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Euthanasia and physician-assisted suicide not meeting due care criteria in the Netherlands: a qualitative review of review committee judgements.

UNLABELLED: ObjectivesTo assess how Dutch regional euthanasia review committees (RTE) apply the euthanasia and physician-assisted suicide (EAS) due care criteria in cases where the criteria are judged not to have been met ('due care not met' (DCNM)) and to evaluate how the criteria function to set limits in Dutch EAS practice. DESIGN: A qualitative review using directed content analysis of DCNM cases in the Netherlands from 2012 to 2016 published on the RTE website (https://www.euthanasiecommissie.nl/) as of 31 January 2017. RESULTS: Of 33 DCNM cases identified (occurring 2012-2016), 32 case

Medical Assistance in Dying in Oncology Patients: A Canadian Academic Hospital's Experience.

BackgroundMedical assistance in dying (MAID) was legislatively enacted in Canada in June 2016. Most studies of patients who received MAID grouped patients with cancer and non-cancer diagnoses. Our goal was to analyze the characteristics of oncology patients who received MAID in a Canadian tertiary care hospital.MethodsWe conducted a retrospective review of all patients with cancer who received MAID between June 2016 and July 2020 at London Health Sciences Centre (LHSC). We describe patients' demographics, oncologic characteristics, symptoms, treatments, and palliative care involvement.ResultsN

Global perspectives on lupus nephritis: a review of clinical trials and therapeutic innovations.

BACKGROUND AND OBJECTIVES: Lupus nephritis (LN) remains a leading cause of morbidity and mortality in systemic lupus erythematosus (SLE). Although recent years have witnessed the approval of several targeted therapies, achieving long-term, drug-free remission remains challenging. This commentary evaluates the global landscape of interventional LN clinical trials from 2001 to 2026 to identify emerging trends and strategic gaps in drug development. METHODS: We analyzed 200 interventional pharmacological trials retrieved from three major global registries: ClinicalTrials.gov, Chinadrugtrials.org

Estimating the Cost of Cancer Care in British Columbia and Ontario: A Canadian Inter-Provincial Comparison.

BackgroundCosting studies are useful to measure the economic burden of cancer. Comparing costs between healthcare systems can inform evaluation, development or modification of cancer care policies.ObjectivesTo estimate and compare cancer costs in British Columbia and Ontario from the payers' perspectives.MethodsUsing linked cancer registry and administrative data, and standardized costing methodology and analyses, we estimated costs for 21 cancer sites by phase of care to determine potential differences between provinces.ResultsOverall, costs were higher in Ontario. Costs were highest in the i

Non-pharmacological interventions feasible in the nursing scope of practice for pain relief in palliative care patients: a systematic review.

BackgroundPalliative care patients desire more symptom management interventions that are complementary to their medical treatment. Within the multi-professional team, nurses could help support pain management with non-pharmacological interventions feasible for their practice and adaptable to palliative care patients' needs.ObjectivesThe objective was to identify non-pharmacological interventions feasible in the nursing scope of practice affecting pain in palliative care patients.DesignA systematic review.Data sources and methodsA defined search strategy was used in PubMed, CINAHL, PsycINFO, an

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… PubMed | Search Domain (#1) | ‘palliative care’[MeSH Terms] OR ‘Hospice and Palliative Care Nursing’[MeSH Terms] OR ‘Palliative Medicine’[MeSH Terms] OR ‘Terminal Care’[MeSH Terms] OR ‘end of life’[Tiab] OR ‘palliation’[Tiab] OR ‘palliative*’[Tiab] OR ‘hospice*’[Tiab] OR ‘terminal care’[Tiab] OR ‘advanced … care’) OR (MH ‘Hospice care’) OR (MH ‘Palliative care’) OR (MH ‘Hospice and Palliative Nursing’)) OR TI (‘end of life care’ OR ‘palliation’ OR ‘palliative*’ OR ‘hospice*’ OR ‘terminal care’ OR ‘terminally ill’ OR ‘advance care’) OR AB (‘end of life care’ OR ‘palliation’ OR ‘palliative*’ OR ‘hospice* …

Emergency Department Management of Common End-of-Life and Palliative Care Symptoms: Three Cases

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… Atropine, hyoscine butylbromide, or scopolamine are equally effective for the treatment of death rattle in terminal care. Wildiers H, Dhaenekint C, Demeulenaere P, et al. J Pain Symptom Manage. 2009;38:124–133. doi: 10.1016/j.jpainsymman.2008.07.007. 18. …

Упущенные возможности для поощрения процветания в лечении рака: краткое исследование множественной миеломы.

Недавние теоретические и эмпирические достижения в области науки о благосостоянии могут иметь существенные последствия для медицинского обслуживания при рассмотрении экзистенциальных проблем, с которыми сталкиваются люди с неизлечимым или ограниченным сроком жизни диагнозом рака. Мы предлагаем, чтобы определенные элементы процветания, такие, как смысл и цель, глубокие личные отношения и воспитание добродетели, могли быть воплощены в жизнь, если они будут надлежащим образом ориентированы на конец жизни. Был проведен качественный тематический анализ полуструктурированных опросов для изучения опы

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… This reluctance is driven by misconceptions equating palliative care with hospice care, as clinicians often associate it with terminal care [ 21 ]. …

Association Between Geriatric Assessment and Post-Chemotherapy Functional Status in Older Patients with Cancer.

BackgroundMaintaining functional status is among the most important patient-centered outcomes for older adults with cancer. This study investigated the association between comprehensive geriatric assessment (CGA) and progressive disease or decline of IADL-independence 1 year after chemotherapy, overall survival (OS), and premature termination of chemotherapy. CGA-based functional status and quality of life (QOL) 1 year after chemotherapy are also described.MethodsThis prospective cohort study involved patients aged ≥65 years treated with chemotherapy for any cancer type. CGA and the G8-screeni

Life-Sustaining Treatment States in Korean Cancer Patients after Enforcement of Act on Decisions on Life-Sustaining Treatment for Patients at the End of Life.

PurposeIn Korea, the "Act on Hospice and Palliative Care and Decisions on Life-sustaining Treatment for Patients at the End of Life" was enacted on February 4, 2018. This study was conducted to analyze the current state of life-sustaining treatment decisions based on National Health Insurance Service (NHIS) data after the law came into force.Materials and methodsThe data of 173,028 cancer deaths were extracted from NHIS qualification data between November 2015 and January 2019.ResultsThe number of cancer deaths complied with the law process was 14,438 of 54,635 cases (26.4%). The rate of patie

End-of-Life Care Practice in Dying Patients after Enforcement of Act on Decisions on Life-Sustaining Treatment For Patients in Hospice and Palliative Care or at the End of Life : A Single Center Experience

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The Economic Burden of Cancer in Canada from a Societal Perspective.

Cancer patients and their families experience considerable financial hardship; however, the current published literature on the economic burden of cancer at the population level has typically focused on the costs from the health system's perspective. This study aims to estimate the economic burden of cancer in Canada from a societal perspective. The analysis was conducted using the OncoSim-All Cancers model, a Canadian cancer microsimulation model. OncoSim simulates cancer incidence and deaths using incidence and mortality data from the Canadian Cancer Registry and demography projections from

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… On average, patients spent 302 h in the initial care phase, 183 h in the terminal care phase, and approximately 20 h annually in the continuing care phase. … Costs incurred by patients and families were highest in the initial care phase and lowest in the terminal care phase. …

Identification of a potentially avoidable cardiopulmonary resuscitation in hematology and oncology wards.

BackgroundIn-hospital cardiopulmonary resuscitation (CPR) is one of undesirable situations. We tried to identify and characterize a potentially avoidable CPR in cancer patients who were hospitalized in hematology and oncology wards.MethodsA potentially avoidable CPR was determined based on chemotherapy setting, disease status and clinical situation at the time when a cardiopulmonary arrest occurred, by using a consensus-driven medical records review of two physicians.ResultsOne hundred thirty-seven patients among 12,437 patients hospitalized at hematology and oncology wards between March 2003

Epimutational profile of hematologic malignancies as attractive target for new epigenetic therapies.

In recent years, recurrent somatic mutations in epigenetic regulators have been identified in patients with hematological malignancies. Furthermore, chromosomal translocations in which the fusion protein partners are themselves epigenetic regulators or where epigenetic regulators are recruited/targeted by oncogenic fusion proteins have also been described. Evidence has accumulated showing that "epigenetic drugs" are likely to provide clinical benefits in several hematological malignancies, granting their approval for the treatment of myelodysplastic syndromes and cutaneous T-cell lymphomas. A

Willingness of advanced cancer patients to receive palliative care and its determinants: A cross-sectional study in Northern Tanzania.

BackgroundThe purpose of this study was to assess willingness of advanced cancer patients to receive palliative care and its determinants at Cancer Care Centre in Kilimanjaro Christian Medical Centre Northern Tanzania.ObjectiveThe purpose of this study was to assess willingness of advanced cancer patients to receive palliative care and its determinants at Cancer Care Centre in Kilimanjaro Christian Medical Centre Northern Tanzania.MethodsThis was an institution-based cross-sectional study and the target population was all advanced cancer patients attending care at Cancer care Centre in Norther

Exploring the ethical decision-making experience of caregivers of end stage cancer patients in Iran: a phenomenological study.

BackgroundEthical decision making is a complex issue because it strongly depends on the religion, beliefs, traditional laws and moral views of each society. The purpose of this study was to explore the experience of Iranian family caregivers of end stage cancer patients about ethical decision making.MethodsThis qualitative study is based on van Manen's method of hermeneutic phenomenology. In-depth interviews were carried out to collect data. Participants were 12 caregiver. Audiotapes were transcribed and analyzed for common themes that represented the participants' experiences. Trustworthiness

Estimating and validating disability-adjusted life years at the global level: a methodological framework for cancer.

BackgroundDisability-adjusted life years (DALYs) link data on disease occurrence to health outcomes, and they are a useful aid in establishing country-specific agendas regarding cancer control. The variables required to compute DALYs are however multiple and not readily available in many countries. We propose a methodology that derives global DALYs and validate variables and DALYs based on data from various cancer registries.MethodsWe estimated DALYs for four countries (Norway, Bulgaria, India and Uganda) within each category of the human development index (HDI). The following sources (indicat

From monoclonals to bispecific T cell engagers: the evolving antibody-based therapy landscape in acute myeloid leukemia.

Acute myeloid leukemia (AML) is an aggressive hematological malignancy with a poor prognosis despite advances in treatment strategies. Standard treatment regimens induce remissions in many patients, but relapse occurs in approximately half, highlighting the urgent need for novel therapeutic strategies. Antibody-based therapies have significantly improved the treatment of acute lymphoblastic leukemia (ALL), but progress in AML has been slower, with only gemtuzumab ozogamicin (GO) receiving FDA approval to date. This is largely due to the absence of AML-specific surface antigens and the challeng

Targeting fibrosis, mechanisms and cilinical trials.

Fibrosis is characterized by the excessive extracellular matrix deposition due to dysregulated wound and connective tissue repair response. Multiple organs can develop fibrosis, including the liver, kidney, heart, and lung. Fibrosis such as liver cirrhosis, idiopathic pulmonary fibrosis, and cystic fibrosis caused substantial disease burden. Persistent abnormal activation of myofibroblasts mediated by various signals, such as transforming growth factor, platelet-derived growth factor, and fibroblast growh factor, has been recongized as a major event in the occurrence and progression of fibrosi

Palliative prognostic scores for survival prediction of cancer patients: a systematic review and meta-analysis.

BACKGROUND: The palliative prognostic score is the most widely validated prognostic tool for cancer survival prediction, with modified versions available. A systematic evaluation of palliative prognostic score tools is lacking. This systematic review and meta-analysis aimed to evaluate the performance and prognostic utility of palliative prognostic score, delirium-palliative prognostic score, and palliative prognostic score without clinician prediction in predicting 30-day survival of cancer patients and to compare their performance. METHODS: Six databases were searched for peer-reviewed stud

Acceptance in Patients With Cancer: A Scoping Review.

BackgroundCancer is generally perceived as a major stressor. Occasionally, patients are able to accept their diagnosis and prognosis, and it is not uncommon for patients who initially experience great distress to eventually learn to accept their disease. A deeper understanding of acceptance can enable clinicians to better support patients in achieving a more peaceful state of mind. The purpose of this literature review was to provide a comprehensive overview of existing research on acceptance in patients with cancer.Recent findingsStudy selection resulted in the inclusion of 54 studies. All st