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Hepatitis B virus-infection related cryoglobulinemic vasculitis. Clinical manifestations and the effect of antiviral therapy: A review of the literature.

OBJECTIVE: Hepatitis B virus (HBV) infection causes chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Furthermore, about 20% of the patients develop extrahepatic manifestations such as cryoglobulinemic vasculitis (CV), polyarteritis nodosa, non-rheumatoid arthritis, glomerulonephritis and non-Hodgkin lymphoma. This review analyzed literature data on clinical manifestations of HBV-related CV and the impact of antiviral therapy with analoques nucleotide. METHODS: A PubMed search was performed to select eligible studies in the literature, up to July 2022. RESULTS: Some studies have an

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… Until the 90’s, MC was associated with HCV infection in nearly 90% of cases ( 10 , 11 ) while 10% of them were secondary either to lymphoproliferative disorders or rheumatologic diseases ( 12 ). … Another important goal of antiviral therapy is the early suppression of HBV-DNA to avoid organ complications and appearance of lymphoproliferative disorders ( 22 ). Figure 1 Therapeutic strategies in HBV-related cryoglobulinemic vasculitis. …

Infectious complications after hematopoietic stem cell transplantation: current status and future perspectives in Korea.

Hematopoietic stem cell transplantation (HSCT) is a treatment for hematologic malignancies, immune deficiencies, or genetic diseases, ect. Recently, the number of HSCTs performed in Korea has increased and the outcomes have improved. However, infectious complications account for most of the morbidity and mortality after HSCT. Post-HSCT infectious complications are usually classified according to the time after HSCT: pre-engraftment, immediate post-engraftment, and late post-engraftment period. In addition, the types and risk factors of infectious complications differ according to the stem cell

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… Clinical characteristics and outcomes of posttransplant lymphoproliferative disorders following allogeneic hematopoietic stem cell transplantation in Korea. J Korean Med Sci. 2006;21:259–264. doi: 10.3346/jkms.2006.21.2.259. 105. Styczynski J, van der Velden W, Fox CP, et al. … Management of Epstein-Barr virus infections and post-transplant lymphoproliferative disorders in patients after allogeneic hematopoietic stem cell transplantation: Sixth European Conference on Infections in Leukemia (ECIL-6) guidelines. …

Psychometric properties of the hematopoietic cell transplantation frailty scale: A prospective observational study.

INTRODUCTION: Frailty is common in patients undergoing hematopoietic stem cell transplantation, thereby increasing toxicity risk and reducing post-transplant survival. This study evaluated the psychometric properties of the Hematopoietic Cell Transplantation Frailty Scale to assess transplant candidates. Additionally, it characterized the participants` sociodemographic and clinical profiles. METHODS: One hundred and two patients with hematologic malignancies participated in the study. Reliability was evaluated through internal consistency (Cronbach's alpha), factorial analysis with varimax ro

Esid 2014 oral presentations.

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Clinical and Therapeutic Implications of Epstein-Barr Virus in HIV-Related Lymphomas.

The incidence of lymphomas is increased in people living with HIV (PLWH). Aggressive B-cell non-Hodgkin lymphomas (NHLs) are the most common and are considered an AIDS-defining cancer (ADC). Although Hodgkin lymphoma (HL) is not considered an ADC, its incidence is also increased in PLWH. Among all HIV-related lymphomas (HRL), the prevalence of Epstein-Barr virus (EBV) is high. It has been shown that EBV is involved in different lymphomagenic mechanisms mediated by some of its proteins, contributing to the development of different lymphoma subtypes. Additionally, cooperation between both HIV an

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… A high expression of EBV lytic genes has been also described in EBV and HHV-8 dual-infected patients with lymphoproliferative disorders, including PEL [ 151 ]. On the other hand, the EBV-protein EBNA-1 contributes to the survival of HHV-8 infected B-cells in PEL [ 152 ]. … Epstein Barr Virus Associated B-Cell Lymphomas and Iatrogenic Lymphoproliferative Disorders. Front. Oncol. 2019;9:109. doi: 10.3389/fonc.2019.00109. 48. Xia T., O’Hara A., Araujo I., Barreto J., Carvalho E., Sapucaia J.B., Ramos J.C., Luz E., Pedroso C., Manrique M., et al. …

The Role of Platelet Dysfunctions in the Pathogenesis of the Hemostatic-Coagulant System Imbalances.

Platelet dysfunction plays a critical role in the pathogenesis of various disorders affecting the hemostatic-coagulant system. This review aims to explore the mechanisms by which platelet dysfunctions contribute to the disruption of hemostasis, leading to an increased risk of both thrombosis and bleeding. Platelets, traditionally known for their role in clot formation, can exhibit altered functionality under pathological conditions such as cardiovascular diseases, metabolic disorders, and autoimmune diseases, impacting their interaction with coagulation factors and vascular endothelium. The re

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… Primary and secondary acquired delta storage pool disease (aδSPD): Among aδSPD cases, autoimmune and connective tissue disorders were most commonly reported, with five cases linked to lupus, rheumatoid arthritis, or unspecified connective tissue diseases, and three linked to lymphoproliferative disorders …

2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference.

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P1513: REDUCTION OF THE PROPHYLACTIC EFFECT OF TIXAGEVIMAB-CILGAVIMAB IN THE OMICRON ERA IN PATIENTS WITH HEMATOLOGICAL MALIGNANCIES AND WITHOUT ANTIBODY RESPONSE FOLLOWING SARS-COV-2 VACCINATION.

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Should treatment of hypogammaglobulinemia with immunoglobulin replacement therapy (IgRT) become standard of care in patients with chronic lymphocytic leukemia?

Hypogammaglobulinemia (HGG) is a frequent finding in patients with hematological malignancies, and is commonly described in chronic lymphocytic leukemia (CLL) before or after treatment. We reviewed published literature available online in the last thirty years through Medline search of indexed articles focusing on the main differences and advantages of the products now available on the market, namely intravenous Ig (IVIg) and subcutaneous Ig (SCIg) preparations. IgRT is effective and safe in the prophylaxis of infections in a selected group of patients with CLL and hypogammaglobulinemia and is

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… Specifically, patients with lymphoproliferative disorders tend to have a more severe course of disease, with reported mortality of up to 37% in the pre-vaccine era ( 82 ). … Subcutaneous immunoglobulin in lymphoproliferative disorders and rituximab-related secondary hypogammaglobulinemia: A single-center experience in 61 patients . …

2018 Ежегодное совещание СНГ: Североамериканская конференция по вопросам неадекватности и регулирования.

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Eosinophilic Dermatosis of Hematological Malignancy.

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… Dear Editor, Eosinophilic dermatosis of hematological malignancy (EDHM) is a cutaneous manifestation reported with various hematoproliferative and lymphoproliferative disorders. …

Semen Quality in Patients with Hematological Malignancies: A Retrospective Monocentric Study in the Perspective of Personalized Oncofertility Medicine.

Background/Objectives: The hypothalamic-pituitary-testis axis is known to be dysregulated in patients with hematological malignancies. However, data on the association between the type of hematological malignancies and semen quality are discordant. In the era of personalized medicine, identifying disease-specific patterns of reproductive impairment is crucial to optimize fertility preservation strategies. While patients with leukemia often show a clear deterioration in semen quality, studies on Hodgkin and non-Hodgkin lymphomas have shown that spermatogenesis is not always compromised. Indeed,

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… Semen Quality in Lymphoproliferative Disorders before Treatment In the era of personalized medicine, increasing attention has been directed toward tailoring supportive care strategies according to individual patient characteristics and disease-specific biological features. … In contrast, patients with testicular cancer often show lower sperm concentration than those with lymphoproliferative disorders, while maintaining semen parameters within normospermic ranges [ 14 , 18 ]. …

Ibrutinib in primary central nervous system diffuse large B-cell lymphoma.

The standard regimen for the treatment of newly diagnosed primary CNS lymphoma (PCNSL) remains regimens that contain high-dose methotrexate (MTX). While these regimens can provide control for some patients, there is a dearth of options for the treatment of patients with PCNSL who cannot tolerate MTX-containing regimens, or whose cancers are refractory to MTX. In this article, we review a promising new option; ibrutinib, a Bruton tyrosine kinase inhibitor, for patients with relapsed and refractory PCNSL.

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… A large, single-institution retrospective study found an overall invasive fungal infection incidence of 3.2% among 1191 patients admitted for chronic lymphoproliferative disorders, including CLL, Hodgkin lymphoma, non-Hodgkin lymphoma and multiple myeloma [ 43 ]. … Invasive fungal infections in chronic lymphoproliferative disorders: a monocentric retrospective study. Haematologica 102(3), e108–e111 (2017). 44. Pretorius L, Du XJ, Woodcock EA. et al. Reduced phosphoinositide 3-kinase (p110alpha) activation increases the susceptibility to atrial fibrillation. …

Связанные с мукосом инвариантные Т клетки в автоматическом иммунитете, заболеваниях, вызванных иммунной медициной, и заболеваниях дыхательных путей.

Инвариантные клетки, связанные с мукосалом Т (MAIT) — это новый класс врожденных Т клеток, выражающий полуинвариантный рецептор Т-клеток (TCR) и способный распознавать небольшие молекулы, представленные на неполиморфическом белоке MHC 1. Их врожденный фенотип фемориального эффекта, позволяющий секретить провоспалительные цитокины, и их относительное изобилие в человеке означает значительный потенциал для содействия аутоиммунным процессам. Однако, поскольку до недавнего времени клетки MAIT были неизвестны, а конкретные иммунологические инструменты отсутствовали, мало что известно об их роли в б

Prior cancer history and suitability for kidney transplantation.

Kidney transplantation is the optimal treatment for most patients with kidney failure. For patients with a prior history of treated cancers, listing and transplant eligibility decisions are complex. Patients and health professionals are obliged to consider the time-periods between cancer cure and transplantation, the risk of cancer recurrence under the influence of immunosuppression and anti-cancer treatment options if the disease recurs. Cancer recurrence is associated with a high mortality rate, thus potentially reduces the projected survival benefit of transplantation, and dampens the utili

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… Outcomes of kidney retransplantation in recipients with prior posttransplant lymphoproliferative disorders: an analysis of the 2000-2019 UNOS/OPTN database. Am J Transplant 2021;21:846–53. 10.1111/ajt.16385. 39. Canadian Cancer Society . …

The Complexities of Diagnosis with Co-Existing Gaucher Disease and Hemato-Oncology-A Case Report and Review of the Literature.

Hematological abnormalities are the most common early symptoms of Gaucher disease (GD), with an increased risk of hematopoietic system malignancies reported in patients with GD. GD may be associated with monoclonal and polyclonal gammopathies; however, the mechanism of association of GD with multiple myeloma (MM) remains uncertain. Enzyme replacement therapy (ERT) has been shown to improve patients' cytopenia and it seems to facilitate anti-myeloma therapy in patients with co-occurring GD and MM. Although it is necessary to demonstrate the deficiency of enzymatic activity, as well as using gen

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… The accumulation of M proteins in the lysosomes of various cells, such as histiocytes in the bone marrow or other tissues, can lead to the development of plasma cell dyscrasia and other lymphoproliferative disorder called crystal storage histiocytosis (CSH) [ 15 ]. … Other hypotheses that might explain the relationship between Gaucher disease and lymphoproliferative disorders include disorders in intercellular transmission, e.g., the occurrence of a cytokine storm secretion of pro- and anti-flooded factors, cytokines/chemokines/hydrolases, or the influence of IL1 …

Impact of Thrombopoietin Receptor Agonists on Pathophysiology of Pediatric Immune Thrombocytopenia.

Immune thrombocytopenia (ITP) in pediatric patients is a common cause of isolated thrombocytopenia. Various pathophysiological mechanisms are implicated in ITP pathogenesis, including the production of autoantibodies against components of platelets (PLTs) by B-cells, the activation of the complement system, phagocytosis by macrophages mediated by Fcγ receptors, the dysregulation of T cells, and reduced bone marrow megakaryopoiesis. ITP is commonly manifested with skin and mucosal bleeding, and it is a diagnosis of exclusion. In some ITP cases, the disease is self-limiting, and treatment is not

Hematopoietic Tumors

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Current State of Knowledge on Primary Sjögren's Syndrome, an Autoimmune Exocrinopathy.

Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune rheumatic disease characterized by lymphoplasmacytic infiltration of the salivary and lacrimal glands, whereby sicca syndrome and/or systemic manifestations are the clinical hallmarks, associated with a particular autoantibody profile. pSS is the most frequent connective tissue disease after rheumatoid arthritis, affecting 0.3-3% of the population. Women are more prone to develop pSS than men, with a sex ratio of 9:1. Considered in the past as innocent collateral passive victims of autoimmunity, the epithelial cells of the saliv

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… Lymphocytic interstitial pneumonitis (LIP) arrives in 3rd position (15% of ILD cases) and can be considered as a more specific benign diffuse lymphoproliferative disorder of pSS, probably starting from the follicular bronchiolitis. … Lymphoproliferative disorders were detected in 4.5% and malignancy in 9% of cases at 10 years post-diagnosis [ 301 ]. 6.4. …

Outcome of therapy-related myeloid neoplasms treated with azacitidine.

BackgroundTherapy-related myeloid neoplasms (t-MN), including myelodysplastic syndromes and acute myeloid leukemia (t-MDS and t-AML) are associated to clinical and biologic unfavorable prognostic features, including high levels of DNA methylation.MethodsWe retrospectively evaluated 50 t-MN patients (34 MDS and 16 AML) selected among all patients receiving azacitidine (AZA) at 10 Italian Hematology Centers. Patients had developed a t-MN at a median of 6.5 years (range 1.7- 29) after treatment of the primary tumor (hematological neoplasm, 27 patients; solid tumor, 23 patients).ResultsThe overall