Результаты поиска

Brucellosis uveitis: A case report and literature review.

RATIONALE: Ocular involvement is an uncommon but serious complication of brucellosis, often leading to diagnostic delays and potential visio … s were excluded. INTERVENTIONS: The patient was treated with a systemic triple-antibiotic regimen (doxycycline, rifampicin, and compound sulfamethoxazole) for 3 months, alongside topical anti-inflammatory and antibiotic-steroid eye drops. OUTCOMES: After 2 months of treatment, the uveitis had resolved significantly, and visual acuity was restored to 1.0 in …

Disseminated Blastomycosis: A Case of Multisite Infection in an Immunocompetent Patient.

BACKGROUND Blastomycosis is a fungal infection caused by Blastomyces spp., a dimorphic fungus hyperendemic in Wisconsin, USA. CASE REPORT A 54-year-old previously healthy man presented with right foot and thigh pain, erythema, and a non-healing purulent ulcer on the right buttock. Initial treatment with oral doxycycline and cephalexin was unsuccessful, and subsequent imaging revealed a thigh hematoma and acute osteomyelitis of the forefoot with an adjacent abscess. The patient underwent 2 incision-and-drainage procedures, which uncovered a disarticulated second toe and persistent purulence. Hi…

Subarachnoid Hemorrhage, CNS Vasculitis and Stroke as a Sequela of Q Fever Infection.

A 64-year-old female with a history of Subarachnoid Hemorrhage (SAH) of non-aneurysmal origin underwent 4 cerebral Digital Subtraction Angio … r systemic or CNS vasculitis. The patient was treated for Q fever and CNS vasculitis with 1 year of doxycycline and hydroxychloroquine. There was no recurrence of symptoms 15 months after treatment. We conclude that Q fever can present with SAH in addition to CNS vasculitis and stroke.

Origin, evolution, and success of pbla, the gonococcal beta-lactamase plasmid, and implications for public health.

Neisseria gonorrhoeae is a leading cause of sexually transmitted infection (STI) and a priority AMR pathogen. Two narrow host range plasmids, pbla and pConj, have contributed to ending penicillin and tetracycline therapy, respectively, and undermine current prevention strategies including doxycycline post-exposure prophylaxis (Doxy-PEP). Here, we investigated the origin and evolution of the beta-lactamase plasmid, pbla. We demonstrate that pbla was likely acquired by the gonococcus from Haemophilus ducreyi, and describe the subsequent evolutionary pathways taken by the three major pbla variant…

Transient dilated cardiomyopathy phenotype and positive Bartonella serology in a cat.

A one-and-a-half-year-old spayed female domestic shorthaired cat, originally obtained as a stray, presented with a two-day history of lethar … estive heart failure with pimobendan, furosemide, and clopidogrel as well as with pradofloxacin and doxycycline for suspected bartonellosis. At 2.5-, 5-, and 9-month rechecks, echocardiogram findings were markedly improved with a reduction in atrial and ventricular chamber enlargement to normal and normal ventricular systolic function and without any further …

Leptospirosis.

Leptospirosis is a zoonotic bacterial infection that is prevalent across all continents and is caused by pathogenic spirochaetes of the genu … noparesis. Leptospira are susceptible to several low-cost antibiotics, including benzyl penicillin, doxycycline, cephalosporins and macrolides, when used in the early phase of infection. Late disease with organ dysfunction is treated with supportive care, and the benefit of antibiotics during late disease is doubtful. Very few countries have licensed a vaccin …

Rat bite fever presenting as localized cellulitis: The first documented presumptive case from Nepal and a call for clinical awareness.

BACKGROUND: Rat bite fever (RBF) is a rare but potentially fatal zoonotic disease caused by Streptobacillus moniliformis or Spirillum minus. … on period, and clinical presentation. She was treated with a combination of intravenous ampicillin, doxycycline and surgical wound debridement. She completed a course of oral antibiotics and recovered fully. CONCLUSION: This case represents the first documented presumptive case of Spirillum minus RBF in Nepal, which presented atypically. It underscores the i …

SOX10 - Mediadated Regulation of Entertic Glial Fenotyp in vitro и его значение для нейроинфламационных расстройств.

Коэффициент транскрипции SOX10 является одним из ключевых регуляторов фенотипа и функции mielinated glial celleris (MS). SOX10 также выражается в энтогенных глиальных клетках (ЭГК) внутри кишечника, однако его регулятивные функции в ЭСУ по-прежнему плохо понимаются. Это исследование было направлено на выявление целевых генов SOX10, которые влияют на фенотип ЭСУ и могут иметь последствия для MS. Была установлена клеточная линия EGC для перевыражения доксициклина SOX10. Воздействие перевыражения SOX10 на фенотип ЭСУ оценивалось с помощью анализа всего генома, а результаты проверялись с помощью R

Совпадение в аннотации оригинала
The transcription factor SOX10 is a key regulator of myelinated glial cell phenotype and function, with a known role in multiple sclerosis ( … that influence EGC phenotype and may have implications for MS. An EGC cell line was established for doxycycline-inducible SOX10 overexpression. Impact of SOX10 overexpression on EGC phenotype was assessed by genome-wide expression analysis and results were validated via RT-qPCR and western blot. Data were compared with SOX10 ChIP-seq and transcriptomic datase …

In vitro activity of selected antimicrobials against methicillin-resistant Staphylococcus pseudintermedius of canine origin in Poland.

BACKGROUND: Methicillin-resistant Staphylococcus pseudintermedius (MRSP) is an important veterinary pathogen. In general, only a few antimic … s, resistance to enrofloxacin and clindamycin was the most prevalent (n = 40; 97.6%). Resistance to doxycycline and gentamicin was observed in 83.0% (n = 34) and 68.3% (n = 28) of the isolates, respectively. Single isolates were resistant to chloramphenicol (n = 5; 12.2%) and rifampicin (n = 3; 7.3%), whereas all showed susceptibility to amikacin, vancomycin, …

Could traces of fluoroquinolones in food induce ciprofloxacin resistance in Escherichia coli and Klebsiella pneumoniae? An in vivo study in Galleria mellonella with important implications for maximum residue limits in food.

We hypothesized that the residual concentrations of fluoroquinolones allowed in food (acceptable daily intake-ADIs) could select for ciprofl … esistance in K. pneumoniae but not E. coli. This resistance was associated with cross-resistance to doxycycline and ceftriaxone. Whole genome sequencing revealed inactivating mutations in the transcription repressors, ramR and rrf2, as well as mutations in gyrA and gyrB. We found that ciprofloxacin doses 10-fold lower than those classified as acceptable for d …

Mycobacterium welchii Vaccine Granuloma - A Cautionary Tale.

BACKGROUND: Mycobacterium welchii (Mycobacterium w) vaccine was one of the many strategies used to both treat and prevent coronavirus diseas … atients should be counseled as such. Patients with persistent ulceration respond to combinations of doxycycline, ofloxacin, and clarithromycin.

Efficacy of Topical Treatments in the Management of Mild-to-Moderate Acne Vulgaris: A Systematic Review.

Acne vulgaris, commonly called acne, is a skin condition affecting many individuals globally. It is a chronic condition characterized by dev … articles focused on topical antibiotics, with findings from 198 subjects indicating the efficacy of doxycycline against inflammatory lesions. Retinoids, such as tretinoin and adapalene, significantly improved both lesion types (open and closed comedones). Niacinamide, examined in a randomized controlled trial involving 41 participants, reduced sebum productio …

Usefulness and limitations of Chat GPT in getting information on teratogenic drugs exposed in pregnancy.

There is a growing interest in using artificial intelligence (AI) technology to obtain information on the risk and safety of drugs in pregnancy. Inadvertent drug exposure in pregnant women is inevitable in acute or chronic diseases, especially in unplanned pregnancies. According to the Korean mother safe counselling center database (2010-2023), many Korean pregnant women and their families asked about the teratogenicity of their exposed drugs. The most frequently used drug was topiramate (n=2,018), followed by isotretinoin (n=1,972), dexamethasone (n=1,279), and doxycycline (n=1,119). Unexpect…

Unveiling Ureaplasma: A Case Report of a Rare Culprit in Pyelonephritis.

Ureaplasma species, typically considered commensal organisms of the human urogenital tract, have been implicated in various urinary tract in … d Ureaplasma urealyticum as the causative agent. This prompted a change in the treatment regimen to doxycycline, to which the patient showed significant clinical improvement. Physicians should be aware of Ureaplasma as a potential cause of pyelonephritis, especially in cases of culture-negative UTIs and when patients do not respond to standard empirical treat …

Brucellosis in pregnancy: a case report.

BACKGROUND: Brucella spp., a gram-negative bacterium, is one of the most prevalent zoonotic illnesses worldwide and is more commonly seen in … ellosis. She was treated with ceftriaxone, rifampin, and gentamicin before delivery and switched to doxycycline and ceftriaxone postpartum until negative. The patient was instructed not to breastfeed. After treatment, the patient felt well and the baby was healthy. CONCLUSIONS: When evaluating patients, it is necessary to obtain a social history including an …

Case Report: Encephalitis with Initial Manifestation of Orientia Tsutsugamushi Infection Detected by Metagenomic Next-Generation Sequencing.

PURPOSE: Scrub typhus, caused by Orientia tsutsugamushi, is characterized by fever, eschars, lymphadenopathy, and rash. The absence of escha … tection, the patient was diagnosed with "Orientia tsutsugamushi encephalitis". After treatment with doxycycline, the patient's symptoms were alleviated. He remained afebrile in follow-up and adhered well to medical advice. CONCLUSION: Our case demonstrates that it is difficult to distinguish Orientia tsutsugamushi encephalitis from central nervous system inf …

Typing of Treponema pallidum in a Brazilian sample and follow-up of treatment using molecular assays.

Syphilis remains a significant public health concern, with serological assays being the primary method for diagnosis. However, molecular techniques have proven to be reliable tools for the diagnosis and understanding of the transmission dynamics of Treponema pallidum infection. This study aimed to evaluate the efficacy of syphilis treatment using molecular assays, perform Enhanced Centers for Disease Control and Prevention (ECDC) typing, and analyze resistance (macrolide and doxycycline) in the T. pallidum isolate. PCR assay amplified treponemal DNA only from the lesion sample, whereas qPCR wa…

Female Pelvic Conditions: Sexually Transmitted Infections.

Sexually transmitted infection rates are increasing in the United States, with significant increases in the rates of syphilis among patients … and dysuria should be tested for gonorrhea and chlamydia using nucleic acid amplification testing. Doxycycline should be used to treat chlamydia because it is more effective in rectal chlamydia, which often coexists with vaginal infection. Single-dose azithromycin is an alternative in populations at risk for poor medication adherence or confidentiality conce …

Massive calvarial melioidosis abscess following minor trauma in rural areas of Thailand.

BACKGROUND: Melioidosis is uncommon but endemic in Southeast Asia and parts of Northern Australia. Cerebral melioidosis is rare but can be s … s was identified from pus culture. Intravenous meropenem with Bactrim was started, followed by oral doxycycline and bactrim. The patient recovered with no seizure episodes. This patient showed a rare but straightforward infection from direct inoculation in a wound contaminated with soil. Incubation time could be up to 2 months. The infection originates from p …

FKBP25 regulates myoblast viability and migration and is differentially expressed in in vivo models of muscle adaptation.

FKBP25 (FKBP3 gene) is a dual-domain PPIase protein that consists of a C-terminal PPIase domain and an N-terminal basic tilted helix bundle … 5 in myoblast viability, migration and differentiation and in adaptation of mature skeletal muscle. Doxycycline-inducible FKBP25 knockdown in C2C12 myoblasts revealed an increase in cell accumulation/viability and migration in vitro that was independent of alterations in tubulin dynamics; however, FKBP25 knockdown had no discernible impact on myoblast differe …