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Abstracts of the 28th Annual San Antonio Breast Cancer Symposium, December 8-11, 2005, San Antonio, Texas, USA.

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… lymph node micrometastasis on survival for patients with invasive breast cancer. … Lee Moffitt Cancer Center, Tampa, FL OBJECTIVE: The overall objective of this study was to test the impact of micrometastatic carcinoma detected by sentinel lymph node (SLN) biopsy on survival in invasive breast cancer patients. …

ESMO/ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2023.

The European Society for Medical Oncology (ESMO) and ASCO are publishing a new edition of the ESMO/ASCO Global Curriculum (GC) with contributions from more than 150 authors. The purpose of the GC is to provide recommendations for the training of physicians in medical oncology and to establish a set of educational standards for trainees to qualify as medical oncologists. This edition builds on prior ones in 2004, 2010, and 2016 and incorporates scientific advances and input from an ESMO ASCO survey on GC adoption conducted in 2019, which revealed that GC has been adopted or adapted in as many a

Efficacy and safety of dupilumab in a patient with metastatic clear cell renal cell carcinoma.

This case report evaluated the efficacy and safety of dupilumab, a monoclonal antibody targeting interleukin-4 and interleukin-13, in a patient with atopic dermatitis (AD) and a history of metastatic renal cancer. Over 20 months of follow-up, the patient experienced significant improvement in AD symptoms without any recurrence of cancer. In addition to not stimulating carcinogenesis, dupilumab might synergistically inhibit tumor-induced immunosuppression, thereby potentially preventing tumor progression. This case suggests that dupilumab could be a viable treatment option for patients with AD

Clinical practice guidelines and consensus statements in oncology--an assessment of their methodological quality.

BackgroundConsensus statements and clinical practice guidelines are widely available for enhancing the care of cancer patients. Despite subtle differences in their definition and purpose, these terms are often used interchangeably. We systematically assessed the methodological quality of consensus statements and clinical practice guidelines published in three commonly read, geographically diverse, cancer-specific journals. Methods Consensus statements and clinical practice guidelines published between January 2005 and September 2013 in Current Oncology, European Journal of Cancer and Journal o

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… Lyman GH, Giuliano AE, Somerfield MR, Benson AB 3rd, Bodurka DC, et al. (2005) American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer. J Clin Oncol 23: 7703–7720. 83. … Wong SL, Balch CM, Hurley P, Agarwala SS, Akhurst TJ, et al. (2012) Sentinel Lymph Node Biopsy for Melanoma: American Society of Clinical Oncology and Society of Surgical Oncology Joint Clinical Practice Guideline. Journal of Clinical Oncology 30: 2912–2918. 106. …

Keyword Index for Volume 90

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… scatter factor 822 SCC of head and neck 471 scFv 1863 screening 299, 314, 393, 1780, 1803 secondary malignancies 2305 secondary resistance 2059 second-line treatment 377 secretion 926 SEER 1771 selenium 1392 self-expanding metal stent 2067 seminoma 55, 1765 sensitivity and specificity 2118 sentinel … lymph node biopsy 1551 sentinel lymph nodes 805, 1531, 1551 sequential chemotherapy 810 serial analysis of gene expression 1600 serous cystadenocarcinoma 1583 serous papillary ovarian cancer 1814 serous papillary uterine cancer 1814 serpin variants 833 serum 1211 serum creatinine 991 sex 2142 …

Множество случаев заболевания раком молочной железы во время лечения: доклад по делу.

Исследования: Рак груди представляет собой злокачественную опухоль, которая угрожает здоровью женщин. Среди больных раком молочной железы от 4,2% до 17% могут страдать многочисленными первичными злокачественными новообразованиями. Случаи заболевания раком груди и множественной миэломой относительно редки в клинической практике. В этом документе сообщается об одном пациенте, у которого во время лечения рака груди развилась миелома. Клинические данные: Пациентка была 56-летней женщиной, попавшей в больницу из-за "животы в течение 4 дней, через год после лечения рака левой груди". Пациенту диагно

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… Half a year ago, the patient underwent left breast-conserving surgery combined with sentinel lymph node biopsy and left axillary lymph node dissection under general anesthesia. …

Mesoporous Silica Nanoparticles as Drug Delivery Vehicles in Cancer.

Even though cancer treatment has improved over the recent decades, still more specific and effective treatment concepts are mandatory. Surgical removal is not always possible, metastases are challenging and chemo- and radiotherapy can not only have severe side-effects but also resistances may occur. To cope with these challenges more efficient therapies with fewer side-effects are required. One promising approach is the use of drug delivery vehicles. Here, mesoporous silica nanoparticles (MSN) are discussed as biodegradable drug carrier to improve efficacy and reduce side-effects. MSN excellen

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… So far, no clinical trials were performed with MSN but an early phase I study ( NCT02106598 ) is conducted with targeted silica nanoparticles for image-guided operative sentinel lymph node mapping [ 10 ]. … Targeted Silica Nanoparticles for Image-Guided Intraoperative Sentinel Lymph Node Mapping in Head and Neck Melanoma, Breast and Gynecologic Malignancies Available online: https://clinicaltrials.gov/ct2/show/NCT02106598?term=silica+nanoparticle&rank=1 (accessed on 6 April 2017) 11. …

Difficulties in diagnosing anorectal melanoma: A case report and review of the literature.

BACKGROUND: Anorectal melanoma is a tumour that is difficult to identify due to its rarity and variability of presentation. Insufficient data published in the literature do not allow for diagnostic and treatment guidelines to be established. Anorectal melanoma has the worst prognosis among mucosal melanomas and is frequently misdiagnosed by standard identification methods. CASE SUMMARY: A 66-year-old woman presented with intermittent anal bleeding, pain, and tenesmus in the past month, with no associated weight loss. Colonoscopy revealed a cauliflower-like tumour with a diameter of 1.5 cm, wi

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… Sentinel lymph node mapping could be used in mucous melanoma to prevent understaging and plan the extent of surgery[ 4 ]. A biopsy is recommended to direct adjuvant treatment or allow entry into a clinical trial. …

ESMO/ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2023.

The European Society for Medical Oncology (ESMO) and ASCO are publishing a new edition of the ESMO/ASCO Global Curriculum (GC) with contributions from more than 150 authors. The purpose of the GC is to provide recommendations for the training of physicians in medical oncology and to establish a set of educational standards for trainees to qualify as medical oncologists. This edition builds on prior ones in 2004, 2010, and 2016 and incorporates scientific advances and input from an ESMO/ASCO survey on GC adoption conducted in 2019, which revealed that GC has been adopted or adapted in as many a

Cancer in pregnancy: FIGO Best practice advice and narrative review.

Cancer during pregnancy is relatively rare. The incidence is underestimated due to the lack of international registries covering both high-income and low- and middle-income countries, and is expected to rise with increasing maternal age and increasing global adoption of cell-free DNA testing for aneuploidy. Physiological changes during pregnancy often make the diagnosis challenging and delayed. Lack of experience and knowledge about this condition may also contribute to late diagnosis, suboptimal management, and occasionally inadvertent fetal and/or maternal harm. The principles of cancer mana

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… Non‐pelvic lymph node biopsies can be performed throughout pregnancy, whereas pelvic lymph node dissection is limited to before 22 weeks of gestation. 29 Sentinel lymph node mapping in breast cancer can be performed throughout pregnancy, ideally using a 1‐day protocol to minimize radiation exposure, … Anaphylactic response to blue dye during sentinel lymph node biopsy. Surg Oncol. 2011;20(1):e55‐e59. 33. Obstetricians ACo , Gynecologists , Practice CoO . Committee opinion no. 656: guidelines for diagnostic imaging during pregnancy and lactation. Obstet Gynecol. 2016;127(2):e75‐e80. 34. …

Modern radiopharmaceuticals for lung cancer imaging with positron emission tomography/computed tomography scan: A systematic review.

IntroductionIn this study, we evaluated the use and the contribution of radiopharmaceuticals to the field of lung neoplasms imaging using positron emission tomography/computed tomography.MethodsWe conducted review of the current literature at PubMed/MEDLINE until February 2020. The search language was English.ResultsThe most widely used radiopharmaceuticals are the following:Experimental/pre-clinical approaches: (18)F-Misonidazole (18F-MISO) under clinical development, D(18)F-Fluoro-Methyl-Tyrosine (18F-FMT), 18F-FAMT (L-[3-18F] (18)F-Fluorothymidine (18F-FLT)), (18)F-Fluoro-Azomycin-Arabinosi

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… In their clinical phase I study, Eo et al. 23 present a promising radiotracer (68) Ga-MSA for the detection-mapping of sentinel lymph node with PET/CT. … Gallium-68 neomannosylated human serum albumin-based PET/CT lymphoscintigraphy for sentinel lymph node mapping in non-small cell lung cancer. Ann Surg Oncol 2014; 22(2): 636–641. …

Keyword Index for Volume 91

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Melanoma and immunotherapy bridge 2015 : Naples, Italy. 1-5 December 2015.

MELANOMA BRIDGE 2015 KEYNOTE SPEAKER PRESENTATIONS Molecular and immuno-advances K1 Immunologic and metabolic consequences of PI3K/AKT/mTOR … Annamaria Anniciello, Paolo Antonio Ascierto, Gerardo Botti, Monica Cantile Other P21 The effect of Sentinel Lymph Node Biopsy in melanoma mortality: timing of dissection Cristina Fortes, Simona Mastroeni, Alessio Caggiati, Francesca Passarelli, Alba Zappalà, Maria Capuano, Riccardo Bono, Maurizio Nudo, Claudia Marino, Paola Michelozzi P22 Epidemiological survey on r …

Artificial Neural Network Prediction of Mortality in Cancer Patients Presenting for Radiation Therapy at a Multisite Institution.

IntroductionFor many decades, the management of cancer has utilized radiation therapy, which continues to evolve with technology to improve patient outcomes. However, despite the standardization of treatment plans and the establishment of best clinical practices based on prospective, randomized trials and adherence to National Comprehensive Cancer Network (NCCN) guidelines, the outcomes from radiation therapy are highly variable and dependent on a number of factors, including patient demographics, tumor characteristics/histology, and treatment parameters. In this study, we attempt to use avail

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… Pts: patients, RSF: random survival forest, LC: local control, DMFS: distant metastasis-free survival, RC: regional control, CR: complete response, CRT: chemoradiation therapy, PPV: positive predictive value, NPV: negative predictive value, SLNB: sentinel lymph node biopsy, ER: estrogen receptor, LVI … Can a machine-learning model improve the prediction of nodal stage after a positive sentinel lymph node biopsy in breast cancer? Madekivi V, Boström P, Karlsson A, Aaltonen R, Salminen E. Acta Oncol. 2020;59:689–695. doi: 10.1080/0284186X.2020.1736332. 17. …

Keyword Index for Volume 108

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Резюме

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ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016.

The European Society for Medical Oncology (ESMO) and the American Society of Clinical Oncology (ASCO) are publishing a new edition of the ESMO/ASCO Global Curriculum (GC) thanks to contribution of 64 ESMO-appointed and 32 ASCO-appointed authors. First published in 2004 and updated in 2010, the GC edition 2016 answers to the need for updated recommendations for the training of physicians in medical oncology by defining the standard to be fulfilled to qualify as medical oncologists. At times of internationalisation of healthcare and increased mobility of patients and physicians, the GC aims to p

Биология и болезни крыс

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Recurrent severe hypocalcemia following chemotherapy regimen changes in advanced breast cancer: two case reports.

BACKGROUND: As an oncologic emergency related to abnormalities in calcium metabolism, hypercalcemia associated with paraneoplastic syndrome and bone metastases is well known. Meanwhile, the incidence of hypocalcemia is low, except in cases associated with bone-modifying agents used for bone metastases. Hypocalcemia induced by bone-modifying agents typically occurs early after the initial administration, and its incidence can be significantly reduced by preventive administration of calcium and vitamin D3 supplements. CASE REPORT: We report two cases of recurrent severe hypocalcemia occurring d

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… Her medical history revealed that, in year X, the patient was diagnosed with right breast cancer and underwent a total right mastectomy and sentinel lymph node biopsy, which revealed invasive lobular carcinoma, estrogen receptor (ER)-positive (> 90%), progesterone receptor (PgR)- positive (> 90%), human …

Резюме ЭСП 2013.

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… Conclusion: Keeping in mind the need for improvement in the therapy of TNBC, we believe that the identification of genes involved in survival and self-renewal of cancer stem cells represents an area of interesrt Acknowledgments Project PN-II-RU-PD-2011-3-0248 OFP-01-007 Sentinel lymph node macrometastasis … Martins * Dept. of Pathology, Hospital Curry Cabral, Lisboa, Portugal Objective: Axillary lymph node dissection (ALND) is the current procedure in breast cancer patients with sentinel lymph node (SN) macrometastasis. …