCP disease and multisystem proteinopathy (MSP 1), is an autosomal dominant disorder caused by monoallelic variants in the VCP gene on human chromosome 9. VCP has also been strongly involved in cancer, with over-activity of VCP found in several cancers such as prostate, pancreatic, endometrial, esophageal ca

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… It is characterized by cognitive deficiencies, including difficulties with comprehension, dysnomia and dyscalculia in the early stages, auditory comprehension deficits, alexia, and agraphia in later stages. It also causes changes in personality and decision making [ 8 ]. …

CAR T-Cell Terrapy Opveiled: Навигация за пределы ССЗ и ИКАНС для решения проблем, связанных с отсроченными последствиями, и оптимизации стратегий управления.

Цимерическая антигенная рецепторная (КАР) T-клетологическая терапия положила начало эпохе преобразований в регулировании рецидивов/отсутствий гематологической гематологии. Кульминацией интенсивных испытаний второго этапа, направленных на борьбу с повторной/охотничьей лимфомой, включая различные подтипы, такие, как диффузная большая лимфома B-клеток, фолликулярная лимфома и лимфома мантичной клетки, а также многочисленные миелома и острая лимфоболическая лейкемия B-клеток, стало одобрение различных продуктов CAR-T-клеток для этих конкретных указаний Администрацией по вопросам продовольствия и н

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… Recommendations include extending the patient's monitoring period beyond 100 days, conducting a complete history and physical at every clinic visit, and assessing the patient's handwriting to detect early signs of neurotoxicity such as micrographia, dysgraphia, or agraphia post–ciltacabtagene autoleucel …

Сбалансирую эффективность и безопасность в нескольких пациентах с миеломой, получающих B-камерную антигенную терапию CAR-Cell.

В качестве новаторского и эффективного метода лечения пациентов с повторной/неизлечимой миеломой (BCMA) вспыхнула антигенная терапия созревания (BCMA), которая была ориентирована на CAR T-клеточную терапию, что свидетельствует о высокой доле респондентов и продолжительной ремиссии. Однако его применение связано с широким спектром токсичных свойств, начиная от хорошо известных общих событий и кончая более редкими и менее хорошо описанными осложнениями. Всеобъемлющее понимание как общих, так и редких токсичных свойств имеет важнейшее значение для своевременного признания и регулирования в целях

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… Early symptoms of ICANS include decreased concentration and word-finding difficulty, but this may progress to dysphasia or aphasia, confusion, and agraphia. ICANS is mostly low-grade and reversible [ 15 ], but seizures and cerebral oedema have also been reported. …

Assessment of Psychiatric Disorders in Consultation-Liaison Setting.

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… lesion | Altered test of proprioception in a patient with complaints of visual difficulty is a strong suspicion of psychogenic condition, as that does not involve any role of vision but does not rule out organic lesion at sensory parietal cortex | Clinical conditions like hemineglect, alexia without agraphia …

Harnessing Immune Response in Acute Myeloid Leukemia.

Despite the results achieved with the evolution of conventional chemotherapy and the inclusion of targeted therapies in the treatment of acute myeloid leukemia (AML), survival is still not satisfying, in particular in the setting of relapsed/refractory (R/R) disease or elderly/unfit patients. Among the most innovative therapeutic options, cellular therapy has shown great results in different hematological malignancies such as acute lymphoblastic leukemia and lymphomas, with several products already approved for clinical use. However, despite the great interest in also expanding the application

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… Its clinical manifestations consist of progressive mental status changes, varying from mild symptoms such as confusion or disorientation to more severe cognitive impairment with agraphia and aphasia. ICANS can also occur in concomitance with CRS [ 108 ]. …