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Structurofunctional resting-state networks correlate with motor function in chronic stroke.

PURPOSE: Motor function and recovery after stroke likely rely directly on the residual anatomical connections in the brain and its resting-s … local histogram-matching technique that alleviates distortions caused by brain lesions. Fractional anisotropy maps and mean BOLD images of each subject were separately registered to the individual's T1-weighted image using affine transformations. White matter fiber orientations within each voxel were estimated with the q-ball model, which approximates the o …

Translating state-of-the-art spinal cord MRI techniques to clinical use: A systematic review of clinical studies utilizing DTI, MT, MWF, MRS, and fMRI.

BackgroundA recent meeting of international imaging experts sponsored by the International Spinal Research Trust (ISRT) and the Wings for Li … d widely across studies, rendering direct comparisons of metrics invalid. The DTI metric fractional anisotropy (FA) had the strongest evidence of utility, with moderate quality evidence for its use as a biomarker showing correlation with disability in several clinical pathologies, and a low level of evidence that it identifies tissue injury (in terms of grou …

Imaging and serum biomarkers reflecting the functional efficacy of extended erythropoietin treatment in rats following infantile traumatic brain injury.

OBJECTIVE Traumatic brain injury (TBI) is a leading cause of death and severe morbidity for otherwise healthy full-term infants around the w … atter in PID16-23 CCI-veh rats showed widespread injury and significant abnormalities of functional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD); MD, AD, and RD improved after EPO treatment. Chronically, P13-P28 CCI-veh rats also had elevated serum CXCL1 levels, which normalized in CCI-EPO rats. CONCLUSIONS Effi …

The Association Between Changes in White Matter Microstructure and Cognitive Function in Older Adults with Mild Cognitive Impairment.

Background: Mild Cognitive Impairment (MCI) is a clinical state between normal aging and dementia. It may involve impairment in one or sever … te matter microstructure in older adults with MCI remain unclear. Most past studies used Fractional Anisotropy (FA) analysis to examine changes in white matter fiber orientation, often ignoring fiber density. As a result, findings are often contradictory or difficult to interpret. Therefore, it is necessary to assess cognitive function in MCI populations usi …

Alterations of the cerebral microstructure in patients with noise-induced hearing loss: A diffusion tensor imaging study.

OBJECTIVE: To explore the changes in the cerebral microstructure of patients with noise-induced hearing loss (NIHL) using diffusion tensor i … lated with the hearing threshold (p < .05). DTI analysis showed that all DTI parameters (fractional anisotropy [FA], axial diffusivity [AD], mean diffusivity [MD], and radial diffusivity [RD]) were significantly different in the left inferior longitudinal fasciculus (ILF) and left inferior fronto-occipital fasciculus (IFOF) for the three groups (p < .05). In …

Оценка МРТ механизмов, лежащих в основе роста и сокращения повреждений при множественном склерозе.

ЦЕЛЬ: Оценка патологических механизмов, способствующих расширению или свертыванию белых веществ (ВМ) и ремиилизации при множественном склерозе (МС). Мы провели оценку 1,613 Повреждения 49 люди с повторной эмиссией MS в CCMR-One Испытание на бексаротене (EudraCT) 2014-003145-99). Мы измерили направление повреждения по отношению к WM трактам, градиентам поверхности и венам. Деформация якоба использовалась для оценки расширения повреждения по сравнению с 6 Месяцы, в то время как для оценки ремиэлизации использовалась визуализация коэффициента передачи магнитизации (MTR). Результаты: 33% Поврежден

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… By applying the diffusion tensor scheme, we calculated lesion anisotropy as follows: Lesion anisotropy = √ 6 6 λ 1 − λ 2 + λ 2 − λ 2 + λ 1 − λ 2 λ . . … We did not set an additional threshold based on lesion anisotropy, as the minimum anisotropy value was already 0.27 units. …

RNA метилтрансферазы METTL8 устанавливает m3C32 в митохондриальном tRNASThr/Ser (UCN) для оптимизации структуры trNA и митохондриального перевода.

Модифицированные нуклеотиды в tRNA являются важными определяющими факторами сворачивания, структуры и функции. Здесь мы идентифицируем METTL8 как митохондриальный белок и активный РНК метилтрансферазы, ответственный за установку m3C32 в митохондриале человека (mt-)tRNAThr и mt-tRNAser (UCN). METTL8 имеет перекрестные связи с антикодоновой стволовой петлей (ASL) многих мт-тРНК в клетках, в связи с чем возникает вопрос о том, каким образом достигается целевая специфичность метилирования. Расчленение элементов распознавания mt-tRNA выявило наличие U34G35 и t6A37/(ms2)i6A37, которые одновременно п

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… To further explore interactions between METTL8 and RNA, fluorescence anisotropy experiments were performed using fluorescein-labelled model substrates together with recombinantly expressed His 14 -MBP-METTL8 purified from E. coli . … Our anisotropy data suggest that binding of METTL8 substrate RNAs is largely independent of sequence, secondary structure and the presence of i 6 A 37 , implying that for METTL8, these features are determinants of methylation rather than binding. …

Glymphatic surrogate, choroid plexus remodeling, and exploratory brain network analysis in the post-acute phase of anti-NMDAR encephalitis: multimodal MRI evidence for cognitive associations and differential white matter mediation.

BACKGROUND: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis typically presents with acute neuroinflammation, and many patients … ing (CP/intracranial volume (ICV) ratio), white matter microstructural integrity (global fractional anisotropy (FA) using tract-based spatial statistics (TBSS)), and structural covariance network (SCN) topology in anti-NMDAR encephalitis using multimodal MRI, and to investigate their associations with cognition, with an exploratory mediation analysis examini …

Neurite orientation dispersion and density imaging in myelin oligodendrocyte glycoprotein antibody-associated disease and neuromyelitis optica spectrum disorders.

BACKGROUND: Aquaporin-4 antibody positive (AQP4+) neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein an … ts association with clinical disability, using NODDI and DTI-derived measures, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity. METHODS: This study included 31 AQP4+ NMOSD, 21 MOGAD patients and 45 healthy controls. Clinical information included disease duration, Expanded Disability Status Scale (ED …

Diagnostic efficacy of tract-specific diffusion tensor imaging in cervical spondylotic myelopathy with electrophysiological examination validation.

PURPOSE: This study aimed to investigate the effectiveness of tract-specific diffusion tensor imaging (DTI) metrics in identifying the respo … ics, such as axial diffusivity (AD), mean diffusivity (MD), radial diffusivity (RD), and fractional anisotropy (FA), were calculated using automatic region-of-interest (ROI) analysis for both whole spinal cord column and dorsal column. Receiver operating characteristic (ROC) curves were constructed to evaluate the diagnostic efficacy of the aspect ratio, tra …

Association of Brain Microstructure and Functional Connectivity With Cognitive Outcomes and Postnatal Growth Among Early School-Aged Children Born With Extremely Low Birth Weight.

IMPORTANCE: Postnatal growth may be associated with longitudinal brain development in children born preterm. OBJECTIVE: To compare brain mi … , 63.5 [9.4]; children without PGF, 55.7 [8.0]; P = .008). Significantly lower mean (SD) fractional anisotropy in the forceps major of the corpus callosum (0.498 [0.067] vs 0.558 [0.044] vs 0.570 [0.038]) and higher mean (SD) mean diffusivity in the left superior longitudinal fasciculus-parietal bundle (8.312 [0.318] vs 7.902 [0.455] vs 8.083 [0.393]; origin …

Associations between arterial stiffening and brain structure, perfusion, and cognition in the Whitehall II Imaging Sub-study: A retrospective cohort study.

BACKGROUND: Aortic stiffness is closely linked with cardiovascular diseases (CVDs), but recent studies suggest that it is also a risk factor … analyses were used to assess grey matter (GM) volume, white matter (WM) microstructure (fractional anisotropy (FA) and diffusivity), white matter lesions (WMLs), and cerebral blood flow (CBF). Cognitive outcomes were performance on verbal memory, semantic fluency, working memory, and executive function tests. Of 542 participants, 444 (81.9%) were men. The m …

Advanced diffusion imaging for assessing normal white matter development in neonates and characterizing aberrant development in congenital heart disease.

BACKGROUND: Elucidating developmental trajectories of white matter (WM) microstructure is critically important for understanding normal deve … easures calculated from the diffusion signal included not only Mean Diffusivity (MD) and Fractional Anisotropy (FA) derived from the standard DTI model, but also three advanced diffusion measures, namely, the fiber Orientation Dispersion Index (ODI), the isotropic volume fraction (Viso), and the intracellular volume fraction (Vic) derived from the NODDI mode …

Correlation of magnetic resonance diffusion tensor imaging and clinical findings of cervical myelopathy.

BACKGROUND CONTEXT: Despite significant advances in the development of diagnostic technology, the diagnosis of cervical myelopathy (CM) stil … ssed levels. Diffusion tensor imaging results were measured according to two parameters, fractional anisotropy (FA) and apparent diffusion coefficient (ADC), at anterior, lateral, and posterior regions of interest (ROIs) in each of five cervical vertebrae, C3-C7. METHODS: On diagnosis of CM by clinical evaluation and findings from T2-weighted MRI, the 15 su …

Distinct cholesterol and phospholipid incorporation at the platelet plasma membrane of hyperlipidemic subjects: structural order and function.

Plasma lipid composition, platelet aggregation, cholesterol (Ch)/glycoprotein IIb-IIIa (GP) and phospholipid (Ph)/GP molar ratios, fatty acid composition and structural order (1, 6-diphenyl-1, 3, 5-hexatriene (DPH) fluorescence anisotropy at 35 degrees C (r(DPH,35)) of human platelet plasma membranes (HPPM) were measured in four DPH,35 groups of hyperlipidemic patients (II: plasma Ch < 250 mg/dl and TG (triglycerides) <220 mg/dl, n = 21; III: Ch > 250 mg/dl and TG < 220 mg/dl, n = 23; IV: Ch < 250 mg/dl and TG > 220 mg/dl, n = 18; and V: Ch > 250 mg/dl and TG > 220 mg/dl, n = 12) and compared …

Prospective evaluation of arterial spin labeling and diffusion tensor imaging-magnetic resonance imaging for the non-invasive assessment of renal allograft dysfunction.

BACKGROUND: The optimal management strategy for end-stage renal disease is renal transplantation, graft function must be monitored regularly … lar filtration rate (eGFR), 24-hour urinary protein (24hUP), renal blood flow (RBF), and fractional anisotropy (FA) values of the subjects were measured. Correlation analysis was applied to assess MRI parameters' association with eGFR, while receiver operating characteristic (ROC) curves were used to evaluate the diagnostic efficacy of fMRI parameters and cl …

Are the Post-COVID-19 Posttraumatic Stress Disorder (PTSD) Symptoms Justified by the Effects of COVID-19 on Brain Structure? A Systematic Review.

COVID-19 affects brain function, as deduced by the "brain fog" that is often encountered in COVID-19 patients and some cognitive impairment that is observed in many a patient in the post-COVID-19 period. Approximately one-third of patients, even when they have recovered from the acute somatic disease, continue to show posttraumatic stress disorder (PTSD) symptoms. We hypothesized that the persistent changes induced by COVID-19 on brain structure would overlap with those associated with PTSD. We performed a thorough PubMed search on 25 April 2023 using the following strategy: ((posttraumatic OR

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… Another study found reduced fractional anisotropy in patients with PTSD undergoing trauma-focused cognitive behavior therapy to correlate with dysphoric symptom reduction [ 75 ]. … White matter anisotropy and response to cognitive behavior therapy for posttraumatic stress disorder. Transl. Psychiatry. 2021;11:14. doi: 10.1038/s41398-020-01143-3. 76. …

Electrical exposure analysis of galvanic-coupled intra-body communication based on the empirical arm models.

BACKGROUND: Intra-body communication (IBC) is one of the highlights in studies of body area networks. The existing IBC studies mainly focus … ed based on the geometrical information of six subjects. The thickness of each tissue layer and the anisotropy of muscle were also taken into account. Considering the International Commission on Non-Ionizing Radiation Protection (ICNIRP) guidelines, the restrictions taken as the evaluation criteria were the electric field intensity lower than 1.35 × 104 f V/ …

[Diffusion tensor imaging and resting-state functional magnetic resonance imaging in patients with delirium in intensive care unit].

OBJECTIVE: To analyze the brain function of patients with delirium in intensive care unit (ICU) using resting-state functional magnetic reso … mogeneity (ReHo) data analysis. The DTI data were processed by the FSL software, and the fractional anisotropy (FA) and mean diffusivity (MD) of the brain were extracted, respectively, to evaluate the damage to brain structure. The values of ReHo, FA and MD were compared between the two groups. The ReHo value of brain region with reduced ReHo value of patien …

Микроглиапозитрон эмиссии томографии и прогресс в множестве склероза: таламус горит.

Усиливающаяся иммунная активность способствует нейродегенерации и прогрессированию в множестве склерозов. Это перспективное тематическое исследование направлено на изучение таламической плотности микроглии на 18kDa транслокаторном протеине PET у пациентов с множественным склерозом с использованием радиолиганда третьего поколения, 11C-ER176, и расследовать деятельность ассоциаций 11C-ER176 Поглощение ПЕТ с помощью изображений и клинических показателей развития в множестве склерозов. Пациенты с множественным склерозом (n = 50) и органов управления (n = 55) были зачислены и прошли 11C-ER176 ПЕТ и

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… FA, fractional anisotropy; FWF, free water fraction; MD, mean diffusivity; NDI, neurite density index; NODDI, neurite orientation dispersion and density imaging; ODI, orientation dispersion index. … FA, fractional anisotropy; FWF, free water fraction; MD, mean diffusivity; NDI, neurite density index; NODDI, neurite orientation dispersion and density imaging; ODI, orientation dispersion index. …