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From static guidelines to dynamic personalization: a novel AI-driven evidence-based paradigm for low-concentration atropine prescribing in myopia control.

BACKGROUND: The rapid increase in the global incidence of myopia poses challenges for prevention and management. Evidence-based low-concentration atropine eye drops can effectively slow down the progression of myopia. However the massive and constantly updated research data place a burden on clinicians, especially in primary care or regions with limited resources, hindering knowledge integration and evidence-based decision-making. There is still a gap in patients' access to reliable and personalized guidance. To address this issue, we developed MyoATP-AI-powered evidence based decision support

Screening 1021 Swedish memory clinic visitors for autoantibody-mediated encephalitis.

INTRODUCTION: A treatable differential diagnosis to neurodegenerative dementia is autoimmune encephalitis (AE). In Sweden, the prevalence of AE varies considerably between regions, suggesting underdiagnosis. We hypothesized that some undetected AE patients would attend Swedish memory clinics. METHODS: We retrospectively screened 1021 individuals attending the Karolinska University Hospital memory clinics for AE autoantibodies. Serum screening was performed with live cell-based assays (CBAs) for antibodies to contactin-associated protein-like 2 (CASPR2), gamma-aminobutyric acid receptor B (GAB

Evaluating Manual Therapy in Musculoskeletal Pain: Why Certain Trial Designs May Overestimate Effectiveness-A Scoping Review.

BACKGROUND AND OBJECTIVE: Atraumatic musculoskeletal pain, regardless of the affected body region, is a highly prevalent condition impacting … ignificant effects in the immediate or short-term follow-up; however, these effects were of limited clinical relevance and susceptible to methodological issues. Furthermore, studies with lower methodological quality were more likely to report significant effects (85%), whereas medium- and high-quality studies showed positive results in only 50% of cases. CONCLUSION …

Assessment of current patient reported outcome measures for three core outcome domains for single-sided deafness device intervention trials.

BACKGROUND: Outcome reporting in clinical trials of auditory interventions for adults with Single-Sided Deafness (SSD) is inconsistent. The Core Rehabilitation Outcome Set for Single-Sided Deafness (CROSSSD) initiative has recommended three outcome domains as a minimum standard in the design of SSD intervention clinical trials. These are, Spatial orientation, Group conversations in noisy social situations, and Impact on social situations. The study objectives were to (i) understand exactly what the outcome domains mean to SSD experts, and (ii) identify and assess candidate PROMs in terms of ho

Cracking the code: how piRNA pathway shapes spermatogenesis and combats male infertility.

Male infertility, accounting for approximately 50% of global infertility cases, is a growing concern in reproductive medicine. A fundamental cause lies in disrupted spermatogenesis-a complex, highly regulated process involving mitotic proliferation, meiotic division, and spermiogenic remodeling. Among the key regulatory pathways, PIWI-interacting RNAs (piRNAs) and their associated PIWI proteins have emerged as essential players in maintaining germline genome integrity and ensuring successful sperm development. However, their clinical relevance remain underexplored. This review provides a compr…

Анализ эффективности затрат, связанных с офатумумабом и терифлюномидом, для повторного выброса нескольких склерозов: A 10-Year Марковская модель.

СПРАВОЧНАЯ ИНФОРМАЦИЯ И ЦЕЛИ: Офатумумаб, полностью человек anti-CD20 Моноклональная антитела является перспективной терапией для изменения заболеваний (DMT) для повторного излучаемого многократного склероза (RRMS). В этом исследовании анализируется его рентабельность по сравнению с терифлюномидом с точки зрения саудовских работников здравоохранения. Это сопоставление имеет важнейшее значение для разработки стратегий лечения и распределения ресурсов в Саудовской Аравии, где ОСРЗ создает значительную нагрузку на здравоохранение и эволюционирует доступ к новым ДМТ. ПАТИЕНТЫ И МЕТОДЫ: Марковская

Совпадение в аннотации оригинала
BACKGROUND AND OBJECTIVES: Ofatumumab, a fully human anti-CD20 monoclonal antibody, is a promising disease-modifying therapy (DMT) for relap … in Saudi Arabia. This model simulates disease progression over 10 years, a timeframe chosen for its clinical relevance and consistency with similar studies. To reflect the Saudi patient population, the model uses a hypothetical cohort with characteristics mirroring those in the ASCLEPIOS I/II clinical trials. The model incorporates transition probabilities between d …

Unraveling the Significance of MET Focal Amplification in Lung Cancer: Integrative NGS, FISH, and IHC Investigation.

MET amplification (METamp) represents a promising therapeutic target in non-small cell lung cancer, but no consensus has been established to … he SCH cohort included 130 cases known to be METamp positive by FISH and 101 negative controls. The clinical relevance of these approaches in predicting the efficacy of MET inhibitors was evaluated. Additionally, next-generation sequencing data from another 2 cohorts including 22,010 lung cancer cases were utilized to examine the biological characteristics of differ …

Methods to appraise available evidence and adequacy of data from a systematic literature review to conduct a robust network meta-analysis of treatment options for patients with hospital-acquired or ventilator-associated bacterial pneumonia.

We aimed to determine if available evidence from a previously conducted systematic literature review was sufficient to conduct a robust network meta-analysis (NMA) using the International Society for Pharmacoeconomics and Outcomes Research Good Practice Task Force NMA study questionnaire to evaluate suitability, relevance, and credibility of available randomized-controlled trials (RCT) of antibacterial therapies for treatment of patients with hospital-acquired or ventilator-associated bacterial pneumonia (HABP/VABP). We assessed feasibility and reliability of an NMA for a connected network of

Recurrent pneumothorax after cesarean delivery in the critically ill pregnant with severe COVID-19 ARDS: a case report.

BACKGROUND: Enamel pits and enamel developmental defects have been reported in patients with tuberous sclerosis complex (TSC), but prevalence estimates and phenotypic descriptions vary widely. A standardized synthesis has been lacking. Recent updates in TSC clinical reviews and dermatologic-dental guidelines highlight the diagnostic relevance of subtle oral findings, underscoring the need for an updated synthesis. MATERIAL AND METHODS: A systematic review with quantitative integration was conducted in accordance with PRISMA 2020 guidelines. Electronic databases were searched from inception to

Ethnicity and differences between clinic and ambulatory blood pressure measurements.

BACKGROUND: This study investigated the relationship of ethnicity to the differences between blood pressure (BP) measured in a clinic settin … dings were higher than ABPM, particularly in the HT group where the systolic differences approached clinical relevance (131 (SE 1.2) vs. 129 (SE 1.0) mm Hg (NHT) and 139 (SE 0.9) vs. 133 (SE 0.7) mm Hg (HT)) and were larger in SA and AC hypertensive individuals (136 (SE 1.5) vs. 133 (SE 1.2) mm Hg (WB), 141 (SE 1.7) vs. 133 (SE 1.4) mm Hg (SA), and 142 (SE 1.6) vs. …

Rapid development of sensitive, high-throughput, quantitative and highly selective mass spectrometric targeted immunoassays for clinically important proteins in human plasma and serum.

OBJECTIVES: The aim of this study was to develop high-throughput, quantitative and highly selective mass spectrometric, targeted immunoassays for clinically important proteins in human plasma or serum. DESIGN AND METHODS: The described method coupled mass spectrometric immunoassay (MSIA), a previously developed technique for immunoenrichment on a monolithic microcolumn activated with an anti-protein antibody and fixed in a pipette tip, to selected reaction monitoring (SRM) detection and accurate quantification of targeted peptides, including clinically relevant sequence or truncated variants.

Predictive biomarkers in cancer immunotherapy for genitourinary malignancies.

Immunotherapy has transformed the management of genitourinary cancers, offering durable responses in selected patient groups. However, the c … iomarkers, microbiome influences, and multi omic integrative approaches. We discuss their potential clinical relevance, limitations, and applicability across different tumor types. Future directions emphasize the development of composite biomarkers, standardization of testing platforms, real time monitoring strategies, and the integration of advanced technologies su …

Mechanisms and Prognostic Assessment Value of Thyroid Hormone in Liver Failure.

Early and accurate prognostic assessment is crucial to avoid serious disease progression in patients with liver failure. Thyroid hormone is an important metabolic regulator involved in hepatic function. This review examines the pathophysiological regulation in detail of the hypothalamic-pituitary-thyroid axis in patients with liver failure and emphasizes the importance of thyroid profiling (thyroid-stimulating hormone, T3, and T4) in prognostic assessment and risk stratification. T3 can enhance liver regeneration. The clinical application of thyroid hormone replacement therapy in patients with

Mitochondrial homeostasis dysregulation: Potential mechanisms of Alzheimer's disease mediated by TDP-43.

Alzheimer's disease (AD) exhibits substantial clinical and pathological heterogeneity that is not fully explained by amyloid-β and tau pathology alone. TAR DNA-binding protein 43 (TDP-43) is increasingly recognized as a frequent copathology in AD, particularly in limbic regions, where its presence is associated with accelerated cognitive decline. Disruption of mitochondrial homeostasis is also an early and consistent feature of AD and contributes to neuronal vulnerability. In this review, we summarize current evidence linking TDP-43 pathology to impaired mitochondrial homeostasis in AD. We out

Marine-Derived Defenses Against HIV: Emerging Bioactive Molecules from the Seas.

Marine ecosystems have yielded a remarkable diversity of bioactive metabolites with relevance for antiviral drug discovery. This article reviews recent advances in marine-derived compounds investigated as anti-HIV agents. Metabolites, such as sulfated polysaccharides, lectins, alkaloids, and terpenoids, display inhibitory activity across multiple stages of the HIV life cycle, including viral entry, reverse transcription, integration, and maturation. From sponge-inspired development of AZT to the application of Griffithin in clinical trials for the prophylaxis of the HIV infection, recent disco

Gait analysis for Parkinson's disease using multiscale entropy.

Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by motor dysfunction and complex gait abnormalities. Traditional … ing. Advances in wearable sensors, artificial intelligence, and machine learning have boosted MSE's clinical relevance by enabling real-time, personalized gait assessments. Despite these benefits, MSE faces challenges such as computational demands and the need for high-resolution data. Addressing these limitations through large-scale studies, standardized protocols, …

Circulating plasma cells: from basic mechanisms to clinical applications.

Circulating plasma cells (CPCs) represent an accessible subset of antibody-secreting cells that provide valuable insights into immune activation and regulation. This review presents the first comprehensive synthesis of CPC biology, with a particular focus on the mechanisms governing their generation under physiological conditions and the distinct pathways that drive their formation within tumor microenvironments. We further summarize the broader clinical relevance of CPCs as potential biomarkers across infections, autoimmune diseases, and plasma cell disorders. With the rapid advancement of li…

[Tinnitus-current developments : Overview and summary of current state of knowledge in 2024].

Chronic tinnitus is a common symptom of the auditory system. Its pathophysiology remains incompletely understood, primarily due to its multi … testing is improving diagnostic precision, while multidisciplinary treatment approaches are gaining clinical relevance and should be increasingly emphasized.

Post-Engraftment Syndrome Following Autologous Haematopoietic Stem Cell Transplantation in a Patient With Relapsed Hodgkin Lymphoma.

Post-engraftment syndrome (PES) is a significant and potentially life-threatening complication of autologous haematopoietic stem cell transplantation (AHSCT) that presents with fever, skin rash and pulmonary involvement. Despite its clinical relevance, PES remains a diagnostic challenge and is often misidentified as an infectious process, leading to a delay in the appropriate treatment. We report the case of a 38-year-old man with relapsed Hodgkin's lymphoma and glucose-6-phosphate dehydrogenase (G6PD) deficiency who developed severe PES following AHSCT. The patient experienced severe respirat…

Case report: Cerebrospinal fluid neutrophilic pleocytosis upon intrathecal triamcinolone injection.

Intrathecal corticosteroids, initially employed in the 1950s, faced declining use due to complications like arachnoiditis and aseptic mening … ase thus highlights a potential side effect of intrathecal triamcinolone injection with yet unclear clinical relevance, underscores the need for further assessment of clinical benefits of intrathecal triamcinolone, and emphasizes potential short and long-term side effects associated with extended intrathecal triamcinolone use.