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Интракорпоральное состояние как фактор риска для дисфагии в небольничных пожилых людях: обновленный систематический обзор.

В соответствии с руководящими принципами PRISMA был проведен систематический поиск по базам данных PubMed, Scopus и Cochrane для проведения первоначальных исследований, опубликованных в период с 2015 по 2025 год. В рамках критериев интеграции основное внимание уделялось исследованиям по предметам в возрасте 65 лет и старше, в ходе которых изучалась взаимосвязь между состоянием перорального здоровья и УВ. Методологическое качество оценивалось с использованием контрольного перечня критических оценок ЯБК. Методы анализа и критерии включения были задокументированы в протоколе, опубликованном в Пер

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… Poor dentition, including tooth loss and ill‐fitting dentures, can significantly impair oral motor function, affecting mastication, bolus manipulation, and oral transit time [ 3 , 4 , 7 , 8 , 9 ]. … Conclusion Poor dentition and reduced salivary flow is linked to the ability to adequately prepare the food bolus for swallowing. Effective bolus preparation, involving mastication and the mixing of food with saliva, is a critical step for safe swallowing. …

Oral toxicity produced by chemotherapy: A systematic review.

IntroductionAntineoplastic chemotherapy remains one of the most widely used management strategies in cancer, either alone or in combination with other types of treatment. The main inconvenience of chemotherapy is its lack of selectivity, since it acts upon both tumor cells and rapidly multiplying normal cells such as bone marrow cells, hair follicle cells and oral and gastrointestinal mucosal cells.Material and methodAn exhaustive search was made of the main oral toxic effects of chemotherapy in the PubMed-Medline, Cochrane Library and Scopus databases. A total of 1293 articles were identified

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… •Crown and root morphology The shape and size of the crown in the temporal dentition are not affected, since crown morphology is determined before birth. … However, in the case of the permanent dentition, we can observe macrodontia with a prevalence of 2.2-5.2%, due to the action of certain chemotherapeutic drugs such as vinblastine and vincristine upon the mature odontoblasts and ameloblasts ( 17 ). …

Oral complications and management strategies for patients undergoing cancer therapy.

With cancer survival rate climbing up over the past three decades, quality of life for cancer patients has become an issue of major concern. Oral health plays an important part in one's overall quality of life. However, oral health status can be severely hampered by side effects of cancer therapies including surgery, chemotherapy, radiotherapy, and hematopoietic stem cell transplantation. Moreover, prevention and treatment of these complications are often overlooked in clinical practice. The present paper aims at drawing health care professionals' attention to oral complications associated wit

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… Although literature has shown that the oral health status in most cancer patients mirrors those of the general population, poorly restored dentition, moderate to advanced periodontal disease, and other pathologies associated with negligence of oral health care, the many oral complications as sequelae … Appropriate prosthetic and functional rehabilitation, which entails the reestablishment of a functional maxillomandibular complex providing for an adequate dentition for mastication with underlying bone support for facial features and soft tissue for the restoration of speech and swallowing, served as …

Periodontal inflamed surface area in oral cavity associated with febrile neutropenia in patients with hematologic malignancy undergoing chemotherapy.

Febrile neutropenia (FN) is an infectious complication that develops during chemotherapy. Although the oral cavity can be an important infection route, it is unknown whether the oral environment is associated with FN. The present study examined the relationship between the oral environment using periodontal inflamed surface area (PISA), a new periodontal disease parameter, and FN in hematologic cancer patients undergoing chemotherapy. In this retrospective cohort study, 157 patients were divided into FN onset during chemotherapy (n = 75) and the FN negative groups (n = 82). The associations of

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… This evaluation method uses the sum of probing pocket depth of bleeding on probing (BOP)-positive sites for the complete dentition for determining the present inflammatory burden in individuals with periodontal disease 11 . … PISA is based on the amount of probing pocket depth of sites with bleeding among the total dentition, whereas PESA is the total amount of surface area of the periodontal pocket. …

Emerging, personalized, and minimally invasive technologies for periodontal and peri-implant soft and hard tissue regenerative therapy.

BACKGROUND: Regenerative therapies have become central to periodontics and implant dentistry and are becoming more widely applied to reconst … l of 2952 teeth), and 24 assessed MT around implants (851 implants). The analysis of GT for natural dentition showed that bilaminar approaches with any of the explored soft tissue grafts (connective tissue graft (CTG), human acellular dermal matrix (hADM), first generation collagen matrix (CMX), "volume stable" collagen matrix (VCMX) yield a statistically s …

Mandibular advancement device vs. CPAP in the treatment of obstructive sleep apnea: are they equally effective in Short term health outcomes?

QUESTION: Is the treatment of obstructive sleep apnea (OSA) with mandibular advancement device (MAD) similar in health outcomes to continuou … ase, and any contraindication for oral appliance therapy (e.g., periodontal disease or insufficient dentition). INTERVENTION: Patients meeting eligibility criteria were randomized to a 4-6 week each, acclimatization to CPAP and MAD. A 2 week wash out period was then followed by initial assignment to CPAP or MAD treatment and subsequent cross over. During e …

Electrical conductance for the detection of dental caries.

BACKGROUND: Caries is one of the most prevalent, preventable conditions worldwide. A wide variety of management options are available at dif … hrough meta-regression we observed no meaningful difference in accuracy according to device type or dentition. Due to the small number of studies we were unable to formally investigate other potential sources of heterogeneity. We judged the certainty of the evidence as very low, and downgraded for risk of bias due to limitations in the design and conduct of …

A Study of Oral Health Parameters and the Properties and Composition of Saliva in Oncological Patients with and without Medication-Related Osteonecrosis of the Jaw Who Take Bisphosphonates.

Background and Objectives: The aim of this study was to examine how the status of the oral cavity, composition and properties of saliva change in oncological patients with and without Medication-Related Osteonecrosis of the Jaw (MRONJ) undergoing bisphosphonate therapy. Materials and Methods: A retrospective case-control study of 49 oncological patients using bisphosphonates (BPs) was conducted. The study population was divided into two groups-Group I consisted of 29 patients with MRONJ and Group II of 20 patients without MRONJ. The control group consisted of 32 persons without oncological his

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… Each participant underwent a standard dental examination, taking into account the condition of the dentition (number of retained teeth, number of teeth with caries—DT, number of teeth with fillings—FT), oral hygiene (Approximal Plaque Index), periodontal status (Bleeding on Probing). … MRONJ in Subjects Taking BPs | At Risk | Stage 0 | Stage 1 | Stage 2 | Stage 3 Group I n = 29 (100%) | 0 (0.0%) | 0 (0.0%) | 6 (20.7%) | 17 (58.6%) | 6 (20.7%) Group II n = 20 (100%) | 20 (100%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) Table 5 presents the results concerning the condition of the dentition …

Adult hypophosphatasia treated with reduced frequency of teriparatide dosing.

We report a 41-year-old man diagnosed with the adult form of hypophosphatasia (HPP) and treated for 4 years with less frequent than conventional daily doses of teriparatide (TPTD). He presented with a history of three low-energy fractures and low bone mineral density (BMD) ineffectively treated with bisphosphonate. We identified within ALPL, the gene that encodes the homodimeric "tissue-nonspecific" isoenzyme of alkaline phosphatase (ALP) and underlies HPP, a heterozygous missense mutation (c.455 G>A→R135H). Characteristic painful periarticular calcification removed at a shoulder did not recur

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… The dentition may also be defective[ 1 , 2 ]. Bone mineral density (BMD) can be low, normal, or high in adult HPP[ 5 ]. Calcific periarthritis may occur, featuring deposition of hydroxyapatite around major joints[ 6 ], and chondrocalcinosis is often prominent. …

Hypophosphatasia.

Hypophosphatasia (HPP) is an inherited metabolic disease caused by loss-of-function mutations in the tissue non-specific alkaline phosphatase (TNAP) gene. Reduced activity of TNAP leads to the accumulation of its substrates, mainly inorganic pyrophosphate and pyridoxal-5'-phosphate, metabolic aberrations that largely explain the musculoskeletal and systemic features of the disease. More than 400 ALPL mutations, mostly missense, are reported to date, transmitted by either autosomal dominant or recessive mode. Severe disease is rare, with incidence ranging from 1:100,000 to 1:300,000 live births

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… Dentition is also affected in adult HPP: early loss of adult teeth is a common feature (25–35%) [ 43 , 44 ]. However, some patients may have experienced a premature loss of their deciduous teeth with intact roots, long before the diagnosis of adult HPP [ 42 , 46 ]. … Primary dentition is more sensitive to low ALP function, and this is important, as premature tooth loss can affect nutrition and speech. The poorly mineralized cementum leads to decreased tooth root anchorage to the periodontal ligament. …

Reducing diagnostic delay in hypophosphatasia: a case series of 14 patients presenting to general rheumatology.

OBJECTIVES: Hypophosphatasia (HPP) is a rare genetic metabolic bone disease that can cause chronic pain and fractures. Its hallmark is a persistently low serum ALP. HPP is now recognised by many osteoporosis specialists, but other specialists, such as rheumatologists and primary care physicians, may be less aware of this condition, causing diagnostic delay and possible harm to these patients. Our objective was to highlight features that can reduce this delay. METHODS: We retrospectively analysed 14 patients that presented with musculoskeletal pain to general rheumatology clinic at St. George'

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… Relevant dental disease occurred in 11 patients (78.6%), in 5, it affected primary dentition. It included premature tooth removal/loss (50%), fillings (29%), tooth decay (14%), gum disease (7%), and jaw displacement (7%). …

Systematic Review of Case Reports and Case Series Published Between 2015 and 2025 on the Use of Biomaterials for Closure of Oroantral Fistula.

Oroantral fistulas (OAFs) challenge the clinical decision-making of oral surgeons, requiring selection of an effective biomaterial for successful closure. This systematic review aims to evaluate recent biomaterials and techniques for closing oroantral fistulas, as reported in case reports and series. The goal of this review was to assess how different biomaterials affect the clinical closure of OAFs and oroantral communication. This systematic review followed PRISMA guidelines. Multiple scientific databases (Scopus, Web of Science, Cochrane Library) were comprehensively searched using relevant

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… The maxillary posterior dentition was the primary site of OAFs, and specific tooth numbers were identified in most cases. …

The preterm child in dentistry. Behavioural aspects and oral health.

BACKGROUND: Advancements in medical care have enabled more children born preterm to survive and develop as healthy individuals alongside the … s prevalence, there were no differences between the group in either the primary or in the permanent dentition. In contrast, PT had more medical health problems, persisting from preschool period in adolescence than C. The results in this thesis indicate more behavioural problems related to dental treatment and more oral health problems in PT than in C. There …

Периодическое заболевание и нейроинфламмация при множественном склерозе: систематический обзор текущих данных.

Множественный склероз (MS) — хроническое, иммунопосредованное неврологическое расстройство, характеризующееся обезвоживанием и нейродегенерацией. Появляющиеся данные свидетельствуют о наличии связи между MS и периодонтальными заболеваниями (PD) через общие иммуновоспалительные пути. В ходе этого обзора оценивается связь между периодонтальными заболеваниями и множественным склерозом с уделением особого внимания взаимодействию между иммунной и воспалением и клинической корреляции. Несмотря на появляющиеся данные, прочность связей остается неясной из-за методологической неоднородности. AIM: Обзор

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… PD is an inflammatory condition that weakens the teeth and their supporting tissues, culminating in loss of dentition. The disease is therefore a result of a multifactorial etiology that influences changes in the pathogenesis. …

A randomized controlled trial of manual versus powered tooth brushing during haematopoietic stem cell transplantation.

AimTo compare manual and powered tooth brushing (MT and PT) with respect to patient compliance to brushing frequency advice, plaque removal and severity of oral mucositis (OM) in patients undergoing hematopoietic stem cell transplantation (HSCT) after high-dose chemotherapy.Materials & methodsA randomized controlled trial was conducted. Forty-six patients scheduled to receive myeloablative conditioning regimen before autologous HSCT were included and randomly assigned to control (MT, n = 23) or test (PT, n = 23) groups. Starting at day 1 (day of hospital admission for HSCT), brushing frequency

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… The DPSI is measured using complete periodontal probing and is determined by the maximum score of each of 6 sextants of the dentition. …

Chronic granulomatous disease secondary to a rare compound heterozygote mutation in an adolescent cured by hematopoietic stem cell transplantation: a case report.

BackgroundChronic granulomatous disease (CGD) is a rare inherited primary immunodeficiency characterized by recurrent infections and aberrant inflammation due to defects in the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex.Case presentationWe report a case of recurrent pneumonia and significantly elevated IgE levels in an adolescent. Metagenomic next-generation (mNGS) sequencing contributed to the identification of Burkholderia multivorans in bronchoalveolar lavage fluid and the initiation of appropriate treatment. Whole exome sequencing (WES) revealed two point mutations

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… Hyper IgE syndrome (HIES) typically presents with elevated serum IgE, eczematous rash, recurrent pneumonia, and characteristic dysmorphic features such as red-hair, retained primary dentition, a high-arched palate, and recurrent oral candidiasis ( 20 ). …

Fluorescence devices for the detection of dental caries.

BACKGROUND: Caries is one of the most prevalent and preventable conditions worldwide. If identified early enough then non-invasive technique … was substantial variability in the results which could not be explained by the different devices or dentition or other sources of heterogeneity that we investigated. The diagnostic odds ratio (DOR) was 14.12 (95% CI 11.17 to 17.84). The estimated sensitivity, at a fixed median specificity of 0.78, was 0.70 (95% CI 0.64 to 0.75). In a hypothetical cohort of …

Improvement of Quality of Life after Surgical Treatment of Patients with MRONJ: A Prospective Analysis Using the SF-12 and OHIP-14 Questionnaires.

BACKGROUND: Medication-related osteonecrosis of the jaw (MRONJ) is a rare, serious, and debilitating disease of unknown cause that can be associated with significant health-related quality of life (HRQOL) impairment. Hematological disease is characterized by a nonhealing exposed jawbone in patients with a history of antiresorptive or antiangiogenic agent use without radiation exposure to the head or neck. Patients and Materials and Methods. This prospective study over the period from May 2020 to December 2021 included a representative sample consisting of 27 patients with at least stage 2 MRON

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… Mental Health (MH) | 9 + 11 7 | Vitality (VT) | 10 8 | Social Functioning (SF) | 12 The OHIP-14 questionnaire, which has also been validated, contains 14 questions on oral health-related quality of life (OHRQOL) and a supplementary question to classify patients according to the prosthetic care of their dentition …

Patients' quality of life improves after surgical intervention of stage III medication-related osteonecrosis of the jaw.

PURPOSE: The treatment of advanced stages of medication-related osteonecrosis of the jaw (MRONJ) remains challenging. In order to improve decision making concerning the therapy, we examined the change of patients' quality of life (QoL) after surgical treatment of MRONJ stage III. METHOD: The primary outcome variable was patients' QoL. It was preoperative (T0), 6 weeks postoperative (T1) and 6 months postoperative (T2) assessed by the European Organisation for Research and Treatment of Cancer QoL-H&N35 (EORTC QoL-H&N35) and the Oral Health Impact Factor-G14 (OHIP-G14) questionnaire in a prospe

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… This uncomfortable feeling in combination with insufficient dentition or bad/non fitting denture due to MRONJ led to “troubles with social eating” and even “troubles with social contact.” Surgery helped to overcome these difficulties in patients’ every day social life. …

Proteomic and transcriptomic analyses to explain the pleiotropic effects of Ankaferd blood stopper.

Ankaferd blood stopper is a standardized mixture of the plants Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, and Urtica dioica and has been used as a topical hemostatic agent and with its clinical application established in randomized controlled trials and case reports. Ankaferd has been successfully used in gastrointestinal endobronchial mucosal and cutaneous bleedings and also in abdominal, thoracic, dental and oropharyngeal, and pelvic surgeries. Ankaferd's hemostatic action is thought to form a protein complex with coagulation factors that facilitate adhesion of

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… bleeding without causing an increase in hemostasis-related complications Pamuk et al. 20 | 2015 | 15 | Prospective, randomized clinical study | Patients with chronic periodontitis | Following the initial periodontal therapy, patients were randomly assigned to two treatments in contralateral areas of the dentition …