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Contemporary Trends and Future Prospects of Genetically Engineered Vaccines in the Management and Prevention of Dental Caries.

Despite conventional preventive measures including dental sealants, dietary changes, and fluoride treatments, dental caries (DC) is still a global health issue. An important pathogen in DC development, Streptococcus mutans, forms biofilms and demineralizes enamel in acidic oral conditions. Promising substitutes are provided by new preventative techniques such as genetic engineering, probiotics, and antibacterial peptides. A potential long-term remedy is the genetically altered BCS3-L1 strain, which is intended to outcompete S. mutans and stop the generation of acid. Even though these developme…

Dietary Strategies to Modulate Gut Microbiota in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).

Gut microbiota has become an area of increasing interest for its potential role in metabolic dysfunction-associated steatotic liver disease … and MASH, exploring how microbial shifts might influence liver health. Emerging strategies-such as probiotics, prebiotics, and targeted dietary changes-that may help prevent or manage these conditions are also discussed. Finally, key areas where further studies are required to understand the role of microbiota and its therapeutic potential are highlighted.

Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharides.

Commensal bacteria affect host health by producing various metabolites from dietary carbohydrates via bacterial glycometabolism; however, th … rgy regulation, suggesting an approach for preventing lifestyle-related diseases via prebiotics and probiotics by targeting bacteria and EPS metabolites.

Нейростероиды, микробиота и нейроинфламмация: механистические понимания и терапевтические перспективы.

Ось кишечника (GBA) представляет собой сложную двунаправленную коммуникационную сеть, связывающую кишечник микробиота (GM) и центральную нервную систему (CNS). Недавние исследования показали, что нейростероиды (НН) играют важнейшую роль в модуляции нейроинфламмативной реакции и содействии нейрозащите. Тем временем, изменения ГМ связаны с различными нейро-воспалительными и нейродегенеративными условиями, такими, как множественный склероз, болезнь Альцгеймера и амиотропический боковой склероз. Цель этого обзора состоит в том, чтобы дать всеобъемлющий обзор сложных взаимосвязей между НС, ГМ и ней

Совпадение в аннотации оригинала
The gut-brain axis (GBA) represents a complex bidirectional communication network that links the gut microbiota (GM) and the central nervous … ulation can impact neurosteroidogenesis, highlighting potential therapeutic strategies that include probiotics, neuroactive metabolites, and targeted interventions. Understanding these interactions may pave the way for innovative treatment approaches for neuroinflammatory and neurodegenerative diseases, promoting a more integrated view of brain health and di …

Oral microbiota in human health and disease: A perspective.

The evolution of medical knowledge about oral microbiota has increased awareness of its important role for the entire human body health. A w … ing human health. In this context, strategies based on oral hygiene and diet as well as the role of probiotics supplementation are discussed.

You Are What You Eat: A Review on Dietary Interventions for Treating Pediatric Nonalcoholic Fatty Liver Disease.

As the obesity pandemic worsens, cases of pediatric nonalcoholic fatty liver disease (NAFLD) and complications of this disease, such as prog … he roles of dietary supplements such as Vitamin E, polyunsaturated fatty acids (PUFAs), ginger, and probiotics have also been investigated. A further understanding of specific dietary interventions and supplements is needed to provide both generalizable and sustainable dietary recommendations to reverse the progression of NAFLD in the pediatric population.

Dietary Strategies for Relieving Stress in Pet Dogs and Cats.

A variety of physical, emotional, and mental factors can induce a stress response in pet dogs and cats. During this process, hypothalamus-pi … effects and mechanisms of dietary regulation strategies (e.g., antioxidants, anxiolytic agents, and probiotics) on relieving stress in pet dogs and cats are summarized and discussed. We aim to shed light on future studies in the field of pet food and nutrition.

Harnessing the power of nutritional antioxidants against adrenal hormone imbalance-associated oxidative stress.

Oxidative stress, resulting from dysregulation in the secretion of adrenal hormones, represents a major concern in human health. The present … ioxidants, namely vitamin C, vitamin E, carotenoids, selenium, zinc, polyphenols, coenzyme Q10, and probiotics, and elucidates their role in mitigating the adverse effects of oxidative stress arising from imbalances in adrenal hormone levels. In conclusion, harnessing the power of nutritional antioxidants has the potential to help with oxidative stress cause …

Gut microbiome and cardiometabolic risk.

The last decade has been characterized by an intense research on the composition of the gut microbiome and the links with human health. While previous work was focused on the effects of prebiotics and probiotics, nowadays several laboratories are describing the gut microbiome and its metabolic functions. Gut microbiome interaction with nutrients allows the gut microbiome to survive and at the same time determines the production of metabolites that are either adsorbed by intestinal cell in a mutual relationship or promote detrimental effect. Metabolomics, a new method to approach identification…

Novel cancer therapy targeting microbiome.

In the human intestinal tract, there are more than 100 trillion symbiotic bacteria, which form the gut microbiota. Approximately 70% of the … iliary, pancreatic, lung and colorectal cancer. Moreover, several animal studies have revealed that probiotics seem to be effective for the prevention of carcinogenesis to some extent. In this review, we focused on this relationship between the microbiota and cancer, and considered how to prevent cancer using strategies involving the gut microbiota.

[Importance of nutritional support in patients with hepatic encephalopathy].

Protein calorie malnutrition is frequently a complication in the chronic liver disease patient and is considered to be a negative prognostic … This article reviews the use of oral branched-chain amino acids and proteins of different sources, probiotics, synbiotics, antioxidants, oral L-Ornithine L-Aspartate and acetyl-L-carnitine in patients with hepatic encephalopathy.

[Intestinal microbiota in short bowel syndrome].

Short bowel syndrome (SBS) is the main cause of intestinal failure especially in children. The colon is a crucial partner for small intestin … otic therapy as a first-line approach remains a matter of debate, while other approaches, including probiotics, offer potential based on experimental evidence, though only few data from human studies are available.

Redefining lactose as a conditional prebiotic.

Lactose in dairy products is maldigested by up to 70% to 75% of the world's population and many people may therefore suffer symptoms reminiscent of irritable bowel syndrome. As a result, most research to date has concentrated on ways of improving lactose tolerance to enhance dairy as a source of nutrition. However, research on other possible benefits of lactose and its maldigestion has lagged. In view of an exponential growth in the understanding of intestinal microfloral host interactions and the expanding therapeutical potential of probiotics, a reassessment of the role of lactose as a poten…

Inflammatory bowel disease.

This article reviews a selection of 50 papers on inflammatory bowel disease published between April 2000 and June 2001. The new information summarized here includes: the discovery of the association of the NOD2 gene with Crohn's disease; the role of bacteria and the modulating effects of probiotics; the inverse association of appendectomy and ulcerative colitis; progress in imaging based on magnetic resonance imaging and leukocyte scintigraphy; assessment of the value of anti-Saccharomyces cerevisiae antibodies in the screening of inflammatory bowel disease and differentiation between ulcerati…

Update on medications used to treat gastrointestinal disease in children.

Progress in the pharmacotherapy of pediatric gastrointestinal diseases continued during 1998 despite ongoing obstacles encountered by clinicians and researchers. The major change involved warnings that cisapride, a widely used prokinetic agent, could cause potentially fatal arrythmias in susceptible people. The risk for children is unclear and a consensus of prescribing guidelines is needed. Excellent pediatric-oriented reviews have been published that summarize our knowledge of proton pump inhibitors, probiotics, 5-hydroxtryptamine-3 (5-HT3) antagonists, and the treatment of gastrointestinal …

Lactobacillus cells in the rabbit digestive tract and the factors affecting their distribution.

Lactobacillus fermentum was present in small numbers in the caecum and colon of only one of 16 rabbits. Studies aimed at elucidating the fac … prevent them from colonizing in the intestinal tract. Therefore, if lactobacilli are to be used as probiotics for rabbit, factors that affect their viability and ability to colonize should be considered.

Central line infections in a haematology-oncology patient associated with Bacillus species-containing cleaning spray.

Haemato-oncological patients are susceptible to infections due to aplasia. This article describes an adolescent with a history of a relapse precursor B-cell acute lymphoblastic leukaemia, who experienced a second leukaemia after CAR-T-cell therapy with a lineage switch to acute myeloid leukaemia. He experienced events of central-line-associated bloodstream infections with Bacillus spp., requiring long-term broad-spectrum antibiotics, central venous line replacements and removal of a port catheter. A commercially available 'synbiotic spray' containing Bacillus strains was identified as the like

An Elderly Patient Developed Ulcerative Colitis after SARS-CoV-2 mRNA Vaccination: A Case Report and Review of the Literature.

An 86-year-old man presented to our hospital with symptoms of diarrhea and bloody stool, which had manifested two weeks after receiving his third severe acute respiratory syndrome coronavirus 2 mRNA vaccination. Colonoscopy revealed diffuse, rough-surfaced mucosa extending from the ascending colon to the rectum. Despite attempting probiotic treatment, the patient's condition did not improve, leading to admission. Endoscopic findings at admission worsened. Based on endoscopic and histopathological findings, the patient was diagnosed with ulcerative colitis. Corticosteroids and 5-aminosalicylic

Genome-Informed Characterization of Lactiplantibacillus plantarum ND88 with Inhibitory Activity against Representative Oral Pathogens.

UNLABELLED: Lactiplantibacillus plantarum ND88, a human-derived strain with putative probiotic-associated traits, was taxonomically confirmed by whole-genome sequencing and comparative genomic analysis. Average nucleotide identity (ANI) analysis showed that ND88 clustered within the L. plantarum species group, sharing > 98% identity with representative reference genomes. Comparative pangenome analysis of ND88 and 20 L. plantarum genomes revealed multiple ND88-specific and enriched orthogroups, indicating strain-level genomic diversification. Genome-informed Pfam domain annotation predicted sev

Postbiotic effects of Enterococcus faecium JB00008 on gut health and IBD vaccination in broiler chickens.

Feeding various probiotic lactic acid bacteria, including Enterococcus faecium, can alleviate intestinal inflammation and improve gut health in animals. Recently, postbiotics-non-living preparations derived from microbial cells or their metabolites-have gained attention. However, studies on the effects of these postbiotics on immune markers and changes in the gut microbiota of chickens are limited. In this study, we evaluated the effects of the probiotic strain E. faecium JB00008 on the chicken intestinal tract and characterized immune markers and gut microbiota following viral vaccination. Ch