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Фульминантный внематочный рецидив множественной миэломы с редким сердцем, сосудистым и многовизорным участием: отчет о деле.

Множественная миелома (ММ) — плазменная злокачественная клетка, которая, как правило, проходит длительный клинический курс. Внешняя болезнь (ЭМД) представляет собой агрессивное проявление MM с относительно низким уровнем заболеваемости, которое традиционно затрагивает кожу и мягкие ткани. В то время как MM, как правило, безжалостно прогрессирует, мощное развитие болезней, характеризующееся обширной многовизорной и сосудистой инфильтрацией, является исключительно редким явлением и редко документируется в медицинской литературе. Этот случай иллюстрирует 64-летнюю женщину, у которой были обнаруже

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… dyspnea and fatigue RA; SVC; IVC Chemotherapy, surgery Alive at 7 mo Aliki Tsagkridi 5 50/M Right chest pain; subcutaneous nodules the atria, inter-atrial septum, the vena cava, and pulmonary artery Radiotherapy; chemotherapy Died at 6 wk Jeet Ram Kashyap 15 64/M Progressive dyspnea Atrium; pericardium … dyspnea and fatigue RA; SVC; IVC Chemotherapy, surgery Alive at 7 mo Aliki Tsagkridi 5 50/M Right chest pain; subcutaneous nodules the atria, inter-atrial septum, the vena cava, and pulmonary artery Radiotherapy; chemotherapy Died at 6 wk Jeet Ram Kashyap 15 64/M Progressive dyspnea Atrium; pericardium …

Recurrent Syncope, a Clue in Amyloid Cardiomyopathy.

Infiltrative cardiomyopathies include a variety of disorders that lead to myocardial thickening resulting in a constellation of clinical manifestations and eventually heart failure that could be the first clue to reach the diagnosis. Among the more described infiltrative diseases of the heart is amyloid cardiomyopathy. The disease usually presents with subtle, nonspecific symptoms. Herein, we illustrate a case of recurrent syncope as the initial presenting symptom for systemic amyloid with polyneuropathy and cardiomyopathy as a cause of syncope. The article illustrates the role of advanced car

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… Cardiac magnetic resonance (CMR) demonstrated suboptimal myocardial nulling with patchy focal late gadolinium enhancement affecting the pericardium and atrial walls, a large pericardial effusion, and a pleural effusion suggestive of amyloid infiltration ( Figure 4 ). … Evidence of patchy focal late gadolinium enhancement of the pericardium with suboptimal nulling of the myocardium. …

[Expert consensus on diagnosis and treatment of severe COVID-19 associated pulmonary aspergillosis and mucormycosis].

The incidence and mortality of COVID-19 associated pulmonary aspergillosis (CAPA) are high in critically ill patients. Although COVID-19 ass … ould be considered16. In patients with CAPA, surgery is not recommended unless large blood vessels, pericardium, or chest wall are involved, or the patient has recurrent or massive hemoptysis. For CAPM patients, early surgical removal of lesions after diagnosis is recommended. Surgery is a high-risk procedure in patients with severe COVID-19, and a multidisci …

Cardio-Oncology and Multi-Imaging Modalities.

Early detection and the rise of targeted cancer treatment have led to increased overall survival and decreased mortality among cancer patients. As the cancer survivor population ages, there is an increased risk for cardiovascular disease due to pre-existing comorbidities, deconditioning during therapy, or the natural progression of aging. Furthermore, with emerging oncologic therapies, there is an increased recognition of their potential cardiovascular toxicities. Indeed, heart disease is the leading cause of death in cancer survivors, which may reflect upon both the success of novel oncologic

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… Cancer patients often suffer from pericardial diseases such as pericardial effusions, acute pericarditis due to cancer therapeutics or radiation therapy, or even direct tumor invasion into the pericardium [ 27 ]. … Finally, CCTA can identify the presence of pericardial effusion, pericardial calcification, or the direct tumor invasion of the pericardium. CCTA allows for the full visualization and imaging of the entire pericardium and is relatively more rapid and cost-effective than CMR. 3.4. …

Predictors for use of temporary epicardial pacing wires after pediatric cardiac surgery.

OBJECTIVE: The objectives of this study were (1) to determine the use of temporary epicardial pacing wires to diagnose and treat early postoperative arrhythmias in pediatric cardiac surgical patients and (2) to determine the predictive factors for the need of pacing wires for diagnostic or therapeutic purposes. METHODS: We collected preoperative, intraoperative, and postoperative data in a prospective, observational format from patients undergoing pediatric cardiac surgery between August 2010 and January 2011 at a single academic children's hospital. RESULTS: A total of 157 patients met the

BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium.

The neural crest is a multipotent, migratory cell population arising from the border of the neural and surface ectoderm. In mouse, the initial migratory neural crest cells occur at the five-somite stage. Bone morphogenetic proteins (BMPs), particularly BMP2 and BMP4, have been implicated as regulators of neural crest cell induction, maintenance, migration, differentiation and survival. Mouse has three known BMP2/4 type I receptors, of which Bmpr1a is expressed in the neural tube sufficiently early to be involved in neural crest development from the outset; however, earlier roles in other domai

Expert consensus on resection of chest wall tumors and chest wall reconstruction.

Chest wall tumors are a relatively uncommon disease in clinical practice. Most of the published studies about chest wall tumors are usually single-center retrospective studies, involving few patients. Therefore, evidences regarding clinical conclusions about chest wall tumors are lacking, and some controversial issues have still to be agreed upon. In January 2019, 73 experts in thoracic surgery, plastic surgery, science, and engineering jointly released the Chinese Expert Consensus on Chest Wall Tumor Resection and Chest Wall Reconstruction (2018 edition). After that, numerous experts put forw

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… Especially for sternal sarcoma, wide excision often requires resection of the adjacent pericardium, thymus, great blood vessels, and other important organs. The larger the defect, the more difficult the reconstruction surgery. … The use of bovine pericardium patch and polylactic acid (PLA) bars used solely or combined for reconstruction and stabilization of the thoracic skeleton have been reported as a valuable option in the management of patients with chest wall tumors. …

Р

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[Analysis of Prenatal Ultrasound Manifestations in 15 Cases of Cantrell Syndrome].

OBJECTIVE: Cantrell syndrome, a rare congenital disorder, is characterized by a unique collection of defects on the midline abdominal wall, the lower sternum, the anterior diaphragm, and the diaphragmatic pericardium in addition to some form of intracardiac defect. So far, most of the reports on fetuses with Cantrell syndrome worldwide are either case reports or literature reviews, and few comprehensive studies on fetuses with Cantrell syndrome have been reported, especially in domestic literature. This study aims to provide a detailed analysis of 15 cases of Cantrell syndrome fetuses, focusin…

The cytoplasmic domain of TGFβR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior.

The epicardium is a major contributor of the cells that are required for the formation of coronary vessels. Mice lacking both copies of the gene encoding the Type III Transforming Growth Factor β Receptor (TGFβR3) fail to form the coronary vasculature, but the molecular mechanism by which TGFβR3 signals coronary vessel formation is unknown. We used intact embryos and epicardial cells from E11.5 mouse embryos to reveal the mechanisms by which TGFβR3 signals and regulates epicardial cell behavior. Analysis of E13.5 embryos reveals a lower rate of epicardial cell proliferation and decreased epica

Surgical treatment for transvenous tumor extension into the heart: four cases.

From 1984 to 1996, four patients with transvenous intracardiac tumor extension underwent operations in the Kobe University Hospital. The primary tumors of two were intravenous leiomyomatoses originating from the uterus; a third patient had invasive thymoma, and the fourth patient had clear cell sarcoma of the kidney. In 1985, one patient had a curative, staged resection. One-stage operations were carried out in three patients, and all intracardiac tumors were successfully resected en bloc with the primary tumors under conditions of electrical ventricular fibrillation and mild hypothermia. Comb

Best of JACC: Case Reports From ACC.23.

This dedicated issue of JACC: Case Reports highlights the top ranked Complex Clinical Cases from the ACC 2023 Scientific Sessions. These cases were reviewed and selected by a committee of peers in the months leading up to the annual meeting. These reviewers were ACC members with no affiliation to the JACC: Case Reports Editorial Board. While the cases were presented at the meeting and included in the formal Abstract Book from ACC, they have not been published elsewhere. These cases illustrate how the ACC can be a place for cardiovascular professionals to come together to learn, grow, and share

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… Echocardiogram, Gated Cardiac Computed Tomography (CT), and Cardiac Magnetic Resonance Imaging together confirmed ring-shaped constriction around a thickened and hypokinetic, lateral LV wall with herniation of inflamed and edematous myocardium through a deformed pericardium. … A 40 mm long device with a 26 mm diameter porcine pericardium valve was landed at 1 cm inferior to pulmonary valve annulus with its inflow portion. The inflow and the valvular portions of the device did not compress surrounding structures. …

Плазменная лейкемия клеток с участием мягких тканей; сообщение о редком случае.

Плазменная лейкемия (PCL) — редкий агрессивный вариант множественной миеломы. PCL диагностируется в тех случаях, когда клональные плазменные клетки составляют более чем 20 % из общего циркулирующего лейкоцита или когда абсолютное количество плазменных клеток превышает 2 × 109 /Л. Во время диагностирования часто наблюдается эксклюзивное участие, включая эфлуцию полости. Однако использование мягких тканей редко встречается только в тех случаях, когда one опубликован в английской литературе. Мы сообщим: 74-year-old Человек, который в течение нескольких месяцев испытывал постепенное дыхание. Лабор

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… PCL tends to present more with extramedullary involvement than MM such as the liver, spleen, body cavities (pleura, pericardium, and peritoneum), and spinal cord [ 3 , 4 , 6 ]. …

Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model.

BACKGROUND: Computational biology is a powerful tool for elucidating arrhythmogenic mechanisms at the cellular level, where complex interactions between ionic processes determine behavior. A novel theoretical model of the canine ventricular epicardial action potential and calcium cycling was developed and used to investigate ionic mechanisms underlying Ca2+ transient (CaT) and action potential duration (APD) rate dependence. METHODS AND RESULTS: The Ca2+/calmodulin-dependent protein kinase (CaMKII) regulatory pathway was integrated into the model, which included a novel Ca2+-release formulati

Intrathoracic manifestations of hematologic malignancies: a narrative review.

BACKGROUND AND OBJECTIVE: Although the global incidence of hematologic malignancies is decreasing, the risk of developing these cancers is increasing due to increased lifespan and modern treatments including targeted therapy, chemotherapy, and radiation. Intrathoracic manifestations of hematologic malignancies may be the presenting sign leading to diagnosis or result from various treatment toxicity. The most common respiratory manifestation of hematologic malignancies is infectious, but up to half of pulmonary findings are from non-infectious etiologies. We aim to summarize the current literat

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… Mechanisms can include direct infiltrations of pericardium or pleura by malignant cells, obstruction of lymphatic drainage by mediastinal lymphadenopathy, and sequelae of therapies including chemotherapy- or radiation-induced serositis ( 13 - 15 ). … It is a rare, aggressive B-cell lymphoma that localizes to serous body cavities with effusions (peritoneum, pleural space, pericardium) in the absence of a discrete mass ( 26 ). It is associated with human herpesvirus 8 (HHV-8) and often co-infected with Epstein-Barr virus (EBV). …

Подозреваемый в причастности центральной нервной системы к множеству миелом на МРТ.

Участие центральной нервной системы в множестве миеломы (КНС-ММ) встречается редко, как правило, при рецидиве и связывается с плохим прогнозом. Мы сообщаем о случае 67-year-old Женщина с повышенным риском IgA lambda multieloma, у которой появился ранний рецидив с обширной дополнительной болезнью и нетипичными результатами МРТ мозга. Воображение выявило аномальное уплотнение и разнородность гипофизического стеблей, а также признаки, указывающие на церебральный венозный тромбоз (CVST), вызывая подозрения в причастности CNS. Анализ цереброспинной жидкости не был проведен из-за быстрого клиническо

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… Follow-up CT imaging of the thorax, abdomen, and brain revealed disease progression with appearance of an extracranial soft tissue mass, calvarial lytic lesions, and extensive tumor infiltration involving the right pleura, thoracic wall, pericardium, and adjacent musculature. …

An Unusual Case of Primary Plasma Cell Leukemia Presenting As Pericardial Effusion.

Plasma cell leukemia represents the rarest form of plasma cell dyscrasias arising from monoclonal proliferation of plasma cells in peripheral blood. Its aggressive natural history raises a significant therapeutic challenge. We present a case of a 58-year-old female who presented with a cough accompanied by exertional dyspnea. Further radiological investigations revealed a circumferential pericardial effusion. A pericardiocentesis was performed, resulting in the drainage of 650 cc of hemorrhagic pericardial fluid. Cytology revealed monoclonal plasma cells expressing CD38 and CD138 with cytoplas

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… Previously described cases of plasma cell infiltration of the pericardium were associated with similar unsatisfactory outcomes [ 16 , 17 ]. …

Abstracts from the World Congress of Cardiology/Brazilian Congress of Cardiology 2022

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SUBJECT INDEX Volume 125 (JANUARY–JUNE, 2004)

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… 288 differential-display polymerase chain reaction identifies nicotinamide adenine dinucleotide-ubiquinone oxidoreductase as an ischemia/reperfusion-regulated gene in cardiomyocytes, 228 lasers, staples, bovine pericardium, talc, glue and…suction cylinders? … flow-type spirometer problems that elevate test results, 1902 lack of efficacy for a cervicomandibular support collar in the management of obstructive sleep apnea, 118 lasers, staples, bovine pericardium, talc, glue and…suction cylinders? …

Treatment of inflammatory dilated cardiomyopathy and (peri)myocarditis with immunosuppression and i.v. immunoglobulins.

OBJECTIVES: Treatment objectives in inflammatory dilated cardiomyopathy (DCMi), myocarditis (M) and peri(myo)carditis are 1) the elimination of inflammatory cells from the myocardium and pericardium, 2) the elimination or (second best) mitigation of B-cell products such as antibodies and immuncomplexes directed against cardiac epitopes such as sarcolemmal, fibrillary and mitochondrial epitopes, and 3) the eradication of the causative viral or microbial agent, if present. ANTIPHLOGISTIC TREATMENT: A "non-specific" anti-inflammatory treatment in peri(myo)carditis can be carried out with antiphl…