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Micafungin-induced hemolytic anemia: a case report and investigation of anti-micafungin antibody prevalence.

Micafungin and other echinocandins are commonly used for the prophylaxis and empirical treatment of invasive fungal infections in neutropenic patients due to their broad-spectrum activity and favorable safety profile. Drug-induced hemolytic anemia (DIHA) is a rare condition, and micafungin-related cases are exceptionally uncommon. We describe a fatal case of intravascular hemolysis triggered by re-administration of micafungin in a patient receiving chemotherapy for peripheral T cell lymphoma. The patient experienced convulsions and shock within minutes of infusion of the drug, followed by seve…

Chicken Infectious Anemia Virus Markedly Enhances the Pathogenicity of Infectious Bronchitis Virus-Infected Chickens.

Chicken infectious anemia virus (CIAV) and infectious bronchitis virus (IBV) represent two of the most economically significant pathogens in the global poultry production. In recent years, coinfections involving CIAV and IBV have become increasingly prevalent in clinical scenarios across Southern China and globally. Nevertheless, the underlying synergistic pathogenic mechanisms remain largely elusive. This study establishes a coinfection model using specific pathogen-free (SPF) chickens infected with field-derived strains CIAV GDHY230813 and IBV CK/CK/GX/LA/071423 to systematically investigate…

Association between periodontitis and anemia: Results from the National Health and Nutrition Examination Survey.

BACKGROUND/PURPOSE: Recently, the association between periodontitis and anemia has raised the attention, however there is still a lack of convincing evidence on the association between periodontitis and anemia. This study aimed to examine the association between periodontitis and anemia by analyzing a large population-based nationally representative sample in American. MATERIALS AND METHODS: The study utilized data collected from 2009 to 2014 of the National Health and Nutrition Examination Survey (NHANES). Participants who had received periodontal examination and hemoglobin tests were enroll…

Ситуационное нарушение эритрополиса приводит к анемии у недавно диагностированных пациентов с несколькими миэлома.

Множественная миелома (ММ), связанная с анемией 60% Пациенты и коррелируют с плохими прогнозами. В то время как в большинстве исследований основное внимание уделяется воздействию микроокружающей среды на эритропоизис в ММ, дефекты эритроидных клеток и лежащие в их основе молекулярные механизмы по-прежнему характеризуются слабой спецификой. МЕТОД: Клинические данные были собраны 300 больные с недавно диагностированным множественным миелом (НДММ) и 300 здоровый контроль. Фенотипический и транскриптомный профили костного мозга на ранней и поздней стадии эритрополии были сопоставлены между здоровы

Совпадение в аннотации оригинала
BACKGROUND: Multiple myeloma (MM) associated anemia affects over 60% of patients and correlates with poor prognosis. While most studies focus on the impact of microenvironment on erythropoiesis in MM, the stage-specific erythroid cell defects and their underlying molecular mechanisms remain poorly characterized. METHOD: Clinical data were collected from 300…

Linking HLA class II susceptibility to HSPC transcriptomics and antigen presentation in aplastic anemia.

BACKGROUND: Acquired aplastic anemia (AA) is an immune-mediated bone marrow failure syndrome characterized by destruction of hematopoietic stem and progenitor cells (HSPCs). Although HLA class II alleles are consistently associated with disease susceptibility, the candidate self-peptides presented by these molecules remain largely unknown. METHODS: We performed a retrospective case-control study evaluating HLA class II associations in 35 patients with AA and 570 unrelated healthy controls. Bulk transcriptomic analysis of untreated Lin-CD34+ HSPCs (GSE165870) identified differentially expresse…

Acute Soft Head Syndrome, A Rare Complication of Sickle Cell Anemia: A Case Report.

Acute soft head syndrome (ASHS) is a rare clinical complication of sickle cell disease (SCD). It presents as a progressive, non-traumatic, and tender swelling of one or more areas of the scalp. Aetiopathophysiology is still less understood but hypothesized to be a result of loss of cortical skull bone integrity from increased extramedullary hematopoiesis. Diagnosis is clinically made. However, imaging is very necessary to rule out an intracranial involvement, commonly an epidural hematoma. ASHS with no intracranial involvement is managed conservatively. We present the case of a 15-year-old ado

Perioperative Anemia Investigation and Management in Vascular Surgery: A Single-Center Retrospective Service Evaluation.

Background Perioperative anemia is common in vascular surgery, but it is unclear how well national guidelines are followed in its investigation. This service evaluation examined how closely routine vascular surgical practice adhered to the British Society for Haematology (BSH) recommendations for investigating iron deficiency. Methods A retrospective service evaluation of consecutive adults undergoing vascular surgery at a single NHS center was performed. Electronic records were reviewed to determine the prevalence of preoperative anemia, adherence to the BSH recommendations for iron deficienc…

Nitrofurantoin-Induced Hemolytic Anemia and Methemoglobinemia in G6PD Deficiency Treated With Hyperbaric Oxygen Treatment.

INTRODUCTION: Methemoglobinemia is a rare but potentially serious condition characterized by an increased level of methemoglobin in the blood, which impairs oxygen delivery to tissues. It occurs when hemoglobin's ferrous iron (Fe2+) is oxidized to ferric iron (Fe3+), rendering it unable to bind oxygen effectively. This leads to tissue hypoxia, which can manifest clinically as cyanosis, shortness of breath, fatigue, and, in severe cases, organ dysfunction. CASE REPORT: Nitrofurantoin-induced hemolytic anemia and methemoglobinemia in patients with glucose-6-phosphate dehydrogenase (G6PD) defici…

The Possible Hematological Cost of Metabolic Success: Do Incretin-Based Therapies Silently Trigger Anemia?

Diabetes mellitus and obesity represent a growing global health burden with high morbidity and mortality. In the last several years, novel incretin-based therapies have been developed, and their use has risen dramatically. Beyond their proven metabolic, glycemic, cardiovascular, renal, and many other benefits, there are some observational data linking anemia development with their use. From the era of gliptins to retatrutide, in this review we tried to explore whether erythroid suppression is the hidden paradigm of advanced incretin-based therapies. Potential pathophysiological explanations in…

Causal association between sarcopenia and iron deficiency anemia: A two-sample Mendelian randomization study.

To investigate potential causal links between sarcopenia and iron deficiency anemia (IDA), we conducted a two-sample Mendelian randomization (MR) study using genome-wide association study data. Instrumental variables were selected based on genome-wide significance (P < 5 × 10-⁸), linkage disequilibrium pruning (r2 < 0.001), minor allele frequency > 0.01, and F-statistics > 10. Analysis used inverse-variance weighted method, with MR-Egger, weighted median, and weighted mode for robustness. Sensitivity analyses included Mendelian randomization pleiotropy residual sum and outlier, MR-Egger regres…

Неонатальная анемия после внутриутробного воздействия на женщин: ретроспективное когортное исследование в реальном мире.

Натальизумаб является моноклонным антителом, который все чаще используется у пациентов репродуктивного возраста с множественным склерозом (MS). Хотя имеющиеся данные свидетельствуют о том, что воздействие беременности в раннем возрасте является безопасным, по-прежнему сохраняется озабоченность по поводу возможных гематоологических осложнений у новорожденных. ЦЕЛЬ: Оценка того, связано ли воздействие на Натальизумаба внутриутробной системы с повышенным риском неонатальной анемии в группе беременных пациентов с синдромом MS. МАТЕРИАЛЫ И МЕТОДЫ: В период с января 2018 года по январь 2023 года мы

Совпадение в аннотации оригинала
BACKGROUND: Natalizumab is a monoclonal antibody increasingly used in patients of reproductive age with multiple sclerosis (MS). Although av … evaluate whether in-utero exposure to Natalizumab is associated with an increased risk of neonatal anemia in a cohort of pregnant patients with MS. MATERIALS AND METHODS: We conducted a retrospective cohort study including all pregnant patients with MS who were monitored throughout their pregnancy between January 2018 and January 2023. Pregnancies were …

Pre-treatment anemia in head and neck cancer: risk factors, subtypes, and survival outcomes.

INTRODUCTION: Anemia in head and neck cancer (HNC) may be due to additive, overlapping or competing causes. Here we aim to investigate the prevalence of pre-therapeutic anemia, associated risk factors, subtypes, and impact on survival among HNC patients, including the clinically relevant subgroups of HPV-associated HNC. MATERIALS AND METHODS: A retrospective chart review of HNC patients diagnosed between 2010 and 2020 identified a study cohort of 921 patients. Every patient was subject to pre-therapeutic laboratory testing which was correlated with clinical data and oncologic outcomes. RESUL…

The New WHO Cut-off Point for Defining High-altitude Anemia may be Inadequate.

INTRODUCTION: Peru carries a high burden of childhood anemia, particularly in high-altitude regions where hemoglobin (Hb) adjustment for altitude is recommended. This study aimed to evaluate whether the proportion of anemia attributable to iron deficiency (ID), inflammation, and red blood cell indices varies by altitude in children, using different diagnostic criteria. METHODS: We conducted a cross-sectional study of 280 children aged 6 to 72 months residing in Arequipa, Peru at altitudes ranging from 9 to 4310 m above sea level. Venous blood samples were collected to assess Hb, complete bloo…

Thrombosis and Anemia in Pediatric Inflammatory Bowel Disease: Pathophysiology, Clinical Impact and Future Directions.

Pediatric inflammatory bowel disease (PIBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is associated with inflammation that extends beyond the gastrointestinal tract. Among the most significant extraintestinal complications are anemia and thrombosis, both of which can impact disease severity, quality of life, and long-term outcomes. This review aims to explore the intertwined pathophysiology of anemia and thrombosis, clinical implications of these two complications, and management strategies for anemia and thrombosis in PIBD. Anemia is the most common systemic complication…

Prevalence of Anemia and Associated Factors Among Undergraduate Students at SIMAD University, Mogadishu, Somalia.

BACKGROUND: Anemia remains a significant public health issue, affecting populations worldwide, particularly in low-income countries. Despite its widespread prevalence, no comprehensive studies have been conducted to assess the prevalence of anemia or its associated factors among university students in Somalia. This study aimed to assess the prevalence of anemia and its associated factors among undergraduate students at SIMAD University, Mogadishu, Somalia. METHODOLOGY: A cross-sectional study was conducted involving 264 participants from various faculties. Data on sociodemographic factors, me…

Rare Autoantibody Mimics Anti-C and Anti-e Specificity in Patient with Aplastic Anemia.

BACKGROUND: Alloantibodies for the Rh blood group are the most immunogenic antibodies found in the Chinese population, typically causing acute or delayed hemolytic transfusion reactions and fetal and neonatal hemolytic diseases. Autoantibodies are generally considered nonspecific, and approximately 50% of warm antibodies are secondary to a variety of diseases, especially hematologic tumors. In this case report, a rare autoantibody that mimics anti-C and anti-e specificity was identified. METHODS: A 17-year-old adolescent with aplastic anemia was awaiting transfusion due to anemia. Routine lab…

Beneath the surface in autoimmune hemolytic anemia: pathogenetic networks, therapeutic advancements and open questions.

In recent years, the pathophysiologic framework of autoimmune hemolytic anemias (AIHAs) has evolved considerably, extending beyond the simplistic paradigm of antibody-mediated red blood cell (RBC) destruction, which is now recognized as a downstream consequence of a broader immune dysregulation. AIHA is fundamentally orchestrated by a complex interplay between innate and adaptive immune components, including autoreactive B and T lymphocytes, macrophages, and the reticuloendothelial system. Central to disease pathogenesis are two interrelated mechanisms: clonal B-cell expansion with autoantibod…

Splenic artery embolization for the management of severe life-threatening warm autoimmune hemolytic anemia.

BACKGROUND: Urgent splenectomy is recommended for the management of highly transfusion-dependent life-threatening warm autoimmune hemolytic anemia, while for individuals unfit for surgery, splenic embolization is an alternative treatment option. However, reports on its use in this context are sparse, and data on patient outcomes, effectiveness, and safety remain limited. CASE PRESENTATION: A 21-year-old female patient presented with severe transfusion-dependent, life-threatening, warm autoimmune hemolytic anemia that was unresponsive to steroids and rituximab, reaching a nadir of 2.3 g/dL. Du…