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Nanodelivery strategies for caloric restriction mimetics in age-associated neurodegeneration.

Brain aging is associated mainly with a decline in cognitive function and is a major risk factor for various neurodegenerative disorders (NDDs). Major hallmarks of aging include oxidative stress, chronic neuroinflammation, mitochondrial dysfunction, and impaired proteostasis. Although caloric restriction (CR) has consistently demonstrated neuroprotective effects, its long-term effects in humans remain challenging. Consequently, CRMs such as metformin, spermidine, and curcumin have been widely used because of their ability to recapitulate key molecular effects of CR. Despite their therapeutic e

Mesalamine in Treatment of Intestinal Inflammatory Diseases-Formulation-Driven Strategies for Targeted Colonic Therapy and Remission Maintenance.

Mesalamine (5‑aminosalicylic acid, mesalazine, or 5‑ASA) remains a cornerstone therapy for mild‑to‑moderate ulcerative colitis because of its local anti‑inflammatory and antioxidant actions on the intestinal mucosa, and its clinical performance has increasingly been refined through advances in synthetic medicinal chemistry and drug‑delivery science. Beyond conventional formulations, medicinal chemistry efforts have explored mesalamine analogues and hybrid molecules, including prodrug approaches and conjugates with anti‑inflammatory or redox‑modulating moieties, to extend target engagement beyo

Controlled delivery of nilotinib using LDH/Fe2O3-modified chitosan nanocomposite hydrogel beads for the treatment of chronic myeloid leukemia.

Chronic myeloid leukemia remains a significant challenge in cancer treatment because conventional drug delivery systems often fail to provide sustained release and targeted therapeutic effects. To address these limitations, this study a chitosan-based nanocomposite hydrogel system for the controlled delivery of nilotinib, a tyrosine kinase inhibitor used to treat chronic myeloid leukemia. Fe2O3-containing layered double hydroxide nanocomposites into were incorporated chitosan hydrogels under controlled synthesis conditions (70 ± 2 °C, stirring speed at 800 rpm) to fabricate chitosan nanocompos…

Alkyl Chain Length in Poly(2-oxazoline)-Based Amphiphilic Gradient Copolymers Regulates the Delivery of Hydrophobic Molecules: A Case of the Biodistribution and the Photodynamic Activity of the Photosensitizer Hypericin.

Self-assembled nanostructures of amphiphilic gradient copoly(2-oxazoline)s have recently attracted attention as promising delivery systems for the effective delivery of hydrophobic anticancer drugs. In this study, we have investigated the effects of increasing hydrophobic side chain length on the self-assembly of gradient copolymers composed of 2-ethyl-2-oxazoline as the hydrophilic comonomer and various 2-(4-alkyloxyphenyl)-2-oxazolines as hydrophobic comonomers. We show that the size of the formed polymeric nanoparticles depends on the structure of the copolymers. Moreover, the stability and

Peripheral Latanoprost Administration Lowers Intraocular Pressure in the Wistar Rat.

PURPOSE: Instillation of latanoprost eye drops into the conjunctival sac to lower intraocular pressure (IOP) is the most frequently used treatment for primary open-angle glaucoma. The aim of this study was to evaluate the influence of latanoprost on IOP in the rat when applied peripherally. METHODS: A rodent-dedicated tonometer was used to measure IOP in conscious adult male normotensive Wistar rats habituated to the measurement procedure. Commercially available 0.005% latanoprost solutions were continuously delivered to the periphery of the eye over 7 days using mini-pumps inserted subcutane

Thermal Therapy Approaches for Treatment of Brain Tumors in Animals and Humans.

Primary brain tumors are often aggressive, with short survival from time of diagnosis even with standard of care therapies such as surgery, … oodbrain barrier to potentially enhance drug delivery, for example in combination with nanoparticle drug delivery systems. Thermal ablation uses high temperatures for direct local tumor destruction, and it found its way into clinical use as laser interstitial thermal therapy (LITT). This review presents various hyperthermia and ablation approaches, including a review o …

Development of a topical polymeric mucoadhesive ocular delivery system for azithromycin.

PURPOSE: Azithromycin is an azalide class of antibiotic with pharmacodynamics that have made it a valuable agent in the treatment of soft tissue infections. In ophthalmology, oral administration of azithromycin has been proven effective for the treatment of trachoma. However, topical formulations of azithromycin to treat ocular surface infections have been challenging to develop because of the drug's hydrophobicity and instability in aqueous solutions at pH levels that are comfortable in the eye. The design of a polycarbophil polymer-based delivery system for a topical formulation of azithromy

Chitosan-celluloses wafers containing emulsified curcumin: a nano-in-matrix approach for buccal delivery.

Oral surgical and periodontal procedures generate localized tissue damage that favors microbial colonization and delayed healing. Local mucoadhesive drug delivery systems capable of prolonged release may overcome the limitations of systemic therapies. Curcumin (CUR) exhibits antimicrobial and anti-inflammatory activities but is hindered by poor aqueous solubility and physiological instability. This study aimed to develop and characterize polymeric buccal wafers containing a CUR-loaded nanoemulsion as a nano-in-matrix system for sustained local delivery and antimicrobial protection in the oral …

Biomaterial-based strategies for osteoporosis treatment and bone regeneration: advances and translational challenges.

Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass, deterioration of bone microarchitecture, and increased susc … acellular matrix quality, and weakened mechanical integrity-can be addressed by scaffolds, targeted drug delivery systems, and biologically derived platforms. Ceramic, polymeric, and composite scaffolds are compared with respect to osteoconduction, ion-mediated signaling, mechanical support, and manufacturability. Bone-targeted nanoparticles, injectable hydrogels, and …

Superparamagnetic iron oxide nanoparticle-based delivery systems for biotherapeutics.

INTRODUCTION: Superparamagnetic iron oxide nanoparticle (SPION)-based carrier systems have many advantages over other nanoparticle-based systems. They are biocompatible, biodegradable, facilely tunable and superparamagnetic and thus controllable by an external magnetic field. These attributes enable their broad biomedical applications. In particular, magnetically driven carriers are drawing considerable interest as an emerging therapeutic delivery system because of their superior delivery efficiency. AREAS COVERED: This article reviews the recent advances in use of SPION-based carrier systems

Mitochondria-mediated tumor drug resistance: From mechanism insights to therapeutic strategies.

Drug resistance remains a major barrier to durable responses to chemotherapy, targeted therapy, radiotherapy, and immunotherapy. Mitochondria, once viewed mainly as bioenergetic organelles, are now recognized as adaptive signaling hubs that shape tumor survival under therapeutic pressure. Here, we review how mitochondrial dynamics, metabolic plasticity, redox remodeling, programmed cell death regulation, epithelial-mesenchymal transition, and intercellular mitochondrial transfer collectively drive tumor drug resistance. We highlight that resistant cancer cells exploit mitochondrial flexibility

pH-responsive delivery of hydrophobic anticancer drugs using boron and nitrogen Co-doped carbon dots as fluorescent nanocarriers.

In recent years, carbon dots have attracted considerable attention within the nanocarbon family due to their remarkable advantages and interesting properties such as high solubility, biocompatibility, tunable photoluminescence, and so on. Carbon dots can also be designed and synthesized according to the desired functionalities (such as sensors, biosensors, or drug delivery systems). In the present study, nitrogen- and boron-co-doped carbon dots (abbreviated as "NBCDs") were successfully used as highly fluorescent and efficient nanocarriers to load two hydrophobic anticancer drugs, namely curcu…

Liposomal Forms of Fluoroquinolones and Antifibrotics Decorated with Mannosylated Chitosan for Inhalation Drug Delivery.

The severe course of COVID-19 leads to the long-terming pulmonary diseases, such as bacterial pneumonia and post-COVID-19 pulmonary fibrosis. Thus, the essential task of biomedicine is a design of new effective drug formulations, including those for inhalation administration. In this work, we propose an approach to the creation of lipid-polymer delivery systems for fluoroquinolones and pirfenidone based on liposomes of various compositions decorated with mucoadhesive mannosylated chitosan. A generalizing study on the physicochemical patterns of the interactions of drugs with bilayers of variou

Достижения в области наномедицины для лечения инфекционных заболеваний, вызываемых вирусами.

Вирусы оказывают всемирное воздействие на здравоохранение и социально-экономический рост, поскольку они являются самой большой причиной смертности от инфекционных заболеваний. Кроме того, долгосрочное потребление обычных наркотиков сопряжено с серьезными рисками для здоровья населения, такими, как быстрая эволюция резистентности к наркотикам и возникновение вторичных побочных эффектов. Поэтому необходимо разработать новые методы лечения связанных с вирусом заболеваний. В этом случае использование наномедицин на основе наноматериалов имеет огромные преимущества по сравнению с традиционным подхо

Совпадение в аннотации оригинала
Viruses have a worldwide impact on healthcare and social and economic growth because they are the largest cause of mortality due to infectio … dicines possesses tremendous advantages over the traditional treatment approach. Nanomaterial-based drug delivery systems have unique features that make them promising candidates in the pursuit of therapeutic benefits. In this review, we present the various biocompatible nanomaterials that show promise as nanomedicines for anti-viral therapy. Also, we include how curre …

Utilization of Lipid-based Nanoparticles to Improve the Therapeutic Benefits of Bortezomib.

Cancer is a condition where there is an uncontrolled growth of cells resulting in high mortality. It is the second most frequent cause of death worldwide. Bortezomib (BTZ) is a Proteasome Inhibitor (PI) that is used for the treatment of a variety of cancers. It is the first PI that has received the approval of the US Food and Drug Administration (FDA) to treat mantle cell lymphoma and multiple myeloma. High incidence of sideeffects, limited dose, low water solubility, fast clearance, and drug resistance are the significant limitations of BTZ. Therefore, various drug delivery systems have been …

Dexibuprofen Biodegradable Nanoparticles: One Step Closer towards a Better Ocular Interaction Study.

Ocular inflammation is one of the most prevalent diseases in ophthalmology, which can affect various parts of the eye or the surrounding tissues. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, are commonly used to treat ocular inflammation in the form of eye-drops. However, their bioavailability in ocular tissues is very low (less than 5%). Therefore, drug delivery systems such as biodegradable polymeric PLGA nanoparticles constitute a suitable alternative to topical eye administration, as they can improve ocular bioavailability and simultaneously reduce drug induced side ef…

Design and in vitro evaluation of polymeric formulae of simvastatin for local bone induction.

Simvastatin (SVS), a cholesterol-lowering drug, has been shown to stimulate bone formation. This study deals with the design and in vitro evaluation of local delivery systems for simvastatin. They are intended to treat bony defects resulting from periodontitis or to induce osteogenesis around the titanium implants. Granules and gels were formulated using bioerodible/biocompatible polymers, namely hydroxypropylmethyl cellulose (H), sodium carboxymethyl cellulose (C), and chitosan (Ch). The in vitro release profiles and kinetics were evaluated and the swelling and/or erosion was monitored. Diffe

Natural Powerhouse Duo: Hierarchical Levan Hydrogels with Nanoencapsulated Cannabidiol as Local Delivery Systems.

INTRODUCTION: The nonpsychoactive cannabinoid cannabidiol (CBD) has shown a wide range of pharmacological effects that are beneficial for wound healing. However, its local delivery is challenged by a very low aqueous solubility. METHODS: In this work, we synthesized hierarchical hydrogels made of the fructan hydrolyzed levan crosslinked with glycerol diglycidyl ether and loaded them with CBD nanoencapsulated within Pluronic® F127 polymeric micelles (25% w/w payload). RESULTS: Hydrogels showed the typical porous structure (high resolution-scanning electron microscopy) and water uptake capacit

The effect of emulgel preparation on the stability of Kojic acid in the topical anti-hyperpigmentation products.

BACKGROUND: The emulgel, a novel drug delivery system, merges emulsion and gel, offering advantages like enhanced stability, precise control over drug release kinetics, and increased drug absorption compared to emulsions alone. Kojic acid (KA) demonstrates potent inhibition of the tyrosinase enzyme, a crucial player in the melanin synthesis pathway. AIMS: The main objective of this experimental study is to formulate KA within an emulgel framework and assess its stability under various environmental conditions. METHODS: One percent of KA emulgel and 1% simple gel, serving as the control produ

An in situ gelling liquid crystalline system based on monoglycerides and polyethylenimine for local delivery of siRNAs.

The development of delivery systems able to complex and release siRNA into the cytosol is essential for therapeutic use of siRNA. Among the delivery systems, local delivery has advantages over systemic administration. In this study, we developed and characterized non-viral carriers to deliver siRNA locally, based on polyethylenimine (PEI) as gene carrier, and a self-assembling drug delivery system that forms a gel in situ. Liquid crystalline formulations composed of monoglycerides (MO), PEI, propylene glycol (PG) and 0.1M Tris buffer pH 6.5 were developed and characterized by polarized light m