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[Effectiveness and complications of bariatric surgery in the treatment of morbid obesity].

INTRODUCTION AND OBJECTIVES: Bariatric surgery represents an affective therapeutic alternative for patients with morbid obesity refractory t … y in patients with gastric bypass. The most frequently observed digestive complication was diarrhea/steatorrhea in 39.1% of the cases. Sixty-four point two percent of the patients considered the surgery outcome as excellent or very good. CONCLUSION: In patients with morbid obesity, bariatric surgery is a technique by which a great improvement in anthropometr …

Adult coeliac disease in Ireland: a case series.

BACKGROUND: The clinical spectrum of adult coeliac disease (ACD) is varied with limited Irish data. AIMS AND OBJECTIVES: The aim of this study was to analyse the presenting symptoms, associated conditions and complications in a consecutive series of patients with ACD. METHODS: Data were obtained from database on patients with ACD between 1988 and 2004. RESULTS: One hundred and six patients (69F:37M, mean age: 46, range: 23-95 years) were included. The modes of presentation were diarrhoea in 44 patients (45%), weight loss in 41 (42%), anaemia in 37 (38%), abdominal pain in 15 (15%), fatigue

Presence of SPINK-1 variant alters the course of chronic pancreatitis.

BACKGROUND AND AIMS: There is growing evidence that genetic mutations/variants increase susceptibility to the development and progression of … luded frequency and severity of pain episodes, presence of exocrine failure (defined by presence of steatorrhea and/or fecal elastase < 200 ug/g), and diabetes. The genetic tests included the cationic trypsinogen gene-1 mutation, cystic fibrosis gene mutations (Genzyme assay), and the SPINK-1/N34S mutation. RESULTS: Of the 239 patients with CP, 13 (5.4%) wer …

Celiac symptoms in patients with fibromyalgia: a cross-sectional study.

Fibromyalgia is a chronic pain syndrome associated with numerous somatic symptoms including gastrointestinal manifestations of nonspecific nature. Celiac disease and nongluten sensitivity frequently evolve in adults with gastrointestinal and extraintestinal symptoms similar to those found among patients with fibromyalgia. The objective of the present study was to evaluate the presence of celiac-type symptoms among patients with fibromyalgia in comparison with healthy subjects and with those experienced by adult celiac patients and subjects with gluten sensitivity. A list of typical celiac-type

Diagnosis and management of chronic pancreatitis: current knowledge.

This paper reviews the current literature on chronic pancreatitis (CP). Despite marked progress in diagnostic tools, predominately imaging m … esis appears valid both in uncomplicated alcoholic and nonalcoholic late-stage CP. For treatment of steatorrhea and diabetes the reader is referred to recent reviews. Mortality and survival are closely related to aetiology with an increased death rate of about 50% within 20 years from onset in alcoholic CP compared to a markedly better prognosis in hereditary …

Comprehensive Outcomes of the Frey Procedure: A Single-center Perspective.

INTRODUCTION: Chronic pancreatitis is a severe, ongoing inflammation of the pancreas, characterized by significant abdominal pain and defici … , quality of life using the SF-6 questionnaire, and nutritional status, considering factors such as steatorrhea, glycemic control, and weight gain. RESULTS: The total number of patients enrolled was 52. Four patients were identified intraoperatively as having malignancy by frozen section and were therefore converted to the Whipple procedure. Therefore, 48 pa …

AGA Clinical Practice Update on Small Intestinal Bacterial Overgrowth: Expert Review.

DESCRIPTION: Thanks to ready access to hydrogen breath testing, small intestinal bacterial overgrowth (SIBO) is now commonly diagnosed among … 2: Symptoms traditionally linked to SIBO include bloating, diarrhea, and abdominal pain/discomfort. Steatorrhea may be seen in more severe cases. BEST PRACTICE ADVICE 3: There is insufficient evidence to support the use of inflammatory markers, such as fecal calprotectin to detect SIBO. BEST PRACTICE ADVICE 4: Laboratory findings can include elevated folate a …

Celiac Disease Spectrum Among Patients With Iron Deficiency Anemia: A Retrospective Study From a Tertiary Care Center in Morocco.

Background Celiac disease is a chronic immune-mediated enteropathy triggered by gluten in genetically susceptible individuals. Its presentat … inal discomfort was the most frequent digestive symptom (83.3%). Weight loss, chronic diarrhea, and steatorrhea were reported in 66.6%, 44.4%, and 27.7% of patients, respectively. Extra-intestinal manifestations included arthralgia (38.9%), bone pain (27.7%), oral aphthous ulcers (11.1%), amenorrhea (22.2%), and recurrent miscarriage (16.7%). Mean hemoglobin …

Long-term outcome after resection for chronic pancreatitis in 224 patients.

INTRODUCTION: Organ complications like biliary or duodenal stenosis as well as intractable pain are current indications for surgery in patie … p (f/up) data were prospectively documented. Exocrine insufficiency was regarded as the presence of steatorrhea and/or the need for oral enzyme supplementation. Multivariate analysis was performed using binary logistic regression. RESULTS: Perioperative surgical morbidity was 28% and did not differ between the types of resection. At last f/up 87% of the pati …

Biallelic deletion in a minimal CAPN15 intron in siblings with a recognizable syndrome of congenital malformations and developmental delay.

Calpainopathies constitute a heterogeneous group of disorders resulting from deficiencies in calpains, calcium-specific proteases that modulate substrates by limited proteolysis. Clinical manifestations depend on tissue-specific expression of the defective calpain and substrate specificity. CAPN15, encoding the Drosophila small optic lobes (sol) homolog, was recently found to cause various eye defects in individuals carrying bi-allelic missense variants. Here we report on two siblings with manifestations reminiscent of Johanson-Blizzard syndrome including failure to thrive, microcephaly, globa

Chronic pancreatitis.

Chronic pancreatitis is a progressive fibroinflammatory disease that exists in large-duct (often with intraductal calculi) or small-duct form. In many patients this disease results from a complex mix of environmental (eg, alcohol, cigarettes, and occupational chemicals) and genetic factors (eg, mutation in a trypsin-controlling gene or the cystic fibrosis transmembrane conductance regulator); a few patients have hereditary or autoimmune disease. Pain in the form of recurrent attacks of pancreatitis (representing paralysis of apical exocytosis in acinar cells) or constant and disabling pain is

[Clinical effect of minimally invasive duodenum preserving pancreatic head resection for benign and pre-malignant lesions of pancreatic head].

Objective: To examine the clinical effect of minimally invasive duodenum preserving pancreatic head resection(DPPHR) for benign and pre-mali … se (NAFLD) was complicated in 2 and 1 patient,respectively,with the supplement of pancreatic enzyme,steatorrhea and weight loss relieved,but NAFLD was awaited to be seen. Conclusions: Minimally invasive DPPHR is feasible and safe for benign or pre-malignant lesions of pancreatic head. Moreover,it is oncological equivalent to pancreaticoduodenectomy with prese …

RETICULUM CELL SARCOMA OF THE SMALL BOWEL AND STEATORRHOEA.

This series presents further evidence for an association between reticulosis of the intestine and steatorrhoea. Although some patients have a definite past history of gluten enteropathy, it seems likely that in certain patients the reticulosis itself is the primary cause of the steatorrhoea.

[Clinical practice guidelines of the Team of Experts of the Polish Gynecological Society: management of the intrahepatic cholestasis of pregnancy].

Intrahepatic Cholestasis of Pregnancy (ICP) constitutes the most common, reversible liver disease closely connected with pregnancy and spont … oms of ICP include: pruritus without skin rash (usually after 30 weeks of gestation), mild icterus, steatorrhea etc. Abnormalities in the laboratory tests of the LFT (liver function tests) encompass: an increase in the serum concentration of fatty acids (BA) which can be the first and only laboratory abnormality. Concentrations surpassing 10 micromol/l are co …

Pancreatic Malnutrition in Children.

Exocrine pancreatic insufficiency in children can lead to lifelong complications related to malnutrition and poor growth. The clinical presentation can be subtle in the early stages of insufficiency as the large functional capacity of the pancreas is gradually lost. The pediatrician plays a crucial role in the early identification of these children to ensure a timely referral so that a diagnosis can be made and therapy initiated. Early nutritional therapy allows for prevention and correction of deficiencies, which leads to improved outcomes and survival. When insufficiency is suspected, the wo

Acute Pancreatitis: Genetic Risk and Clinical Implications.

Acute pancreatitis (AP) is one of the most common gastroenterological indications for emergency admittance and hospitalization. Gallstones, alcohol consumption or the presence of additional initiating factors give rise to a disease with a diverse clinical appearance and a hard-to predict course of progression. One major challenge in the treatment of AP patients is the early identification of patients at risk for the development of systemic complications and organ failure. In addition, 20%-30% of patients with a first episode of AP later experience progress to recurrent or chronic disease. Comp

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… General symptoms like abdominal pain (quality, frequency, intensity, need of analgesia), weight loss and stool behavior (quality, frequency, steatorrhea) should be recorded. The pathognomonic symptom for pancreatitis is belt-like abdominal pain. … Lipoprotein lipase mutation S447X associated with pancreatic calcification and steatorrhea in hyperlipidemic pancreatitis. J. Clin. Gastroenterol. 2009;43:591–596. doi: 10.1097/MCG.0b013e3181734a30. 37. Melitas C., Meiselman M. …

Computed tomography-based conventional imaging features and texture analysis characteristics of chemotherapy drug-related acute pancreatitis.

PurposeChemotherapy drug-related acute pancreatitis (CDRAP) is a rare adverse event that poses significant challenges to clinicians. This study aimed to describe plain computed tomography (CT)- and contrast-enhanced computed tomography (CECT)-based conventional imaging features and texture analysis characteristics of CDRAP.MethodsA total of 62 patients with initial clinical and/or biochemical evidence of pancreatitis and 34 patients with normal pancreatic manifestations who underwent CT during chemotherapy were retrospectively included. The diagnosis of CDRAP was established based on clinical,

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… pancreatitis, days | 181.33 ± 179.70 Time from the onset of clinically suspected acute pancreatitis to CT examination, hours | 66.33 ± 60.72 Following the resolution of pancreatic development, n (%) Pseudocyst | 10 (16.13) Pancreatic atrophy | 21 (33.87) Pancreatic exocrine dysfunction (diarrhea or steatorrhea … A total of 21 (33.87%) patients developed pancreatic atrophy, 4 patients developed pancreatic exocrine dysfunction, 2 patients presented with diarrhea, and 2 patients presented with both diarrhea and steatorrhea. …

Amyloidosis for the Gastroenterologist: A Comprehensive Systematic Review of Diagnosis and Management of Gastrointestinal Manifestations.

BackgroundAmyloidosis is a rare, multisystem disorder characterized by extracellular deposition of misfolded protein fibrils. Gastrointestinal (GI) amyloidosis is uncommon but under-recognized due to nonspecific symptoms, but early diagnosis is critical to improve quality of life and prognosis. This comprehensive systematic review aimed to summarize current literature on GI and hepatic manifestations of amyloidosis, highlighting diagnostic and management strategies across the major subtypes of amyloidosis, in particular AL (immunoglobulin light chain), ATTR (transthyretin), and AA (serum amylo

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… Occasionally, some individuals can present with steatorrhea (< 5%). Predominant physical findings are weight loss and hypotension or orthostatic changes [ 24 ]. … Diarrhea can result from rapid intestinal transit or bacterial overgrowth, leading to secondary malabsorption of proteins, bile acids, and fats, with consequent steatorrhea and weight loss [ 49 ]. …

Light-Chain Amyloidosis: The Great Impostor.

Light-chain amyloidosis (AL) is a disease of protean manifestations due to a wide spectrum of organs that can be affected. The disorder is caused by the deposition of an extracellular amorphous material, the amyloid, which is produced by malignant plasma cells. The latter usually reside in the bone marrow; plasma cell infiltration is often low, in sharp contrast to what we observe in multiple myeloma. The disease may run below the physician's radar for a while before clinical suspicion is raised and targeted tests are performed. In this short review, we try to answer most of the questions that

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… Patients might present with GI bleeding, signs and symptoms of malabsorption (weight loss, diarrhea, and steatorrhea) [ 24 ], and protein-losing gastroenteropathy with excessive hypoalbuminemia [ 25 ]; more mild cases present with symptoms of chronic dysmotility such as constipation and/or diarrhea, …