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History of head trauma in a 6-year-old boy: maybe more than meets the eye (and head).

It is spring and you are meeting for the first time, Eddie, a recently turned 6-year-old boy who moved to the area in September of the previ … asks why, he will say "I don't know why." Mother is worried that Eddie is sad, although she denies suicidal ideation. She reports he used to like making noise with other kids, and now he cannot stand when the children are noisy. Eddie will comment he does not want to go to school because the kids make lots of noise and his head hurts. He complains of headaches as …

Review article: intestinal metaplasia and gastric carcinogenesis.

Dear Editor, Next to focal neurological symptoms, epileptic seizures and head aches, brain tumors can less frequently bring about cognitive … ases of depression due to somatic disease are less associated with family history of depression and suicidal ideation and attempts, while cognitive symptoms come to the foreground during mental status examination. (Sertöz and Mete 2004, Rouchell et al. 2002). Our patient did not have suicidal ideation or attempts, or a family history of depression. In apathy, which …

[Socio-demographic and clinical assessment, and trajectory of a sample of French pathological gamblers].

INTRODUCTION: International studies estimate the incidence of pathological gambling among adults at 0.2-3%. Following the lead of Anglo-Saxon countries, France has only just begun to consider this "new" addiction in studying its own population of pathological gamblers, attempting to understand the causes of the illness, and proposing specific treatments. OBJECTIVE: The purpose of this study was to carry out a multiaxial assessment of French pathological gamblers, current or former outpatients of the addiction ambulatory care center of the University Hospital of Nantes, in order to compare our

Fitusiran prophylaxis in people with severe haemophilia A or haemophilia B without inhibitors (ATLAS-A/B): a multicentre, open-label, randomised, phase 3 trial.

BACKGROUND: Fitusiran, a subcutaneous investigational siRNA therapeutic, targets antithrombin with the goal of rebalancing haemostasis in pe … (13%) participants in the on-demand clotting factor concentrates group (gastroenteritis, pneumonia, suicidal ideation, diplopia, osteoarthritis, epidural haemorrhage, humerus fracture, subdural haemorrhage, and tibia fracture [all n=1, 3%]). No treatment-related thrombosis or deaths were reported. INTERPRETATION: In participants with haemophilia A or B without inh …

Efficacy of Transcendental Meditation to Reduce Stress Among Health Care Workers: A Randomized Clinical Trial.

IMPORTANCE: Health care workers (HCWs) have been experiencing substantial stress and burnout, and evidence-based mitigation strategies are n … sful script. Exclusion criteria included the use of antipsychotic or β blocker medications, current suicidal ideation, or previous TM training. Of 213 HCWs who participated in prescreening, 95 attended in-person visits, resulting in 80 eligible participants who were randomized to receive a TM intervention (TM group) or usual treatment (control group). INTERVENTION …

Depression and the Use of Selective Serotonin Reuptake Inhibitors in Patients with Acute Intracerebral Hemorrhage.

Introduction Depression is a common psychiatric complication associated with stroke. However, while most studies focus on post-stroke depres … ess (55%), and loss of interest or pleasure in life activities (53%). None of the patients reported suicidal ideation. Only seven patients (2%) were seen by a psychiatrist. The presence of depression was not significantly associated with hemorrhage sites [prabability value (p): 0.55] or the extent of disability (p: 0.09). Among the 103 depressed patients, only 25 ( …

Resilience in patients with psychotic disorder.

The recovery movement differentiated clinical, which is related to disorder's symptoms, from personal recovery, which is outlined by a subje … tive psychology have been implemented in schizophrenia research. Positive self-appraisals moderated suicidal ideation, even when patients experienced high levels of hopelessness.1 Additionally, among other factors, better self-images, internal locus of control (i.e. the perception that events in one's life relate to one's actions) and emphasis on personal efforts p …

Adverse effects of cannabis.

Cannabis, Cannabis sativa L., is used to produce a resin that contains high levels of cannabinoids, particularly delta9-tetrahydrocannabinol … fteen longitudinal cohort studies that examined the influence of cannabis on depressive thoughts or suicidal ideation have yielded conflicting results and are inconclusive. Several longitudinal cohort studies have shown a statistical association between psychotic illness and self-reported cannabis use. However, the results are difficult to interpret due to methodol …

[Sleep in adolescents and its disorders. A survey in schools].

OBJECTIVES: Numerous studies emphasized the high prevalence of sleep problems in adolescents. However, it remains to be seen whether these p … group". Risk behaviours were also significantly more frequent in the "insomnia group" adolescents: suicidal ideation (25.1% vs 11.7%; p<0.001), suicide attempt (7.3% vs 3.6%; p<0.05), psychotropic drug use (11% vs 4.9%; p<0.02), regular stimulant drug use (10% vs 5.1%; p<0.005), regular tobacco use (7.8% vs 2.2%; p<0.001), regular alcohol use (13.3% vs 8.3%; p<0.0 …

Recommendations for the presurgical psychosocial evaluation of bariatric surgery patients.

Psychosocial factors have significant potential to affect long-term outcomes of bariatric surgery, including emotional adjustment, adherence to the recommended postoperative lifestyle regimen, weight loss outcomes, and co-morbidity improvement and or resolution. Thus, it is recommended that bariatric behavioral health clinicians with specialized knowledge and experience be involved in the evaluation and care of patients both before and after surgery. The evaluating clinician plays a number of important roles in the multidisciplinary treatment of the bariatric patient. Central among these is th

Оценка риска и прогнозирование самоубийств у нескольких пациентов с миэломой.

ЦЕЛЬ: Несмотря на успехи в лечении, позволившие выжить, множество миеломы (ММ) по-прежнему является тревожным диагнозом со значительными последствиями для здоровья, включая повышенный риск самоубийства. Целью этого исследования является изучение риска самоубийств среди пациентов с ОМ и разработка модели прогнозирования для выявления лиц с высокой степенью риска. Методы: Мы проанализировали 83,333 Случаи MM из последней базы данных наблюдения, эпидемиологии и конечных результатов (SEER)2001-2020) для выявления предсказателей риска самоубийства и разработки предсказуемых номограмм. Эта группа бы

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… This rise in malignant diseases is linked to higher rates of mental health issues such as depression, cancer recurrence fears, and suicidal ideation [ 9 ]. … Patient-oncologist alliance as protection against suicidal ideation in young adults with advanced cancer. Cancer. 2014;120(15):2272–81. …

The Association of Mental Health Symptoms to Post-Traumatic Nightmares Among Treatment Seeking Active Duty Service Members.

INTRODUCTION: Posttraumatic nightmares (PTNs) are common among service members with a history of combat or mission-related trauma and are associated with decreased well-being. Unfortunately, beyond establishing an association between mental health symptoms and PTNs, the existing literature fails to provide a more comprehensive understanding of factors associated with PTNs. The effectiveness of current recommended treatments is frequently debated, with the literature varying in levels of support. Treatment of PTN is complicated, given their association with a number of mental health difficultie

[The clinic of apathy in schizophrenia: a critical review of the issue].

INTRODUCTION: Today the concept of apathy is subject to many questions. This psychological state is present and predominant in different dis … . loss of interest), but they also have distinct clinical signs (lack of motivation for apathy, and suicidal ideation for depression). Authors have shown that the presence of one symptom (apathy or depression) does not predict the presence of the other. An apathetic patient does not have to be necessarily in a depressive state and vice versa. However, to our knowle …

Incidence and risk factors for suicide and attempted suicide following a diagnosis of hematological malignancy.

Solid tumors are associated with an increased risk of suicide, however, there is limited detailed information on the risk of suicide in patients with hematological malignancies. Therefore, we conducted a population-based study including 47,220 patients with hematological malignancies (diagnosed 1992-2006) and their 235,868 matched controls to define the incidence and risk factors for suicide and suicide attempt. Information on suicides, suicide attempts, and preexisting psychiatric disorders was obtained from Swedish registers and individual medical records. There was a twofold increased (haza

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… The majority of the recently introduced treatments have a favorable effect on both survival and quality of life but their potential impact on risk of suicide and suicidal ideation needs to be elucidated. … Therefore, a high awareness of suicidal ideation in patients shortly after diagnosis but also during follow-up is important. …

Association, haplotype, and gene-gene interactions of the HPA axis genes with suicidal behaviour in affective disorders.

Family twin and adoption studies have noted the heritability of specific biological factors that influence suicidal behaviour. Exposure to stress is one of the factors that strongly contribute to suicide attempts. The biological response to stress involves the hypothalamic-pituitary-adrenal axis (HPA). Therefore, we found it interesting to study polymorphisms of genes involved in the HPA axis (CRHR1, NR3C1, and AVPBR1). The study was performed on 597 patients, 225 of whom had a history of suicide attempts. We did not observe any significant differences in the studied polymorphisms between the

Defining the psychiatric and financial burden of mental and substance use disorders in cancer patients.

PurposeTo identify the proportion of Emergency Department (ED) visits in cancer patients associated with a mental and substance use disorder (MSUD) and the subsequent healthcare costs.MethodsNationally representative data on ED visits from 2009 to 2018 was obtained from the Nationwide Emergency Department Sample (NEDS). We identified cancer-related visits with or without a MSUD using the Clinical Classifications Software diagnoses documented during the ED visit. Survey-adjusted frequencies and proportions of ED visits among adult cancer patients with or without a MSUD was evaluated. Survey-adj

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… The three most common primary MSUD in this patient group were alcohol‐related disorders (51%), suicidal ideation or attempt (22%), and opioid‐related disorders (15%). … The six most frequent primary MSUD diagnoses were alcohol‐related disorders, anxiety disorders, depressive disorders, opioid‐related disorders, schizophrenia and related disorders, and suicidal ideation or attempt. …

Drug Repurposing for the Management of Depression: Where Do We Stand Currently?

A slow rate of new drug discovery and higher costs of new drug development attracted the attention of scientists and physicians for the repurposing and repositioning of old medications. Experimental studies and off-label use of drugs have helped drive data for further studies of approving these medications. A deeper understanding of the pathogenesis of depression encourages novel discoveries through drug repurposing and drug repositioning to treat depression. In addition to reducing neurotransmitters like epinephrine and serotonin, other mechanisms such as inflammation, insufficient blood supp

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… ideation, suicide attempts | R, SG, QB | NA | None | Angina pectoris, tinnitus, vision blurred, diarrhea, dry mouth, coordination abnormal, dizziness, dysmetropsia, hypoesthesia, sedation, restlessness, depression, suicidal ideation, acute kidney injury, dry skin, hypertension Antimanic agents Lithium … ideation, nasopharyngitis, cough | Mania, psychotic disorder, suicidal ideation, pulmonary embolism, abortion spontaneous, accidental overdose, non-cardiac chest pain, coronary artery disease Armodafinil Phase III/2010 [ 49 , 114 ] | Tablet, PO, QD in the morning, started at 50 mg/kg and titrated up …

Psychiatric morbidity and poor follow-up underlie suboptimal functional and survival outcomes in Huntington's disease.

BackgroundHuntington's disease (HD), an inherited, often late-onset, neurodegenerative disorder, is considered to be a rare, orphan disease. Research into its genetic correlates and services for those affected are inadequate in most low-middle income countries, including India. The apparent 'incurability' often deters symptomatic and rehabilitative care, resulting in poor quality of life and sub-optimal outcomes. There are no studies assessing disease burden and outcomes from India.MethodsWe attempted to evaluate individuals diagnosed to have HD at our tertiary-care center between 2013 and 201

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… Suicidal ideation in Huntington disease: the role of comorbidity. Psychiatry Res. 2011;188(3):372–376. doi: 10.1016/j.psychres.2011.05.006. 21. Hubers AA, van Duijn E, Roos RA, Craufurd D, Rickards H, Landwehrmeyer GB, et al. Suicidal ideation in a European Huntington's disease population. … Risk factors of suicidal ideation in Huntington’s disease: literature review and data from enroll-HD. J Neurol. 2018;265(11):2548–2561. doi: 10.1007/s00415-018-9013-6. 24. van Duijn E, Craufurd D, Hubers AA, Giltay EJ, Bonelli R, Rickards H, et al. …

Trauma-focused therapy integrated with cognitive behavioural therapy for psychosis for people with post-traumatic stress disorder and psychosis (the STAR trial): a multicentre, pragmatic, randomised trial in the UK.

BACKGROUND: People with psychosis have high rates of post-traumatic stress disorder (PTSD), which is associated with a poor prognosis. We ai … derealisation and depersonalisation); delusions, paranoia, and hallucinations in other modalities; suicidal ideation, depression, anxiety, and stress; and psychological recovery. There were no effects on voices, referential beliefs, substance use, or social functioning (Cohen's d ranging from -0·05 to -0·28). 62 (50%) of 125 participants in the therapy group showe …

Efficacy of standalone smartphone apps for mental health: an updated systematic review and meta-analysis.

BACKGROUND: To map out the potential benefits of widely available smartphone apps for mental health, especially in contexts where face-to-fa … significant pooled effects were found for smoking (six comparisons), self-injury (six comparisons), suicidal ideation (five comparisons), and alcohol misuse (five comparisons). Effect sizes for obsessive-compulsive disorders (two comparisons) and schizophrenia (one comparison) ranged from 0·10 to 0·96 (-0·12 to 1·51). Risk of bias was moderate to high. Publication …