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Development, acceptability and uptake of an on-line communication skills education program targeting challenging conversations for oncology health professionals related to identifying and responding to anxiety and depression.

BackgroundAnxiety and depression screening and management in cancer settings occurs inconsistently in Australia. We developed a clinical pathway (ADAPT CP) to promote standardized assessment and response to affected patients and enhance uptake of psychosocial interventions. Health professional education is a common strategy utilised to support implementation of practice change interventions. We developed an interactive on-line education program to support staff communication and confidence with anxiety/depression screening and referral prior to the ADAPT CP being implemented in 12 oncology ser

Effect of the national reimbursement drug list negotiation policy on utilization of negotiated anticancer drugs in Chinese public hospital: a quasi-natural experiment.

BackgroundHigh prices have limited access to targeted anticancer drugs in China. In 2017, 18 such drugs were added to the National Reimbursement Drug List (NRDL) through national price negotiation.MethodMonthly hospital procurement data (2015-2019) from 887 public hospitals across 30 provinces were analyzed. Drug utilization was measured by expenditures and defined daily doses (DDDs). A difference-in-differences (DID) model and interrupted time series (ITS) analysis were employed to estimate policy effects.ResultsFollowing policy implementation, total DDDs of negotiated drugs rose 4.03-fold an

Advancing patient-centered cancer care: a systematic review of electronic patient-reported outcome measures.

BackgroundElectronic Patient-Reported Outcome Measures (ePROMs) have emerged as valuable tools in cancer care, facilitating the comprehensive assessment of patients' physical, psychological, and social well-being. This study synthesizes literature on the utilization of ePROMs in oncology, highlighting the diverse array of measurement instruments and questionnaires employed in cancer patient assessments. By comprehensively analyzing existing research, this study provides insights into the landscape of ePROMs, informs future research directions, and aims to optimize patient-centred oncology care

Efficacy of expressive helping in adult hematologic cancer patients undergoing stem cell transplant: protocol for the Writing for Insight, Strength, and Ease (WISE) study's two-arm randomized controlled trial.

BackgroundDuring, shortly after, and sometimes for years after hematopoietic stem cell transplant, a large proportion of hematological cancer patients undergoing transplant report significant physical and psychological symptoms and reduced health-related quality of life. To address these survivorship problems, we developed a low-burden, brief psychological intervention called expressive helping that includes two theory- and evidence-based components designed to work together synergistically: emotionally expressive writing and peer support writing. Building on evidence from a prior randomized c

The 11th NORDIC NUTRITION CONFERENCE NNC2016.

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Digital therapeutics from bench to bedside.

As a new therapeutic technique based on digital technology, the commercialization and clinical application of digital therapeutics (DTx) are increasing, and the demand for expansion to new clinical fields is remarkably high. However, the use of DTx as a general medical component is still ambiguous, and this ambiguity may be owing to a lack of consensus on a definition, in addition to insufficiencies in research and development, clinical trials, standardization of regulatory frameworks, and technological maturity. In this study, we conduct an in-depth investigation and analysis of definitions,

Токсичность тяжелых металлов в клиническом и экологическом здравоохранении: источники, механизмы, диагностика и научно обоснованное управление ртутью, свинцом, кадмием и арсеником.

Тяжелые металлы, включая ртуть (Hg), свинец (Pb), кадмий (Cd) и мышьяк (As), по-прежнему остаются значительными глобальными токсинами в силу их экологической стойкости, широкомасштабного антропогенного высвобождения и серьезного биологического воздействия. Этот обзор укрепляет нынешнее понимание их природных и промышленных источников, круговорота окружающей среды, маршрутов воздействия на человека и факторов уязвимости на уровне населения. Она охватывает их токсикокинетику и токсикодинамику, делая акцент на специфических для каждого вида механизмах поглощения, распределения и травмирования, вк

Совпадение в полном тексте источника
… Population-based evidence highlights risks at biomarker levels common in everyday life; clinical trials determine where drugs are effective; implementation science explores how to deliver prevention and care within limited settings [ 228 ]. … Implementation science and equity are crucial. Even the most effective interventions will not succeed if they are not accessible where risk is highest. …

The advantages, disadvantages, threats, and opportunities of electronic patient-reported outcome systems in cancer: A systematic review.

ObjectiveElectronic patient-reported outcome (ePRO) systems hold promise for revolutionizing communication between cancer patients and healthcare providers across various care settings. This systematic review explores the multifaceted landscape of ePROs in cancer care, encompassing their advantages, disadvantages, potential risks, and opportunities for improvement.MethodsIn our systematic review, we conducted a rigorous search in Scopus, Web of Science, and PubMed, employing comprehensive medical subject heading terms for ePRO and cancer, with no date limitations up to 2024. Studies were criti

Совместные мероприятия по самоуправлению взрослых, живущих с кишечной остомией: обзор.

Справочная информация/задачи: Цель этого аналитического обзора заключалась в определении существующих данных о целях, характеристиках, результатах и посредниках по осуществлению, а также о препятствиях, с которыми сопряжены мероприятия по поддержке со стороны сверстников, направленные на содействие самоуправлению у лиц, живущих с кишечной остомией. Методы: В соответствии с методологией Института Джоанны Бриггс был проведен обзор аналитического исследования, результаты которого были представлены в соответствии с программой PRISMA Presponse for Screpting Reviews (PRISMA-ScR). В декабре был прове

Self-rated health and health-related quality of life among cancer patients: the serial multiple mediation of anxiety and depression.

BackgroundHealth-related quality of life (HRQOL) in cancer patients has attracted increasing attention, which may be associated with self-rated health (SRH), anxiety, and depression. However, limited studies have focused on the mediating role of anxiety and depression in the relationship between SRH and HRQOL among cancer patients. Therefore, this study aims to explore the serial multiple mediating effects of anxiety and depression between SRH and HRQOL in cancer patients.MethodsThis cross-sectional study investigated a total of 565 hospitalized cancer patients in Anhui province in China from

Outpatient CAR T-Cell Therapy as Standard of Care: Current Perspectives and Considerations.

Chimeric antigen receptor T-cell therapy (CAR-T) has altered the treatment landscape of several hematologic malignancies. Until recently, most CAR-T infusions have been administered in the inpatient setting, due to their toxicity profile. However, the advent of new product constructs, as well as improved detection and management of adverse effects, have greatly increased the safety in administering these therapies. CAR-T indications continue to expand, and inpatient administration is associated with increased healthcare resource utilization and overall cost. Therefore, transitioning CAR-T admi

'Lessons learned' from trialists who adapted a complex intervention for remote delivery within a trial as a result of the COVID-19 pandemic: a scoping review.

BackgroundDuring the COVID-19 pandemic, complex interventions being evaluated in randomised controlled trials were often rapidly adapted from in-person to remote delivery. Such adaptations to intervention delivery have the potential to cause unintended consequences and affect important aspects of trial generalisability and interpretation. This scoping review aimed to identify the 'lessons learned' from trialists who adapted and remotely delivered a complex intervention within a trial because of the COVID-19 pandemic. Gaining a better understanding of trialists' experiences of adapting interven

Цифровые биомаркеры и АИ для дистанционного мониторинга утомительного прогресса в области неврологических расстройств: подключение механизмов к клиническому применению.

Цифровые биомаркеры для мониторинга усталости в неврологических расстройствах представляют собой новаторский подход к преодолению разрыва между механистическим пониманием и клиническим применением. В настоящем перспективном документе рассматривается вопрос о том, каким образом меры, разработанные с помощью смартфонов и проанализированные с помощью искусственных методов интеллекта, могут трансформировать оценку усталости из субъективной, эпизодической отчетности в непрерывный, объективный мониторинг. Предлагаемые рамки для цифровой фенотификации на основе смартфонов содержат пассивные данные (о

Comparative efficacy of moxibustion in chemotherapy-induced leukopenia: A Bayesian network meta-analysis.

BackgroundMoxibustion has been applied in various clinical treatments, including chemotherapy-induced leukopenia. Using a Bayesian network meta-analysis, this study assessed a wide range of published data to identify the most efficient and effective method of moxibustion therapy for treating chemotherapy-induced leukopenia.MethodsPubMed, EMBASE, and eight other databases plus two clinical trial registration platforms were searched from their respective inception date to January 2024. All randomized controlled trials (RCTs) of moxibustion for chemotherapy-induced leukopenia were included. The p

Abstracts From JADPRO Live at APSHO 2017.

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Полифенолы и нейродегенеративные заболевания: понимание знаний, механистические свидетельства и новые виды применения в области питания.

Полифенолы представляют собой разнообразную группу биоактивных веществ растительного происхождения, которые были исследованы в качестве многоцелевых возможностей для потенциальной профилактики и лечения нейродегенеративных заболеваний (НДИ). Мы провели комплексный библиометрический и механистический обзор, охватывающий 12 классов полифенола и семь основных НИЗ, с использованием записей из PubMed, Embase, Cochrane Bibrary и Web of Science (1940-2024). Для картирования исследовательских ландшафтов и новых тем использовались ключевые слова, анализы по группам и модели BERTopic. Механистические до

Risk of infections associated with the use of bispecific antibodies in multiple myeloma: a pooled analysis.

The use of bispecific antibodies (BsAbs) in the treatment of relapsed/refractory multiple myeloma (MM) is showing early promising overall response rates in heavily pretreated patients. Infectious complications related to the use of BsAbs are not well described. We conducted a pooled analysis that included all single-agent BsAbs used in MM with no prior use of different BsAbs. A total of 1185 patients with MM were treated with a BsAb in the studied period (71.6% of the patients treated with an agent targeting B-cell maturation antigen (BCMA). Pooled median follow-up was short at 6.1 months (7.5

Risk sharing arrangements for pharmaceuticals: potential considerations and recommendations for European payers.

BackgroundThere has been an increase in 'risk sharing' schemes for pharmaceuticals between healthcare institutions and pharmaceutical companies in Europe in recent years as an additional approach to provide continued comprehensive and equitable healthcare. There is though confusion surrounding the terminology as well as concerns with existing schemes.MethodsA literature review was undertaken to identify existing schemes supplemented with additional internal documents or web-based references known to the authors. This was combined with the extensive knowledge of health authority personnel from

Managing hematological cancer patients during the COVID-19 pandemic: an ESMO-EHA Interdisciplinary Expert Consensus.

BackgroundThe COVID-19 pandemic has created enormous challenges for the clinical management of patients with hematological malignancies (HMs), raising questions about the optimal care of this patient group.MethodsThis consensus manuscript aims at discussing clinical evidence and providing expert advice on statements related to the management of HMs in the COVID-19 pandemic. For this purpose, an international consortium was established including a steering committee, which prepared six working packages addressing significant clinical questions from the COVID-19 diagnosis, treatment, and mitigat

Письменные исследования по показателям полигенного риска в общих нейродегенеративных заболеваниях - Протокол обзора.

ЦЕЛЬ: Цель настоящего протокола заключается в четком описании процесса аналитического обзора, который мы планируем провести по теме оценки полигенного риска (ПСОК) общих нейродегенеративных заболеваний. Мы представим цель обзора, стратегию поиска доказательств, процедуру извлечения и анализа данных и порядок представления результатов. МЕТОДЫ: Критерии включения в запланированное аналитическое исследование будут сосредоточены на источниках доказательств, которые включают в себя ССН, применяемые к нейрогенеративным заболеваниям, таким, как Множественный склероз, болезнь Паркинсона, болезнь Альцг