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New nanomanufacturing strategy through bioinspired design, for promising treatment of Parkinson's disease.

This study attempts to develop a new nanomanufacturing strategy for Parkinson's disease using natural biodegradable components (chitosan, albumin, and dopamine) that can penetrate the blood-brain barrier (BBB) due to biocompatibility, biodegradability, targeted delivery, and controlled drug release. It was prepared, thoroughly optimized and characterized using various biophysical and chemical techniques. Results showed that the nanomanufactured system (molar ratio of 1:0.25:0.5 and particle size range: 38-190 nm) exhibited a zeta potential of + 73 mV facilitating efficient pentration of BBB th

Chitosan nanocarriers: A promising approach for glioblastoma therapy.

Glioblastoma is a rapidly growing form of brain tumour originating from the supportive tissues present in the brain or spinal cord. The conventional therapeutic options include the use of alkylating agents, radiation and surgical procedures, that exhibits numerous limitations. The considerably less survival rate, very high incidence of recurrence and lack of effective therapeutic options has made the disease as the most lethal brain cancer. Being widely investigated, nanocarriers assure efficacy in brain targeting. Nano-based systems also hold the edge of higher encapsulation efficiency, abili

Pulmonary delivery of anti-infectives from natural sources: Development and characterization of liposomal sanggenon formulations.

Sanggenon C (SGC) and sanggenon D (SGD) are stereoisomeric natural products with promising anti-infective potential, especially against pathogens involved in acute respiratory infections. However, their bulky structures, poor aqueous solubility, and low oral bioavailability present major therapeutic challenges. Inhalation enables direct delivery to the site of infection while minimizing systemic exposure. Liposomal formulations DMPC:DMPG (2:1 w/w) of SGC and SGD, prepared via ethanol injection, achieved high drug loadings (> 3.5 mg/mL). Drug-lipid interactions were evaluated via DSC, Langmuir

From conventional therapy to novel nano-based approaches. A focus on prostate cancer.

The currently available clinical anticancer approaches pertaining to the treatment of prostate cancer are summarized here. After providing an overview of the main features of this highly impactful global disease, the currently available clinical treatments are briefly reviewed. Then, alternative and innovative nano-based therapeutic options that have been proposed or are currently being explored to significantly improve prostate cancer management (i.e. anti-prostate cancer polymeric nanoparticles loaded with drugs to promote their release and biological activity, including non-targeted and fun

Magnetically Controllable and Degradable Milliscale Swimmers as Intraocular Drug Implants.

Intraocular drug implants are increasingly used for retinal treatments, such as age-related macular degeneration and diabetic macular edema, due to the rapidly aging global population. Although these therapies show promise in arresting disease progression and improving vision, intraocular implant-based therapies can cause unexpected complications that require further surgery due to implant dislocation or uncontrolled drug release. These frequent complications of intraocular drug implants can be overcome using magnetically controllable degradable milliscale swimmers (MDMS) with a double-helix b

Unique Polyester-Based Biodegradable Multiarm Nano-Carrier for Cancer Cell Specific Mitochondrial Delivery of Chemotherapeutics.

Biodegradable polymeric nanocarriers hold significant potential for various biomedical applications, enabling the targeted and controlled delivery of drugs and bioactive molecules. In this context, pendant-functionalized polycaprolactone has garnered tremendous attention over the past few decades. Herein, we developed a mitochondria-targeted polycaprolactone-based polyprodrug, TPP PCL CPT PEG BTN, for the site-specific delivery of camptothecin (CPT). The design incorporates triphenylphosphonium (TPP+) and tertiary amine moieties for mitochondrial targeting, biotin (BTN) for receptor-mediated u

Short-chain dense brush PEGylation on rigid nanocarriers overcomes anti-PEG antibody recognition for immune-stealth drug delivery.

The clinical utility of PEGylated nanomedicines is constrained by anti-polyethylene glycol (PEG) immunity, which drives accelerated blood clearance and infusion reactions. We address this by rationally tuning polymer architecture: a short-chain, high-density PEG brush (PEG500) grafted onto rigid mesoporous silica nanoparticles (MSNs). This design limits immune recognition through three synergistic features: (i) shortened PEG chains reduce epitope accessibility, (ii) high grafting density (4.43 chains/nm2) provides a strong steric barrier, and (iii) the rigid silica surface minimizes PEG backfo

Allosteric targeted drug delivery for enhanced blood-brain barrier penetration via mimicking transmembrane domain interactions.

Current strategies for active targeting in the brain are entirely based on the effective interaction of the ligand with the orthosteric sites of specific receptors on the blood-brain barrier (BBB), which is highly susceptible to various pathophysiological factors and limits the efficacy of drug delivery. Here, we propose an allosteric targeted drug delivery strategy that targets classical BBB transmembrane receptors by designing peptide ligands that specifically bind to their transmembrane domains. This strategy prevents competitive interference from endogenous ligands and antibodies by using

Smart polymersome carriers for osteoporosis treatment: Enhanced bone regeneration via targeted teriparatide delivery.

Targeted drug delivery improves therapeutic efficacy while minimizing off-target effects. In this study, PLGA-PEG-Su-Asp (PPSA) copolymers were synthesized to develop teriparatide-loaded nano-polymersomes (PPSA-PTH1-34 NP) for bone-targeted delivery. Nanoparticles were prepared by nanoprecipitation and optimized using a central composite design. The optimized nanoparticles had a size of 245.78 ± 8.2 nm, PDI of 0.352 ± 0.12, ZP of -18.89 ± 0.1 mV, and 72.20 ± 2.9 % drug entrapment efficiency. PPSA-PTH 1-34 exhibited strong affinity (64.86 %) to hydroxyapatite, enhancing targeting efficiency. In

Smart bioconjugated MOFs for targeted drug delivery: Albumin and globulin effects on mebeverine release dynamics.

Mebeverine (MBV) is a clinically approved antispasmodic agent indicated for irritable bowel syndrome (IBS) that functions via direct calcium channel inhibition in gastrointestinal smooth muscle, alleviating spasmodic pain without central anticholinergic effects. Optimal oral delivery mandates protection from gastric acidity (pH ~1.5-3.0) and targeted release in the small intestine (pH ~6.0-7.4) for prompt onset and sustained action. Here, we report a comparative evaluation of tartaric acid-iron(III) metal-organic frameworks (TF-MOFs) functionalized with globulin (TF-GLB) or human serum albumin

Formulation and characterization of transfersomes for ocular delivery of tonabersat.

Transfersomes (TFS) are deformable vesicles, known for their ability to enhance transdermal drug penetration. This study aimed to evaluate whether TFS can also enhance ocular delivery of poorly soluble tonabersat. TFS were prepared using Phospholipon® 90G with Tween® 80 as the edge activator. The effect of formulation parameters (edge activator and cryoprotectant concentrations) on TFS characteristics were evaluated using a full factorial design. The optimized TFS eyedrop was characterized for particle size, zeta potential, deformability, entrapment efficiency (EE), drug content, pH, osmolalit

Targeting local glucocorticoid metabolism with a silk fibroin microneedle for more effective hypertrophic scar repair.

Hypertrophic scars (HS) are pathological cutaneous scars characterized by excessive collagen deposition and fibrosis. Intralesional glucocorticoid injections remain the standard treatment for HS, but it is often associated with side effects. In this study, we developed a novel silk fibroin microneedle (SF-MN) loaded with prednisone for localized delivery and glucocorticoid metabolism. The SF-MNs were fabricated using 10 % (w/v) silk fibroin. Prednisone-loaded SF-MNs were characterized by SEM and evaluated for biocompatibility, mechanical strength, and preclinical efficacy. Overall, the results

Diroximel Fumarate-Loaded Solid Lipid Nanopides (DRF-SLNs) в качестве потенциальных перевозчиков для лечения множественного склероза: предварительное исследование.

Diroximel fumarate (DRF) — пероральный препарат, используемый для лечения нескольких склерозов (MS). Несмотря на то, что он более терпим, чем его аналоги, является более желудочно-кишечным, чем его аналоги, многие пациенты по-прежнему прекращают лечение из-за частых неблагоприятных событий, связанных с ГИ. Для преодоления этих ограничений необходимы альтернативные системы доставки наркотиков в обход трассы ГИ. Прямая доставка носового мозга представляет собой многообещающий подход к обходу кровеносного барьера и направлению центральной нервной системы; однако ограниченное носовое слизистое пог

Совпадение в аннотации оригинала
Diroximel fumarate (DRF) is an orally administered prodrug used in multiple sclerosis (MS) treatment. Although it exhibits better gastrointestinal (GI) tolerability than its analogues, many patients still discontinue therapy due to frequent GI adverse events. To overcome these limitations, alternative drug delivery systems that bypass the GI tract are needed…

Metabolism and structure of PDA as the target for new therapies: possibilities and limitations for nanotechnology.

INTRODUCTION: Certainly, pancreatic ductal adenocarcinoma poses one of the greatest challenges in current oncology. The dense extracellular matrix and low vessel density in PDA tumor impede the effective delivery of drugs, primarily due to the short pharmacokinetics of most drugs and potential electrostatic interactions with stroma components. AREA COVERED: Owing to the distinctive metabolism of PDA and challenges in accessing nutrients, there is a growing interest in cell metabolism inhibitors as a potential means to inhibit cancer development. However, even if suitable combinations of inhib

Hydrogel design and applications for periodontitis therapy: A review.

Periodontitis is a prevalent oral disease characterized by microbial infection, inflammation, and damage to periodontal tissues. Hydrogels have emerged as promising carriers and regenerative biomaterials in periodontitis therapy. This review provides a comprehensive overview of recent advances in hydrogel applications for treating periodontitis. We begin by examining the design principles of hydrogels, including their thermosensitive, self-healing, photo-crosslinkable, and adhesive properties. We then explore the innovations in drug delivery and release mechanisms within hydrogel-based systems

How nanomaterials act against bacterial structures? a narrative review focusing on nanoparticle molecular mechanisms.

OBJECTIVE: In recent years, significant progress has been made in the field of nanotechnology for the treatment and prevention of biofilm formation and Multidrug-resistant bacteria (MDR). MDR bacteria challenges is hazardous when microorganisms induce the formation of biofilms, which amplify resistance to antibiotics and promote the development of multidrug-resistant conditions. The unique physicochemical properties of certain nanomaterials make nanotechnology a promising option for combating MDR infections. Several studies have introduced nanomaterials with different antibacterial mechanisms

Carbohydrate polymer-driven nanoparticle synthesis and functionalization in the brain tumor therapy: A review.

The brain tumors have been characterized with aggressive and heterogeneous nature. The treatment of brain tumors has been challenging due to their sensitive location and also, presence of blood-brain barrier (BBB) that reduces the entrance of bioactive compounds to the brain tissue. Therefore, the new treatment strategies should be focused on improving the efficacy of conventional therapeutics, crossing over biological barriers and introducing new kinds of methods for brain tumor elimination. In the recent years, the application of carbohydrate polymers in the treatment of human cancers has be

Advancing Liposomal Coating Approaches for Improved Anticancer Drug Delivery.

Quercetin, a natural flavonoid with antioxidant, anti-inflammatory, and anticancer properties, faces limitations in clinical application due to its poor solubility and bioavailability. This study presents a novel delivery system utilizing a combination of polyoxyethylene (100) stearyl ether and folic acid to enhance quercetin's effectiveness. We developed folate-conjugated polyoxyethylene (100) stearyl ether-coated liposomes (FA-Brij-LPs) to leverage the unique properties of polyoxyethylene (100) stearyl ether in conjunction with folic acid for targeted delivery. The FA-Brij-LPs were prepared

Mammalian Target of Rapamycin (mTOR) Signalling Pathway-A Potential Target for Cancer Intervention: A Short Overview.

BACKGROUND: The mammalian role of the rapamycin (mTOR) pathway is the practical nutrient-sensitive regulation of animal growth and plays a central role in physiology, metabolism, and common diseases. The mTOR is activated in response to nutrients, growth factors, and cellular energy. The mTOR pathway activates in various cellular processes and human cancer diseases. Dysfunction of mTOR signal transduction is associated with metabolic disorders, cancer for instance. OBJECTIVE: In recent years, significant achievements envisaged in developing targeted drugs for cancer. The global impact of canc

Dexamethasone Pretreatment Potentiates a Folic Acid-Functionalized Delivery System for Enhanced Lung Cancer Therapy.

Folic acid (FA) has been widely engineered to promote the targeted delivery of FA-modified nanoparticles (NPs) by recognizing the folate receptor α (FRα). However, the efficacy of FA-targeted therapy significantly varied with the abundance of FRα and natural immunoglobulin levels in different tumors. Therefore, a sequential therapy of dexamethasone (Dex)-induced FRα amplification and immunosuppression combined with FA-functionalized doxorubicin (DOX) micelles to synergistically suppress tumor proliferation was proposed in this study. In brief, a pH/reduction-responsive FA-functionalized micell