Результаты поиска

The role and mechanisms of mesenchymal stem cells in postoperative cognitive dysfunction via immune network regulation.

Postoperative cognitive dysfunction (POCD) is a common neurological complication in elderly patients after surgery. Its pathophysiology is complex. Neuroinflammation, oxidative stress, and immune imbalance are all involved in this process. These changes can affect postoperative recovery and reduce patients' quality of life. As population aging continues to increase, the prevention and treatment of POCD have become important clinical issues. In recent years, mesenchymal stem cells (MSCs) have attracted attention in neurological diseases because of their immunomodulatory and tissue healing abili

Совпадение в полном тексте источника
… This process further triggers a neuroinflammatory cascade and finally affects synaptic plasticity and neurogenesis in the hippocampus [ 2 , 5 ]. The hippocampus plays an important role in learning and memory. …

Sympathetic nervous system in tumor progression and metabolic regulation: mechanisms and clinical potential.

Tumor progression is characterized by profound metabolic alterations and dynamic interactions within the tumor microenvironment (TME), which enable rapid proliferation, immunoinvasion, and metastasis. The sympathetic nervous system (SNS), which has been best known for its role in stress regulation, has emerged as a critical regulator of tumor metabolism. The SNS influences glucose, lipid and glutamine metabolism in tumor cells and stromal components by releasing neurotransmitters such as norepinephrine (NE), creating a pro-tumor metabolic and immunosuppressive microenvironment. SNS signaling e

Совпадение в полном тексте источника
… Cancer-Associated neurogenesis and Nerve-Cancer Cross-talk. Cancer Res. 2021;81(6):1431–40. 21. Cole SW, Nagaraja AS, Lutgendorf SK, Green PA, Sood AK. Sympathetic nervous system regulation of the tumour microenvironment. Nat Rev Cancer. 2015;15(9):563–72. 22. Eubank TD. …

New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer.

Cancer is the second most common cause of death among humans in the world, and the threat that it presents to human health is becoming more and more serious. The mechanisms of cancer development have not yet been fully elucidated, and new therapies are changing with each passing day. Evidence from the literature has validated the finding that the composition and modification of gut microbiota play an important role in the development of many different types of cancer. The results also demonstrate that there is a bidirectional interaction between the gut microbiota and radiotherapy treatments f

Совпадение в полном тексте источника
… Irradiation of the head reduces adult hippocampal neurogenesis and impairs spatial memory, but leaves overall health intact in rats Eur. J. Neurosci. 2021 53 1885 1904 10.1111/ejn.15102 33382141 99. Li W. Lu L. Liu B. Qin S. …

Role of TRP Channels in Cancer-Induced Bone Pain.

The burden of cancer is growing in almost every country. Bone metastases significantly affect the prognosis and lead to an increase in mortality and morbidity. The management of cancer-induced bone pain (CIBP) still shows various unmet needs. Opioid use is burdened by a number of possible side effects. Moreover, recent progresses in cancer treatment significantly increased the life expectancy of cancer patients, even those with metastatic disease. In this narrative review, we reported the main findings regarding TRP channel function in cancer pain models. TRP cation channels play a key role in

Совпадение в полном тексте источника
… Tumours, indeed, display their own innervation, a well-known phenomenon called “neo-neurogenesis”; the more prominent the innervation, the more aggressive the cancer and the worse the prognosis [ 75 ]. …

World Trade Center Health Program: First Decade of Research.

The terrorist attacks on 11 September 2001 placed nearly a half million people at increased risk of adverse health. Health effects research began shortly after and continues today, now mostly as a coordinated effort under the federally mandated World Trade Center (WTC) Health Program (WTCHP). Established in 2011, the WTCHP provides medical monitoring and treatment of covered health conditions for responders and survivors and maintains a research program aimed to improve the care and well-being of the affected population. By 2020, funds in excess of USD 127 M had been awarded for health effects

Совпадение в полном тексте источника
… found to be dysregulated in neurodegenerative disorders [ 158 ] and, when interrogating gene expression in cell subpopulations among responders ( n = 39) with/without PTSD, also identified PI4KAP1, REST, and SEPT4 genes in monocyte populations that have been previously implicated in neuronal loss and neurogenesis …

Immunological Approaches Towards Cancer and Inflammation: A Cross Talk.

The inflammation is the protective response of the body against various harmful stimuli; however, the aberrant and inappropriate activation tends to become harmful. The acute inflammatory response tends to resolved once the offending agent is subside but this acute response becomes chronic in nature when the body is unable to successfully neutralized the noxious stimuli. This chronic inflammatory microenvironment is associated with the release of various pro-inflammatory and oncogenic mediators such as nitric oxide (NO), cytokines [IL-1β, IL-2, interleukin-6 (IL-6), and tumor necrosis factor-α

Совпадение в полном тексте источника
… A new perspective on the role of the CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis . Front Mol Neurosci ( 2015 ) 8 : 46 . 10.3389/fnmol.2015.00046 26379491 PMC4549561 74 Steven A Seliger B . …

Marine Bioactive Compounds from Functional Seafoods: Pharmacological Mechanisms and Health Applications.

Functional seafoods derived from marine organisms, including fish, shellfish and algae, are gaining increasing attention due to their high content of bioactive compounds, such as omega-3 fatty acids, peptides, polysaccharides and antioxidants, which provide health benefits beyond basic nutrition. These marine-derived compounds exhibit a wide range of biological activities and have been investigated for their potential roles in the prevention and management of chronic diseases, including cardiovascular, neurodegenerative, cancer and gastrointestinal disorders. Their effects are largely mediated

Googling the Guggul (Commiphora and Boswellia) for Prevention of Chronic Diseases.

Extensive research during last 2 decades has revealed that most drugs discovered today, although costs billions of dollars for discovery, and yet they are highly ineffective in their clinical response. For instance, the European Medicines Agency has approved 68 anti-cancer drugs, and out of which 39 has reached the market level with no indication of increased survival nor betterment of quality of life. Even when drugs did improve survival rate compared to available treatment strategies, most of these were found to be clinically insignificant. This is a fundamental problem with modern drug disc

Совпадение в полном тексте источника
… | ↑Caspase-3 | Büchele et al., 2006 d | ↓VEGFR-2 | Pang et al., 2009 d | ↓MMP; ↓PARP-1 | Pathania et al., 2015 d Colitis | ↓NF-κB | Kim et al., 2010 c | ↓ICAM-1; ↓NF-κB | Cheon et al., 2006 c Dementia | ↓AChE activity; ↓MDA; ↑GSH | Saxena et al., 2007 c Depression | ↑BDNF signaling; ↑Hippocampal neurogenesis …

Mechanisms of chemotherapy-induced behavioral toxicities.

While chemotherapeutic agents have yielded relative success in the treatment of cancer, patients are often plagued with unwanted and even debilitating side-effects from the treatment which can lead to dose reduction or even cessation of treatment. Common side effects (symptoms) of chemotherapy include (i) cognitive deficiencies such as problems with attention, memory and executive functioning; (ii) fatigue and motivational deficit; and (iii) neuropathy. These symptoms often develop during treatment but can remain even after cessation of chemotherapy, severely impacting long-term quality of lif

Совпадение в полном тексте источника
… Several mechanisms underlying cognitive impairment have been proposed including direct neurotoxic injury, decreased neurogenesis, hormonal pathways, and neuroinflammation (Seigers et al., 2013 ). …

Cyclic nucleotide phosphodiesterases as drug targets.

Cyclic nucleotides are synthesized by adenylyl and/or guanylyl cyclase, and downstream of this synthesis, the cyclic nucleotide phosphodiesterase families (PDEs) specifically hydrolyze cyclic nucleotides. PDEs control cyclic adenosine-3',5'monophosphate (cAMP) and cyclic guanosine-3',5'-monophosphate (cGMP) intracellular levels by mediating their quick return to the basal steady state levels. This often takes place in subcellular nanodomains. Thus, PDEs govern short-term protein phosphorylation, long-term protein expression, and even epigenetic mechanisms by modulating cyclic nucleotide levels

Клеточные иммунотерапии для множественного склероза: механистические интуиции и клинические достижения.

Множественный склероз (MS) представляет собой хроническое, разнородное, многофакторное, иммунно-дегенеративное заболевание центральной нервной системы, которое влияет на население трудоспособного возраста. На его развитие влияют как генетические, так и экологические факторы. Патологическая характеристика MS - это образование демиелинизирующих повреждений мозга и спинного мозга, которые связаны с нейронными повреждениями, вызванными аутоагрессивными иммунными факторами (Т клетки, В клетки и миэлоидные клетки). Считается, что координационные повреждения вызваны инфильтрацией иммунных клеток в це

Совпадение в полном тексте источника
… They can differentiate into oligodendrocytes or astrocytes to directly facilitate remyelination and neurogenesis. These cells migrate to lesion sites, where they secrete LIF and BDNF to reduce T-cell infiltration and modulate macrophage metabolism, thereby preventing axonal degeneration. …

Influence of gut microbial metabolites on tumor immunotherapy: mechanisms and potential natural products.

In recent years, tumor immunotherapy has made significant breakthroughs in the treatment of malignant tumors. However, individual differences in efficacy have been observed in clinical practice. There is increasing evidence that gut microbial metabolites influence the efficacy of distal tumor immunotherapy via the gut-liver axis, the gut-brain axis and the gut-breast axis, a process that may involve modulating the expression of immune cells and cytokines in the tumor microenvironment (TME). In this review, we systematically explore the relationship between gut microbial metabolites and tumor i

Совпадение в полном тексте источника
… Tryptophan-metabolizing gut microbes regulate adult neurogenesis via the aryl hydrocarbon receptor . Proc Natl Acad Sci United States America . ( 2021 ) 118 . doi: 10.1073/pnas.2021091118 PMC8271728 34210797 39 Bhattarai Y Jie S Linden DR Ghatak S Mars RAT Williams BB . …

Liposomes for the Treatment of Brain Cancer-A Review.

Due to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate targeted delivery across the blood-brain barrier (BBB). Additionally, strategies have been explored to synthesize liposomes that respond to internal and/or external stimuli to release their payload controllably. Although research into liposomes for brain cancer treatment is still in its infancy, these systems have great potential to fundamentally change the drug delivery landscape. This review paper attempts to consol

Совпадение в полном тексте источника
… Astrocytes regulate brain activities involved in neurogenesis and synaptogenesis by controlling BBB permeability and maintaining extracellular homeostasis [ 13 ]. This form of tumor often does not extend beyond the brain and spinal cord, nor does it damage other organs. …

Tumour-associated macrophages: versatile players in the tumour microenvironment.

Tumour-Associated Macrophages (TAMs) are one of the pivotal components of the tumour microenvironment. Their roles in the cancer immunity are complicated, both pro-tumour and anti-cancer activities are reported, including not only angiogenesis, extracellular matrix remodeling, immunosuppression, drug resistance but also phagocytosis and tumour regression. Interestingly, TAMs are highly dynamic and versatile in solid tumours. They show anti-cancer or pro-tumour activities, and interplay between the tumour microenvironment and cancer stem cells and under specific conditions. In addition to the c

Совпадение в полном тексте источника
… Conversely, MNTs highlight the transformation of TAMs into neuron-like entities, influencing de novo neurogenesis in the TME ( Tang et al., 2022b ) and contributing to cancer-associated pain ( Shepherd et al., 2018 ). …

The emerging role of exosomes in innate immunity, diagnosis and therapy.

Exosomes, which are nano-sized transport bio-vehicles, play a pivotal role in maintaining homeostasis by exchanging genetic or metabolic information between different cells. Exosomes can also play a vital role in transferring virulent factors between the host and parasite, thereby regulating host gene expression and the immune interphase. The association of inflammation with disease development and the potential of exosomes to enhance or mitigate inflammatory pathways support the notion that exosomes have the potential to alter the course of a disease. Clinical trials exploring the role of exo

Совпадение в полном тексте источника
… Another promising study in this direction is from the Shetty group, which demonstrated that extracellular vesicles isolated from induced pluripotent stem cells effectively induce neurogenesis and treat neurodegenerative disorders in animal models ( 231 ). …

Biobehavioral Pathways and Cancer Progression: Insights for Improving Well-Being and Cancer Outcomes.

The relationship between psychosocial factors and cancer has intrigued people for centuries. In the last several decades there has been an expansion of mechanistic research that has revealed insights regarding how stress activates neuroendocrine stress-response systems to impact cancer progression. Here, we review emerging mechanistic findings on key pathways implicated in the effect of stress on cancer progression, including the cellular immune response, inflammation, angiogenesis, and metastasis, with a primary focus on the mediating role of the sympathetic nervous system. We discuss converg

Совпадение в полном тексте источника
… The clinicopathological significance of neurogenesis in breast cancer. BMC Cancer. 2014;14:484. 51. Ferdoushi A, Griffin N, Marsland M, et al. Tumor innervation and clinical outcome in pancreatic cancer. Sci Rep. 2021;11:7390. 52. Zhao CM, Hayakawa Y, Kodama Y, et al. …

Metronomic Anti-Cancer Therapy: A Multimodal Therapy Governed by the Tumor Microenvironment.

The concept of cancer as a systemic disease, and the therapeutic implications of this, has gained special relevance. This concept encompasses the interactions between tumor and stromal cells and their microenvironment in the complex setting of primary tumors and metastases. These factors determine cellular co-evolution in time and space, contribute to tumor progression, and could counteract therapeutic effects. Additionally, cancer therapies can induce cellular and molecular responses in the tumor and host that allow them to escape therapy and promote tumor progression. In this study, we descr

Совпадение в полном тексте источника
… Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts Nature 1999 401 670 677 10.1038/44334 10537105 101. Lyden D. Hattori K. Dias S. Costa C. Blaikie P. Butros L. Chadburn A. Heissig B. Marks W. Witte L. …

YKL-40-A Protein in the Field of Translational Medicine: A Role as a Biomarker in Cancer Patients?

YKL-40 is a 40 kDa glycoprotein produced by cancer cells, inflammatory cells and stem cells. It probably has a role in cell proliferation and differentiation, inflammation, protection against apoptosis, stimulation of angiogenesis, and regulation of extracellular tissue remodelling. Plasma levels of YKL-40 are often elevated in patients with localized or advanced cancer compared to age-matched healthy subjects. Several studies have demonstrated that high plasma YKL-40 is an independent prognostic biomarker of short survival in patients with different types of cancer. However, there is not yet

Совпадение в полном тексте источника
… Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis Cancer Cell 2006 9 157 173 10.1016/j.ccr.2006.02.019 16530701 86. Kroes R.A. Dawson G. Moskal J.R. …

ISEV2021 Abstract Book

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Invited Lectures : Overviews Purinergic signalling: past, present and future.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… A novel and interesting function of nucleotides uncovered more recently concerns their role in adult and embryonic neurogenesis where ATP and UTP cooperate with growth factor receptors in activating progenitors (Mishra et al., 2006) [ 3 ]. …