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Intestinal Bacteroides species associated with coeliac disease.

AIMS: To characterise the predominant species of bacterial populations associated with duodenal biopsies of paediatric patients with active and treated coeliac disease. METHODS: 20 biopsy specimens from patients with active coeliac disease, 12 from patients with treated coeliac disease, and eight from age-matched controls were evaluated for comparative purposes. Bacteroides, Bifidobacterium and lactic acid bacteria (LAB) populations were analysed by PCR-denaturing gradient gel electrophoresis using group-specific primers. RESULTS: Bacteroides diversity was higher in biopsy specimens from con…

Bifidobacteria and Celiac Disease: Mechanisms of Probiotic Action in Reducing Gluten-Induced Cytotoxicity and Inflammation.

Celiac disease (CD) is an immune-mediated systemic disorder triggered by gluten peptides present in the diets of genetically susceptible ind … vitro studies, primarily using Caco-2 cells and immune cell models, have shown that strains such as Bifidobacterium longum IATA-ES1, Bifidobacterium lactis, Bifidobacterium bifidum IATA-ES2, and B. lactis Natren Life Start super strain (NLS-SS) can induce COX-1 expression and reduce COX-2, inhibit zonulin release, degrade gliadin-derived peptides, and suppress CX …

Establishment of a sensitive system for analysis of human vaginal microbiota on the basis of rRNA-targeted reverse transcription-quantitative PCR.

Ten specific primer sets, for Lactobacillus gasseri, Lactobacillus crispatus, Atopobium vaginae, Gardnerella vaginalis, Mobiluncus curtisii, Chlamydia trachomatis/muridarum, Bifidobacterium longum subsp. longum, Bifidobacterium longum subsp. infantis, Bifidobacterium adolescentis, and Bifidobacterium angulatum, were developed for quantitative analysis of vaginal microbiota. rRNA-targeted reverse transcription-quantitative PCR (RT-qPCR) analysis of the vaginal samples from 12 healthy Japanese volunteers using the new primer sets together with 25 existing primer sets revealed the diversity of th…

Strain-specific impacts of probiotics are a significant driver of gut microbiome development in very preterm infants.

The development of the gut microbiome from birth plays important roles in short- and long-term health, but factors influencing preterm gut microbiome development are poorly understood. In the present study, we use metagenomic sequencing to analyse 1,431 longitudinal stool samples from 123 very preterm infants (<32 weeks' gestation) who did not develop intestinal disease or sepsis over a study period of 10 years. During the study period, one cohort had no probiotic exposure whereas two cohorts were given different probiotic products: Infloran (Bifidobacterium bifidum and Lactobacillus acidophil…

Can probiotic-rich yogurt help prevent colorectal cancer in humans?

•Yogurt consumption is linked to 20-40% lower colorectal cancer risk, especially proximal colon tumors with high Bifidobacterium levels.•Probiotics modulate gut microbiota, reduce inflammation, and produce protective metabolites against cancer development.•Bifidobacterium strains in yogurt suppress tumor growth through various signaling and immune pathway regulation.•Early screening age reduction and increased fiber intake are recommended for enhanced colorectal cancer prevention.•Probiotic therapy shows promise for reducing treatment side effects and improving patient quality of life.

The Role of Bifidobacteria in Predictive and Preventive Medicine: A Focus on Eczema and Hypercholesterolemia.

Bifidobacteria colonize the human gastrointestinal tract early on in life, their interaction with the host starting soon after birth. The health benefits are strain specific and could be due to the produced polysaccharides. The consumption of probiotics may prevent obesity, irritable bowel syndrome, eczema or atopic dermatitis, and asthma. Non-replicative strains of Bifidobacterium longum (NCC3001 and NCC2705) promote the differentiation of normal human epidermal keratinocytes (NHEKs), inducing a high expression of differentiation markers (keratin -KRT1-, and transglutaminase -TGM1-) and pro-r…

Which is the best probiotic treatment strategy to prevent the necrotizing enterocolitis in premature infants: A network meta-analysis revealing the efficacy and safety.

BACKGROUND: Previous studies have neglected to report the specific action of different probiotic genera in preterm infants. To evaluate the … intervention in the observation group was to add probiotics for feeding: Lactobacilli in 6 studies; Bifidobacterium in 8 studies; Bacillus in 1 study; Saccharomyces in 4 studies and probiotic mixture in 15 studies. This NMA showed a significant advantage of probiotic mixture and Bifidobacterium to prevent the incidence of necrotizing enterocolitis in preterm infa …

Gut microbiome shifts in chronic systolic heart failure are associated with disease severity and clinical improvement.

The contribution of the gut microbiome to chronic heart failure (HF) remains poorly defined. We performed integrated microbiome and host multi-omic profiling of adults with chronic systolic HF due to nonischemic cardiomyopathy (n = 59) and healthy participants (n = 50), including longitudinal sampling in some cases. Here we show that patients with HF have depletion of anti-inflammatory Bifidobacterium and reduced short-chain fatty acid biosynthetic potential, alongside altered microbiome-immune system interactions. Longitudinal analysis revealed that higher Bifidobacterium abundance was associ…

Changes in Lactate-related Fecal Microbiome in Hyperlactatemia Diabetic Dogs.

BACKGROUND/AIM: The correlation between the intestinal microbiome and endocrine disorders has recently been drawing attention as an importan … LTS: Expression levels of the lactate-producing bacteria Lactobacillus spp., Enterococcus spp., and Bifidobacterium spp., were confirmed in patients with high concentrations of lactate in the blood. The abundance of Enterococcus and Bifidobacterium was higher in diabetic dogs compared to that of non-diabetic dogs. When blood lactate concentrations were high, the …

Natural transformation drives large-scale genome mosaicism in human gut bifidobacteria.

Although horizontal gene transfer drives bacterial diversification, its contribution to chromosome-scale variation in human gut commensals remains unclear. This study demonstrated that human-associated bifidobacteria undergo extensive chromosomal transfer through natural transformation. Comparative genomics of coexisting Bifidobacterium pseudocatenulatum isolates from a single individual revealed extensive recombination signatures between the lineages. We experimentally reproduced this recombination by co-culturing strains, resulting in the transfer of multiple chromosomal regions and generati…

Identification of fecal microbes as potential biomarkers for early diagnosis of fatty liver disease in cattle.

Fatty liver disease is prevalent during parturition in dairy cattle. Therefore, there is an urgent need to develop novel, sensitive biomarke … on Receiver Operating Characteristics analysis, of using the combination of Lachnoanaerobaculum and Bifidobacterium (at the genus level) to discriminate MFL and SFL animals reached 0.944 and 0.867, respectively, and 0.922 and 0.985, respectively, for the combination of Bifidobacterium pseudolongum and Lachnospiraceae bacterium (at the species level). Interestingl …

Salivary levels of five microorganisms of root caries in nursing home elderly: a preliminary investigation.

BACKGROUND: Streptococcus, Bifidobacteria, Lactobacillus and Actinomyces are acidogenic aciduria that may be associated with root caries (RC). The aim of the study was to analyze Streptococcus mutans (S. mutans), Streptococcus sobrinus (S. sobrinus), Bifidobacterium spp., Lactobacillus spp. and Actinomyces naeslundii (A. naeslundii) in the saliva of nursing home elderly, to assess the correlation between bacterial composition and RC for five putative catiogenic organisms. METHODS: In this study, we collected 43 saliva samples and divided into two groups: the root caries group (RCG, n = 21) an…

Probiotics Reduce Mortality and Morbidity in Preterm, Low-Birth-Weight Infants: A Systematic Review and Network Meta-analysis of Randomized Trials.

BACKGROUND & AIMS: We aimed to compare the effectiveness of single- vs multiple-strain probiotics in a network meta-analysis of randomized t … nfants. Compared with placebo, a combination of 1 or more Lactobacillus species (spp) and 1 or more Bifidobacterium spp was the only intervention with moderate- or high-quality evidence of reduced all-cause mortality (odds ratio [OR], 0.56; 95% confidence interval [CI], 0.39-0.80). Among interventions with moderate- or high-quality evidence for efficacy compared …

[Assessment of species diversity of anaerobic intestinal microbiota in children and adolescents with exogenous constitutional obesity].

The problem of the increasing obesity among children and adolescents is urgent. One of the most interesting and promising directions in this … n between obesity and individual taxa, statistically significant differences were obtained only for Bifidobacterium spp. (p=0.045). The analysis of the correlation between obesity and the isolation of individual microorganisms has shown that Bifidobacterium pseudocatenulatum (p=0.012), Candida albicans (p=0.012), Streptococcus salivarius (p=0.016), Bifidobacteriu …

Probiotics restore GABAergic neurons and attenuate postnatal seizures in periventricular leukomalacia.

Objectives: Postnatal epilepsy often arises after periventricular leukomalacia (PVL) in preterm infants and resists to treatment. Its underl … ic administration. The probiotic formulation included Lactobacillus rhamnosus, Lactobacillus casei, Bifidobacterium bifidum, Bifidobacterium lactis, Bifidobacterium longum and Bifidobacterium breve in galacto-oligosaccharide and Fructooligosaccharides.Results: PVL rats exhibited microgliosis, reduced density of premyelinating oligodendrocytes, and decreased myeli …

Interactions between a pathogenic Blastocystis subtype and gut microbiota: in vitro and in vivo studies.

BACKGROUND: Blastocystis is a common gut eukaryote detected in humans and animals. It has been associated with gastrointestinal disease in the past although recent metagenomic studies also suggest that it is a member of normal microbiota. This study investigates interactions between pathogenic human isolates belonging to Blastocystis subtype 7 (ST7) and bacterial representatives of the gut microbiota. RESULTS: Generally, Blastocystis ST7 exerts a positive effect on the viability of representative gut bacteria except on Bifidobacterium longum. Gene expression analysis and flow cytometry indica…

Роль лактической кислотной бактерии в улучшении поведенческого дефицита, серных уровней витамина D3, B12 и снижении окислительного стресса и демиелиции в модели разложения крысы, вызванной купризоной.

Множественный склероз представляет собой хроническое, подстрекательское и демиелионирующее расстройство, затрагивающее центральную нервную систему, где, по оценкам, в мире насчитывается 2,5 миллиона человек. Появляющиеся исследования подчеркивают значительное влияние микробиота кишечника на иммунную систему, что указывает на потенциальную роль в инициировании и развитии подстрекательских заболеваний. В рамках этого исследования изучалось потенциальное терапевтическое воздействие видов лактобациля и бифидобакерия, изолированных от традиционных молочных продуктов, на демиелинизацию, вызванную ку

Совпадение в аннотации оригинала
Multiple sclerosis constitutes a chronic, inflammatory, and demyelinating disorder affecting the central nervous system, with an estimated g … flammatory diseases. This study investigated the potential therapeutic effects of Lactobacillus and Bifidobacterium species isolated from traditional dairy products on cuprizone-induced demyelination in a rat model. 48 adults male Wistar rats were randomly assigned to six groups. Demyelination was induced by daily oral administration of 0.6% (w/w) cuprizone mixed …

Bifidobacteria and its rice fermented products on diet induced obese mice: analysis of physical status, serum profile and gene expressions.

Obesity is highly correlated with the dysbiosis of intestinal microbiota, and bifidobacteria are one of the soft targets of this metabolic syndrome. The aim of this study is to evaluate the efficacy of Bifidobacterium sp. MKK4 and rice-based fermented foods on physical, haematological, gut microbiota and lypogenic-lypolytic marker genes in diet-induced obese mice. Adult male mice (21±0.7 g) were randomly divided into four groups (n=10) according to the type of diet: normal diet (ND), high fat diet (HFD), HFD supplemented with Bifidobacterium sp. MKK4 and HFD supplemented with MKK4 associated r…

Influence of colonic dialysis using Chinese medicine on creatinine decomposition by intestinal bacteria in uremia rats.

OBJECTIVES: This study aims to investigate influence of colonic dialysis using Chinese medicine on creatinine decomposition by intestinal ba … Histopathological changes of rat kidney were observed by hematoxylin-eosin staining. The numbers of Bifidobacterium, Lactobacillus and E.coli in the intestinal tract were quantitatively determined by real-time fluorescent quantitative PCR with 16S RNA. RESULTS: Compared with sham group, the number of E.coli in the jejunum increased significantly, while that of B …

Fermented milk derived from a novel probiotic strain enhances digestive function and attenuates dextran sulfate sodium-induced colitis via the microbiota-metabolite-immune axis.

Probiotic-fermented dairy products are increasingly recognized for their dual role in nutrient optimization and disease prevention. This study investigated the mechanisms by which Bifidobacterium animalis subsp. lactis Probio-M8 fermented milk enhances digestive efficiency and protects against dextran sulfate sodium-induced colitis in rats. FM8 supplementation promoted weight gain without excessive adipogenesis, elevated leptin levels, and amplified sucrase, lactase, aminopeptidase, and lipase activities, outperforming conventional fermented milk. Metagenomic analysis revealed microbial restru…