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Characteristics of ocular findings of patients with coronavirus disease 2019 in China.

PURPOSE: This study aimed to report the ocular manifestations in individuals with coronavirus disease 2019 (COVID-19) and investigate any co … associated with a higher prevalence of conjunctivitis, iritis, uveitis, retinal vein occlusion and optic neuritis. The majority of individuals (51.0%) developed eye symptoms after the onset of COVID-19 systemic symptoms. There was no significant association between the severity of systemic symptoms and ocular symptoms. CONCLUSION: Individuals with COVID-19 wer …

Orbital Apex Syndrome Secondary to Herpes Zoster Ophthalmicus: A Literature Review and In-Depth Understanding.

PURPOSE: The aim of this study was to report our experience and to provide a comprehensive understanding of the onset and course of orbital … oncomitant ocular involvement, i.e. keratitis, anterior uveitis or both. Seven (87.5%) patients had optic neuritis. All patients were treated with intravenous acyclovir at neuro-meningeal doses. Oral steroids were prescribed in 62.5% of patients with gradual tapering. The mean BCVA was 20/87 at 3 months. Almost all patients experienced a complete resolution of o …

Clinical outcomes with all-oral regimens in patients of drug-resistant tuberculosis: A prospective study in a tertiary hospital in North India.

The study aimed to analyze therapeutic outcomes with bedaquiline-based all-oral regimens for drug-resistant tuberculosis. A prospective obse … ), and thrombocytopenia (25.7%) were other common adverse events in longer-oral regimen recipients. Optic neuritis occurred in two patients in the longer-oral regimen. Hepatitis and thrombocytopenia were common with regimens combining bedaquiline and delamanid. Linezolid dose was reduced in 44.6% and was replaced in 17.8% of the patients. Fluoroquinolone resista …

Варианты лечения под воздействием болезней при очень раннем многоразовом склерозе - какие варианты имеются для включения под действием 5 Годы? Систематический обзор.

Фон/задачи: Очень ранний педиатрический множественный склероз (POMS) встречается редко; клинические исследования с использованием методов коррекции заболеваний (DMT) не проводились. Клинические работники полагаются на исследования, проводимые в пожилом возрасте. Этот обзор стал результатом трудностей, с которыми сталкиваются врачи, и несанкционированного использования ДМТ в этом возрасте. Методы: Обзор литературы исследований, проведенных в период между 1982 и 2025 на очень раннем этапе ПОМС, особенно с наступлением до достижения возраста 5, был выполнен в поисках результатов без DMT или без D

Совпадение в аннотации оригинала
Background/Objectives: Very early pediatric-onset multiple sclerosis (POMS) is rare; clinical studies using disease-modifying treatments (DM … d, at onset, with ataxic syndrome (57.4%), pyramidal syndrome (41.4%), ophthalmoplegia (10.3%), and optic neuritis (6.9%). In evolution, 22.7% had seizures. Half of the patients were not treated. Among those treated, acute steroid therapy was administered; 11 received the DMTs interferon, Glatiramer acetate, Dimethyl fumarate, and Azathioprine (three), with only …

Расследование случайной или причинно-следственной связи церебрального венозного тромбоза и миэлина олигодендроцита гликопротеина противомоскитного заболевания: доклад о деле и обзор литературы.

Myelin oligodendrocyte glycoprotein-сопутствующая антителу болезнь (MOGAD) — синдром демиелинирования центральной нервной системы (DS), обычно содержащий оптический неуриит или миелит. Связь между церебральным венозным тромбозом (CVT) и демиелинизирующими заболеваниями, включая множественный склероз (MS), является редкой. В настоящем исследовании 37-летний мужчина столкнулся с сенсорными нарушениями нижних конечностей и недержанием мочевого мозга в соответствии с миелитом. Диагностика MOGAD была подтверждена результатами наблюдений спинного магнитного резонанса и сывороткой антиМОГ с помощью к

Совпадение в аннотации оригинала
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a central nervous system demyelinating syndrome (DS) typically presenting with optic neuritis or myelitis. The association between cerebral venous thrombosis (CVT) and demyelinating diseases, including multiple sclerosis (MS), is rare. In the present study, a 37-year-old man presented…

Потенциальный потенциал визуального видения, вызывающий запоздалость и амплитуду, является субклиническим прогнозом клинического прогноза в множестве склерозов.

Множественный склероз (MS) является хроническим воспалительным заболеванием центральной нервной системы, характеризующимся поражением мозга, аксонной дисфункцией/дегенерацией и глиозом, что может привести к различным клиническим расстройствам. Визуальный потенциал (ВЭП) представляет собой чувствительные и повторяющиеся методы, способные отслеживать значительные краткосрочные изменения в нейроаксональной целостности и изменения в нервном проводе, вызываемые острым оптическим невритом. АИМ: Цель данного исследования состоит в том, чтобы оценить, могут ли ПВП запоздалость и амплитуда служить в ка

Совпадение в аннотации оригинала
BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by focal demyelinating les … short-term changes in neuroaxonal integrity and alterations in nerve conduction triggered by acute optic neuritis. AIM: This study aims to evaluate whether VEP latency and amplitude could serve as subclinical predictors of clinical outcomes in MS patients over short-term follow-ups. METHODS: This study was planned to include MS patients diagnosed according to …

Isolated Depo-Medrol Administration under Tenon's Capsule for Post-COVID-19 Uveitis in a Child: A Case Report and Literature Review.

Coronavirus disease 2019 (COVID-19) can manifest with ocular symptoms. These symptoms can be divided into isolated events attributed to COVID-19, and those occurring in multisystem inflammatory syndrome in children (MIS-C), a newly diagnosed disease entity associated with COVID-19 infection. Currently, the literature lacks specific guidelines and treatment regimens for COVID-19 ocular symptoms, especially in children. The authors present the case of a 14-and-a-half-year-old boy with bilateral uveitis of the anterior and posterior segments along with vasculitis and optic neuritis associated wit…

Mimickers of nervous system involvement among patients with Behçet's syndrome.

OBJECTIVES: We aimed to identify conditions mimicking nervous system involvement among patients with Behçet's syndrome (BS) and to determine … entrapment neuropathy, and 1 each had epilepsy, glial tumor, multiple sclerosis, Meniere's disease, optic neuritis, neuroretinitis, steroid myopathy and polyneuropathy. CONCLUSION: Nervous system conditions other than NeuroBS are frequent among BS patients referred to neurology. Caution is required to avoid misdiagnosis of these patients as NeuroBS.

Approach to Managing the Initial Presentation of Multiple Sclerosis: A Worldwide Practice Survey.

BACKGROUND AND OBJECTIVES: Available disease-modifying therapies (DMTs) for multiple sclerosis (MS) are rapidly expanding; although escalati … Neurology® Clinical Practice. Questions pertained to a case of a 37-year-old woman presenting with optic neuritis. Respondents were asked to indicate their initial investigations, relapse management strategy, choice of disease-modifying therapy, and plan for follow-up imaging (contrast/noncontrast). Survey responses were stratified by key demographic variables …

Vogt-Koyanagi-Harada disease after SARS-CoV-2 infection: Case report and literature review.

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), a complex and multifaceted illness. COVID-19 is associated with various ocular manifestations including conjunctivitis, retinal vein occlusion and optic neuritis. However, the case of Vogt-Koyanagi-Harada (VKH) disease associated with SARS-CoV-2 is infrequent, and the specific association is still unclear. CASE PRESENTATION: In the present study, a 35-year-old female patient without any significant medical history presented with 1 week of bilateral blurred vision, o…

Совместное централизованное и периферальное обезвоживание: связанное или совпадение?

Наследственные сенсорные датчики моторного Neurophy (HSMN) 1A и множественный склероз (MS) являются различными демиелионирующими расстройствами, влияющими соответственно на периферийные и центральные нервные системы. Мы представляем пример одновременного возникновения обоих заболеваний, изучения клинического представления, диагностического анализа и потенциального взаимодействия между этими заболеваниями. Презентация дел и клинический подход: 49-летний мужчина с историей зрительного неврата, с прогрессивной онемением, слабостью и сенсорными потерями во всех конечностях на протяжении четырех ле

Совпадение в аннотации оригинала
BACKGROUND: Hereditary Sensory Motor Neuropathy (HSMN) 1A and Multiple Sclerosis (MS) are distinct demyelinating disorders affecting the per … tween these diseases. Case presentation and clinical approach: A 49-year-old male with a history of optic neuritis presented with progressive numbness, weakness, and sensory loss in all extremities over four years. Neurological examination revealed distal weakness, sensory deficits in a stocking-glove distribution, pes cavus, and hammer toes. Nerve conduction st …

Pathophysiology of myelin oligodendrocyte glycoprotein antibody disease.

Myelin Oligodendrocyte Glycoprotein Antibody Disease (MOGAD) is a spectrum of diseases, including optic neuritis, transverse myelitis, acute disseminated encephalomyelitis, and cerebral cortical encephalitis. In addition to distinct clinical, radiological, and immunological features, the infectious prodrome is more commonly reported in MOGAD (37-70%) than NMOSD (15-35%). Interestingly, pediatric MOGAD is not more aggressive than adult-onset MOGAD, unlike in multiple sclerosis (MS), where annualized relapse rates are three times higher in pediatric-onset MS. MOGAD pathophysiology is driven by a…

Evaluation of the safety profile of COVID-19 vaccines in patients with MS, NMOSD, and MOGAD.

INTRODUCTION: Vaccination against the coronavirus disease 2019 (COVID-19) is recommended for patients with multiple sclerosis (MS), neuromye … elitis occurred in a MOGAD patient receiving azathioprine maintenance therapy. The first episode of optic neuritis occurred in a patient who was later diagnosed with MOGAD. CONCLUSIONS: Our study demonstrated a favorable safety profile with no serious adverse events associated with COVID-19 vaccines in patients with MS, NMOSD, and MOGAD.

Juvenile multiple sclerosis: addressing epidemiology, diagnosis, therapeutic, and prognostic updates along with cognitive dysfunction and quality of life.

Juvenile multiple sclerosis (JMS) is a rare but significant subtype of multiple sclerosis (MS) that affects a small percentage of patients u … may include atypical clinical features such as seizures, acute disseminated encephalomyelitis, and optic neuritis, making diagnostic evaluations challenging. Whilst the biology of JMS shares similarities with adult-onset MS, there exist notable distinctions in disease progression, clinical manifestations, and ultimate prognoses. The International Pediatric MS S …

Phenotypic characteristics of myelin oligodendrocyte glycoprotein antibody-associated disease in children: a single-center, retrospective study.

OBJECTIVE: To analyze the clinical characteristics and follow-up data of children with different clinical phenotypes of myelin oligodendrocy … types of MOGAD included acute disseminated encephalomyelitis (ADEM; n = 37), encephalitis (n = 11), optic neuritis (ON, n = 9), neuromyelitis optica spectrum disorder (NMOSD; n = 9), transverse myelitis (TM; n = 6), leukodystrophy-like manifestations (n = 1), and meningitis (n = 1). The mean age of disease onset was 86 months. The number of leukocytes in the cer …

Clinical characteristics and long-term follow-up outcomes of myelin oligodendrocyte glycoprotein antibody-associated disease in Han Chinese participants.

Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is an immune-mediated inflammatory demyelinating disease of th … s (33.3%), including visual impairment, incapacitation, cognitive impairment, and speech reduction. Optic neuritis was the most common clinical manifestation of MOGAD. magnetic resonance imaging findings were heterogeneous and the cerebral cortex/subcortical white matter was the most susceptible brain region. Although patients in the acute phase responded well t …

Retinal transcriptome profiling identifies novel candidate genes associated with visual impairment in a mouse model of multiple sclerosis.

Visual impairment is occasionally observed in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Although uveitis and optic neuritis have been reported in MS and EAE, the precise mechanisms underlying the pathogenesis of these visual impairments remain poorly understood. This study aims to identify differentially expressed genes (DEGs) in the retinas of mice with EAE to identify genes that may be implicated in EAE-induced visual impairment. Fourteen adult mice were injected with myelin oligodendrocyte glycoprotein35-55 to induce the EAE model. Transc…

Anti-aquaporin-4 immunoglobulin G/anti-myelin oligodendrocyte glycoprotein immunoglobulin G double-positive paraneoplastic neurological syndrome in a patient with triple-negative breast cancer.

We report a rare case of paraneoplastic neurological syndrome with dual seropositivity of anti-aquaporin-4 and myelin oligodendrocyte glycop … th pembrolizumab. She first developed longitudinally extending transverse myelitis followed by left optic neuritis and meningoencephalitis with new enhancing lesions in the brain and spinal leptomeninges. Cerebrospinal fluid analysis during both episodes showed normal glucose and protein, and elevated white blood cell count. Cytology was negative for malignancy. …

Autoimmune Cerebellar Ataxia Associated with Anti-Glutamate Receptor δ2 Antibodies: a Rare but Treatable Entity.

We report two novel cases of autoimmune cerebellar ataxia (ACA) associated with anti-glutamate receptor δ2 antibodies (Gluδ2-Abs). The first case was confirmed by indirect immunofluorescence and cell-based assays: a 29-year-old woman presented after 5 days of headache and vomiting, a pancerebellar syndrome, downbeat nystagmus, decreased visual acuity linked to bilateral retrobulbar optic neuritis (RON), and lymphocytic pleocytosis in the cerebrospinal fluid (CSF) without any abnormality detected using cerebral magnetic resonance imaging (MRI). Second-line immunotherapy allowed progressive clin…

Tocilizumab treatment in MOGAD: a case report and literature review.

Myelin oligodendrocyte glycoprotein-immunoglobulin G associated disease (MOGAD) is an autoimmune demyelinating disorder of the central nervous system (CNS) which usually occurs with recurrent optic neuritis, transverse myelitis, acute disseminating encephalomyelitis, or brainstem encephalitis. To date, the anti-CD 20 drug rituximab (RTX) is employed in MOGAD although some authors reported the efficacy of Tocilizumab (TCZ) in refractory patients. We present the case of a woman affected by refractory MOGAD who was treated with TCZ after therapy with RTX had failed to prevent relapses. We also co…