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Continuous support for women during childbirth.

BACKGROUND: Historically, women have generally been attended and supported by other women during labour. However, in hospitals worldwide, continuous support during labour has often become the exception rather than the routine. OBJECTIVES: The primary objective was to assess the effects, on women and their babies, of continuous, one-to-one intrapartum support compared with usual care, in any setting. Secondary objectives were to determine whether the effects of continuous support are influenced by:1. Routine practices and policies in the birth environment that may affect a woman's autonomy, fr

Tatami Mats: A Source of Pitted Keratolysis in a Martial Arts Athlete?

Dear Editor, Pitted keratolysis (PK), also known as keratosis plantaris sulcatum, is a non-inflammatory, bacterial, superficial cutaneous infection, characterized by many discrete superficial crateriform ''pits'' and erosions in the thickly keratinized skin of the weight-bearing regions of the soles of the feet (1). The disease often goes unnoticed by the patient, but when it is noticed it is because of the unbearable malodor and hyperhidrosis of the feet, which are socially unacceptable and cause great anxiety to many of the patients. PK occurs worldwide, with the incidence rates varying base

Hail Lifestyle Medicine consensus position statement as a medical specialty: Middle Eastern perspective.

BACKGROUND AND IMPORTANCE: Lifestyle choices and practices are often the primary contributors to most preventable chronic diseases encountered in both outpatient and inpatient settings worldwide. Lifestyle medicine (LM) therapeutic interventions have consistently been shown through numerous scientific studies to improve and, in many cases, reverse chronic diseases. Globally, there is widespread acceptance of the 15 core competencies, 6 pillars, and the overarching definition of Lifestyle Medicine (LM) established by the American College of Lifestyle Medicine and its partners. While these 6 pil

[Chinese expert consensus on the diagnosis and treatment of pneumoconiosis complicated with tuberculosis].

Pneumoconiosis complicated with pulmonary tuberculosis is characterized by high prevalence and disability rates, as well as difficulty in early diagnosis, constituting a serious public health problem. The Chinese Society of Tuberculosis (Chinese Medical Association) and the Society of Labor Hygiene and Occupational Diseases (Chinese Preventive Medicine Association) organized multidisciplinary experts in respiratory diseases, occupational diseases, tuberculosis and other related fields to formulate the Chinese expert consensus on the diagnosis and treatment of pneumoconiosis complicated with tu

Decompressive craniectomy for the treatment of high intracranial pressure in closed traumatic brain injury.

BACKGROUND: High intracranial pressure (ICP) is the most frequent cause of death and disability after severe traumatic brain injury (TBI). It is usually treated with general maneuvers (normothermia, sedation, etc.) and a set of first-line therapeutic measures (moderate hypocapnia, mannitol, etc.). When these measures fail, second-line therapies are initiated, which include: barbiturates, hyperventilation, moderate hypothermia, or removal of a variable amount of skull bone (secondary decompressive craniectomy). OBJECTIVES: To assess the effects of secondary decompressive craniectomy (DC) on ou

Paroxetine : a review of its pharmacology and therapeutic potential in the management of panic disorder.

SYNOPSIS: Paroxetine is the first selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor (SSRI) to be approved for the treatment of patients with panic disorder with or without agoraphobia. It is a highly selective inhibitor of presynaptic serotonin reuptake and does not interact with adrenergic, dopaminergic, histaminergic or serotonergic receptors to any significant extent. Oral paroxetine 10 to 60 mg/day is significantly more effective than placebo in reducing the frequency of panic attacks and improving associated symptoms, as shown in short term trials in patients with panic d

Do's and Don'ts of Taking Care of Deaf Patients.

AUDIENCE: Emergency medicine residents, fellows, and attending physicians, any practicing provider in a medical setting that may serve Deaf patients. INTRODUCTION: Emergency medicine providers often interact with Deaf and Hard of Hearing (DHH, or just HOH, for only hard of hearing) patients. Various limitations, however, affect their ability to effectively engage with DHH patients such as acuity, lack of time, and/or readily available communication tools (eg. virtual or in-person interpreters), among other challenges. These barriers contribute to numerous DHH healthcare disparities. Estimatin

The effectiveness of web-based programs on the reduction of childhood obesity in school-aged children: A systematic review.

REVIEW OBJECTIVE: The objective of this review is to synthesise the best available evidence on the effectiveness of web-based programs on the reduction of childhood obesity in school age children. BACKGROUND: Childhood obesity is one of the most serious public health challenges of the 21st century. The problem is global and is steadily affecting many low- and middle-income countries, particularly in urban settings.[1] The prevalence has increased at an alarming rate globally.[2] The International Association for the Study of Obesity; estimates that up to 200 million school aged children are e

Структурный анализ процесса сбора света с помощью антенн, содержащих родопсины в морской архееи Асгарда.

Акватические бактериальные редопсиновые протонные насосы собирают световую энергию для фотогетертрофного роста и, как известно, содержат гидроксилированные каротеи, расширяющие волны используемого света, но они не характеризуются морской археей. Здесь, комбинируя морскую хромофорную экстракт с очищенными архейскими родопсинами, выявленными в морских метагеномах, мы показываем передачу легкой энергии из различных гидроксилоидных каротеоидных в геймдаллархаэ (HeimdallRs) из некультурных морских планктонных членов «Candidatus Cariarachaeceae» (Candidatus Asgardarchaeota). Эти светообрабатывающие

Patient-Centered Insights on Treatment Decision Making and Living with Acute Myeloid Leukemia and Other Hematologic Cancers.

Expectations relating to treatment and survival, and factors influencing treatment decisions are not well understood in adult patients with acute myeloid leukemia. This study analyzed combined findings from a targeted literature review with patient-reported information shared on YouTube to further understand patient perspectives in hematologic cancers and, in particular, acute myeloid leukemia. The targeted literature review included articles concerning patient (aged ≥ 18 years) experiences or perspectives in acute myeloid leukemia or other hematologic cancers. YouTube video selection criteria

Selective JAK2/ABL dual inhibition therapy effectively eliminates TKI-insensitive CML stem/progenitor cells.

Polymyalgia rheumatica (PMR) is a common disorder in the elderly population. The diagnosis is based upon recognition of a clinical syndrome, consisting of pain and stiffness in the shoulder and pelvic girdle, muscle tenderness of the upper and lower limbs and nonspecific somatic complaints. In addition, in most cases the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) concentration are highly elevated. Although PMR and giant cell arteritis (GCA) are commonly regarded as two clinical variations of the same disease, their clinical picture is quite different. Whilst in PMR the m

Navigating Hope and Illness Cognition in Advanced Ovarian Cancer Patients: A CSM-Based Phenomenological Study.

BACKGROUND: Advanced ovarian cancer patients face profound psychosocial challenges in maintaining hope amidst terminal illness and treatment uncertainty. Understanding mechanisms supporting adaptive hope could inform psychosocial interventions. METHODS: Phenomenological qualitative study of 16 women with advanced ovarian cancer receiving platinum-based and/or targeted therapies at a tertiary center in southern China. Semi-structured interviews conducted across 11-month observation period; thematic analysis guided by Leventhal's Common-Sense Model (CSM). RESULTS: Participants demonstrated a t

Целые пищевые рационы на основе растений являются практически осуществимыми при автоматическом воздействии на организм человека и связаны с модификацией микробиома в зависимости от дозы.

Целые пищевые рационы, основанные на кратком планете, могут представлять собой целенаправленный подход к смягчению последствий нарушения микробиома и улучшению последствий для пациентов, проходящих аутологическую трансплантацию гематопоиетических клеток (auto-HCT) в случае множественной миеломы, в которой кишечный дисбиоз связан с более низким уровнем выживаемости. Мы провели одностороннее клиническое испытание в нашем центре, в ходе которого участники прошли автоHCT (n = 22) получили свежее, заранее подготовленное, растительное питание 5 Недели, охватывающие кондиционирование, нейтрализацию и

A Comprehensive Analysis of the Cancer Chronic Pain Experience: A Narrative Review.

Cancer-related chronic pain (CP) represents a critical clinical issue through the disease, severely compromising the quality of life (QoL) of patients and the family environment. The current review employed a narrative method to synthesize the main results about the impact of cancer-related CP on QoL, adopting a multidimensional and threefold vision: patients, caregivers, and patient-caregiver perspective. Evidence emphasizes the importance of considering a bidirectional perspective (patient-caregiver) to understand better the pain experience throughout the cancer continuum and its consequence

The End-of-Life Experience of Patients With Rare Cancers and Their Caregivers.

Little is known about the end-of-life (EOL) experience of patients with rare cancers (PRC) or their caregivers. From September 2002 to August 2008, 618 stage IV cancer patients [195 PRC and 423 patients with common cancers (PCC)] and their caregivers participated in an interview-based cohort study. Patients were interviewed about EOL preferences, planning, medical care, and followed until death. Interviews with caregivers at baseline assessed caregiver mental and physical health; and postmortem, assessed EOL patient care. PRC were four times more likely than PCC to be receiving both radiation

Спектр и эпидемиология неврологических расстройств и нервно-мышечных аномалий у педиатрического населения Сиалкота, Пакистан.

СВЕДЕНИЕ И ЦЕЛЬ: Неврологические заболевания и нейромускульные аномалии являются сложными условиями, влияющими как на центральную, так и на периферию нервной системы. Цель этого исследования заключалась в изучении частотности, характерных особенностей, фенотипных особенностей и семейных характеристик педиатрических неврологических расстройств и нейромускульных аномалий в пакистанском районе Сиалкот. МЕТОДОЛОГИЯ: С февраля было проведено перекрестное исследование, в ходе которого пациенты были набраны из больниц третичной медицинской помощи по всему району Сиалкот, 2024 до декабря, 2024. Для ан

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… While extended family was a risk factor in the crude model (OR: 1.69), this association lost significance after adjustment. … Extended family appeared protective in the crude model (OR: 0.59), but this was not significant after adjustment. …

iPREFER: Опыт пациентов и предпочтение лечения множественной миеломы после нескольких линий лечения - качественное исследование.

ЦЕЛЬ: Ежегодно в Соединенном Королевстве примерно 6000 У людей диагностируется Множественная миелома (ММ) и лечатся с помощью целевых раковых препаратов. Продолжительность и периодичность такого лечения варьируются и включают пероральное, внутривенное (IV) и подкожное управление. Пациенты часто проходят несколько направлений лечения и живут в условиях неопределенности в течение многих лет и десятилетий. Данное исследование (Идентифицирующий орган Клинического производства.Государства): NCT06322927) изучает опыт лиц, проходящих курс лечения MM, то, что наиболее важно при принятии решений о лече

End-of-life Care Experience of Home-Based Hospice Nurses

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Окисляющий стресс как терапевтическая цель в амиотропическом боковом склерозе: возможности и ограничения.

Амиотропический боковой склероз (ALS), известный также как болезнь моторных нейронов (MND) и болезнь Лу Гехрига, характеризуется потерей нижних моторных нейронов в спинном мозге и верхних моторных нейронов в коре головного мозга. Ввиду сложного и многофакторного характера различных факторов и механизмов риска, связанных с механическим нейронным дегенерацией, патологические механизмы БАС не в полной мере понимаются. Окисляющий стресс one из известных причин патогенез АБС. Это наблюдалось у пациентов, а также у клеточных и животных моделей и, как известно, вызывало митохондриальную дисфункцию и

Longevity leap: mind the healthspan gap.

Life expectancy has increased by three decades since the mid-twentieth century. Parallel healthspan expansion has however not followed, largely impeded by the pandemic of chronic diseases afflicting a growing older population. The lag in quality of life is a recognized challenge that calls for prioritization of disease-free longevity. Contemporary communal, clinical and research trends aspiring to extend the health horizon are here outlined in the context of an evolving epidemiology. A shared action integrating public and societal endeavors with emerging interventions that target age-related m