Результаты поиска

Infections in Recipients of Hematopoietic Stem Cell Transplants

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Prophylaxis of Pneumocystis jirovecii infection with trimethoprim-sulfamethoxazole (TMP-SMX), dapsone, atovaquone, or aerosolized pentamidine is required for 6 to 12 months or, if chronic GVHD is continuing, longer. 88 , 89 , 90 , 91 , 92 Reactivation of CMV predictably occurs in 20% to 40% of patients … For patients who do not tolerate medications containing sulfa, prophylaxis options include desensitization with TMP-SMX and use of dapsone, 92 , 232 atovaquone, 233 and inhaled pentamidine. 89 , 234 The treatment of choice for P. jirovecii infection is TMP-SMX. 88 , 90 Candida Candidiasis is an infection …

Human herpes virus co-infection is associated with mortality in HIV-negative patients with Pneumocystis jirovecii pneumonia.

The purpose of this investigation was to characterize the management and prognosis of severe Pneumocystis jirovecii pneumonia (PJP) in human immunodeficiency virus (HIV)-negative patients. An observational cohort study of HIV-negative adults with PJP documented by bronchoalveolar lavage (BAL) through Gomori-Grocott staining or immunofluorescence, admitted to one intensive care unit (ICU) for acute respiratory failure, was undertaken. From 1990 to 2010, 70 patients (24 females, 46 males) were included, with a mean age of 58.6 ± 18.3 years. The mean Simplified Acute Physiology Score (SAPS)-II wa

Совпадение в полном тексте источника
… Patients were then switched to pentamidine ( n = 9) or atovaquone ( n = 2). Data on corticosteroids use after PJP diagnosis were available for 51 patients. Of these, 43 (84.3 %) received corticosteroids: methylprednisolone ( n = 39) or hemisuccinate hydrocortisone ( n = 4). …

Malaria Surveillance - United States, 2016.

PROBLEM/CONDITION: Malaria in humans is caused by intraerythrocytic protozoa of the genus Plasmodium. These parasites are transmitted by the … %), to sulfadoxine in 98 (70.5%), to chloroquine in 67 (44.7%), to mefloquine in six (4.3%), and to atovaquone in one (<1.0%). The completeness of key variables (e.g., species, country of acquisition, and resident status) was 79.4% in 2016 and 75.7% in 2015. INTERPRETATION: The number of reported malaria cases in 2016 continued a decades-long increasing tre …

Akathisia induced by concurrent use of mirogabalin and sulfamethoxazole-trimethoprim: a case report.

BACKGROUND: Mirogabalin and trimethoprim-sulfamethoxazole (TMP/SMX) are frequently used as supportive purpose during and/or after chemotherapy. Mirogabalin is used to treat neuropathic pain, whereas TMP/SMX is used to prevent pneumocystis pneumonia (PCP) in patients who are immunocompromised. The interaction between mirogabalin and TMP/SMX has not been reported. Here, we report a case of akathisia that developed after concurrent administration of mirogabalin and TMP/SMX. CASE PRESENTATION: We report the case of a 69-year-old male patient who experienced akathisia twice. The patient was diagnos

Совпадение в полном тексте источника
… Furthermore, TMP/SMX is considered to have a higher prophylactic efficacy than inhaled pentamidine or oral atovaquone, which are also used as preventive treatments for PCP [ 8 ]. The risk of PCP is high in patients who are immunosuppressed. …

Recommendations of the SFH (French Society of Haematology) for the diagnosis, treatment and follow-up of hairy cell leukaemia.

Hairy cell leukaemia (HCL) is a rare haematological malignancy, with approximately 175 new incident cases in France. Diagnosis is based on a careful examination of the blood smear and immunophenotyping of the tumour cells, with a panel of four markers being used specifically to screen for hairy cells (CD11c, CD25, CD103 and CD123). In 2011, the V600E mutation of the BRAF gene in exon 15 was identified in HCL; being present in HCL, it is absent in the variant form of HCL (HCL-v) and in splenic red pulp lymphoma (SRPL), two entities related to HCL. The management of patients with HCL has changed

Совпадение в полном тексте источника
… In cases of allergy to Bactrim® or cytopenias potentially linked to Bactrim®, Pentacarinat® or atovaquone (Wellvone®) aerosols may be used. Prevention of zoster infections with aciclovir or valaciclovir should also be started 1 week after PNAs. …

Practical management of disease-related manifestations and drug toxicities in patients with multiple myeloma.

Multiple myeloma (MM) is a very heterogeneous disease with multiple symptoms and clinical manifestations. MM affects mainly elderly patients and is difficult to manage in the presence of comorbidities, polypharmacy, frailty and adverse events of disease-targeted drugs. The rapid changes in MM treatment resulting from constant innovations in this area, together with the introduction of numerous new drugs with distinct mechanisms of action and toxicity profiles, have led to an increased complexity in the therapeutic decision-making and patient management processes. The prolonged exposure to nove

Совпадение в полном тексте источника
… Levofloxacin 500 mg qd | Levofloxacin 500 mg qd Anti-fungal | not recommended | Fluconazole or micafungin in case of severe mucositis and/or prolonged neutropenia (ANC ≤100 cells/µL for≥7 days) Cotrimoxazole in patients on high-dose dexamethasone (doses ≥40mg x 4 days per week) or with RRMM; dapsone or atovaquone … infection) | Fluconazole or micafungin in case of severe mucositis and/or prolonged neutropenia (ANC ≤100 cells/µL for≥7 days) Voriconazole or posaconazole if ANC ≤100 cells/µL for 7 days) Cotrimoxazole in patients on high-dose dexamethasone (doses ≥40mg x 4 days per week) or with RRMM; dapsone or atovaquone …

Регулирование заразительных осложнений в создании химической антигенной приемной клетки (CAR-T)

Химерическая антигенная рецепторная T-клетка (CAR T-клетка) изменила парадигму управления лимфомой не Ходжкина (NHL) и множественной миеломой. Осложнения, связанные с инфекцией, стали предметом озабоченности, которая может возникнуть в процессе лечения и привести к заболеваемости и смертности. В ходе этого обзора мы классифицировали осложнения, связанные с инфекцией, в three Категория, этап предварительного вливания с момента предварительного лимфодерации (LD) до дня zero, ранний этап от дня вливания до дня 30 после введения в эксплуатацию и с запозданием изо дня в день 30 и дальше. Инфекции,

Совпадение в полном тексте источника
… Otherwise, other less myelosuppressive options such as inhaled pentamidine, dapsone or atovaquone, should be instituted, typically until the CD4+ count is over 200/uL. 11,61 3.2.4. … Atovaquone 1500 mg PO daily | Day 28 | Continue at least 3 months, until CD4 > 200/uL Hepatitis B carriers/exposed ( HBs Ag positive or Anti-HBc Ab IgG positive) | Entecavir | | | At least 6 months and surveillance of LFT and HBV DNA as indicated. 3.3. …

Epidemiology, Risk Factors, and Prophylaxis Use for Pneumocystis jirovecii Pneumonia in the Non-HIV Population: A Retrospective Study in Québec, Canada.

BACKGROUND: Pneumocystis jirovecii pneumonia (PJP) remains a significant threat in immunocompromised cases. Recent data on epidemiology and risk factors for PJP in non-HIV cases are scarce, and guidelines on appropriate prophylaxis are lacking. METHODS: In this multicenter retrospective trial, all non-HIV adult cases admitted to hospitals in Québec City, Canada, between January 2011 and January 2021 with a diagnosis of PJP were assessed for eligibility. RESULTS: An overall 129 cases of PJP were included. More than two-thirds had an underlying hematologic disease or an autoimmune/inflammatory

Совпадение в полном тексте источника
… . (%) Pharmacologic therapies | First-line treatment | TMP-SMX | 110/129 (85.2) Primaquine + clindamycin | 14/129 (10.9) Atovaquone | 2/129 (1.55) Pentamidine | 1/129 (0.78) No antimicrobial/palliative care | 2/129 (1.55) Adverse events under TMP-SMX prompting a change to other antimicrobials | 42/ …

Наркотики, основанные на сходстве генных экспрессионных сигнатур, чтобы исследовать потенциальные признаки кексетина: тематическое исследование множественных склерозов.

Quercetin (QR) — природный флавонол, широко распространенный в королевстве растений с обширными фармакологическими последствиями. Чтобы найти потенциальные клинические показатели QR, 156 Дифференциально выраженные гены (DEG), регулируемые QR, были получены из базы данных Gene Express Omnibus, и новые потенциальные фармакологические эффекты и клинические показатели QR были перенаправлены путем интегрирования соединений с аналогичными генными сигнатурами возмущения и соответствующими сигнатурами болезни QR на основе карты связи и платформ Coexedia. Предлагаемые результаты QR оказывают главным об

Совпадение в полном тексте источника
… immunosuppressive agents transplanted organ rejection and MS * Pimentel Maldonado et al. (2023) immunosuppressant; blocking the proliferation of T and B cells norgestrel 1.31 progestin contraceptives abnormal uterine bleeding and endometriosis progesterone receptor agonist; contraception atovaquone …

Профилактика Tocilizumab для пациентов с множественной миэломой, которые лечатся биконкретными антителами.

Обобщение антител для лечения множественной миеломы является весьма эффективным, но обычно вызывает синдром высвобождения цитокина (CRS) и синдром нейротоксичности, связанный с иммунным действием клеток (ICANS). Появляющиеся данные свидетельствуют о том, что профилактическая токсилизумаб может привести к сокращению ДУС без ущерба для эффективности. Мы провели одну дозу тоцилизумаба перед первой дозой биконкретных антител 119 пациентов для определения воздействия на ДУС в реальном мире, включая группу рецепторов типа C в виде антигена х CD3- и G-протеина 5 Член D х CD3-targeted антитела. Наилуч

Совпадение в полном тексте источника
… Diphenhydramine | Before initial step-up dosing schedule following USPI recommendations Dexamethasone | Before initial step-up dosing schedule following USPI recommendations Acyclovir (valacyclovir alternative) | Before the first step-up dose and continued throughout treatment Sulfamethoxazole/trimethoprim (atovaquone …

SARS-CoV-2 Persistent Viral Shedding in the Context of Hydroxychloroquine-Azithromycin Treatment.

SARS-CoV-2 nasopharyngeal shedding contributes to the spread of the COVID-19 epidemic. Among 3271 COVID-19 patients treated at the Hospital University Institute Méditerranée Infection, Marseille, France from 3 March to 27 April 2020, tested at least twice by qRT-PCR, the median SARS-CoV-2 nasopharyngeal shedding duration was 6 days (range 2-54 days). Compared with short shedders (qRT-PCR positivity < 10 days), 34 (1.04%) persistent shedders (qRT-PCR positivity ≥ 17 days; mean ± SD: 23.3 ± 3.8 days) were significantly older, with associated comorbidities, exhibiting lymphopenia, eosinopenia, in

Совпадение в полном тексте источника
… . | Follicular lymphoma | 59 days | No | No | Obinutuzumab bimonthly, acyclovir, atovaquone, favipiravir, ciclesonide, lopinavir/ritonavir | No genome sequencing reported | Discharge on day 69 [ 29 ] | Not reported, median (range), 58 y. …

A review on in silico virtual screening methods in COVID-19 using anticancer drugs and other natural/chemical inhibitors.

The present coronavirus disease 2019 (COVID-19) pandemic scenario has posed a difficulty for cancer treatment. Even under ideal conditions, malignancies like small cell lung cancer (SCLC) are challenging to treat because of their fast development and early metastases. The treatment of these patients must not be jeopardized, and they must be protected as much as possible from the continuous spread of the COVID-19 infection. Initially identified in December 2019 in Wuhan, China, the contagious coronavirus illness 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (S

Совпадение в полном тексте источника
… .: reference; WT: wild type; ATV: atovaquone; DLT: delta mutated RBD of S-protein; LMB: lambda mutated RBD of S-protein; PRZ: praziquantel; TMPRSS2: transmembrane serine protease 2; MPPs: main protease proteins; MTase: methyltransferase; -: blank cell Compound | Binding affinity (kcal/mol) | Target | … Abbreviations 3-chymotrypsin-like protease three-dimensional angiotensin-converting enzyme two antiretroviral nucleoside/nucleotide analogs atovaquone binding free energies Bruton tyrosine kinase coronavirus coronavirus disease 2019 deep learning delta mutated receptor binding domain of spike …

Malaria Surveillance - United States, 2018.

PROBLEM/CONDITION: Malaria in humans is caused by intraerythrocytic protozoa of the genus Plasmodium. These parasites are transmitted by the … oroquine in 50 (45.5%), and to mefloquine in two (2.0%); no specimens tested contained a marker for atovaquone or artemisinin resistance. INTERPRETATION: The importation of malaria reflects the overall trends in global travel to and from areas where malaria is endemic, and 15.6% fewer cases were imported in 2018 compared with 2017. Of imported cases, 59.3% …

COVID-19 in patients with anemia and haematological malignancies: risk factors, clinical guidelines, and emerging therapeutic approaches.

Extensive research in countries with high sociodemographic indices (SDIs) to date has shown that coronavirus disease 2019 (COVID-19) may be directly associated with more severe outcomes among patients living with haematological disorders and malignancies (HDMs). Because individuals with moderate to severe immunodeficiency are likely to undergo persistent infections, shed virus particles for prolonged periods, and lack an inflammatory or abortive phase, this represents an overall risk of morbidity and mortality from COVID-19. In cases suffering from HDMs, further investigation is needed to achi

Совпадение в полном тексте источника
… [ 264 ] Abemaciclib, Dasatinib and Spiperone * | Omicron | N.A | • Block the interaction between the omicron spike protein and the host cell receptor ACE2 | [ 265 ] Azacytidine * | Delta | N.A | • As a potent inhibitor of DNA methylation, both in preclinical models and in cancer patients | [ 266 ] Atovaquone … concern including the alpha, beta, and delta variants | N.A | • Inhibits replication • Its ability is partly related to the expression of TMPRSS2, and the drug can prevent the spike protein from binding to the viral receptor, ACE2 • Spike-mediated membrane fusion was also reduced in the presence of atovaquone …

Prophylaxis and Empirical Therapy of Infection in Cancer Patients

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… solid tumors (e.g., brain cancer) Dapsone | 2 mg/kg/day (max., 100 mg), on alternate days three times/wk | In patients who cannot tolerate TMP-SMX Aerosolized pentamidine | 300 mg once a month with nebulizer | In patients who cannot tolerate TMP-SMX; effective, but it is more difficult to administer Atovaquone … Other drugs, such as daily oral dapsone or atovaquone or monthly aerosolized pentamidine, have demonstrated efficacy and are alternative options in patients who cannot tolerate TMP-SMX (see Chapter 271). …

Malaria Surveillance - United States, 2017.

PROBLEM/CONDITION: Malaria in humans is caused by intraerythrocytic protozoa of the genus Plasmodium. These parasites are transmitted by the … , to sulfadoxine in 77 (69.4%), to chloroquine in 38 (33.3%), to mefloquine in three (2.7%), and to atovaquone in three (2.7%); no specimens tested contained a marker for artemisinin resistance. The data completeness of key variables (species, country of acquisition, and resident status) was lower in 2017 (74.4%) than in 2016 (79.4%). INTERPRETATION: The nu …

Эффективность импульса стволовых клеток (SCB) для химериковой антигенной рецепторной-Т клеточной терапии (CAR-T) в связи с гематологической токсичностью у пациентов с повторной/реактивной множественной миеломой (RRMM)-реальным мировым опытом работы консорциума иммунотерапии США с множественными миеломами.

Продолжительные цитопении - это широко признанное осложнение после лечения CAR-T. Автономный SCB предлагает потенциальную стратегию по содействию быстрому гематологическому восстановлению. Мы провели ретроспективное многоинституциональное сопоставление результатов SCB в сравнении с поддержкой только у пациентов с продолжительными цитопентиями после вливания CAR-T. Пациенты включаются, если они получают SCB внутри 1 год, следующий за коммерческим 6/2021 и 3/2024. Чтобы определить соответствующие механизмы контроля, мы проверили 590 Число получателей ЦАР-Т и отобранных пациентов с ПНК и пороговы

Совпадение в полном тексте источника
… infectious work-up, bone marrow biopsy) CD34+ Cell Dose Range | • Minimal recommended dose: No minimum dose Growth Factor Use | • GCSF support recommended both pre- and post- boost Anti-infective Prophylaxis | • Bacterial: Levofloxacin • Fungal: Fluconazole/Voriconazole/Posaconazole • PJP: Pentamidine/Atovaquone …

Bispecific Antibodies in Hematologic Malignancies in the Outpatient and Community Settings.

Bispecific antibodies (BsAbs) are novel antitumor agents that simultaneously engage tumor-associated antigens with CD3 on endogenous effector T cells, leading to cancer cell death. The immune-mediated toxicity rates associated with BsAbs are considerably lower than those seen with CAR T-cell therapy. Hence, widespread utilization of BsAb products in outpatient and community settings will allow greater and more homogeneous access and thus improve patient outcomes. In this review, we discuss the unique toxicities associated with BsAbs currently approved by the U.S. Food and Drug Administration a

Совпадение в полном тексте источника
… Likewise, patients are recommended to take Bactrim or Atovaquone throughout treatment to mitigate the risk of developing Pneumocystis jirovecii infection. …

The Role of the Research Advanced Practice Provider in CAR T-Cell Clinical Trials.

In recent years, chimeric antigen receptor (CAR) T-cell therapy has emerged as an effective and potentially paradigm-shifting therapy for patients with refractory lymphoma and myeloma. This novel therapy involves engineering T cells to recognize specific antigens on the surface of cancer cells. Several CAR T-cell products are approved by the US Food and Drug Administration as a result of numerous clinical trials. Due to the complexity of these studies and the high level of care required for CAR T-cell therapy patients, the role of the research advanced practice provider (APP) has become increa

Совпадение в полном тексте источника
… preferably with pentamidine until blood counts recover and then with trimethoprim/sulfamethoxazole or alternative Monitor blood counts; if cytopenia develops, consider switching to alternative May stop after 1 year if CD4 count is > 200 cells/mL | Dapsone 100 mg orally daily or 50 mg orally every 12 hr, OR Atovaquone …

Pneumonia in the Cancer Patient

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Oral atovaquone and parenteral pentamidine may be given to patients who are intolerant to sulfa-containing regimens. Invasive Pulmonary Mycosis . Invasive pulmonary aspergillosis is the most common fungal pneumonia in cancer patients. …