Результаты поиска

Development of a machine learning-based predictive risk model combining fatty acid metabolism and ferroptosis for immunotherapy response and prognosis in prostate cancer.

Prostate cancer (PCa) remains a leading cause of cancer-related mortality, necessitating robust prognostic models and personalized therapeutic strategies. This study integrated bulk RNA sequencing, single-cell RNA sequencing (scRNA-seq), and spatial transcriptomics to construct a prognostic model based on genes shared between ferroptosis and fatty acid metabolism (FAM). Using the TCGA-PRAD dataset, we identified 73 differentially expressed genes (DEGs) at the intersection of ferroptosis and FAM, of which 19 were significantly associated with progression-free survival (PFS). A machine learning-

Выражения и индукции MHC классов I и II в олигодендроцитах варьируются в зависимости от возраста.

Олигодендроглия, выражающая основные молекулы гистокомпьютерного комплекса (MHC), стала представлять большой интерес для многочисленных исследований склероза (MS), однако их роль в старении все еще проясняется. Используя мышей I и II классов MHC, мы сравнили выражение MHC у неонатальных, молодых взрослых (8-16 недель) и стареющих (52 недели) мышей в исходном режиме и после стереотактических родов AAV-GFAP-IFN. Мы обнаружили, что в наивном мозге и спинном мозге присутствовали MHC класса I, выражающие олигодендроглию, в то время как MHC II-выражающий олигодендроглия был виден только в спинном мо

Frequent co-reactivation of Epstein-Barr virus in patients with cytomegalovirus viremia under immunosuppressive therapy and/or chemotherapy.

OBJECTIVE: Co-reactivation of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) occurs in iatrogenically immunosuppressed patients, but the clinical relevance of this is unknown. We aimed to determine the frequency of EBV reactivation in patients with CMV viremia and to explore its clinical significance. METHODS: Serum or plasma CMV and EBV DNA was detected by quantitative real-time PCR in 82 patients who received immunosuppressive therapy and/or chemotherapy and underwent CMV antigenemia tests. RESULTS: CMV DNA was positive in 55 patients, with EBV reactivation being found in 29 of these (

Совпадение в полном тексте источника
… The immunoregulatory effects of CMV-infection in human fibroblasts and the impact on cellular senescence. Immun Ageing 2012 ; 9 : 1 . 22455503 10.1186/1742-4933-9-1 PMC3364840 13 Caruso C Buffa S Candore G , et al Mechanisms of immunosenescence. …

Clinical and Histopathological Aspects of MRONJ in Cancer Patients.

Medication-related osteonecrosis of the jaw (MRONJ) is a major complication of bisphosphonate treatment in cancer patients, and its etiology is not completely clarified. The study's goal is to find connections between the clinical and histopathological characteristics of osteonecrosis and bisphosphonates in a cohort of cancer patients who had osteonecrosis treated surgically. The retrospective study includes 51 patients of both sexes, aged 46 to 85 years, who underwent surgical treatment for MRONJ in two oral and maxillofacial surgery clinics (Craiova and Constanța). Demographic, clinical, and

Bone metastasis and pain research through the dual lens of bibliometrics and bioinformatics: knowledge structure, frontiers, and core pathway analysis (2015-2024).

BackgroundCancer-induced bone pain (CIBP) represents a formidable clinical challenge with complex mechanisms, and existing treatments remain unable to effectively control pain in many patients. This study combined bibliometric and bioinformatic approaches to delineate key research trends, principal themes and future directions in the field of bone metastasis and pain research over the past decade (2015-2024).MethodsWe selected 1,822 relevant documents from the Web of Science Core Collection for bibliometric analysis to identify major research characteristics, collaboration networks and emergin

Совпадение в полном тексте источника
… Cellular process pathways: Such as Cellular senescence, Focal adhesion, Regulation of actin cytoskeleton, etc. … These results indicated that the development and progression of CIBP involved complex molecular network regulation, closely associated with multiple biological processes including cancer progression, key signal transduction, cellular senescence, inflammatory immune responses, and endocrine metabolism …

Resveratrol and Tumor Microenvironment: Mechanistic Basis and Therapeutic Targets.

Resveratrol (3,4',5 trihydroxystilbene) is a naturally occurring non-flavonoid polyphenol. It has various pharmacological effects including antioxidant, anti-diabetic, anti-inflammatory and anti-cancer. Many studies have given special attention to different aspects of resveratrol anti-cancer properties and proved its high efficiency in targeting multiple cancer hallmarks. Tumor microenvironment has a critical role in cancer development and progression. Tumor cells coordinate with a cast of normal cells to aid the malignant behavior of cancer. Many cancer supporting players were detected in tum

Совпадение в полном тексте источника
… Resveratrol Promotes Oxidative Stress to Drive DLC1 Mediated Cellular Senescence in Cancer Cells Elsevier Inc. Houston, TX, USA 2018 Volume 370 292 302 10.1016/j.yexcr.2018.06.031 29964052 64. Lee Y.-J. Lee G.J. Shin S. Heo S.-H. Park C.-R. Nam H.-S. Cho M.-K. Lee S.-H. …

NK Cell-Based Immunotherapy in Renal Cell Carcinoma.

Natural killer (NK) cells are cytotoxic lymphocytes that are able to kill tumor cells without prior sensitization. It has been shown that NK cells play a pivotal role in a variety of cancers, highlighting their relevance in tumor immunosurveillance. NK cell infiltration has been reported in renal cell carcinoma (RCC), the most frequent kidney cancer in adults, and their presence has been associated with patients' survival. However, the role of NK cells in this disease is not yet fully understood. In this review, we summarize the biology of NK cells and the mechanisms through which they are abl

Levels of active tyrosine kinase receptor determine the tumor response to Zalypsis.

BackgroundZalypsis(®) is a marine compound in phase II clinical trials for multiple myeloma, cervical and endometrial cancer, and Ewing's sarcoma. However, the determinants of the response to Zalypsis are not well known. The identification of biomarkers for Zalypsis activity would also contribute to broaden the spectrum of tumors by selecting those patients more likely to respond to this therapy.MethodsUsing in vitro drug sensitivity data coupled with a set of molecular data from a panel of sarcoma cell lines, we developed molecular signatures that predict sensitivity to Zalypsis. We verified

Совпадение в полном тексте источника
… Paediatr Drugs 2008 10 5 315 327 10.2165/00148581-200810050-00005 18754698 Leal JF Fominaya J Cascon A Guijarro MV Blanco-Aparicio C Lleonart M Castro ME Ramon YCS Robledo M Beach DH Carnero A Cellular senescence bypass screen identifies new putative tumor suppressor genes Oncogene 2008 27 14 1961 1970 …

Sending the Signal to Bone: How Tumor-Derived EVs Orchestrate Pre-Metastatic Niche Formation and Skeletal Colonization.

Bone is a preferred site for disseminated tumor cells, yet the molecular mechanisms that prepare the skeletal microenvironment for metastatic colonization are only beginning to be understood. At the heart of this process are extracellular vesicles (EVs), nano-sized, lipid-encapsulated particles secreted by cancer cells and stromal components. This review consolidates current findings that position EVs as key architects of the bone-metastatic niche. We detail the biogenesis of EVs and their organotropic distribution, focusing on how integrin patterns and bone-specific ligands guide vesicle homi

Integrating Single-Cell Transcriptome and Network Analysis to Characterize the Therapeutic Response of Chronic Myeloid Leukemia.

Chronic myeloid leukemia (CML) is a myeloproliferative disease characterized by a unique BCR-ABL fusion gene. Tyrosine kinase inhibitors (TKIs) were developed to target the BCR-ABL oncoprotein, inhibiting its abnormal kinase activity. TKI treatments have significantly improved CML patient outcomes. However, the patients can develop drug resistance and relapse after therapy discontinues largely due to intratumor heterogeneity. It is critical to understand the differences in therapeutic responses among subpopulations of cells. Single-cell RNA sequencing measures the transcriptome of individual c

Risk factors for osteoporosis in the elderly and predictive value of age, body mass index, and visceral fat area.

BACKGROUND/OBJECTIVES: Osteoporosis (OS) is a systemic bone disease that increases bone fragility and fracture susceptibility, which is characterized by reduced bone mass, poor bone quality, and decreased bone strength. This study examined the risk factors for OS in the elderly. SUBJECTS/METHODS: Two hundred elderly patients who underwent examinations in the authors' hospital from July 2021 to October 2023 were selected as the research subjects. The subject's clinical data were analyzed retrospectively to understand the characteristics or changes of the study subjects during the period. The s

Усиление ремиэлизации в множестве склероза через M1 Muscarinic ацетилхолиновый рецептор.

Растет распространенность склероза (MS), однако по-прежнему требуется лечение, способное обратить вспять прогресс в развитии болезни. Одна из стратегий, которая продемонстрировала многообещающее изменение режима MS, заключается в воспрещении рецептора M1 — члена семейства мускаринических ацетилхолинов (mAChR). Считается, что антагонизм M1 mAChR является механизмом, с помощью которого Клемастин, развивающийся препарат, который был замечен в целях усиления миелинизации в исследованиях животных и клинических испытаниях этапа II, вызывает его эффект, стимулирующий миелинацию. Недавние исследования

Factors Associated With Mortality in Leukemia and Lymphoma With COVID-19: A National Inpatient Sample Analysis (2020-2021).

Background Patients with hematological malignancies face a substantially increased mortality from COVID-19. Although the peak of the COVID-19 pandemic has passed, the virus remains common, and understanding its impact on vulnerable groups such as those with hematologic malignancies remains crucial. Limited research exists on mortality patterns in leukemia and lymphoma patients during the pandemic. Studying these outcomes provides important insights into how different waves of COVID-19 affected immunocompromised individuals and supports the development of strategies for prevention, patient care

Thrombotic risk in hepatitis C: Interplay between hepatic dysfunction, viral-driven inflammation, and cardiovascular consequences.

Hepatitis C virus (HCV) infection, traditionally regarded as a hepatotropic disease, is increasingly recognized as a systemic condition with significant thrombotic implications. Chronic HCV induces a persistent proinflammatory and prothrombotic state that substantially elevates the risk of both venous and arterial events. Mechanistically, HCV drives endothelial dysfunction, enhances platelet activation, disrupts coagulation and fibrinolytic balance, and promotes immune-mediated vascular injury through cryoglobulinemia and chronic systemic inflammation. Clinical manifestations range from portal

Тематический анализ прогноза, диагностики и терапии циркулирующих биомаркеров миРНА в борцезомибно-стойких миеломах.

ЦЕЛЬ: Растущий спрос на точную медицину стимулировал молекулярные диагностические исследования, с тем чтобы подчеркнуть полезность микроРНК в качестве важных биомаркеров. В недавних исследованиях подчеркивается роль МИРНА как перспективных, диагностических и терапевтических биомаркеров в управлении и мониторинге нескольких пациентов, страдающих миеломой. Цель этого обзора заключается в том, чтобы представить последние сведения о потенциале распространения миРНА в качестве прогнозирующих, диагностических и терапевтических биомаркеров в нескольких миеломах, устойчивых к бортезомибу. МЕТОДЫ: С эт

Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets.

Zinc metabolism at the cellular level is critical for many biological processes in the body. A key observation is the disruption of cellular homeostasis, often coinciding with disease progression. As an essential factor in maintaining cellular equilibrium, cellular zinc has been increasingly spotlighted in the context of disease development. Extensive research suggests zinc's involvement in promoting malignancy and invasion in cancer cells, despite its low tissue concentration. This has led to a growing body of literature investigating zinc's cellular metabolism, particularly the functions of

Обнаружение корневых причинных генов с вспышками с высокой пропускной способностью.

Уровни корневой причинно-следственной экспрессии - или коренные причинные гены для короткого периода - соответствуют первоначальным изменениям генной экспрессии, которые порождают симптомы пациента как эффект ниже по течению. Выявление коренных причинно-следственных генов имеет решающее значение для разработки методов лечения, которые изменяют болезнь в момент ее возникновения, однако никакие существующие алгоритмы не пытаются определить коренные причинно-следственные гены на основе данных. Данные РНК-последовательность (RNA-seq) создают такие проблемы, как погрешность измерения, высокомерност

Совпадение в полном тексте источника
… The RPE absorbs light in the back of the retina, but the combination of light and oxygen induces oxidative stress, and then a cascade of events such as immune cell activation, cellular senescence, drusen accumulation, neovascularization and ultimately fibrosis ( Barouch and Miller, 2007 ). … Pathway p-value q-value Effect Size Leading Edge Amino acid transport across the plasma membrane 2.44e-05 0.038 0.995 81,406,510 RHO GTPases Activate ROCKs 2.09e-03 0.388 0.976 46,595,500 Endosomal/Vacuolar pathway 2.32e-03 0.388 0.998 3107 Diseases of Cellular Senescence 2.97e-03 0.388 0.997 1021 Binding …

Клемастин фумарат ускоряет аккумуляцию инвалидности в прогрессивном множественном склерозе, усиливая пироптоз.

Множественный склероз (MS) — иммунопосредованное демиелинизирующее заболевание CNS. Клемастин фумарат, внезапный антигистамин и мускариновый блокатор рецепторов, обладает ремиелионирующим потенциалом в MS. Климастичная рука была добавлена в текущее клиническое исследование платформы, нацеленное на остаточную активность на основе точности, биомаркированной комбинированной терапии множественных склерозов (TRAP-MS) (Clinical Procures.gov). NCT03109288), для выявления сигнатуры ремиелинирования цереброспиновой жидкости (CSF) и для сбора данных о безопасности клемастина у пациентов независимо от ре

A comprehensive prognostic score for head and neck squamous cancer driver genes and phenotype traits.

BackgroundHead and neck squamous cancer (HNSCC) presents variable phenotype and progression features. Clinically applicable, high-accuracy multifactorial prognostic models for HNSCC survival outcomes are warranted and an active area of research. This study aimed to construct a comprehensive prognostic tool for HNSCC overall survival by integrating cancer driver genes with tumor clinical and phenotype information.MethodsKey overall survival-related cancer driver genes were screened from among main effector and reciprocal gene pairs using TCGA data using univariate Cox proportional hazard regres

Совпадение в полном тексте источника
… The oncogene KAT6A promotes cancer by inhibiting cellular senescence [ 43 ]. Among the 6 signature genes, CRLF2 as part of an immune score-related risk signature, performed well in the prognostic stratification of OSCC patients and could effectively distinguish their survival status [ 44 ]. …

Human inhibitory leukocyte Ig-like receptors: from immunotolerance to immunotherapy.

In recent decades, immunotherapeutic strategies have been used to treat a wide range of pathologies, many of which were previously incurable, such as cancer and autoimmune disorders. Despite this unprecedented success, a considerable number of patients fail to respond to currently approved immunotherapies or develop resistance over time. Therefore, there is an urgent need to develop the next generation of immune-targeted therapies. Various members of the Ig superfamily play essential roles in regulating leukocyte functions. One such group, the leukocyte Ig-like receptors (LILRs), have been imp