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Daratumumab plus bortezomib, lenalidomide and dexamethasone for transplant-ineligible or transplant-deferred newly diagnosed multiple myeloma: the randomized phase 3 CEPHEUS trial.

Frontline daratumumab-based triplet and quadruplet standard-of-care regimens have demonstrated improved survival outcomes in newly diagnosed multiple myeloma (NDMM). For patients with transplant-ineligible NDMM, triplet therapy with either daratumumab plus lenalidomide and dexamethasone (D-Rd) or bortezomib, lenalidomide and dexamethasone (VRd) is the current standard of care. This phase 3 trial evaluated subcutaneous daratumumab plus VRd (D-VRd) in patients with transplant-ineligible NDMM or for whom transplant was not planned as the initial therapy (transplant deferred). Some 395 patients wi

Получил от "Puff of Domoke"-A Case-Review on the Challenging Discrimination of CNS Demielining Beace and Moyamoya Angiopatia.

Moyamoya aнгиопатия (MMA) — цереброваскулярное заболевание, определяющее хроническое прогрессивное включение надклиноидных внутренних артерий сонной артерии и их основных веток. Патогенез ММА по-прежнему в значительной степени неизвестен. Множественный склероз (MS) является хроническим, подстрекательским и демиелинизирующим заболеванием центральной нервной системы, характеризующимся постепенным накоплением фокусных демиелионирующих повреждений, патофизиология которых была теоретической, но до сих пор не до конца понята. Помимо неправильной диагностики из-за имитирующих эти два расстройства осо

Effects of Obesity and Calorie Restriction on Cancer Development.

The risk of malignant tumor development is increasing in the world. Obesity is an established risk factor for various malignancies. There are many metabolic alterations associated with obesity which promote cancerogenesis. Excessive body weight leads to increased levels of estrogens, chronic inflammation and hypoxia, which can play an important role in the development of malignancies. It is proved that calorie restriction can improve the state of patients with various diseases. Decreased calorie uptake influences lipid, carbohydrate and protein metabolism, hormone levels and cell processes. Ma

Biopharmaceutical and pharmacokinetic attributes to drive nanoformulations of small molecule tyrosine kinase inhibitors.

Buoyed by the discovery of small-molecule tyrosine kinase inhibitors (smTKIs), significant impact has been made in cancer chemotherapeutics. However, some of these agents still encounter off-target toxicities and suboptimal efficacies due to their inferior biopharmaceutical and/or pharmacokinetic properties. Almost all of these molecules exhibit significant inter- and intra-patient variations in plasma concentration-time profiles. Thus, therapeutic drug monitoring, dose adjustments and precision medicine are being contemplated by clinicians. Complex formulations or nanoformulation-based drug d

Fit theory: A cancer experience grounded theory emerging from semi-structured interviews with cancer patients and informal caregivers in Manitoba Canada during the COVID-19 pandemic.

BackgroundIt is not clear how changes to healthcare delivery related to the COVID-19 pandemic, including virtual care and social distancing restrictions, have impacted the experience of living with cancer. This study aimed to discover a theory capable of describing the cancer experience, how the pandemic impacted it, and for guiding predictions about how to improve it.MethodsBetween October 2020 and July 2021 digitally recorded semi-structured one-on-one interviews were conducted virtually with adult cancer patients and informal caregivers in Manitoba, Canada. Transcriptions and field notes fr

Clinical Genetics of Cancer 2017 : Szczecin, Poland. 21-22 September 2017

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The Role of Fc-like Receptor 3 in the Pathophysiology of Rheumatoid Arthritis.

The pathogenesis of rheumatoid arthritis involves a complex interplay of genetic predisposition, environmental factors, and autoimmune mechanisms that lead to chronic inflammation of the synovial membrane. Fc-like receptor 3 (FcRL3) is a receptor encoded by the FCRL3 gene, located on the long arm of chromosome 1 at 1q23.1. Polymorphisms in the promoter region of FCRL3, rather than elsewhere in the gene, primarily affect the level of protein expression, which is of clinical significance. Understanding the structure of FcRL3, particularly in the context of genetic variants, is therefore importan

Определение воздействия методов эмоциональной свободы на сексуальную дисфункцию и самообслуживание женщин, страдающих множественным склерозом.

АИМ: Данное исследование направлено на определение воздействия методов эмоциональной свободы (ЭФТ) на сексуальную дисфункцию и уход за собой у женщин, у которых диагностирован множественный склероз (МС). МЕТОД: Настоящее исследование проводилось с использованием экспериментальной схемы, разработанной до проведения испытаний, включая последующие оценки для оценки устойчивости последствий вмешательства. В выборку входили 16 женщин в возрасте от 19 до 49 лет, которым был поставлен диагноз MS и которые были представлены в неврологическую клинику университетской больницы в Тюркийе в период с октябр

Совпадение в полном тексте источника
… Variable Mean ± SD Age 37.31 ± 7.95 MS age 27.25 ± 5.37 n (%) Marital status Married Single 12 (75.0) 6 (25.0) Educational level Middle school High school College and higher 5 (31.3) 5 (31.3) 6 (37.5) Family type Nuclear family Extended family 12 (75.0) … Marital status Married Single 12 (75.0) 6 (25.0) Educational level Middle school High school College and higher 5 (31.3) 5 (31.3) 6 (37.5) Family type Nuclear family Extended family 12 (75.0) 4 (25.0) Income status Income = expenses Income > expenses Income < expenses 11 (68.8) …

More often than not, we're in sync: patient and caregiver well-being over time in stem cell transplantation.

BackgroundHematopoietic stem cell transplantation (HSCT) is an aggressive medical procedure which significantly impacts the shared emotional well-being of patients and family caregivers (FC). Prior work has highlighted the significant overlap in well-being among patients and FCs; however, how this interdependence may change over the course of HSCT has received less attention.MethodsWe conducted secondary analyses of a supportive intervention delivered to 154 FCs of HSCT patients and examined relationships at baseline, 6 weeks, 3 and 6 months post-HSCT. Actor Partner Interdependence Modeling ex

Construction and validation of nomogram prediction model for anxiety and depression in chemotherapy patients with multiple myeloma.

ObjectiveTo construct and validate a nomogram prediction model for anxiety and depression in chemotherapy patients with multiple myeloma (MM).MethodsFrom May 2021 to May 2023, 333 MM chemotherapy patients treated at our hospital were selected. The patients were randomly divided into a modeling group and a validation group in a 7:3 ratio (using a random number table method). According to whether the modeling group patients had anxiety and depression, they were grouped into a non-anxiety and depression group and an anxiety and depression group; a nomogram model constructed using R software was b

Health literacy, eHealth literacy and their association with burden, distress, and self-efficacy among cancer caregivers.

PurposeHealth literacy skills are vital for cancer caregivers in helping cancer survivors to navigate their diagnosis, treatment, and recovery but little is known. This study explored health literacy and eHealth literacy among cancer caregivers and the relationship between health literacy/eHealth literacy and potential associated factors.MethodsInformal caregivers who had cared for an individual with cancer completed a survey which collected demographic data and measured caregiver health literacy, eHealth literacy, self-efficacy, burden, and distress.ResultsSeven percent of caregivers had inad

Совпадение в полном тексте источника
… Post-hoc tests in which a Bonferroni adjustment was applied indicated that there was a significant difference between extended family/close friends ( Md = 4) and children ( Md = 3.5) and partner/spouse ( Md = 3.75). … Cancer caregivers who were extended family or close friends to the care recipient scored higher than those who were children or a partner in their capacity to process information. …

Exploring the characteristics of conversational agents in chronic disease management interventions: A scoping review.

ObjectiveWith the increasing global burden of chronic diseases, there is the potential for conversational agents (CAs) to assist people in actively managing their conditions. This paper reviews different types of CAs used for chronic condition management, delving into their characteristics and the chosen study designs. This paper also discusses the potential of these CAs to enhance the health and well-being of people with chronic conditions.MethodsA search was performed in February 2023 on PubMed, ACM Digital Library, Scopus, and IEEE Xplore. Studies were included if they focused on chronic di

Множественный опыт и предпочтения в области миеломы: исследование смешанных методов лечения пациентов и партнеров по уходу в Соединенных Штатах.

ЦЕЛЬ: Множественная миелома (ММ) характеризуется рецидивом лечения и сопротивлением, что требует принятия последовательных решений о лечении на протяжении всего курса лечения. Для того чтобы понять, каким образом состояние заболеваний и изменение условий лечения влияют на решения, принимаемые пациентами и партнерами по уходу, было проведено исследование по изучению неинтервенционных смешанных методов. ПАТИЕНТЫ И МЕТОДЫ: Пациенты, самоотчитывающиеся MM и партнеры по уходу, были набраны через Гритское сообщество по борьбе с раком, социальные сети и снежные шары для участия в этом исследовании, п

Patient perspectives on BCMA-targeted therapies for multiple myeloma: a survey conducted in a patient advocacy group.

BackgroundAdvances in multiple myeloma (MM) treatment have shifted the therapeutic landscape. Understanding patients' perspectives can assist physicians in helping patients make informed decisions. This study aimed to understand the patient decision-making process and gain insights into patient perspectives on B-cell maturation antigen (BCMA)-targeted therapies for MM.MethodsAn 18-question survey was completed by patients with MM enrolled in HealthTree® Cure Hub, an online portal helping patients with plasma cell dyscrasias navigate their disease.ResultsFrom October 28, 2022, to January 12, 20

Neutrophil diversity and function in health and disease.

Neutrophils, the most abundant type of granulocyte, are widely recognized as one of the pivotal contributors to the acute inflammatory response. Initially, neutrophils were considered the mobile infantry of the innate immune system, tasked with the immediate response to invading pathogens. However, recent studies have demonstrated that neutrophils are versatile cells, capable of regulating various biological processes and impacting both human health and disease. Cytokines and other active mediators regulate the functional activity of neutrophils by activating multiple receptors on these cells,

Longer Follow-Up Confirms Relapse-Free Survival Benefit With Adjuvant Dabrafenib Plus Trametinib in Patients With Resected BRAF V600-Mutant Stage III Melanoma.

PurposeDabrafenib plus trametinib improved relapse-free survival (RFS) versus placebo (hazard ratio [HR], 0.47; P BRAF V600-mutant stage III melanoma (BRF115532; COMBI-AD; ClinicalTrials.gov identifier: NCT01682083). We present an updated RFS analysis on the basis of extended study follow-up and a cure-rate model analysis to estimate the fraction of patients expected to remain relapse free long term.MethodsIn this phase III trial, patients with resected BRAF V600-mutant stage III melanoma were randomly assigned to 12 months of adjuvant dabrafenib plus trametinib versus placebo. We report updat

The Association Between Social Support and Psychosomatic Status in Cancer Patients During Mid-Course Radiotherapy: The Chain Mediating Roles of Psychological Capital and Coping Styles.

Background: Cancer patients undergoing mid-course radiotherapy frequently experience psychosomatic distress, yet the psychosocial correlates and indirect pathways associated with this phenomenon remain insufficiently understood. Objective: To examine the direct and indirect associations between social support and psychosomatic status through psychological capital and coping styles in cancer patients undergoing mid-course radiotherapy. Methods: A cross-sectional study was conducted among 327 cancer patients recruited from the radiotherapy center of a tertiary-level general hospital between Augu

Виром ДНК связан с аутоиммунными заболеваниями и COVID-19.

Аберрантная иммунная реакция на вирусные патогены способствует патогенезу, но наше понимание патологических иммунных реакций, вызванных вирусами в вироме человека, особенно в масштабе населения, остается ограниченным. Мы проанализировали наборы данных о последовательности целых генов 6,321 Японцы, включая пациентов с аутоиммунными заболеваниями (псориаз вульгарис, ревматоидный артрит (RA), системный волшебный эритематос (SLE), легочный альвеолярный протеиноз (PAP) или множественный склероз) и коронавирусное заболевание 2019 (В тыс.COVID-19) или здоровый контроль. Систематическая количественная

Acute pancreatitis with hypercalcemia caused by primary hyperparathyroidism associated with paraneoplastic syndrome: A case report and review of literature.

BACKGROUND: Although acute pancreatitis associated with hyperparathyroidism has occasionally been reported, acute pancreatitis with metabolic encephalopathy caused by hyperparathyroidism combined with paraneoplastic syndrome is an extremely rare entity and poorly described in the literature. CASE SUMMARY: We present a case of a 56-year-old female with upper abdominal discomfort and intermittent nausea and vomiting for 1 wk, without apparent abdominal pain or bloating, no jaundice and decreased blood pressure at the outset. The patient was ultimately diagnosed with moderately severe acute panc

Эпидемиология, патология и патогенез MS: терапевтические последствия.

Множественный склероз (MS) является хроническим и потенциально деактивирующим воспалительным заболеванием центральной нервной системы (CNS). МS, как правило, характеризуется повторяющимися и самоограниченными эпизодами неврологической дисфункции, которые происходят непредсказуемо и часто приводят к множественным повреждениям тканей в рамках CNS. В настоящее время женщины страдают в два-три раза чаще, чем мужчины, хотя это, возможно, не произошло в предыдущие периоды времени. Известно, что патогенез MS связан как с критическими генетическими, так и с экологическими механизмами. Тем не менее, по