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An integrated lifestyle intervention for mitigation of adverse effects associated with androgen deprivation therapy for prostate cancer (STAMINA): a multicentre, randomised trial.

BACKGROUND: Androgen deprivation therapy (ADT) for prostate cancer causes substantial adverse effects. Despite consistent national and international guideline recommendations, supervised exercise is rarely integrated into care. We aimed to determine whether the STAMINA lifestyle intervention, embedded into cancer care, would improve cancer-specific quality of life and fatigue versus behaviourally Optimised Usual Care in men with prostate cancer in England. METHODS: STAMINA was a multicentre, randomised trial done across 15 UK National Health Service (NHS) trusts in England. Men on ADT for pro

Radioactive 125I seed implantation for locally advanced pancreatic cancer: A retrospective analysis of 50 cases.

BACKGROUND: Pancreatic cancer is one of the common malignant tumors of the digestive system, and radical resection is the first choice of treatment for pancreatic cancer. If patients with locally advanced pancreatic cancer cannot be treated in time and effectively, their disease often develops rapidly and their survival period is very short. AIM: To evaluate the therapeutic effect of 125I seed implantation in patients with locally advanced pancreatic cancer. METHODS: The demographics and perioperative outcomes of a consecutive series of patients who underwent 125I seed implantation to treat

18F-Fluciclovine Uptake in Acute Appendicitis.

An 85-year-old man with biochemical recurrence of prostate cancer after prostatectomy was imaged with F-fluciclovine PET/CT. Images incidentally revealed F-fluciclovine uptake in a dilated appendix with associated fat stranding, suggestive of acute appendicitis. The patient was then questioned about abdominal symptoms, and he reported severe right lower quadrant pain. He then underwent laparoscopic appendectomy with pathology confirming acute appendicitis.

[Pneumopericardium 4 Years after Surgery of Thymic Cancer].

A 67-year-old man had undergone thymectomy with partial resection of the left upper lobe and pericardium for thymic cancer. Four years later, he visited our hospital due to chest pain. Chest computed tomography revealed pneumopericardium. Nine months later, surgical treatment was performed due to the development of the left pneumothorax. Air leak was found from the bulla which was partially incarcerated into the pericardial space.

Perinephric urinoma due to locally advanced recto-sigmoid tumor: incidental finding on bone scan.

We are presenting a 59 years old man with locally advanced recto-sigmoid colon cancer; complaining of left flank pain and bone scan was done to rule out bone metastases. Findings in bone scan were suggesting left renal obstruction, but further SPECT/CT imaging to localize the uptake revealed a perinephric collection likely due to leak from the left ureter close to tumor site.

Toothache as a presenting symptom of metastatic renal cell cancer.

A 53-year-old man with a 14-year history of renal cell carcinoma (RCC) presented with a 2-month history of right-sided upper jaw pain and severe bleeding during tooth extraction. Pathology review of a lower maxillary sinus/upper gingival mass revealed metastatic RCC. The presentation, differential diagnosis and literature review of this uncommon presentation of metastatic kidney cancer are discussed in this report.

Benign breast disease: when to treat, when to reassure, when to refer.

Many women have breast symptoms-swelling and tenderness, nodularity, pain, palpable lumps, nipple discharge, or breast infections and inflammation. Fortunately, relatively few have breast cancer. Physicians must distinguish benign breast conditions from malignant ones, and know when to refer the patient to a specialist. We have included some of the newer diagnostic techniques and the approach to patients with nonpalpable lesions detected on a screening mammogram.

Stenting the sigmoid colon in a terminally ill patient with prostate cancer.

Large bowel obstruction in the terminally ill patient can be difficult to manage. We describe a patient with sigmoid colon obstruction caused by metastatic prostate cancer in the pelvis who required hospitalization because of severe pain and obstructive symptoms. Treatment with an endoscopically placed self-expandable metal stent allowed the patient to have immediate resolution of symptoms and to receive hospice care at home.

A rare malformation of the pancreaticobiliary junction long common channel choledochal cyst and pancreas divisum in a patient with pancreatic cancer.

Congenital variants of the pancreaticobiliary junction are rare anomalies that are usually diagnosed in childhood because of recurrent abdominal pain and jaundice. These lesions are associated with several pancreaticobiliary diseases including pancreatitis and malignancy. We observed a rare anomaly of the pancreaticobiliary tract with a combination of several ductal malformations, i.e., choledochal cyst, long common channel and incomplete pancreas divisum in a patient with pancreatic cancer.

Chronic abdominal pain secondary to omental J-flap: report of two patients.

Two patients with a history of stage IB cervical cancer who had undergone prior radical abdominal hysterectomy, omental J-flap placement, and postoperative whole pelvic radiation therapy required subsequent exploratory laparotomy with resection of omental J-flap for treatment of chronic abdominal pain 5 and 2 years, respectively, following J-flap placement. Issues relating to this unusual possible long-term complication of omentoplasty are discussed.

Videolaseroscopy for oophorectomy.

Laparoscopic oophorectomy was performed on 94 ovaries in 76 patients. Indications included recurrent pain associated with endometriosis and adhesions in 17 patients (18 ovaries), ovarian endometriomas in 40 patients (40 ovaries), prophylactic oophorectomy (breast cancer) in one patient (2 ovaries), removal of the ovaries at the time of laparoscopic assisted vaginal hysterectomy in 15 patients (30 ovaries), and other indications in three patients (four ovaries).

[A case of breast cancer with multiple bone metastases effectively treated with UFT and tamoxifen].

A 51-year-old female with advanced breast cancer involving multiple bone metastases was daily administered 400 mg of UFT and 20 mg of tamoxifen. X-ray examination revealed remarkable osteosclerosis. Laboratory data revealed a high serum alkali phosphatase level of 820 mU/ml(at 3 months), which gradually decreased to 274 mU/ml with pain relief at 11 months after the beginning of this chemotherapy.

[Aminoglutethimide in the treatment of advanced prostatic cancer].

A total of ten previously castrated men with stage D carcinoma received 1000 mg aminoglutethimide and 50 mg/die cortisoneacetate. The patients were evaluated using the criteria of the National Prostate Cancer Project. No patients showed objective response, three patients had reduction of bone pain and subjective improvement. Pretreatment testosterone, prolactine and estradiol levels were measured. Three patients had a statistically significant elevation of testosterone levels.

Perspectives on Palliative Care Among Patients With Pancreatic Cancer: A Pilot Study.

BACKGROUND: Palliative care (PC) is specialized health care that can improve quality of life for patients with cancer. However, PC tends to be underutilized or relegated to end-of-life care, limiting patients' ability to benefit from patient-centered, goal-concordant care. Patients with pancreatic cancer, who are often diagnosed at an advanced stage and with high symptom burdens, could benefit from PC. A chart review conducted in 2022 at a southern New Jersey academic medical center and cancer center found that among 77 patients diagnosed with cancer, only 26 were referred to palliative care s

Exploring the Impact of Physical Therapy on Patient Outcomes Across the Cancer Care Continuum: A Narrative Review.

Cancer and its treatments frequently lead to functional impairments, physical limitations, and reduced quality of life (QOL), posing significant challenges for patients across the cancer care continuum. Physical therapy (PT) is a critical intervention to mitigate these effects, from diagnosis through survivorship and palliative care. This narrative review synthesizes evidence on PT's role in improving functional capacity, managing treatment-related side effects, and enhancing overall well-being in cancer patients and survivors. A comprehensive literature search was conducted on PubMed, Science

Effectiveness of Colonoscopy Screening in Identifying Colorectal Cancer in Young Patients: A Retrospective Cohort Study in a Single Saudi Institution.

Background Globally, the incidence of colorectal cancer (CRC) is rising, with a notable increase seen in younger people. When detected early, CRC is a relatively curable illness with a 90% survival rate. Only those over 50 are recommended to be screened for colorectal cancer in those at average risk. The purpose of this study is to determine the likelihood of cancer in the community and to examine the dubious clinical signs that lead to colonoscopy in younger patients. Methods  This retrospective cohort study analyzed medical records of patients aged ≤35 years who underwent colonoscopy between

Mexican Multicenter Experience of Metastatic Spinal Disease.

Background Spinal metastatic disease is a silent progressive cancer complication with an increasing prevalence worldwide. The spine is the third most common site where solid tumors metastasize. Complications involved in spinal metastasis include root or spinal cord compression, progressing to a declining quality of life as patient autonomy reduces and pain increases. The main objective of this study is to report the incidence of patients and typology of spinal metastases in three reference centers in Mexico. Methodology Retrospective cohorts of patients diagnosed with spinal metastases from Ja

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… Management of cancer pain due to bone metastasis. Takei D, Tagami K. J Bone Miner Metab. 2023;41:327–336. doi: 10.1007/s00774-022-01382-y. 35. Molecular mechanisms of osteosarcoma metastasis and possible treatment opportunities. Du X, Wei H, Zhang B, et al. …

Outcome of surgical treatment for bone metastases caused by colorectal cancer.

BACKGROUND: Cancer of the lower intestinal tract, although relatively common, rarely metastasizes to the skeleton. The treatment of metastatic bone disease due to colorectal cancer has thus been poorly described and treatment decisions are therefore difficult. The aim of this study was to describe the outcome of orthopedic surgery in patients with pathological fractures from colorectal cancer and investigate factors that correlate with patient survival, since it influences treatment decisions. METHODS: Retrospective review of data collected in a prospectively collected database. 36 patients (

Creating a priority list of non-communicable diseases to support health research funding decision-making.

OBJECTIVE: To develop and pilot a framework based on multi-criteria decision analysis (MCDA) to prioritize non-communicable diseases (NCDs) to support health research funding decision-making. METHODS: The framework involves identifying NCDs to be prioritized, specifying prioritization criteria and determining their weights from a survey of stakeholders. The mean weights from the survey are applied to the NCDs' ratings on the criteria to generate a 'total score' for each NCD, by which the NCDs are prioritized. RESULTS: Nineteen NCDs and five criteria were included. The criteria, in decreasing

Metastatic breast cancer patients' expectations and priorities for symptom improvement.

PURPOSE: Little research has examined cancer patients' expectations, goals, and priorities for symptom improvement. Thus, we examined these outcomes in metastatic breast cancer patients to provide patients' perspectives on clinically meaningful symptom improvement and priorities for symptom management. METHODS: Eighty women with metastatic breast cancer participated in a survey with measures of comorbidity, functional status, engagement in roles and activities, distress, quality of life, and the modified Patient-Centered Outcomes Questionnaire that focused on 10 common symptoms in cancer pati