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Adenocarcinoma Developing Overlying a Colonic Lipoma: A Case Report.

INTRODUCTION: Colonic lipomas are benign mesenchymal tumors composed of mature adipocytes and are most commonly located in the submucosal layer. They are usually asymptomatic and are often managed conservatively. Although adenomas arising overlying colonic lipomas have been reported, the coexistence of adenocarcinoma directly overlying a lipoma is extremely rare. The pathogenic relationship between submucosal tumors and epithelial malignancies remains unclear. CASE PRESENTATION: A 76-year-old man was diagnosed with a lipoma in the descending colon (diameter, approximately 30 mm) and was manag…

Application of paracrine effect of fallopian tube stem cells derived from Holstein cattle to bovine mastitis.

OBJECTIVE: Mastitis in dairy cows is a major cause of economic loss, and conventional antibiotic treatments often result in antimicrobial re … with no hematopoietic marker expression. The cells successfully differentiated into osteoblasts and adipocytes. In the mastitis treatment trial, 66% of cows in the antibiotic-treated group and 46% in the C-DPBS group reached the milk collection threshold by Day 8. SCC in the C-DPBS group was significantly reduced on Day 8 compared to Day 0 (P < 0.05), with n …

Development of In Vitro Parkinson's Disease Model Mediated by MPP+ and α-Synuclein Using Wharton's Jelly Mesenchymal Stem Cells.

MAIN PROBLEM: The mechanism behind Parkinson's disease (PD) is still unclear, and a cure to stop its progression is yet to be found. This is … er degeneration. RESULTS: WJMSCs were positive for MSC markers and were able to differentiate into adipocytes, chondrocytes, and osteocytes. DAN obtained after the differentiation of WJMSCs for 48 h expressed neuronal markers such as synapsin 1, neuropilin, neurofilament, and MAPT along with dopaminergic markers such as Nurr1, DAT, TH, DDC, and KCNJ6 and we …

Effects of dietary sodium butyrate supplementation on fat metabolism in lamb adipose and liver tissues.

OBJECTIVE: Sodium butyrate (SB) is a potentially useful feed additive; however, its effects on lipid metabolism in adipose and liver tissues … ly reduces abdominal and perirenal adipose tissue mass, as well as the average area and diameter of adipocytes (p<0.05). Dietary supplementation with SB activated adenosine 5'-monophosphate-activated protein kinase α1 (AMPKα1) in lamb adipose tissue, resulting in upregulated mRNA expression of hormone-sensitive triglyceride lipase (HSL) and downregulated mRN …

Visceral Adiposity and Cardiometabolic Risk: Clinical Insights and Assessment.

With obesity assuming pandemic proportion, cardiometabolic diseases are also increasing across the globe. Obesity defined as excess and dysf … al physiological functions and pathophysiological links to cardiometabolic diseases. VAT has unique adipocytes with various paracrine and endocrine functions. It not only stores lipids but also contributes significantly to energy homeostasis. Sexual dimorphism in relation to VAT and cardiometabolic health has been described. VAT is metabolically active, with …

Adipokines as Prognostic Biomarkers in Multiple Myeloma: A Case-Control Study.

Background and Objectives: Multiple myeloma (MM) remains an incurable plasma cell malignancy with heterogeneous clinical outcomes. Although current prognostic systems integrate biochemical and cytogenetic parameters, they do not fully capture disease complexity. Adipocytes within the bone marrow microenvironment secrete adipokines that regulate inflammation, metabolism, and immune interactions and may influence disease progression. This study aimed to assess circulating adipokines and related microenvironmental mediators as potential biomarkers of disease activity and treatment response in MM.…

Invasive Lobular Carcinoma Has Higher Immune Response Than Invasive Ductal Carcinoma in Estrogen Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Breast Cancers.

BACKGROUND: Invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) are two major pathological diagnoses of breast cancer, but … cells, regulatory T cells and M1 and M2 macrophages in both cohorts (all P < 0.05). Stromal cells, adipocytes and lymphatic endothelial cells were highly infiltrated in ILC, and cytolytic activity that represented the global anti-tumor immunity was significantly elevated in ILC in TCGA and subsequently validated in METABRIC. CONCLUSIONS: ILC has higher imm …

An inducible mouse model of osteogenesis imperfecta type V reveals aberrant osteogenesis caused by Ifitm5 c.-14C>T mutation.

Osteogenesis imperfecta (OI) type V is typically characterized by radial head dislocation, calcification of interosseous membrane, and hyper … tant mice confirmed delayed osteocyte maturation and compromised osteogenesis. Elevated bone marrow adipocytes were found in the adult mutant mice. Ectopic chondrogenesis and SOX9 expression were also observed in the perichondrium regions of Col1a1-Cre; Ifitm5flox c.-14C>T and Ocn-Cre; Ifitm5flox c.-14C>T mutant mice. The inducible Ifitm5flox c.-14C>T mouse …

Peripheral Nerve Injury After Deoxycholic Acid (ATX-101) Injection in an Experimental Rat Model.

BACKGROUND: Deoxycholic acid (ATX-101) is a drug administered by subcutaneous injection for local fat reduction. However, ATX-101 treatment has been reported to cause marginal mandibular nerve injury with noticeable functional deficits when targeting submental fat. As a cytolytic agent with some selectivity for adipocytes, ATX-101 may damage the lipid-rich myelin surrounding peripheral nerves. OBJECTIVES: The aim of this study was to characterize nerve injury caused by ATX-101 injection in an experimental rat sciatic nerve model. METHODS: Injuries to the sciatic nerve caused by intrafascicul…

Irisin reshapes bone metabolic homeostasis to delay age-related osteoporosis by regulating the multipotent differentiation of BMSCs via Wnt pathway.

INTRODUCTION: Bone aging is linked to changes in the lineage differentiation of bone marrow stem cells (BMSCs), which show a heightened tendency to differentiate into adipocytes instead of osteoblasts. The therapeutic potential of irisin in addressing age-related diseases has garnered significant attention. More significantly, irisin has the capacity to enhance bone mass recovery and sustain overall bone health. Its mechanism of action in preventing osteoporosis has generated considerable interest within the research community. Nonetheless, the targeting effect of irisin on age-related osteopo…

Hip osteoarthritis - histopathological aspects.

Osteoarthritis is a complex, degenerative disease that can affect all the anatomical structures of the synovial joints. Most frequently, the … and perisynovial connective tissue contained immune cells, vascular endothelial cells, fibroblasts, adipocytes, and other mesenchymal-derived stromal cells. The immunohistochemical study highlighted the presence of T-lymphocytes, B-lymphocytes, and macrophages, cells capable of synthesizing and releasing matrix metalloproteinases that are involved in the deg …

Lipidomic signatures of tracheal aspirate diagnostic biomarkers in preterm infants with bronchopulmonary dysplasia.

UNLABELLED: Bronchopulmonary dysplasia (BPD) is a significant pulmonary disorder that often leads to prolonged respiratory complications in … n pathways related to insulin resistance, vitamin digestion and absorption, lipolysis regulation in adipocytes, glycerolipid metabolism, fat digestion and absorption, and cholesterol metabolism. After intubation, infants with BPD exhibited 26 up-regulated and 19 down-regulated lipid metabolites, with enrichment primarily in metabolic pathways, including glyc …

Integrative UHPLC-HRMS and computational biology reveal ferroptosis and anoikis targeting by Wenpitongluo decoction in cardiorenal syndrome.

BACKGROUND: The Wenpitongluo Decoction (WPTLD) was a classical herbal formula composed of medicinal herbs with both edible and therapeutic p … onent-disease interaction targets were identified, predominantly localized in kidney, thymus, lung, adipocytes, adrenal gland, and heart tissues. Topological analysis of PPI networks revealed eight core targets, including ferroptosis-/anoikis-associated SIRT1, PTGS2, and PRKCA. KEGG analysis highlighted critical pathways such as AMPK and PI3K-Akt signaling. …

Partial removal of visceral epididymal white adipose tissue in obese Ldlr-/-.Leiden mice impacts adipokine secretion, plasma free fatty acids, and improves cerebrovascular health.

Visceral white adipose tissue (WAT) dysfunction may contribute to obesity-related brain impairments but causal relationship has not been dem … fect liver disease and atherosclerosis development, but reduced the number of severely hypertrophic adipocytes in the residual-eWAT. This was consistent with reduced secretion of adipokines (e.g., leptin, adiponectin) and pro-inflammatory mediators (e.g., PAI-1, MIP-1α/CCL3, IL-17) from the residual-eWAT in the ex vivo culturing experiments. Importantly, lip …

Intrathoracic Extrapulmonary Pleomorphic Liposarcoma: A Rare Presentation.

Liposarcoma (LPS) is a malignant mesenchymal neoplasm originating from adipocytes. LPS comprises several histological variants, among which pleomorphic liposarcoma (PL) constitutes a rare and highly aggressive subtype. PL is most commonly found in the extremities and presents primarily in individuals aged 50 and above. Primary thoracic presentations of PL are exceedingly rare, particularly in young adults, and are often associated with metastases to the lungs. This case reports a 28-year-old white male with no significant past medical history presenting with shortness of breath, left posterior…

Оценка взаимодействия между седловатыми стержневыми клетками Уортона и β-Меркаптоэтанолом.

ЦЕЛЬ: Железные мезенхимальные стволовые клетки Уортона (WJ-MSC) являются саморегенеративными и способными дифференцировать в многопоточные стволовые клетки. Могут существовать различные источники мезенхимальных стволовых клеток (МСЦ), задействованных в механизме ремонта поврежденных тканей в организме. WJ-MSC могут проводить различие между остеоцитами, хондроцитами, адипоцитами и миокитными клетками. Кроме того, MSC показывает нейрозащитное воздействие на нейроны. В настоящее время многие методы нейрорегенеративного лечения МСЦ доказали свою эффективность. Исследования показали, что МСЦ в боль

Совпадение в аннотации оригинала
PURPOSE: Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) are self-regenerative and able to differentiate into multipotent stem cells. There may be different sources of mesenchymal stem cells (MSCs) involved in the repair mechanism of damaged tissues in the organism. WJ-MSCs may differentiate into osteocytes, chondrocytes, adipocytes, and myocyte cel…

Obesity Induces Temporally Regulated Alterations in the Extracellular Matrix That Drive Breast Tumor Invasion and Metastasis.

Obesity is associated with increased incidence and metastasis of triple-negative breast cancer, an aggressive breast cancer subtype. The ext … stem and progenitor cells were primarily responsible for secreting collagen IV and collagen VI, not adipocytes. Longer exposure to HFD increased the invasive potential of ECM isolated from the lungs and liver, with significant changes in ECM composition found in the liver with short-term HFD exposure. Together, these data suggest that changes in the breast, …

Inflammatory Cells in Adipose Tissue and Skeletal Muscle of Patients with Peripheral Arterial Disease or Chronic Venous Disease: A Prospective, Observational, and Histological Study.

The main goal of this study was to assess whether the presence of peripheral arterial disease (PAD) correlates with increased inflammatory c … ar adipose tissue (PVAT) were collected from the femoral region. We analysed the characteristics of adipocytes and the presence of haemorrhage and inflammatory cells in the samples of PVAT and SAT via haematoxylin-eosin staining. We found that patients with PAD had significantly more inflammatory cells in PVAT [16 (43.24%) vs. 0 (0%) p = 0.008]. Analysing SA …

Immunohistochemical expression of the cation channel TRPC6 in the submandibular and lacrimal gland and in salivary gland tumors.

BACKGROUND: Canonical transient receptor potential channels play a crucial role in cancer cell proliferation. While TRPC6 subtype detection … d nuclei. Excretory ducts consistently showed TRPC6. Mucous tubules, their nuclei and the nuclei of adipocytes generally showed no signal while serous acini and their nuclei showed a weak TRPC6 signal. CONCLUSION: The discovery of TRPC6 in glandular tissue indicates a role in salivary gland function and calcium homeostasis is a basis for further research in …

Butein derivatives prevent obesity and improve insulin resistance through the induction of energy expenditure in high-fat diet-fed obese mice.

Obesity is a global public health problem and is related with fatal diseases such as cancer and cardiovascular and metabolic diseases. Medic … T browning. Compound 3 s exhibited a significantly higher ability to induce Ucp1 in white and brown adipocytes than did compound 1. A daily injection of compound 3 s at 5 mg/kg prevented weight gain by 13.6 % in high-fat diet-fed mice without any toxicological observation. In addition, compound 3 s significantly improved glucose homeostasis, decreased serum …