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Chronic ketamine use resulting in a reversible cholangiopathy: A case series from a single Canadian centre and review of the literature.

BACKGROUND: Ketamine-related cholangiopathy is increasingly being described in America, Europe, and Asia, paralleling increases in ketamine use globally. However, ketamine-related cholangiopathy has not been described in Canada previously. We report three cases of ketamine-related cholangiopathy in Calgary, Alberta. RESULTS: Between May 2024 and April 2025, three patients were assessed by the University of Calgary Liver Unit in Calgary, Alberta, Canada. Case 1 was a 28-year-old female referred for elevated liver enzymes and features concerning for sclerosing cholangitis identified on magnetic…

Clinical outcomes in Caroli disease and Caroli syndrome: a longitudinal observational cohort study.

Caroli's disease (CD) and Caroli's syndrome (CS) are rare congenital fibropolycystic liver disorders. While CS is known to be associated wit … ical, laboratory, endoscopic, and imaging assessments during follow-up. Outcomes included recurrent cholangitis, portal hypertension-related complications, hepatic decompensation, cholangiocarcinoma, and all-cause mortality. Statistical analyses were descriptive and exploratory. Patients with CS exhibited more frequent portal hypertension, lower platelet coun …

Longitudinal health-related quality of life and associated factors in autoimmune liver diseases.

INTRODUCTION AND OBJECTIVES: Autoimmune liver diseases (AILD), including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC), can significantly influence patients' health-related quality of life (HRQOL). Understanding longitudinal HRQOL trends and associated factors may help identify patients at risk for poor HRQOL long-term. This longitudinal, single-center observational study aimed to assess longitudinal changes in HRQOL and identify baseline factors associated with HRQOL over time among patients with AILD. PATIENTS AND METHODS: Adult pati…

Assessement of Survival and its Affecting Factors in Adult Liver Transplant Patients: A Retrospective Cohort Study.

BACKGROUND: Liver disease is a leading cause of mortality among adults worldwide. Liver transplantation (LT) remains the only definitive tre … er time. Additionally, compared to acute liver failure (ALF), etiologies such as primary sclerosing cholangitis (PSC), autoimmune hepatitis (AIH), Budd-Chiari syndrome, cryptogenic liver disease, hepatitis B virus (HBV), and primary biliary cholangitis (PBC) were associated with significantly lower mortality risk and improved long-term survival.

Предлагаемые причинно-следственные связи между 17 аутоиммунные заболевания и панкреатит: A two- Выбрать менделианское исследование случайности.

В ходе эпидемиологических исследований сообщалось о взаимосвязи между различными аутоиммунными заболеваниями (АД) и панкреатитом. В ходе этого исследования систематически проводилось изучение причинно-следственного воздействия факторов АД на панкреатит с использованием менделийской случайности (МС). Мы выбрали 17 Обычные АД как воздействие из самого крупного набора данных исследований в рамках всей ассоциации геномов в Европе. К числу результирующих переменных относятся острый панкреатит (АП), хронический панкреатит (CP), острый панкреатит, вызванный алкоголем, и хронический панкреатит, вызван

Совпадение в аннотации оригинала
The relationship between different autoimmune diseases (ADs) and pancreatitis has been reported in epidemiological studies. This study syste … , 95% CI = 1.012-1.121, P = .0151) were associated with an increased risk of AP. primary sclerosing cholangitis (OR = 1.080, 95% CI = 1.013-1.153, P = .0194) increased the risk of CP. Reverse MR analysis suggested a potential protective causal association between alcohol-induced acute pancreatitis and hashimoto's thyroiditis (OR = 0.962, 95% CI = 0.936-0.989, …

Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) Increases in Patients With Obstructive Jaundice through the Activation of Hepatic Stellate Cells by Bile Acids.

BACKGROUND: Mac-2 binding protein glycosylation isomer (M2BPGi) is a reliable serum marker for assessing liver fibrosis and is secreted by h … ed M2PBGi levels after biliary drainage; nine showed increased levels, even after biliary drainage. Cholangitis during biliary drainage was more common in patients with increased M2BPGi levels. Cholic acid-treated LX-2 cells upregulated α-SMA expression and M2BPGi secretion in culture media relative to non-treated LX-2 cell. CONCLUSIONS: M2BPGi levels are si …

Impact of internal stent placement on late biliary complications after robot-assisted pancreaticoduodenectomy.

BACKGROUND: Late biliary complications, consisting of anastomotic stricture and cholangitis, are known to impair long-term quality of life and significantly impact patient outcomes following robot-assisted pancreaticoduodenectomy (RPD). The role of stent placement in HJ remains debatable. This study aimed to investigate the incidence of late biliary complications and the impact of stent placement on long-term outcomes after RPD. METHODS: This retrospective observational study included patients who underwent RPD from November 2009 to April 2024 at two institutions. Patients were categorized in…

Mortality in Autoimmune Liver Disease in Sweden: A Population-Based Cohort Study of 9,654 Patients.

BACKGROUND/AIMS: Epidemiological data on mortality in autoimmune liver diseases (AILDs) are scarce. We examined all-cause and cancer-related mortality in individuals with AILD from Sweden. METHODS: We identified 9654 individuals with AILD (3342 with autoimmune hepatitis (AIH), 3751 with primary biliary cholangitis (PBC), and 2561 with primary sclerosing cholangitis (PSC)) using national Swedish registries between 2001 and 2020. These were matched with 80 685 comparators from the general population at a ratio of 1:10 on age, sex, year of diagnosis and municipality. Rates of outcomes were estim…

Pathogenesis, Non-Invasive Assessments and Treatment of Hepatic Fibrosis in Autoimmune Liver Diseases.

BACKGROUND AND AIMS: Autoimmune liver diseases (AILD), including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), can lead to progressive liver fibrosis, development of cirrhosis, decompensation, hepatocellular carcinoma (HCC), and need for liver transplantation (LT). METHODS: This review aims to provide a comprehensive overview of the mechanisms of liver fibrogenesis, non-invasive methods to assess hepatic fibrosis and potential anti-fibrotic interventions in AILD. RESULTS AND CONCLUSIONS: Current management for AILD should incorporate …

The Incidence of Pouch Neoplasia Following Ileal Pouch-Anal Anastomosis in Patients With Inflammatory Bowel Disease.

BACKGROUND: Ileal pouch-anal anastomosis (IPAA) is the standard restorative procedure following proctocolectomy in patients with inflammator … cosa-associated lymphoid tissue lymphoma (n = 1). Presence of extensive colitis, primary sclerosing cholangitis, backwash ileitis, and rectal dysplasia at the time of IPAA were significantly associated with increased risk of pouch neoplasia. CONCLUSIONS: The incidence of pouch neoplasia in IBD patients who have undergone IPAA is relatively low. Extensive col …

The association between trajectory of serum cholesterol, statin dosage, and the risk of recurrent biliary stone diseases.

BACKGROUND: Statins may reduce the risk of recurrent gallstone disease by decreasing bile cholesterol saturation and pathogenicity. However, … % CI, 0.24-0.34; p < 00.0001), acute pancreatitis (aHR = 0.24, 95% CI, 0.17-0.32, p < 00.0001), and cholangitis (aHR = 0.28, 95% CI, 0.25-0.32, p < 00.0001). Cholecystectomy was also a protective factor for recurrent biliary stones (aHR = 0.41, 95% CI, 0.37-0.46; p < 00.0001). The higher trajectory serum cholesterol group (Group 3) had a lower risk trend for …

The addition of endoscopic sphincterotomy to biliary stent placement and its impact on the risk of adverse events: an updated meta-analysis of randomized controlled trials.

BACKGROUND AND AIMS: Endoscopic sphincterotomy (ES) is not mandatory before biliary stenting. The impact of ES before biliary stent placemen … were postprocedural bleeding, perforation, stent/catheter occlusion, stent/catheter migration, and cholangitis. Heterogeneity was examined with I2 statistics, and a random-effects model was used. Review Manager 5.4 was used for statistical analyses. RESULTS: Seven RCTs with 1022 patients were included. There was no significant difference between the ES and …

Prevalence and clinicopathological Spectrum of Auto-Immune Liver Diseases & Overlap syndrome.

AIMS: Autoimmune liver diseases (AILD) represent a spectrum of related yet distinct immune-mediated disorders. The literature on the prevale … we had 721 cases which revealed a distribution of autoimmune hepatitis (AIH)-64.7%, primary biliary cholangitis (PBC)-14.8%, primary sclerosing cholangitis (PSC)-7.6%, overlap AIH-PBC 11%, and overlap AIH-PSC 1.7%. AIH patients had significantly higher prevalence for severe lobular inflammation (27%, P ≤ 0.001), several lobular plasma cells (37%, P ≤ 0.001), …

Autoantibodies to beta tubulin in autoimmune liver diseases-Relation to pANCA and clinical relevance.

There was evidence that perinuclear antineutrophil cytoplasmic antibodies (pANCA) in autoimmune liver diseases react with human beta-tubulin-5 (TBB5). Here, we reevaluate the specificity and clinical relevance of anti-TBB5 antibodies. Patients with untreated autoimmune hepatitis (AIH; n = 53), AIH under immunosuppressive therapy (AIH-IS; n = 125), primary sclerosing cholangitis (PSC; n = 40), primary biliary cholangitis (PBC; n = 250), nonautoimmune liver diseases (n = 158), inflammatory bowel diseases (IBD; n = 30), and healthy individuals (n = 62) were tested by enzyme-linked immunosorbent a…

Preliminary feasibility study of a new partially covered self-expandable metal stent with an anchoring flange for EUS-guided hepaticogastrostomy (with videos).

BACKGROUND AND AIMS: EUS-guided hepaticogastrostomy (EUS-HPG) has a risk of serious procedural adverse events (AEs), but few dedicated devic … 00% (24/24) and 91.7% (22/24), respectively. AEs developed after EUS-HPG in 8.3% of patients (2/24, cholangitis). RBO developed in 29.2% of patients (7/24), with a median cumulative time to RBO of 6.7 months. The causes of RBO were sludge formation (n = 4), hyperplasia at an uncovered portion (n = 2), and nonocclusive cholangitis (n = 1). Reintervention for R …

Laparoscopic anatomical left hemihepatectomy guided by middle hepatic vein in the treatment of left hepatolithiasis with a history of upper abdominal surgery.

BACKGROUND: This study aimed to investigate the safety and efficacy of laparoscopic anatomical left hemihepatectomy guided by the middle hep … one residual rate (2.7% vs 20.5%, P = 0.015), stone recurrence rate (5.4% vs 22.7%, P = 0.028), and cholangitis recurrence rate (2.7% vs 22.7%, P = 0.008).There were no significant differences in the results of other observation indices between the groups. CONCLUSIONS: Laparoscopic anatomical left hepatectomy guided by the MHV is safe and effective in the tr …

Causal relationships between autoimmune diseases and celiac disease: A Mendelian randomization analysis.

The aim of this study was to investigate the causal relationship between autoimmune disorders and celiac disease (CeD) through Mendelian ran … with CeD: Crohn's disease (CD) (OR [95%CI] = 1.156 [1.106 ± 1.208], P = 1.27E-10), primary biliary cholangitis (PBC) (1.229 [1.143 ± 1.321], P = 2.53E-08), primary sclerosing cholangitis (PSC) (1.688 [1.466 ± 1.944], P = 3.56E-13), rheumatoid arthritis (RA) (1.231 [1.154 ± 1.313], P = 2.74E-10), systemic lupus erythematosus (SLE) (1.127 [1.081 ± 1.176], P = …