Результаты поиска

Cancer Screening in Renal Transplant Recipients: Real-World Data.

BackgroundMultiple international guidelines have endorsed cancer screening in renal transplant patients. This study aimed to describe a series of patients with post-transplant cancer and to report physicians' adherence to cancer screening guidelines.MethodsThis is a retrospective study of cancer patients who had a history of renal transplant. Charts of patients who were treated at our institution between 2012 and 2023 were reviewed, patients' clinical data were collected.ResultsThirty-nine patients were identified. The most common types of cancer were lymphoma (n = 9, 23%), squamous cell carci

Совпадение в полном тексте источника
… A study by Opelz et al [ 27 ] has demonstrated a strong link between EBV infection and post-transplant lymphoproliferative disorder (PTLD), a group of conditions that includes lymphomas. … Post-transplant lymphoproliferative disorders. Nat Rev Dis Primers. 2016;2:15088. doi: 10.1038/nrdp.2015.88. 29. Abdel-Razeq H, Mansour A, Jaddan D. Breast cancer care in Jordan. JCO Glob Oncol. 2020;6:260–268. doi: 10.1200/JGO.19.00279. …

Skin manifestations associated with systemic diseases - Part I.

The skin demonstrates what is happening in the body in many diseases, as it reflects some internal processes on the surface. In this sense, skin as an organ, goes beyond its protective and barrier functions, as it provides clues for the identification of some systemic diseases. The dermatologist then raises diagnostic hypotheses for conditions related to all systems and refers them to the appropriate specialty. With easy access to examination by trained eyes and biopsies, the skin can present specific or non specific alterations on histopathology. In the first case this combination establishes

Совпадение в полном тексте источника
… According to the deposited cryoglobulins, they can be divided into type I (monoclonal), type II (mono and polyclonal), or type III (polyclonal). 32 Type I is related to lymphoproliferative disorders of B lymphocytes, such as multiple myeloma, and manifests as a thrombotic vasculopathy ( Fig. 8 ). …

Multiple cystic lung disease.

Multiple cystic lung disease represents a diverse group of uncommon disorders that can present a diagnostic challenge due to the increasing number of diseases associated with this presentation. High-resolution computed tomography of the chest helps to define the morphological aspects and distribution of lung cysts, as well as associated findings. The combination of appearance upon imaging and clinical features, together with extrapulmonary manifestations, when present, permits confident and accurate diagnosis of the majority of these diseases without recourse to open-lung biopsy. The main dise

I

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Autoimmune Cytopenias Post Hematopoietic Stem Cell Transplantation in Pediatric Patients With Osteopetrosis and Other Nonmalignant Diseases.

Autoimmune cytopenia (AIC) is a rare complication post hematopoietic stem cell transplantation (HSCT), with a higher incidence in nonmalignant diseases. The etiology of post-HSCT AIC is poorly understood, and in many cases, the cytopenia is prolonged and refractory to treatment. Diagnosis of post-HSCT AIC may be challenging, and there is no consensus for a standard of care. In this retrospective study, we summarize our experience over the past five years with post-HSCT AIC in pediatric patients with osteopetrosis and other nonmalignant diseases. All pediatric patients who underwent HSCT for no

A case report of multiple extramedullary plasmacytoma of the head and neck.

RATIONALE: Multiple extramedullary plasmacytoma (EMP) of the head and neck is rare and a definitive first-line treatment has not been established. EMP successively as a benign mass occurring in multiple areas of the head and neck is rare. This report describes an atypical case with EMP occurring in multiple areas of the head and neck. PATIENT CONCERNS: A 35-year-old woman was admitted due to complaints of sore throat discomfort accompanied by hoarseness. The patient had undergone surgical excision of the thyroid gland and parotid gland excision several years ago. Postoperative pathological ex

Диабет мелитус в множестве миэломы и связанных с ним расстройства плазменных клеток: обзор риска, прогноза и результатов.

Существует четкая связь между типом 2 сахарный диабет и общий риск заболевания раком. Однако исследования, посвященные оценке типа 2 Риск ДМ и множественной миэломы (ММ) ограничен, и связь менее ясна. Понимание воздействия давнишнего типа 2 Важнейшее значение имеет DM о системах органов и симптоматологии у пациентов с последующим диагнозом MM, а также потенциальные перекликающиеся токсичные вещества, связанные с лечением MM. В настоящем обзоре резюмируется роль вида 2 ДМ о рисках и результатах ММ и изучает различные механизмы, лежащие в основе этих ассоциаций. Более глубокое понимание этой асс

Совпадение в полном тексте источника
… Furthermore, a large population-based matched case-control study in Sweden assessed the risk of nine lymphoproliferative disorders as well as unspecified amyloidosis after a DM diagnosis in about 94,579 cases. … The study found an initial increase in lymphoproliferative disorders within the first six months. …

Advances in the understanding of IgM monoclonal gammopathy of undetermined significance.

Among monoclonal gammopathies of undetermined significance (MGUSs), the immunoglobulin M (IgM) MGUS subtype stands as a unique entity and plays a pivotal role as a pre-malignant condition for multiple B-cell non-Hodgkin lymphomas, most notably Waldenström macroglobulinemia (WM). A relationship between IgM MGUS and WM has been proposed for decades. However, insight regarding the pathobiology of these two conditions improved significantly in recent years, strengthening the hypothesis that WM and IgM MGUS are different stages of the same disease. Therefore, the understanding of IgM MGUS and that

Совпадение в полном тексте источника
… IgM paraprotein can be present in virtually all B-cell lymphoproliferative disorders. a Constitutional symptoms: hepatosplenomegaly, lymphadenopathy, anemia, hyperviscosity, solid organ involvement, and rarely lytic lesions. b CRAB (hypercalcemia, renal failure, anemia, and bone lesions) features. c … Xu L, Hunter ZR, Yang G, et al. : MYD88 L265P in Waldenström macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction. …

Rare Diseases of the Orbit.

This article provides an overview of rare orbital diseases. Congenital malformations, inflammatory diseases, benign and malignant neoplasias are described. Although it represents a relatively small area of the body the orbit contains multiple different tissues. Therefore, a great variety of diseases can be found within the orbital space. That is the reason, why both the completeness and the level of detail in the description of particular diseases must be somewhat limited. Nevertheless, clinical manifestations, important aspects of diagnosis, treatment strategies, and, when specific data are a

Patient-reported outcomes of chimeric antigen receptor T-cell therapy in hematologic malignancies: a systematic review and meta-analysis.

Few studies evaluated patient-reported outcomes (PROs) for patients with hematologic malignancies receiving with Chimeric Antigen Receptor T (CAR-T) cell therapy. We performed a systematic review and meta-analysis to evaluate the benefits of CAR-T cell therapies focused on PROs. A systematic literature searched from PubMed, Cochrane, and the Web of Science from inception to September 2023. Study selection and data extraction were conducted independently by two reviewers based on pre-specified criteria. The COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) R

Extraintestinal Cancers in Inflammatory Bowel Disease: A Literature Review.

BackgroundInflammatory bowel disease (IBD) is a group of chronic multifactorial inflammatory disorders including two major entities: Crohn's disease (CD) and ulcerative colitis (UC). Preliminary evidence suggests that patients with IBD may be at increased risk of developing intestinal and extraintestinal cancers (EICs). Actually, little is known about the association between IBD and EICs, and there is ever-growing concern regarding the safety of immunomodulators and biological therapy, which may represent a risk factor for carcinogenesis.AimsThe aim of this review is to summarize the evidence

Совпадение в полном тексте источника
… Similarly, the ENCORE registry, which involved 1541 patients with CD treated with IFX, found no association between IFX and lymphoproliferative disorders or malignancies [ 152 ]. … EBV-Driven Lymphoproliferative Disorders and Lymphomas of the Gastrointestinal Tract: A Spectrum of Entities with a Common Denominator (Part 1) Cancers. 2021;13:4578. doi: 10.3390/cancers13184578. 68. …

Low hemoglobin as a novel prognostic biomarker in EBV-positive diffuse large B-cell lymphoma patients: a clinical feature analysis of 99 cases from Zhejiang, Southeast China.

Epstein-Barr virus-positive diffuse large B-cell lymphoma (EBV+DLBCL) is a rare and clinically aggressive subtype of DLBCL, distinguished by its notably unfavorable prognosis. The clinical characteristics of this entity remain insufficiently characterized in the Chinese population. This study retrospectively analyzed 99 cases of EBV+DLBCL with available clinical data from Zhejiang Province, southeastern China. We comprehensively characterized the clinicopathological features of these patients and performed both univariate and multivariate survival analyses to identify independent prognostic fa

Совпадение в полном тексте источника
… Oyama T et al (2007) Age-related EBV-associated B-cell lymphoproliferative disorders constitute a distinct clinicopathologic group: a study of 96 patients. Clin Cancer Res 13(17):5124–5132 17. … Shimoyama Y et al (2009) Age-related EBV-associated B-cell lymphoproliferative disorders: diagnostic approach to a newly recognized clinicopathological entity. Pathol Int 59(12):835–843 24. …

II Brazilian Consensus on the use of human immunoglobulin in patients with primary immunodeficiencies.

In the last few years, new primary immunodeficiencies and genetic defects have been described. Recently, immunoglobulin products with improved compositions and for subcutaneous use have become available in Brazil. In order to guide physicians on the use of human immunoglobulin to treat primary immunodeficiencies, based on a narrative literature review and their professional experience, the members of the Primary Immunodeficiency Group of the Brazilian Society of Allergy and Immunology prepared an updated document of the 1st Brazilian Consensus, published in 2010. The document presents new know

Совпадение в полном тексте источника
… Subcutaneous immunoglobulin in lymphoproliferative disorders and rituximab-related secondary hypogammaglobulinemia: a single-center experience in 61 patients. Haematologica. 2014;99(6):1101–1106. doi: 10.3324/haematol.2013.101261. 88. Aguiar R, Araújo C, Martins-Coelho G, Isenberg D. …

Изучение последствий трансплантации гематопоиетических клеток: 18- годовое исследование посттрансплантационных новообразований.

ВВЕДЕНИЕ: Улучшается трансплантация стволовых клеток после гематотипии (ХХТ) с увеличением числа выживших жертв. Особую озабоченность вызывают последующие новообразования (СН) в связи с ПЗТ. МЕТОДЫ: С января 2003 и декабрь 2022, учетные записи получателей ВСТ были ретроспективно проанализированы. Результаты: на медианной основе 108 месяцев (дальность, 0.13-215), 2659 Пациенты получали ТХТ. Из них 1131 (В тыс.43%) были <18 ..старше. Аллогенетические ЦХТ были проведены в 1476 (В тыс.56%) пациентов. Myeloablatory (MAC) была использована в 2157 (В тыс.81%) и 583(В тыс.22%) получил TBI. При медиане

Unraveling the Role of Allo-Antibodies and Transplant Injury.

Alloimmunity driving rejection in the context of solid organ transplantation can be grossly divided into mechanisms predominantly driven by either T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR), though the co-existence of both types of rejections can be seen in a variable number of sampled grafts. Acute TCMR can generally be well controlled by the establishment of effective immunosuppression (1, 2). Acute ABMR is a low frequency finding in the current era of blood group and HLA donor/recipient matching and the avoidance of engraftment in the context of high-titer, pref

Совпадение в полном тексте источника
… Immunity ( 1994 ) 1 ( 5 ): 405 – 13 . 10.1016/1074-7613(94)90071-X 7882171 40 Waterhouse P Penninger JM Timms E Wakeham A Shahinian A Lee KP Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4 . … Clin Infect Dis ( 2009 ) 48 ( 6 ): 772 – 86 . 10.1086/597089 19207081 80 Epstein-Barr Virus and Posttransplant Lymphoproliferative Disorder in Solid Organ Transplantation . …

Subcutaneous immunoglobulin replacement for treatment of humoral immune dysfunction in patients with chronic lymphocytic leukemia.

BackgroundPatients with chronic lymphocytic leukemia (CLL) experience hypogammaglobinemia and non-neutropenic infections. In this exploratory proof of concept study, our objective was to determine the prevalence of humoral immunodeficiency in patients with CLL and serum IgG ≥ 400 mg/dL, and to evaluate the efficacy of subcutaneous immunoglobulin (SCIG) in this population.Patients and methodsPatients with CLL with serum IgG ≥ 400 mg/dL were evaluated for serum IgG, IgM, IgA, along with pre/post vaccine IgG titers to diphtheria, tetanus, and Streptococcus pneumoniae. Patients with evidence of hu

Совпадение в полном тексте источника
… Subcutaneous immunoglobulin in lymphoproliferative disorders and rituximab-related secondary hypogammaglobulinemia: a single center experience in 61 patients. Haematologica 2014; 99(6): 1101–1106. doi: 10.3324/haematol.2013.101261 27. …

Clinical Comparison of Non-Myeloablative Conditioning with Anti-Thymocyte Globulin and Fludarabine for Patients with Hematologic Malignancies.

BackgroundThe influence of different non-myeloablative conditioning regimens on clinical outcome remains undefined.Material and methodsWe retrospectively analyzed the hematopoietic reconstitution, graft-versus-host disease (GVHD), and quality of life (QOL) in 56 patients with hematologic malignancies who underwent non-myeloablative stem cell transplantation (NST) with a conditioning regimen based on anti-thymocyte globulin (ATG), followed by donor lymphocyte infusion (n=24), or Fludarabine (FLU) (n=32). Hematopoietic stem cells were derived from low-resolution HLA-matched identical sibling don

Acquired platelet disorders.

Platelets are essential to primary hemostasis, and defects in their number or function can lead to clinically significant bleeding or thrombosis. Acquired platelet disorders are far more common than the inherited forms and arise in a wide range of settings, including drug exposure, autoimmune, systemic, and critical illnesses. This review examines current understanding of the mechanisms driving acquired platelet dysfunction and outlines the diagnostic and therapeutic approaches that are shaping contemporary standards of care. Drug-related and immune-mediated platelet defects remain the most re

Совпадение в полном тексте источника
… These conditions can occur in the background of hematological neoplasms (e.g., lymphoproliferative disorders) or complicate other autoimmune disorders, including ITP. … o Other hematological disorders: paraproteinemia and lymphoproliferative disorders Patients with paraproteinemia and lymphoproliferative disorders (LPD) can experience both quantitative and qualitative platelet defects. …

Tumor Lysis Syndrome Triggered by Acalabrutinib in Chronic Lymphocytic Leukemia (CLL): Diagnostic and Therapeutic Implications.

Tumor lysis syndrome (TLS) is an uncommon but potentially life-threatening oncologic emergency, typically associated with highly proliferative hematologic malignancies. It is rarely encountered in chronic lymphocytic leukemia (CLL), a generally indolent B-cell neoplasm. We report a unique case of therapy-induced TLS in a patient newly diagnosed with CLL, following the initiation of acalabrutinib, a Bruton's tyrosine kinase (BTK) inhibitor. The patient presented with marked hyperleukocytosis, severe thrombocytopenia, and acute kidney injury at diagnosis. Immunophenotyping and histopathological

Canine laryngotracheal plasma cell tumors: Ten cases and literature review.

Canine extramedullary plasma cell tumors (EMPs) most commonly arise in the skin, oral cavity, rectum, and colon. This retrospective study describes the histopathological and immunohistochemical characteristics and associated clinical signs and outcomes of laryngeal and tracheal EMPs in dogs. Five tracheal and 5 laryngeal EMPs were diagnosed at the Penn Vet Diagnostic Laboratory. Clinical information was obtained via submission forms and follow-up questionnaires. All dogs were male (9 castrated), 7 to 15 years old, and of different breeds. Neoplasms were composed of well-differentiated (n = 6)

Совпадение в полном тексте источника
… However, positive immunoreactivity to MUM-1 has also been reported in cutaneous histiocytomas and in subsets of canine lymphomas and lymphoproliferative disorders. 7 , 10 , 11 , 16 MUM-1 should be run in conjunction with other round cell markers such as IBA-1, CD3, CD79, and CD20. …