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Национальное Геномическое наблюдение за респираторными аденовирусами человека в 2023 - 2024 годах: свидетельства широкого разнообразия и рекомбинации в России.

Человеческие аденовирусы (HAdVs) распределены по всему миру патогенами, способными вызывать широкий спектр клинических проявлений, особенно острые респираторные инфекции. Однако их геномное разнообразие по-прежнему недостаточно характеризуется наличием значительных географических пробелов в имеющихся данных о последовательности, в том числе по России, где до начала этой работы было сдано лишь несколько полных геномов. В ходе этого исследования мы проанализировали более 1200 PCR-позитивных дыхательных путей, собранных у госпитализированных пациентов в рамках обычных проектов наблюдения и Глобал

Совпадение в аннотации оригинала
Human adenoviruses (HAdVs) are globally distributed pathogens capable of causing a wide range of clinical manifestations, particularly acute respiratory infections. However, their genomic diversity remains insufficiently characterized, with substantial geographic gaps in available sequence data, including for Russia, where only a few complete genomes have be…

Empathetic Reporting Surrounding the Violence Against LGBTIQ+ Activists in Russia (The Case of Dmitry Chizhevsky and Anna Prutskova).

This article serves two interconnected purposes. First, it examines media coverage of the violent attack on LGBTIQ+ activists Dmitry Chizhevsky and Anna Prutskova at the St. Petersburg community center LaSky on 3 November 2013. Two masked assailants entered the center and opened fire, severely injuring Dmitry and wounding Anna. The attack occurred amid heightened public debates surrounding the "gay propaganda" law, which intensified hostility toward LGBTIQ+ individuals. This study critically assesses how Russian media framed the violence, shaping public perception of activists at the forefront…

Characterization of H5N1 avian influenza virus isolated from bird in Russia with the E627K mutation in the PB2 protein.

Currently A(H5Nx) avian influenza viruses are globally widespread and continue to evolve. Since their emergence in 2020 novel highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b reassortant viruses have become predominant in the world and caused multiple infections in mammals. It was shown that some of A(H5N1) viruses mostly isolated from mammals contain an E627K mutation in the PB2 protein which can lead to adaptation of influenza viruses to mammalian cells. In 2023 in Russia we have isolated two highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b viruses from birds one of which con…

Mental Health Stigma and Mental Health Literacy in Russia: Their Prevalence and Associations with Somatic, Anxiety, and Depressive Symptoms.

BACKGROUND: Mental health stigma and mental health literacy can be potential targets of public education and health development. These areas are culturally specific and have so far been almost unexplored in Russia. OBJECTIVE: This study aimed at examining mental health stigma and mental health literacy in Russia, their prevalence, and their associations with somatic, anxiety, and depressive symptoms. DESIGN: The participants were 1,068 Russian adults. They completed the online questionnaire with measures assessing their mental health stigma (Perceived Devaluation and Discrimination Scale; Li…

[In-hospital mortality in acute abdominal diseases in the Central Federal District of Russia depending on availability of laparoscopic procedures].

OBJECTIVE: To study in-hospital mortality in acute abdominal diseases in the Central Federal District and compared effectiveness of laparoscopic and open surgeries. MATERIAL AND METHODS: The study was based on the previous data for 2017-2021. The odds ratio (OR) was used to assess significance of between-group differences. RESULTS: The absolute number of deceased patients with acute abdominal diseases increased significantly and exceeded 23 thousand in the Central Federal District between 2019 and 2021. This value approached 4% for the first time over the last 10 years. In-hospital mortality

Prevalence of depression, anxiety and suicidal ideas and associated factors, in particular sensory impairments, in a population of Bashkortostan in Russia.

To assess prevalence and associated factors of depression, anxiety and suicidal ideas in populations from Russia, we conducted in rural and urban regions in Bashkortostan/Russia two population-based studies (Ural Eye and Medical Study (UEMS), performed from 2015 to 2017; Ural Very Old Study (UVOS), performed from 2017 to 2020) which included participants aged 40 + years and 85 + years, respectively. Depression was assessed using the questionnaire of the Center for Epidemiologic Studies Depression Scale Scoresheet, and anxiety was examined applying the State Trait Inventory Anxiety Test. Suicid…

Spatial patterns of West Nile virus distribution in the Volgograd region of Russia, a territory with long-existing foci.

Southern Russia remains affected by West Nile virus (WNV). In the current study, we identified the spatial determinants of WNV distribution in an area with endemic virus transmission, with special reference to the urban settings, by mapping probable points of human infection acquisition and points of virus detection in mosquitoes, ticks, birds, and mammals during 1999-2016. The suitability of thermal conditions for extrinsic virus replication was assessed based on the approach of degree-day summation and their changes were estimated by linear trend analysis. A generalized linear model was used…

[Coverage of issues of professional malignant neoplasms of the respiratory tract in modern clinical guidelines of the Ministry of Health of Russia].

OBJECTIVE: Analysis and comparison of clinical guidelines (CG) on malignant neoplasms of the respiratory system, placed in the CG rubricator of the Ministry of Health of Russia, for the information they contain on the role of factors and working conditions of the working environment in the etiology of respiratory diseases, including the upper respiratory tract, and comparison this information with published and regularly updated data from the International Agency for Research on Cancer (IARC). MATERIAL AND METHODS: Clinical recommendations from the heading of the Ministry of Health of Russia …

Tapeworms in Rodents from the Lower Anabar River Basin, with a Review of Species Diversity of Cestodes in Yakutia, Russia.

PURPOSE: We aimed to explore the first data on the fauna of cestodes in rodents from the Lower Anabar River Basin situated in extreme north-western Yakutia, Russia and to develop a biological and biogeographical framework for examination of the species diversity of cestodes from Yakutia, which is an important faunal transition zone in the eastern Palaearctic. METHODS: Field inventory of cestodes from rodents was conducted for the first time in the region of north-western Yakutia. Species diversity, intensity and prevalence of infection were assessed. RESULTS: It was noted a rather high (up t…

Daratumumab Monotherapy for Relapsed or Refractory Multiple Myeloma: Results of an Early Access Treatment Protocol in Europe and Russia.

INTRODUCTION: Daratumumab is a human IgGκ monoclonal antibody targeting CD38. Despite the demonstrated benefit of daratumumab in multiple myeloma, not all patients have access to commercially available daratumumab. Here we report a pooled analysis of patients from the UK, Spain, Italy, and Russia enrolled in an open-label, early access treatment protocol (EAP) that provided daratumumab (16 mg/kg) monotherapy to patients with heavily pre-treated relapsed or refractory multiple myeloma (RRMM). METHODS: Intravenous daratumumab 16 mg/kg was administered to patients who had received ≥ 3 prior line…

Unusual congenital polydactyly in mini-pigs from the breeding group of the Institute of Cytology and Genetics (Novosibirsk, Russia).

The article describes a new phenomenon in the breeding group of mini-pigs at the Institute of Cytology and Genetics (ICG, Novosibirsk): polydactyly (extra digits), which is unusual because the additional digits are situated at the lateral surface of legs or at the lateral and medial ones. This anomaly was f irst found here in 2017 in adult animals intended for culling due to incorrect positioning of the legs caused by f lexor tendon laxity and resulting in weight-bearing on the palmar surface of the proximal phalanges ("bear's paw"). Therefore, the polydactyly of mini-pigs has a pronounced neg

[History of the discovery and study of tick-borne encephalitis in Russia: three Far Eastern expeditions (1937-1939)].

The review provides a brief historical outline of the discovery and study of tick-borne encephalitis (TBE) during three expeditions to the Far East (19371939). As a result of the Far Eastern expeditions, the TBE virus was discovered, numerous strains were isolated, a vector-borne transmission pathway was established, the main features of epidemiology, clinic and pathomorphology of the disease were described, serotherapy was tested, first inactivated "brain" vaccine against TBE was developed and its effectiveness was proved. The history of the discovery and study of TBE is marked by the heroism

[Clinical analysis of the short-term and long-term results of the implant-supported Trefoil dental rehabilitation in Russia].

THE AIM OF THE STUDY: Was to presents the first clinical medium-term (18 months) results of implant-supported rehabilitation using this method in Russia, with the special attention paid to the assessment of the patient's quality of life on the GOHAI scale. MATERIALS AND METHODS: The authors performed a clinical and paraclinical examination of 29 patients (20 women and 9 men). The age of the patients ranged from 47 to 88 (average value - 65.45±9.7). We performed a retrospective analysis of all patients operated from June 2017 till March 2019. The patients filled in GOHAI questionnaires about t…

Description of a novel HLA-A allele, HLA-A*03:365, identified in a bone marrow donor from Russia.

The novel allele HLA-A*03:365 showed a single nucleotide difference from A*03:01:01:01 where 135 Alanine is changed to Proline.

Real-world study of efficacy, risk management and reasons for discontinuation of natalizumab for treatment of multiple sclerosis in Russia.

BACKGROUND: NTZ is approved in Russia for the treatment of highly active relapsing remitting multiple sclerosis and is reimbursed via federal budget program. However, no data about NTZ treatment in Russia and the effect of federal reimbursement have been performed so far. OBJECTIVE: To characterize the population of patients receiving natalizumab and assess the efficacy and risk-management plan (RMP) implementation of NTZ therapy in routine clinical practice in Russia. METHODS: We analyzed data for 334 patients, who received at least one infusion of NTZ. Relapse rate, MRI activity, NEDA-3 st…

Ixodid ticks and tick-borne encephalitis virus prevalence in the South Asian part of Russia (Republic of Tuva).

The most significant processes of arbovirus evolution can be expected to occur in the territories where ticks of different species cohabitate and at the boundaries of virus occurrence, where the probability of the appearance of new virus variants is high due to the possible shift in the main vectors and/or vertebrate hosts. One of the most interesting regions in this regard is the Republic of Tuva. Since most of its territory is covered by mountain ranges and intermountain basins, we were able to study the distribution of vectors and viruses in geographically isolated areas at different altitu

[Dietary intake of calcium in pre-school and school children in Russia: main food sources and eating occasions].

It is known that adequate calcium intake determines formation of skeleton and genetic predisposition of its weight and density peak. Optimal … ld income has been analysed. Nationally representative sample of preschool and school age children, Russia National Nutritional Survey, was conducted in all regions of Russia in 2013 by state Federal Statistics Service - Rosstat. Sample size was 22 771 children split in four age groups: 4-6 y.o. (n=7303), 7-8 y.o. (n=4391), 9-10 y.o. (n=4691) and 11-13 y …

[THE SEASON DYNAMICS OF MAIN INDICES OF LIPID AND CARBOHYDRATE METABOLISM IN STUDENTS ABORIGINES AND CAUCASIANS OF THE NORTHERN-EAST OF RUSSIA].

The article presents analysis of main indices of lipid specter and level of glucose in blood of aborigines and Caucasians during winter and … characteristics of lipid and carbohydrate metabolism in aborigines and natives of the North-East of Russia from among Caucasians in102 generation (autochthonic population). The results of biochemical analyses, obtained in various seasons, demonstrated that average values of all analyzed characteristics of lipid profile approximated to lower limit of norm …

Inter-individual and intragenomic variations in the ITS region of Clonorchis sinensis (Trematoda: Opisthorchiidae) from Russia and Vietnam.

Here we examined the intraspecific genetic variability of Clonorchis sinensis from Russia and Vietnam using nuclear DNA sequences (the 5.8S gene and two internal transcribed spacers of the ribosomal cluster). Despite the low level of variability in the ITS1 region, this marker has revealed some features of C. sinensis across multiple geographic regions. The genetic diversity levels for the Russian and Vietnamese populations were similar (0.1 and 0.09%, respectively) but were significantly lower than the C. sinensis from China (0.31%). About half of the sequences of the Chinese (53%) and Korean…