Результаты поиска

Efficacy and safety of flecainide acetate in the maintenance of sinus rhythm after electrical cardioversion of chronic atrial fibrillation or atrial flutter.

The efficacy and safety of flecainide were studied in the maintenance of sinus rhythm after electrical cardioversion for chronic atrial fibrillation or atrial flutter. Eighty-one patients were randomized to flecainide treatment or no treatment. Baseline characteristics of both groups were comparable. Compared to previous studies, patients could be classified as difficult-to-treat patients. Multiple regression analysis showed New York Heart Association class I for exercise tolerance (p = 0.0004) and flecainide treatment (p = 0.01) to be the main factors increasing the arrhythmia-free episode. H…

Release of somatic embryogenic potential from excised zygotic embryos of carrot and maintenance of proembryonic cultures in hormone-free medium.

Excised zygotic embryos, mericarps ("seeds") and hypocotyls of seedlings of cultivated carrot Daucus carota cv. Scarlet Nantes were evaluate … e of events leading from excised broken zygotic embryos to the formation of somatic embryos and the maintenance of somatic proembryos are demonstrated by scanning electron microscopy and histological preparations. Germination levels from intact zygotic embryos on media with varying levels and ratios of unreduced vs. reduced inorganic nitrogen were determined …

Maintenance therapy: a two year comparison between Caved-S and cimetidine treatment in the prevention of symptomatic gastric ulcer recurrence.

Eighty two patients with an endoscopically healed gastric ulcer, were treated for two years with either Caved-S tablets, two twice daily or … than 0.05), or a past history of a gastric ulcer (p less than 0.001). Ulcers recurred rapidly after maintenance therapy; Caved-S two out of 22; cimetidine seven out of 23, within four months (NS). This study shows that long term maintenance therapy is safe and reasonably effective. The high recurrence rate after stopping treatment suggests that therapy in hig …

Objective evaluation of the role of vincristine in induction and maintenance therapy for myelomatosis. Medical Research Council Working Party on Leukaemia in Adults.

In the Medical Research Council's IVth trial in Myelomatosis the possible benefit of adding vincristine to first line treatment with intermittent melphalan and prednisone has been assessed. This was analysed in 530 patients who were randomly allocated to receive vincristine or not. Survival was not improved by the addition of vincristine. A total of 268 patients reached plateau phase on first line therapy. Of these 226 patients were rerandomised either to continue receiving first line therapy for a further year or to cease therapy. At the present time there is a slight but not significant surv

Совпадение в полном тексте источника
… Treatment of multiple myeloma with M-2 protocol and without maintenance therapy. 19 10 10 1983 1345 1351 Eur J Cancer Clin Oncol 6688993 10.1016/0277-5379(93)90002-m Salmon S. E. Expansion of the growth fraction in multiple myeloma with alkylating agents. 45 1 1 1975 119 129 Blood 803104 …

Maintenance of Glossina morsitans morsitans on antiserum to procyclic trypanosomes reduces infection rates with homologous and heterologous Trypanosoma congolense stocks.

Three experimental groups of male Glossina morsitans morsitans were infected at their first feed with procyclic forms of different stocks of Trypanosoma congolense and subsequently maintained on a diet containing rabbit antiserum to one of these stocks. Control flies were similarly infected but were then maintained on normal rabbit serum. Dissection of the flies 19-21 days post infection showed a reduction in both immature and mature infection rates in all groups fed on antiserum by comparison with control flies. These results suggest that vaccination with a single procyclic T. congolense stra

Comparative efficiency of quinidine and verapamil in the maintenance of sinus rhythm after DC conversion of atrial fibrillation. A controlled clinical trial.

Fifty-three patients with chronic atrial fibrillation participated in a randomized cross-over trial in order to compare the ability of two drug regimens to establish and maintain sinus rhythm. The patients were given orally either sustained release quinidine 0.4 g twice day or verapamil 80 mg three times a day. Thirty-one patients tried both regimens. Quinidine was found to have a greater ability to induce conversion to sinus rhythm by drug alone (p less than 0.05) and also a greater ability to maintain sinus rhythm after conversion (after 3 months p less than 0.05). There was, however, also a

The laboratory maintenance and rearing of Simulium damnosum complex species as a research tool for the Onchocerciasis Control Programme in the Vola River Basin.

The laboratory maintenance and rearing of Stimulium damnosum complex species and the cytotaxonomic determination of reared larvae, has been useful to OCP in the following fields of investigation: 1. Species identification of reinvading females. 2. Distribution of biting populations of S. damnosum complex species. 3. Identification of eggs and small larvae found within the OCP area. 4. Host preferences of species within the complex. 5. Vector potential of S. damnosum complex species for Onchocerca volvulus and O. ochengi. 6. Provision of identified material for morphological investigation. The …

A feed-forward UHRF1 read-write mechanism supports H3 multi- mono-ubiquitination and DNA methylation maintenance at CpG-sparse regions.

The epigenetic inheritance of mammalian DNA methylation requires DNMT1 and its E3 ligase cofactor UHRF1. At newly replicated chromatin, UHRF … gent evidence that both writing and reading of H3 ubiquitination support CpG-sparse DNA methylation maintenance. Together, these findings establish a feed-forward ubiquitin read-write mechanism that generates multi-mono-ubiquitinated H3 and safeguards DNMT1-dependent DNA methylation maintenance at vulnerable genomic regions of the mammalian methylome.

Nurse-led, multidisciplinary strategies to reduce central line-associated bloodstream infections: Parenteral nutrition stewardship and central venous access device maintenance.

BACKGROUND: Central line-associated bloodstream infections (CLABSIs) remain a major source of preventable patient harm and are associated with increased mortality, longer hospital stays, and higher health care costs. Reducing central venous access device (CVAD) utilization and improving line maintenance practices are key strategies for prevention. PURPOSE: To reduce CLABSIs through a nurse-led, multidisciplinary initiative focused on parenteral nutrition (PN) stewardship, CVAD maintenance, and shared accountability for line necessity and care. METHODS: Using Plan-Do-Study-Act cycles, an inte…

Real-world comparison of avelumab maintenance versus pembrolizumab at progression after first-line platinum-based chemotherapy in metastatic urothelial cancer.

BACKGROUND: For patients with metastatic urothelial cancer of the bladder (mUCB), the standard of care after first-line (1L) platinum-based chemotherapy has shifted from immune checkpoint inhibitor (ICI) treatment upon progression to maintenance ICI, without a direct comparison between both treatment strategies. We aimed to estimate the effect of the introduction of maintenance avelumab on overall survival (OS) compared with pembrolizumab at disease progression. MATERIALS AND METHODS: This nationwide cohort study included patients with synchronous mUCB between November 2017 and December 2023 …

Nuclear protein 1 defends against acute pancreatitis by mitigating pancreatic acinar cell ferroptosis through the maintenance of cellular iron homeostasis.

Acute pancreatitis (AP) is a severe inflammatory condition marked by pancreatic acinar cell death, with ferroptosis emerging as a critical factor in its pathogenesis. The nuclear protein 1 (Nupr1) has been identified as a key regulator of ferroptosis; however, its role in modulating pancreatic acinar cell ferroptosis and its involvement in AP remain unexplored. The objective of this research was to examine whether Nupr1 regulates ferroptosis in pancreatic acinar cells and influences the progression of AP, while elucidating the underlying molecular mechanisms. Nupr1 was significantly upregulate

Real-world patterns of maintenance therapy after allogeneic transplant in older adults with acute myeloid leukemia: A Medicare cohort study.

INTRODUCTION: Older adults represent the majority of patients with acute myeloid leukemia (AML), and an increasing proportion receive allogeneic hematopoietic cell transplantation (alloHCT). Mutations in the FMS-like tyrosine kinase 3 gene (FLT3) confer high relapse risk, and post-transplant maintenance with FLT3 tyrosine kinase inhibitors (FLT3-TKIs) is guideline-recommended. However, real-world utilization, adherence, and tolerability of FLT3-TKIs in older adults remain poorly characterized. MATERIALS AND METHODS: Using 100% Medicare claims (Parts A/B/D and Medicare Advantage encounter data…

Optimizing an extended care intervention to promote weight loss maintenance: Protocol for the OPT-X multiphase optimization strategy factorial trial.

BACKGROUND: Weight loss maintenance (WLM) remains a limitation of behavioral obesity interventions, as long-term adherence is burdensome and diminishes over time. Simplified recommendations and/or alternative delivery methods that target evidence-based WLM strategies may reduce burden to improve long-term outcomes. METHODS: This protocol describes a multiphase optimization strategy (MOST) trial using a 2x2x2x2 factorial design to optimize a 12-month extended care program for weight loss maintenance. Adults with obesity who achieve at least 5% weight loss during an initial 4-month behavioral w…

Nintedanib as switch maintenance treatment in malignant pleural mesothelioma (NEMO): A double-blind randomized phase II trial (EORTC-08112-LCG).

INTRODUCTION: Pleural mesothelioma (PM) is a lethal malignancy in which angiogenesis and progressive fibrosis drives disease. We evaluated angiogenesis inhibition using nintedanib monotherapy as switch maintenance in patients with PM that completed 4-6 cycles of prior platinum-pemetrexed chemotherapy. The trial was performed in parallel to the LUME-Meso trial in an era prior to routine immune checkpoint inhibitor use, when platinum-pemetrexed was standard of care. METHODS: This is a triple-blind, placebo-controlled, multicentric, randomized, phase II study. Patients with inoperable PM (all hi…

Association between physical performance and cognitive frailty in middle-aged and older adults undergoing maintenance hemodialysis: a cross-sectional study.

Cognitive frailty (CF), defined as the coexistence of physical frailty and cognitive impairment, may be reversible under certain conditions. Identifying factors associated with CF in patients undergoing maintenance hemodialysis (MHD) is important for early recognition and risk stratification. This cross-sectional study examined the association between physical performance and CF in 282 Chinese MHD patients aged ≥ 45 years. CF was assessed using standardized cognitive and frailty assessment tools, and physical performance was evaluated using handgrip strength (HGS), gait speed (GS), the Five Ti…

Soluble suppression of tumorigenicity 2 and cardiovascular outcomes across serum uric acid strata in maintenance hemodialysis: an exploratory secondary analysis.

BACKGROUND: In maintenance hemodialysis (MHD), serum uric acid (UA) is influenced by nutritional, inflammatory, and dialysis-related factors. Whether the prognostic association of soluble suppression of tumorigenicity 2 (sST2) differs according to UA remains uncertain. METHODS: This retrospective secondary analysis included 358 MHD patients with baseline UA and sST2 measurements. UA was evaluated continuously and by rank-based quartiles; sST2 was evaluated continuously and in exploratory sample-median combined groups. Cardiovascular death was the primary outcome and major adverse cardiovascul…

Association Between Nutritional Status and Severe Sarcopenia in Maintenance Hemodialysis Patients: A Multicenter Cross-Sectional Study with Diagnostic Model Development.

BACKGROUND: Sarcopenia is highly prevalent in maintenance hemodialysis (MHD) patients and is associated with adverse outcomes, yet simple bedside tools to identify those with severe sarcopenia remain scarce. We aimed to develop and internally validate a nomogram-based diagnostic model for severe sarcopenia using routine nutritional indicators. METHODS: This multicenter cross-sectional study enrolled 131 MHD patients from two Chinese tertiary hospitals (2024-2026). Sarcopenia was classified by AWGS 2019 criteria into non‑sarcopenia (n=68), sarcopenia (n=29), and severe sarcopenia (n=34). Nutri…

Financial burden of immune checkpoint inhibitor maintenance therapy in Japan: a real-world cost analysis from an academic medical center.

BACKGROUND: Although immune checkpoint inhibitors (ICIs) have transformed cancer care today, they have also imposed substantial financial pressure on publicly funded healthcare systems. In clinical practice, ICI maintenance therapy (MT) is often continued for prolonged periods in patients without disease progression. However, analyses of the economic structure of ICI-MT remain limited. METHODS: We retrospectively analyzed regimen-based billing data patients who received outpatient drug therapy for 16 types of cancer at Iwate Medical University Hospital during the 2022 fiscal year. MT was defi…

Self-management behaviors and its correlation with maintenance blood glucose level control among diabetes mellitus patients: A longitudinal design study.

BACKGROUND: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia resulting from insulin resistance and/or impaired insulin secretion. Effective self-management behaviors are essential for maintaining glycemic control and preventing long-term complications. This longitudinal study aimed to evaluate diabetes self-management behaviors and examine their correlation with blood glucose maintenance among patients with DM. MATERIALS AND METHODS: A longitudinal study was conducted at Al-Diwaniyah Teaching Hospital, Iraq, involving 120 patients recruited thro…