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The Oral Microbiota May Have Influence on Oral Cancer.

The oral microbiota plays an important role in the human microbiome and human health, and imbalances between microbes and their hosts can le … including Fusobacterium, Alloprevotella and Porphyromonas. At the species level, the abundances of Fusobacterium nucleatum, Prevotella intermedia, Aggregatibacter segnis, Capnocytophaga leadbetteri, Peptostreptococcus stomatis, and another five species were significantly increased, suggesting a potential association between these bacteria and OSCC. Furthermore, the func …

Gut microbiota and diet in colorectal cancer: Converging determinants of carcinogenesis.

Diet and the gut microbiome are major, interdependent determinants of colorectal cancer (CRC) risk. This review discusses current evidence on how dietary patterns reshape microbial ecology, modulate microbial virulence, and alter host metabolic, inflammatory, and oncogenic pathways to influence colorectal carcinogenesis. We highlight key CRC-associated microbes, including pks⁺ Escherichia coli, Fusobacterium nucleatum, enterotoxigenic Bacteroides fragilis, and Streptococcus gallolyticus, and discuss how diet governs their abundance, toxin production, and oncogenic potential. Mechanistic invest…

Re-arming checkpoint blockade in MSS colorectal cancer: A precision-microbiome playbook from mechanisms to clinic.

Immune checkpoint blockade transforms outcomes for the 15% of colorectal cancers (CRCs) with mismatch-repair deficiency; yet most tumours remain refractory. Beneficial gut microbes can change this. Akkermansia muciniphila, Bacteroides fragilis, and short-chain fatty acid producers prime dendritic cells to produce interleukin (IL)-12, polarise Th1 cells, and reinvigorate CD8+ T-cells. Antibiotics, Western-style diets, and Fusobacterium nucleatum foster myeloid suppression and β-catenin- or IL-17-mediated signalling, which blunt checkpoint activity. Multi-omics analyses link biosynthetic genes f…

Intratumoral microbiota in the growth of CRC and lung cancer: Comprehensive insights from etiology to therapy.

The tumor microenvironment (TME) contains a diverse intratumoral microbiota (ITM) governing cancer onset, progression, and therapeutic response. This review compares ITM profiles of colorectal and lung cancer, two anatomically distinct malignancies linked via the gut-lung axis, and summarizes microbial detection strategies ranging from cultivation and sequencing to spatial and single-cell technologies. Oral pathobionts such as Fusobacterium nucleatum, Streptococcus, and Veillonella accumulate in both cancers, promoting tumorigenesis through chronic inflammation, immune evasion, genotoxic insul…

Увязка антимикробного потенциала природных продуктов, полученных из акватических организмов, и микробов, связанных с болезнью Альцгеймера - обзор.

Приводимый ниже обзор ориентирован на микробы, связанные с болезнью Альцгеймера (АБ), и антимикробное воздействие соединений и экстрактов, полученных из водных организмов, на конкретные бактерии, грибы и вирусы, которые ранее были обнаружены у пациентов, страдающих АД. Основная группа микробов, связанных с АД, включает бактерии: хламидиозная пневмония, геликобактотер пилори, порфиромоны ингивалис, нуклеатум Фусобактерия, нуклеатум Превотелла, межмедиа Actimonices naeslundii, спирошетическая группа; грибы: Candida sp., Cryptoccus sp., Saccharomyces sp., Malassezia sp., Botritis sp., и вирусы: г

Совпадение в аннотации оригинала
The following review is oriented towards microbes linked to Alzheimer's disease (AD) and antimicrobial effect of compounds and extracts deri … linked to AD include bacteria: Chlamydia pneumoniae, Helicobacter pylori, Porphyromonas gingivalis, Fusobacterium nucleatum, Prevotella intermedia, Actinomyces naeslundii, spirochete group; fungi: Candida sp., Cryptococcus sp., Saccharomyces sp., Malassezia sp., Botrytis sp., and viruses: herpes simplex virus type 1 (HSV-1), Human cytomegalovirus (CMV), hepatitis C virus …

Development of a multiplex PCR assay and quantification of microbial markers by ddPCR for identification of saliva and vaginal fluid.

The identification of biological fluids at crime scenes contributes to crime scene reconstruction and provides investigative leads. Traditio … ivarius were selected because of high abundance within vaginal fluid and saliva respectively. While Fusobacterium nucleatum and Gardnerella vaginalis, though present in healthy humans, are also frequently found in oral and vaginal infections, respectively. The multiplex PCR assay detected L. crispatus and G. vaginalis in vaginal fluid while F. nucleatum and S. salivarius …

Probiotic intervention modulates volatile sulfur compound-associated pathways and oral microbiome balance in ligature-induced periodontitis rats.

BACKGROUND: Halitosis is driven by volatile sulfur compounds (VSCs) produced by anaerobic oral bacteria and commonly worsens with periodonti … omposition. RESULTS: Complex OK reduced mgl expression and inhibited Streptococcus mutans (98.2%), Fusobacterium nucleatum (91.2%), Porphyromonas gingivalis (99.1%), and Prevotella intermedia (96.6%). High-dose supplementation increased body weight (329.02 ± 14.59 g) and saliva secretion (4.03 ± 2.06 mg), lowered TCI (6.40 ± 2.60), decreased Fusobacterium abundance, red …

Subgingival biodiversity in subjects with uncontrolled type-2 diabetes and chronic periodontitis.

BACKGROUND AND OBJECTIVE: There is a bidirectional relationship between periodontal disease and type-2 diabetes mellitus (DM). Inflammatory … la and Treponema genera than nondiabetic individuals (p < 0.05). Moreover, some phylotypes, such as Fusobacterium nucleatum, Veillonella parvula, V. dispar and Eikenella corrodens were detected significantly more often in diabetic subjects than in nondiabetic subjects (p < 0.05). CONCLUSION: Subjects with uncontrolled type-2 diabetes and chronic periodontitis presented …

Parvimonas micra stimulates expression of gingipains from Porphyromonas gingivalis in multi-species communities.

Dental biofilms are complex ecosystems containing many bacterial species that live in mutualistic relationships. These interactions can profoundly affect the virulence properties of the community. In this study we investigated how the production of gingipains, virulence factors from Porphyromonas gingivalis important in periodontal disease, was affected by other commonly found members of the sub-gingival microbiome. To mimic the subgingival microbiome, multispecies consortia (P. gingivalis, Fusobacterium nucleatum, Actinomyces naeslundii, Streptococus oralis, Streptococcus mitis, Streptococcus…

An in Silico Characterisation of ATP-Binding Cassette Transporter Proteins Across Five Endodontic Pathogens: Implications for Antimicrobial Resistance and Virulence.

AIM: ATP-binding cassette (ABC) transporter proteins play pivotal roles in antimicrobial resistance and bacterial virulence. However, their characterisation across major endodontic pathogens remains limited. This study aimed to characterise ABC transporter proteins in silico across five endodontic pathogens and to investigate their implications for antimicrobial resistance and virulence. METHODOLOGY: Reference genome-predicted proteomes of Enterococcus faecalis, Porphyromonas gingivalis, Fusobacterium nucleatum, Actinomyces naeslundii and Dialister invisus were retrieved from the National Cen…

A Systematic Review and Meta-Analysis of Animal Models on the Possible Link Between Periodontitis and Inflammatory Bowel Diseases.

BACKGROUND: Rapidly evolving evidence, from preclinical and clinical studies, indicates a possible connection between inflammatory bowel dis … cant negative overall effect on body weight, colon length, DAI, and IHA. Among the tested bacteria, Fusobacterium nucleatum had the strongest effect followed by Porphyromonas gingivalis. The results of the remaining interactions and comparisons are inconclusive due to a limited number of studies and differences in study design. CONCLUSIONS: Inoculation with the periodon …

Oral care tablet containing kiwifruit powder affects tongue coating microbiome.

OBJECTIVES: Tongue coating, a kind of biofilm formed on the tongue dorsum, is the cause of various clinical conditions, such as oral halitosis and periodontal diseases, because Fusobacterium nucleatum acts as a bridge between other oral bacteria and periodontopathogenic bacteria in biofilm formation. Our previous clinical study revealed that taking oral care tablets containing kiwifruit powder significantly reduced not only tongue-coating index and volatile sulfur compounds but also total bacteria and F. nucleatum in tongue coating. In this study, we analyzed the microbiome of tongue coating s…

Damage-regulated autophagy modulator 1 in oral inflammation and infection.

OBJECTIVES: Damage-regulated autophagy modulator (DRAM) 1 is a p53 target gene with possible involvement in oral inflammation and infection. This study sought to examine the presence and regulation of DRAM1 in periodontal diseases. MATERIAL AND METHODS: In vitro, human periodontal ligament fibroblasts were exposed to interleukin (IL)-1β and Fusobacterium nucleatum for up to 2 days. The DRAM1 synthesis and its regulation were analyzed by real-time PCR, immunocytochemistry, and ELISA. Expressions of other autophagy-associated genes were also studied by real-time PCR. In vivo, synthesis of DRAM1…

Real-time polymerase chain reaction to determine the prevalence and copy number of epstein-barr virus and cytomegalovirus DNA in subgingival plaque at individual healthy and periodontal disease sites.

BACKGROUND: Detection of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in plaque from patients with periodontal disease provides suppor … patients who had chronic periodontitis were evaluated for the presence and amount of EBV, CMV, and Fusobacterium nucleatum DNA using real-time polymerase chain reaction. Patient serum was evaluated for antibodies against EBV and CMV using enzyme-linked immunosorbent assays. RESULTS: EBV DNA was detected in 18.5% of subgingival plaque samples (72/390) and in at least on …

Porphyromonas gingivalis Bundled Fimbriae Interact with Outer Membrane Vesicles, Commensals and Fibroblasts.

Porphyromonas gingivalis plays a key role in periodontal disease and has been associated with several serious systemic diseases. Its fimbria … ivalis strains (ATCC 49417 and OMI 1127) were investigated in dual-species approaches together with Fusobacterium nucleatum or Streptococcus oralis as well as in co-culture with human gingival fibroblasts (HGFs). To evaluate the role of fimbriae accessory proteins FimCDE, proteomic analysis of outer membrane vesicles (OMVs) was performed. Bundling was confirmed to occur …

Protease Amplification of the Inflammatory Response Induced by Commensal Bacteria: Implications for Racial Disparity in Term and Preterm Birth.

Decidual macrophages secrete proteases that activate protease-activated receptor 1 (PAR-1). We hypothesized that activation of the inflammat … lus crispatus, prevalent in the vaginal microbiome of women of European ancestry, with L. iners and Fusobacterium nucleatum, which are more prevalent in vaginal samples collected from African-American women. Decidual tissue was collected at term not-in-labor (TNL), term labor (TL), spontaneous preterm labor (sPTL), and infected preterm labor (iPTL) and immunostained for …

Experimental evidence supports the abscess theory of development of radicular cysts.

OBJECTIVE: The objective of this study was to experimentally induce inflammatory cysts in an animal model so as to test the hypothesis that … of each animal were trials. Seven days post epithelial cell inoculation; a suspension of 0.2 mL of Fusobacterium nucleatum (10(8) bacteria per mL) was injected into each of the 3 trial cages. Two, 12, and 24 weeks after the inoculation of the bacteria, the cages were taken out, and the tissue contents were fixed and processed by correlative light and transmission electr …

Beta-lactamases in anaerobic, intestinal bacteria: a narrative review.

Anaerobic bacteria in the human intestinal microbiota play a pivotal role in antibiotic resistance, primarily through the production of β-la … rinases to carbapenemases and oxacillinases. Other gut members, including Clostridioides difficile, Fusobacterium nucleatum, and Acidaminococcus fermentans, also encode specific β-lactamases. These enzymes contribute to microbiota resilience following β-lactam exposure and can protect neighboring bacteria via extracellular degradation. This protective mechanism has inspi …

Poly(2-oxazoline) micelles for co-delivery of paclitaxel and metronidazole benzoate for dual chemotherapeutic and antibacterial targeting in the tumor microenvironment.

Tumor-resident pathogenic bacteria can promote cancer progression and reduce chemotherapy efficacy, yet strategies to simultaneously target … ivity against two triple-negative breast cancer (TNBC) cell lines and bactericidal activity against Fusobacterium nucleatum. POx/PTX/MB micelles were well-tolerated at pharmacologically relevant doses in a murine model. This work provides a feasible strategy to integrate antimicrobial therapy with chemotherapy, highlighting the potential of POx micelles as a versatile pl …

The Role of Selected Bacteria in Breast Cancer Initiation and Development.

The breast tissue microbiome is increasingly recognized as a contributor to breast cancer development. Both resident and translocated bacteria can influence carcinogenesis through several mechanisms, including chronic inflammation that promotes DNA damage, bacterial toxins with direct genotoxic effects, and microbial metabolites that alter host physiology-particularly estrogen metabolism via the "estrobolome." Disruptions in microbial balance (dysbiosis) may further increase disease risk. Among the taxa most frequently linked to breast cancer are Fusobacterium nucleatum, Escherichia coli, Bact…