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Projection of age-standardised mortality rates for 23 cancer types in India: a nationwide projection until 2030 using autoregressive integrated moving average (ARIMA) models.

ObjectivesTo project the future burden of cancer mortality in India by forecasting age-standardised mortality rates (ASMRs) for 23 major cancer types up to the year 2030, providing crucial evidence for long-term health planning and resource allocation.DesignA retrospective analysis and time-series forecasting study. Participants Aggregated, national-level cancer mortality data for the population of India from 2000 to 2019 were used.ParticipantsAggregated, national-level cancer mortality data for the population of India from 2000 to 2019 were used.MethodsAnnual ASMR data for 23 cancer types wer

Current and Future Role of Medical Imaging in Guiding the Management of Patients With Relapsed and Refractory Non-Hodgkin Lymphoma Treated With CAR T-Cell Therapy.

Chimeric antigen receptor (CAR) T-cells are a novel immunotherapy available for patients with refractory/relapsed non-Hodgkin lymphoma. In this indication, clinical trials have demonstrated that CAR T-cells achieve high rates of response, complete response, and long-term response (up to 80%, 60%, and 40%, respectively). Nonetheless, the majority of patients ultimately relapsed. This review provides an overview about the current and future role of medical imaging in guiding the management of non-Hodgkin lymphoma patients treated with CAR T-cells. It discusses the value of predictive and prognos

Retrospective Review of Outcomes of Multiple Myeloma (MM) Patients With COVID-19 Infection (Two-Center Study).

IntroductionCOVID-19 has profound effects on patients with multiple myeloma (MM) mainly due to underlying immune dysfunction and associated therapies leading to increased susceptibility to infections. The overall risk of morbidity and mortality (M&M) in MM patients due to COVID-19 infection is unclear with various studies suggesting case fatality rate of 22% to 29%. Additionally, most of these studies did not stratify patients by their molecular risk profile.MethodsHere, we aim to investigate the effects of COVID-19 infection with associated risk factors in MM patients and the effectiveness of

Gut microbiota deficiency ameliorates multiple myeloma and myeloma-related bone disease by Th17 cells in mice models.

Purpose: Multiple myeloma, the second most common hematological tumor, is currently incurable. Multiple myeloma-related bone disease is a characteristic clinical symptom that seriously affects the survival and prognosis of patients. In recent years, gut microbiota has been shown to play an important role in the occurrence and development of multiple myeloma. However, whether and how it affects the development of myelomatous bone disease is unclear. Methods: To investigate the mechanism and influence of the microbiota on multiple myeloma and myeloma bone disease, a myeloma-gut microbiota deleti

Challenges Faced by Clinicians in the Personalized Treatment Planning: A Literature Review and the First Results of the Russian National Cancer Program.

Advances in cancer molecular profiling have enabled the development of more effective approaches to the diagnosis and personalized treatment of tumors. However, treatment planning has become more labor intensive, requiring hours or even days of clinician effort to optimize an individual patient case in a trial-and-error manner. Lessons learned from the world cancer programs provide insights into ways to develop approaches for the treatment strategy definition which can be introduced into clinical practice. This article highlights the variety of breakthroughs in patients' cancer treatment and s

A Bibliometric Analysis and Visualization of Decision Support Systems for Healthcare Referral Strategies.

BackgroundThe referral process is an important research focus because of the potential consequences of delays, especially for patients with serious medical conditions that need immediate care, such as those with metastatic cancer. Thus, a systematic literature review of recent and influential manuscripts is critical to understanding the current methods and future directions in order to improve the referral process.MethodsA hybrid bibliometric-structured review was conducted using both quantitative and qualitative methodologies. Searches were conducted of three databases, Web of Science, Scopus

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… Using behaviour change and implementation science to address low referral rates in oncology 11 Medical and Health Sciences 1117 Public Health and Health Services BMC Health Serv Res. 2018 18 904 10.1186/s12913-018-3653-1 30486812 PMC6263048 151. Borooah S. Grant B. Blaikie A. Styles C. …

What Is Precision Psychotherapy?

Precision medicine impacts virtually all medical specializations, including psychiatry. Although precision psychiatry, in general, is a flourishing area of research and debate, psychotherapy as one pillar of psychiatry receives little attention. Theoretical discussions about precision psychotherapy are rare; research on precision in psychotherapy is just evolving. In this paper, we provide a conceptualization of precision psychotherapy providing a common idea of what should be understood as precision in the context of psychotherapy and what kind of psychotherapy research is considered to contr

Individualized survival prediction and risk stratification using machine learning for patients with malignant struma ovarii: a population-based study with external validation.

BACKGROUND: Malignant struma ovarii (MSO) is a rare thyroid-type cancer originating in ovarian teratoma. Prognosis of MSO is less studied without unanimous staging or stratification system. This study aimed to developed and validated a machine learning (ML)-based model to predict overall survival (OS) for patients with MSO and to risk-stratify them. METHODS: Patients with histologically confirmed MSO diagnosed in 1975-2021 from the Surveillance, Epidemiology, and End Results (SEER) program were identified as the training cohort. Patients in a systematic literature review were collected as the

Interferon-α Nasal Spray Prophylaxis Reduces COVID-19 in Cancer Patients: A Randomized, Double-Blinded, Placebo-Controlled Trial.

BACKGROUND: We evaluated whether a daily nasal spray of interferon-alpha (IFN-α) would reduce the incidence of COVID-19 or community-acquired respiratory viral infections in adult cancer patients. METHODS: In this multicenter, randomized, double-blinded, placebo-controlled trial, participants were randomized 1:1 to receive daily 40 000 IU IFN-α nasal spray or normal saline placebo. Participants who developed influenza-like symptoms self-collected nasal swabs for PCR testing of SARS-CoV-2, influenza A/B, respiratory syncytial virus, parainfluenza, adenovirus, seasonal coronavirus, picornavirus

A Novel Telehealth Exercise Program Designed for Rural Survivors of Cancer With Cancer-Related Fatigue: Single-Arm Feasibility Trial.

BackgroundExercise interventions are among the best-known interventions for cancer-related fatigue (CRF). Rural survivors of cancer, however, report specific barriers to engaging in exercise programs and lack overall access to effective programs.ObjectiveThe purpose of this investigation was to assess the feasibility of a novel telehealth exercise program designed specifically for rural survivors of cancer with CRF.MethodsA single-arm clinical trial of the BfitBwell Telehealth Program was performed. Based on an established clinical program, this adapted 12-week program addressed barriers previ

Balancing Quality, Cost, and Access During Delivery of Newer Cellular and Immunotherapy Treatments.

Purpose of reviewThe chimeric antigen receptor (CAR) T-cell therapy is currently changing the landscape of hematologic malignancies with multiple FDA-approved cell therapy products in the USA. The current administration process of the CAR T-cell therapy is complicated, labor-intensive, and expensive.Recent findingsThe chimeric antigen receptor (CAR) T-cell therapy is currently changing the landscape of hematologic malignancies with multiple FDA-approved cell therapy products in the USA. The current administration process of the CAR T-cell therapy is complicated, labor-intensive, and expensive.

Advancing Palliative Care Integration in Hematology: Building Upon Existing Evidence.

Opinion statementPatients with hematologic malignancies and their families are among the most distressed of all those with cancer. Despite high palliative care-related needs, the integration of palliative care in hematology is underdeveloped. The evidence is clear that the way forward includes standard-of-care PC integration into routine hematologic malignancy care to improve patient and caregiver outcomes. As the PC needs for patients with blood cancer vary significantly by disease, a disease-specific PC integration strategy is needed, allowing for serious illness care interventions to be ind

Roles of circadian clocks in cancer pathogenesis and treatment.

Circadian clocks are ubiquitous timing mechanisms that generate approximately 24-h rhythms in cellular and bodily functions across nearly all living species. These internal clock systems enable living organisms to anticipate and respond to daily changes in their environment in a timely manner, optimizing temporal physiology and behaviors. Dysregulation of circadian rhythms by genetic and environmental risk factors increases susceptibility to multiple diseases, particularly cancers. A growing number of studies have revealed dynamic crosstalk between circadian clocks and cancer pathways, providi

Decreasing Pain Intensity in Adult Patients With Cancer Through Music Therapy: A Complementary Non-Pharmacological Approach.

BackgroundAdequate pain management continues to be an unmet need in patients with cancer. Pain is known to impact the quality of life. It is recommended that treatment plans include pharmacological and complementary non-pharmacological methods for managing pain. Music listening therapy is an evidence-based intervention used to manage acute and chronic pain in adult patients with cancer.MethodsThis evidence-based practice project applied the use of music therapy in adult patients with cancer experiencing moderate to severe pain despite current pharmacological treatment in a rural outpatient onc

Symptom tracking made simple? Observational data on the clinical use of the PERS2ON score in cancer patients receiving palliative care.

ContextA standardized assessment of symptoms is essential for individualized palliative care (PC). While numerous tools exist, many are too complex for daily clinical use.ObjectiveThe PERS2ON score was developed as a brief and practical tool to assess symptom burden in PC. This study aimed to evaluate its feasibility in a rural hospital setting, although it did not include formal feasibility metrics such as recruitment or adherence rates.MethodsPatients admitted to the palliative care unit of a rural hospital were assessed using the PERS2ON score, which includes seven items: pain, eating, reha

Резюме МКАРЕ 2023 77th Национальный конгресс " СИААРТИ "

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A Randomized Placebo-Controlled Trial of the Anti-Nerve Growth Factor Antibody Tanezumab in Subjects With Cancer Pain Due to Bone Metastasis.

BackgroundThis phase III, randomized, double-blind, placebo-controlled, parallel-group study assessed the efficacy and safety of tanezumab in subjects with cancer pain predominantly due to bone metastasis receiving background opioid therapy.MethodsSubjects were randomized (stratified by (1) tumor aggressiveness and (2) presence/absence of concomitant anticancer treatment) to placebo or tanezumab 20 mg. Treatment was administered by subcutaneous injection every 8 weeks for 24 weeks (3 doses) followed by a 24-week safety follow-up period. The primary outcome was change in daily average pain in t

The Effect of Family-Centered Supportive Program on Chemotherapy-Induced Symptoms in Patients with Acute Lymphoblastic Leukemia (ALL).

Background: Acute lymphoblastic leukemia is a disease of the hematopoietic system and chemotherapy is recommended as the primary treatment. As many chemotherapeutic agents have severe adverse effects, patients require to be supported by their family to deal with chemotherapy-related symptoms. This study attempted to investigate the effect of family-centered supportive programs on chemotherapy symptom control in patients with acute lymphoblastic leukemia. Materials and Methods: Sixty-six patients with acute lymphoblastic leukemia undergoing chemotherapy along with their caregivers participated

Communicating Health Literacy on Prescription Medications on Social Media: In-depth Interviews With "Patient Influencers".

BackgroundHistorically, pharmaceutical companies have struggled with trust and brand reputation among key stakeholders and have adopted innovative marketing strategies to reach patients directly and rebuild those relationships. Social media influencers are a popular strategy to influence younger demographics, including Generation Z and millennials. It is common for social media influencers to work in paid partnerships with brands; this is a multibillion-dollar industry. Long have patients been active in online health communities and social media platforms such as Twitter and Instagram, but in

Социальные детерминанты здоровья, качества ухода за больными и результаты лечения неврологических расстройств: систематический обзор.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Социальные детерминанты здоровья (SDOH) оказывают значительное влияние на оказание медицинской помощи и ее результаты, однако их конкретное воздействие на качество неврологической медицинской помощи по-прежнему недостаточно синтезировано. ЦЕЛЬ: Цель этого систематического обзора заключалась в обобщении данных о связях между СДОГ и качеством медицинского обслуживания и результатах лечения пациентов в связи с серьезными неврологическими расстройствами. МЕТОДЫ: ПОСЛЕ ПРИСМА 2020 Руководящие принципы, мы систематически искали Пуббмеда, Интернет науки и Эмбазу для исследовани

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… science approaches demonstrating real-world effectiveness; requirements for diversity and inclusion in neurological clinical trials through mandated recruitment targets, analysis of treatment effects across subgroups, and funding specifically for studies in underrepresented populations; support for … Translating descriptive epidemiology into actionable interventions requires different study designs including implementation science approaches, comparative effectiveness research, and policy evaluations—which represent important next steps beyond this review’s scope. …