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Estimating summary measures of health: a structured workbook approach.

BACKGROUND: Summary measures of health that combine mortality and morbidity into a single indicator are being estimated in the Canadian context for approximately 200 diseases and conditions. To manage the large amount of data and calculations for this many diseases, we have developed a structured workbook system with easy to use tools. We expect this system will be attractive to researchers from other countries or regions of Canada who are interested in estimating the health-adjusted life years (HALYs) lost to premature mortality and year-equivalents lost to reduced functioning, as well as pop

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… life expectancies 2003 Chichester (UK): Wiley 247 261 Peto R Lopez AD Boreham J Thun M Heath C Jr Mortality from tobacco in developed countries: indirect estimation from national vital statistics Lancet 1992 339 1268 78 1349675 10.1016/0140-6736(92)91600-D Jekel JF Katz DL Elmore JG Epidemiology, Biostatistics …

The evolving global landscape of first-in-class oncology drug innovation.

First-in-class (FIC) oncology drugs-defined by their novel mechanisms of action or targeting of previously unaddressed molecular targets-have emerged as a leading force in cancer therapeutic innovation. In this Review, we delineate the global landscape of FIC oncology drug approvals between 2009 and 2024 and analyze the evolving characteristics of both approved FIC therapies and potential FIC (PFIC) candidates in clinical development. To clarify the underlying dynamics of this evolution, we construct an analytic framework encompassing four distinct archetypes of FIC development: new targets, n

Selected abstracts from the XXXVIII National Congress of the Italian Society of Hypertension (SIIA)

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… Ferrante 4 , Stefano Lucreziotti 4 , Stefano Carugo 4 , Maria Grazia Valsecchi 3 , Fabrizio Oliva 5 , Cristina Giannattasio 1,2 1 Cardiology 4, Cardio Center, ASST GOM Niguarda, Milan, Italy, 2 School of Medicine and Surgery, Milano-Bicocca University, Milan, Italy, 3 Bicocca Center of Bioinformatics, Biostatistics … Francesca Spano 2 , Gloria Maria Santambrogio 2 , Francesca Casadei 2 , Antonella Moreo 2 , Maria Grazia Valsecchi 3 , Cristina Giannattasio 1,2 1 Cardiology IV, “A.De Gasperis”, ASTT GOM Niguarda Ca’ Granda, Milan, Italy, 2 University of Milano Bicocca, Milan, Italy, 3 Center for Bioinformatics, Biostatistics …

Response-adapted lenalidomide-dexamethasone (LenDex) intensification after CyBorD induction for transplant-eligible multiple myeloma: the PIANO study.

PURPOSE: Combination therapy with novel agents is the standard initial treatment for transplant-eligible patients with newly diagnosed multiple myeloma. However, the benefit of additional induction therapy for insufficient response remains unclear. This multicenter prospective study investigated response-adapted intensification with lenalidomide and dexamethasone (LenDex) after cyclophosphamide, bortezomib, and dexamethasone (CyBorD) in patients who did not achieve a very good partial response (VGPR) or better, followed by autologous stem cell transplantation (ASCT) and lenalidomide maintenanc

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… All statistical analyses were performed using EZR (Saitama Medical Center, Jichi Medical University, Saitama, Japan), a modified version of R Commander that includes statistical functions frequently used in biostatistics [ 20 ]. …

Work Ability in Patients with Chronic Myeloid Leukemia: A Danish Nationwide Cohort Study.

Background/Objectives: Patients with chronic myeloid leukemia (CML) have a long life expectancy due to modern treatment. However, treatment may have adverse effects that hamper work ability. Methods: Patients aged 25-60 years diagnosed in 2002-2020 were included in this nationwide matched cohort study examining work ability from diagnosis (index date), including the need for permanent disability compensation (flexible job or disability pension). Each patient was matched 1:5 on sex, birth year, and level of comorbidity with citizens from the general Danish population without CML. The risks of r

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… Tutorial in Biostatistics: Competing Risks and Multi-State Models. Stat. Med. 2007;26:2389–2430. doi: 10.1002/sim.2712. 28. Gray R.J. A Class of K-Sample Tests for Comparing the Cumulative Incidence of a Competing Risk. Ann. Stat. 1988;16:1141–1154. doi: 10.1214/aos/1176350951. 29. …

Понятия, полученные из ОРЭ-МЗ: проницаемость кровеносных барьеров в контексте рецидивов MS и метилпреднизолона.

ОКРУЖАЮЩАЯ СРЕДА: Обнаружение множественных рецидивов склероза (MS) по-прежнему сопряжено с трудностями из-за изменчивости симптомов и смешения факторов, таких, как вспышки и инфекции. Метилпреднизолон (МП) используется для серьезных рецидивов, снижая количество контрастных повреждений на МРТ. Константа притока (Ki), вытекающая из динамического противопоказательного MRI (DCE-MRI), маркера проницаемости кровеносного барьера (BBB), продемонстрировала многообещающее значение в качестве предсказателя активности заболеваний в репродукционных MS (RRMS). ЦЕЛИ: Изучение прогнозируемого значения Ki при

Внеклеточная везиклерозовая микроРНК как биомаркер для терапической реакции при множественном склерозе.

Множественный склероз (MS) является основной причиной неврологических расстройств у молодых людей во всем мире. Несмотря на развитие 20 :: медикаментозное лечение (ДМТ), направленное на сокращение масштабов инвалидности; 30% :: пациенты страдают от неудовлетворительного лечения. Таким образом, для повышения эффективности терапевтической деятельности существенно важное значение имеет выявление ранних биомаркеров для терапевтического реагирования. Таким образом, данное исследование направлено на изучение роли распространения внеклеточных везиклах (ЭМ) в качестве ранних биомаркеров клинических па

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… Statistics The statistical analysis was supervised by the Biostatistics Unit of the La Paz University Hospital using Statistical Package for the Social Sciences 23.0 (IBM). …

Functional outcomes of cancer patients in an acute inpatient setting at King Fahad Medical City.

[Purpose] Cancer survivors have functional impairments that adversely affect patients' quality of life (QoL). Acute rehabilitation helps to reduce disability and improves QoL in cancer survivors. This study investigated the potential improvement in mobility levels and QoL of cancer patients during acute inpatient physical therapy (PT) from admission to discharge. [Participants and Methods] This was a cross-sectional study conducted at King Fahad Medical City, Riyadh. Acute inpatient cancer survivors (n=99) were assessed at their admission and discharge. The primary outcome measure was the AM-P

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… In addition, we would thank the biostatistics department in the research center at King Fahad Medical City, for the data analysis and review of the result part. We also wish to thank Dr. Sana Madi and Dr. Balaji for editing the manuscript. Special thanks also go to Dr. …

Machine learning-based identification of co-expressed genes in prostate cancer and CRPC and construction of prognostic models.

The objective of this study was to employ machine learning to identify shared differentially expressed genes (DEGs) in prostate cancer (PCa) initiation and castration resistance, aiming to establish a robust prognostic model and enhance understanding of patient prognosis for personalized treatment strategies. mRNA transcriptome data associated with Castration-Resistant Prostate Cancer (CRPC) were obtained from the GEO database. Differential expression analysis was conducted using the limma R package to compare normal prostate samples with PCa samples, and PCa samples with CRPC samples. Next, w

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… A nonparametric test for the association between longitudinal covariates and censored survival data - PubMed[EB/OL]. [2024-02-25]. https://pubmed.ncbi.nlm.nih.gov/30796830/ . 10.1093/biostatistics/kxz002 30796830 12. …

Artificial intelligence enabled interpretation of ECG images to predict hematopoietic cell transplantation toxicity.

AbstractArtificial intelligence (AI)-enabled interpretation of electrocardiogram (ECG) images (AI-ECGs) can identify patterns predictive of future adverse cardiac events. We hypothesized that such an approach would provide prognostic information for the risk of cardiac complications and mortality in patients undergoing hematopoietic cell transplantation (HCT). We retrospectively subjected ECGs obtained before HCT to an externally trained, deep-learning model designed to predict the risk of atrial fibrillation (AF). Included were 1377 patients (849 autologous [auto] HCT and 528 allogeneic [allo

Multicenter phase 2 study of romidepsin plus lenalidomide for previously untreated peripheral T-cell lymphoma.

Peripheral T-cell lymphomas (PTCLs) are associated with poor prognosis when treated with cytotoxic chemotherapy. We report the findings of a phase 2 study evaluating a chemotherapy-free combination of romidepsin plus lenalidomide as initial treatment for patients with PTCL who were aged >60 years or noncandidates for chemotherapy. Treatment was initiated with romidepsin 10 mg/m2 IV on days 1, 8, and 15 and lenalidomide 25 mg taken orally from days 1 to 21 of 28-day cycle for up to 1 year. The primary objective was overall response rate (ORR). Secondary objectives included safety and survival.

Symptom burden and health-related quality of life impacts of smoldering multiple myeloma: the patient perspective.

Abstract Background Smoldering multiple myeloma (SMM) is an early form of multiple myeloma (MM). SMM is typically considered asymptomatic, and research on how it affects health-related quality of life (HRQoL) is limited. This study assessed the symptoms and HRQoL of patients with SMM and those who progressed from SMM to MM and evaluated the content validity of two patient-reported outcome instruments (EORTC QLQ-C30 and nine items from the EORTC QLQ-MY20) for use in SMM clinical trials. To address these objectives, concept elicitation and cognitive interviews were conducted with SMM patients an

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… Finally, authors would also like to thank members of the Evidera biostatistics and editorial teams for relevant statistical analyses and editorial support. Declaration of funding Janssen Global Services, LLC provided the funding for the study and for the manuscript. …

Phase II trial to investigate the safety and efficacy of orally applied niclosamide in patients with metachronous or sychronous metastases of a colorectal cancer progressing after therapy: the NIKOLO trial.

BackgroundColorectal cancer (CRC) is the second most common cause of all cancer deaths in Europe and the Western world with a lifetime risk of approximately 5%. Despite several improvements in the treatment of patients with unresectable CRC prognosis is poor and there is the need of developing new treatment strategies for patients with metastatic chemorefractory disease. The S100 calcium binding protein A4 (S100A4) predicts metastasis formation and reduced CRC patient survival. S100A4 was previously identified as transcriptional target of the Wnt/β-catenin signaling pathway. The Food and Drug

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… Konrad Neumann: Charité Comprehensive Cancer Center, Invalidenstraße 80, 10117 Berlin, Germany, Department for Biostatistics and Clinical Epidemiology, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, Germany. …

Prognostic role of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with bone metastases.

BackgroundSkeletal metastases are a common problem in patients with cancer, and surgical decision making depends on multiple factors including life expectancy. Identification of new prognostic factors can improve survival estimation and guide healthcare providers in surgical decision making. In this study, we aim to determine the prognostic value of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in patients with bone metastasis.MethodsOne thousand and twelve patients from two tertiary referral centers between 2002 and 2014 met the inclusion criteria. Bivariate and multiv

Prevalence and risk of skeletal complications and use of radiation therapy in elderly women diagnosed with metastatic breast cancer.

OBJECTIVE: Real-world data regarding patient factors associated with the occurrence of spinal cord compression (SCC) or pathological fracture (PF), or need for bone surgery (BS), or use of radiation therapy (RAD) (i.e. skeletal complications and radiation therapy; SCRT) are limited for women with metastatic breast cancer (BCa). Given the substantial clinical and economic burden of these events in advanced BCa, we conducted the present study to understand the prevalence and identify the risk factors associated with these events among elderly women presenting with de novo metastatic BCa. METHOD

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… Tutorial in biostatistics: competing risks and multi-state models. Stat Med. 2007;26(11):2389–430. doi: 10.1002/sim.2712 21. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68(1):7–30. doi: 10.3322/caac.21442 22. …

Совокупное и интерактивное воздействие тяжелых металлов на нейродегенеративные заболевания: сравнительный обзор болезни Альцгеймера, Паркинсона, амиотропического бокового склероза и множественного склероза.

Тяжелые металлы и металллоиды являются стойкими загрязнителями окружающей среды, которые накапливаются в центральной нервной системе и взаимодействуют с местными основными металлами, однако в большинстве нейротоксических исследований металлы по-прежнему рассматриваются как независимые агенты, а не как смешанные смеси. В настоящем обзоре систематически сопоставляются данные о совокупном и интерактивном воздействии смесей тяжелых металлов на четыре основных нейродегенеративных заболевания: болезнь Альцгеймера (AD), болезнь Паркинсона (PD), амиотропический боковой склероз (ALS) и множественный ск

Proceedings of ICIS SGCR-WIRES 2024, held jointly with the 23rd International Cancer Imaging Society Annual Conference, collaborating with the Singapore Radiological Society and College of Radiologists Singapore.

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… of Radiology, Christian Medical College Vellore, India; 2 Department of Gynecological Oncology, Christian Medical College Vellore, India; 3 Department of Pathology, Christian Medical College Vellore, India; 4 Department of Medical Oncology, Christian Medical College Vellore, India; 5 Department of Biostatistics … Chin Ooi 2 , James Thomas Patrick Decourcy Hallinan 1 1 Department of Diagnostic Imaging, National University Hospital, Singapore; 2 Department of Computer Science, School of Computing, National University of Singapore, Singapore; 3 Department of Radiology, Ng Teng Fong General Hospital, Singapore; 4 Biostatistics …

The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability.

BackgroundCancer evolution depends on epigenetic and genetic diversity. Historically, in multiple myeloma (MM), subclonal diversity and tumor evolution have been investigated mostly from a genetic perspective.MethodsHere, we performed an analysis of 42 MM samples from 21 patients by using enhanced reduced representation bisulfite sequencing (eRRBS). We combined several metrics of epigenetic heterogeneity to analyze DNA methylation heterogeneity in MM patients.ResultsWe show that MM is characterized by the continuous accumulation of stochastic methylation at the promoters of development-related

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… sequencing reads to differentially methylated regions Genome Biol 2012 13 10 83 10.1186/gb-2012-13-10-r83 PMC3491411 23034175 37 Korthauer K Chakraborty S Benjamini Y Irizarry RA Detection and accurate false discovery rate control of differentially methylated regions from whole genome bisulfite sequencing Biostatistics … 2018 20 3 367 83 10.1093/biostatistics/kxy007 PMC6587918 29481604 38 Dobin A Davis CA Schlesinger F Drenkow J Zaleski C Jha S Batut P Chaisson M Gingeras TR STAR: ultrafast universal RNA-seq aligner Bioinformatics 2012 29 1 15 21 10.1093/bioinformatics/bts635 23104886 PMC3530905 39 Picard toolkit. …

Measurable residual disease (MRD) as a surrogate end point for clinical drug approval in acute myeloid leukemia (AML): Perspectives from the MRD Partnership and Alliance in AML Clinical Treatment Consortium.

Despite advances in acute myeloid leukemia (AML) treatment, significant unmet medical needs remain. Surrogate end points for overall survival can accelerate the approval of novel therapies. Measurable residual disease (MRD) is a promising surrogate end point candidate, providing a sensitive and quantitative assessment of disease burden. Numerous studies have demonstrated that negative MRD status-across diverse methodologies, assessment timepoints and thresholds, patient subgroups, and clinical settings-independently predicts improved survival. Although MRD can inform therapeutic decisions at t

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… Biostatistics. 2000;1(1):49‐67. doi: 10.1093/biostatistics/1.1.49 24. Chen X, Wood BL. Monitoring minimal residual disease in acute leukemia: technical challenges and interpretive complexities. Blood Rev. 2017;31(2):63‐75. doi: 10.1016/j.blre.2016.09.006 25. U.S. …

2022 NATIONAL CONGRESS OF THE ITALIAN SOCIETY OF HYPERTENSION (SIIA)

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