Результаты поиска

Individualized management of primary hyperparathyroidism.

Primary hyperparathyroidism (PHPT) is a common endocrine disease that typically presents in peri- and postmenopausal women. PHPT is due to a single parathyroid adenoma in most cases, which leads to stable hypercalcemia over years. Nowadays, the diagnosis is often coincidental, reached by chance in subjects without specific symptoms-asymptomatic PHPT. However, the patients might have subtle disease-related manifestations. Management standards have been reviewed through international workshops over more than three decades, leading to absolute and relative indications for parathyroidectomy (PTX),…

Cognitive and Memory Decline in Thyroid Disorders: A Biomarker Based Cross Sectional Study in Aging Adults.

BACKGROUND: The pathophysiology of Alzheimer's disease (AD) involves a complex interplay of several factors like oxidative stress, hypercalcemia, decreased acetylcholine, which may act independently or synergistically to drive cognitive decline. The accumulation of Aβ42 fragments derived from amyloid precursor protein is hall mark of AD. Epidemiologic studies suggest that thyroid dysfunction may increase the risk of early-onset AD. This study aims to provide the potential mechanisms linking thyroid dysfunction and AD, both common in older adults by evaluating serum memory and cognitive biomark…

Progression of primary mediastinal T-cell lymphoma to a multicentric form in a young dog.

Canine lymphoma is the most common hematopoietic malignancy, but the primary mediastinal form is rare. Progression from this form to systemi … ted, with all peripheral lymph nodes within normal limits. Laboratory abnormalities included severe hypercalcemia, elevated symmetric dimethylarginine, and the presence of large lymphocytes on blood smear. Cytology, polymerase chain reaction for antigen receptor rearrangements, and flow cytometry confirmed CD4+ T-cell mediastinal lymphoma. Initial treatment wit …

Endoscopic detection of near-infrared autofluorescence in the parathyroid glands: a case report of two patients.

INTRODUCTION AND IMPORTANCE: Preservation of the parathyroid glands during thyroid surgery is crucial to prevent postoperative hypocalcemia. … nce. The second patient was a 53-year-old woman with primary hyperparathyroidism who presented with hypercalcemia and elevated intact parathormone levels. We performed a right parathyroidectomy using VANS with the same endoscope. A parathyroid tumor showing heterogeneous and relatively weak autofluorescence was identified on the posterior aspect of the right th …

Факторы риска и клиническое воздействие боли в костях у пациентов с множественной миеломой - перспективное междисциплинарное исследование.

Боль в костях доходит до 80% :: количество пациентов с множественными миеломами (ММ) и значительно ухудшает качество жизни (КОЛ), однако его конкретные прогнозы по-прежнему плохо характеризуются. Определение факторов риска имеет важнейшее значение для раннего вмешательства и индивидуального лечения. МЕТОДЫ: Это перспективное исследование, рассчитанное на один центр 352 Пациенты. Боль в костях регистрируется с использованием стандартного вопросника. Для выявления независимых прогнозов боли в костях использовалась многовариантная логистическая регрессия с поэтапным отбором. QoL и состояние здоро

Совпадение в аннотации оригинала
BACKGROUND: Bone pain affects up to 80% of patients with multiple myeloma (MM) patients and significantly impairs quality of life (QoL), yet … 6.40, p = 0.003) and pre-existing orthopedic disease (OR 2.78, 95% CI 1.77-4.36; p < 0.0001). CRAB (hypercalcemia, renal failure, anemia, bone lesions)-B at initial diagnosis (OR 1.74, 95% CI 0.92-3.29, p = 0.09) and progressive disease (OR 1.68, 95% CI 0.93-3.05, p = 0.09) showed an elevated risk for bone pain. No associations were observed for age, sex, CRAB- …

Multiple Myeloma: 2026 Update on Diagnosis, Risk-Stratification and Management.

DiagnosisThe diagnosis of multiple myeloma requires ≥ 10% clonal bone marrow plasma cells or a biopsy proven plasmacytoma plus evidence of one or more multiple myeloma defining events (MDE): CRAB (hypercalcemia, renal failure, anemia, or lytic bone lesions) attributable to the plasma cell disorder, bone marrow clonal plasmacytosis ≥ 60%, serum involved/uninvolved free light chain (FLC) ratio ≥ 100 (provided involved FLC is ≥ 100 mg/L and urine monoclonal protein is ≥ 200 mg/24 h), or > 1 focal lesion on magnetic resonance imaging.Risk stratificationHigh-risk multiple myeloma is defined by the …

Hyperviscosity Syndrome as a Rare Presentation of Immunoglobulin G Kappa Smoldering Multiple Myeloma Successfully Treated With Daratumumab.

Hyperviscosity syndrome (HVS) is an oncologic emergency most commonly associated with Waldenstrom macroglobulinemia and immunoglobulin (Ig)M paraproteinemia. Clinically, significant HVS in smoldering multiple myeloma (SMM), particularly IgG-associated disease without overt CRAB (hypercalcemia, renal insufficiency, anemia, and bone lesions) criteria, is exceedingly rare. We report a unique case of IgG kappa smoldering myeloma complicated by symptomatic HVS, manifesting with retinal hemorrhage, epistaxis, and gross hematuria, despite the absence of overt end-organ myeloma-defining events. A 70-y…

Voriconazole-Induced Pancreatitis Despite Therapeutic Trough Concentrations During Treatment of Disseminated Fusariosis in a Hospitalized Patient.

BACKGROUND Invasive fungal infections are a major cause of morbidity and mortality in immunocompromised patients, particularly those with he … al edematous pancreatitis. Alternative etiologies were excluded, including gallstones, alcohol use, hypercalcemia, and severe hypertriglyceridemia. Voriconazole was discontinued due to concern for drug-induced pancreatitis despite therapeutic trough levels between 1 and 2.1 mcg/mL, and antifungal therapy was transitioned back to isavuconazonium while continuing …

Six-factor-based stratification system for enfortumab vedotin monotherapy in pre-treated patients with metastatic or locally advanced urothelial carcinoma.

PURPOSE: This study aimed to identify prognostic factors and develop a prognostic stratification system for progression-free survival (PFS) … f bone metastasis, anemia (hemoglobin < 10 g/dL), high C-reactive protein levels (> 0.5 mg/dL), and hypercalcemia (corrected calcium > 10.2 mg/dL). Based on the number of positive factors, patients were categorized into three groups: 147 patients with none or one factor (low-risk group), 92 patients with two factors (intermediate-risk group), and 148 patients w …

Retrospective Study Evaluating the Outcome and Efficacy of Stereotactic Body Radiation Therapy for the Treatment of Metastatic Abdominal Lymph Nodes in Dogs With Apocrine Gland Anal Sac Adenocarcinoma.

Local treatment for dogs with regional lymph node metastasis secondary to apocrine gland anal sac adenocarcinoma (AGASACA) includes nodal ex … experienced gait changes in the hind limbs during the late radiation effects period. Resolution of hypercalcemia in 5 dogs was inconsistent and transient. The best response was complete in 21%, partial in 58%, and stable disease in 17% at a median of 100 days. Three dogs (12%) developed progression of treated lymph nodes at 157, 498, and 644 day. Eight dogs (3 …

Cholecalciferol (vitamin D3): efficacy, safety, and implications in public health.

Vitamin D₃ (cholecalciferol) is a fat-soluble secosteroid with essential roles in calcium-phosphorus metabolism, bone health, and an expandi … e vitamin D supplementation is generally safe within recommended limits, excessive intake may cause hypercalcemia or nephrolithiasis, emphasizing the need for personalized strategies. Food fortification and targeted screening remain underutilized yet cost-effective public health interventions. Overall, vitamin D₃ represents a promising but complex therapeutic a …

Machine learning-based prediction of delirium in older patients with chronic kidney disease requiring intensive care: A hospital-based retrospective cohort study.

OBJECTIVES: Delirium is a common complication in intensive care units (ICUs), especially among older adults with chronic kidney disease (CKD … Coma Scale score, high white blood cell count, hypernatremia, fever, advanced age, hypoalbuminemia, hypercalcemia, low hemoglobin, high Acute Physiology and Chronic Health Evaluation II (APACHE II) score, hyperkalemia, mechanical ventilation, sedation, and elevated C-reactive protein. CONCLUSION: Our ML model demonstrated good performance in predicting deliriu …

A novel electrochemical sensor based on MIP technology for sensitive determination of cinacalcet hydrochloride in tablet dosage form and serum samples.

Cinacalcet hydrochloride (CIN) is a calcium-sensing receptor agonist used to treat hypercalcemia in the parathyroid. The molecularly imprinted polymer (MIP)-based sensor (CIN@MIP/GCE) was electropolymerized using cyclic voltammetry (CV) of the functional monomer o-phenylenediamine (o-PD) with a template molecule CIN on a glassy carbon electrode (GCE). The optimum performance of the MIP-based electrode for CIN detection was obtained with parameters of a 1:7 monomer ratio, a 15-min removal time, ethanol as a removal solution, and a 15-min rebinding time. The surface characterization of the CIN@M…

Lifetime follow-up of an adult patient with pediatric-onset hypophosphatasia complicated with advanced chronic kidney disease.

Hypophosphatasia (HPP) is a rare inborn-error-of-metabolism caused by mutations in the ALPL gene, resulting in deficient activity of tissue- … zation, less bone pain, and no new fractures during 9 months of treatment, which was stopped due to hypercalcemia and hyperphosphatemia. She began peritoneal dialysis at age 55 and received a kidney transplant at age 58. At age 65, seven years post-transplantation, she remained free of new fractures and significant bone pain. This case illustrates the long-term …

Synergistic effects of sequential treatment with doxorubicin and zoledronic acid on anticancer effects in estrogen receptor-negative breast cancer cells.

Zoledronic acid (ZA), a bisphosphonate, is commonly used in breast cancer patients with bone metastases to treat hypercalcemia and osteolysis. Recent studies showed the anti-cancer effects of ZA in breast cancer. This study further explored the synergistic effects of sequential and nonsequential ZA and doxorubicin (DOX) administration on estrogen receptor (ER)-positive and -negative breast cancer cell lines. Anti-cancer and anti-invasion effects were evaluated using MTT and Matrigel invasion assays. The synergistic effects were analyzed using the Chou-Talalay method. The protein levels of inva…

Phase 1 studies of the indenoisoquinolines LMP776 and LMP744 in patients with solid tumors and lymphomas.

PURPOSE: Indenoisoquinolines are a class of topoisomerase I (TOP1) inhibitors designed to overcome clinical limitations of camptothecins. Th … mg/m2/day and that of LMP744 was 190 mg/m2/day. Dose-limiting toxicities (DLTs) for LMP776 included hypercalcemia, anemia, and hyponatremia; DLTs for LMP744 included hypokalemia, anemia, and weight loss. There was 1 confirmed partial response (cPR) among 35 patients receiving LMP744 (overall response rate 3%) and no objective responses in patients receiving LMP …

Doxorubicin-mediated retardation of aggresome formation enhances Carfilzomib-induced cell death synergistically by augmenting ER stress and proapoptotic signaling.

Multiple myeloma (MM), the second most common hematological malignancy, is associated with anemia, renal dysfunction, bone pain, and hypercalcemia. Proteasome inhibitors are a mainstay in MM therapy, but resistance, often mediated by aggresome formation, remains a challenge. Aggresomes sequester misfolded proteins and facilitate their clearance via autophagy. This study focused on identifying anticancer agents that inhibit aggresome formation in response to carfilzomib and exploring their mechanisms of action. We employed MM cell lines U266B1, LP-1, RPMI-8266, and NCI-H929, assessing cell viab…

A mouse model of Jansen's metaphyseal chondrodysplasia for investigating disease mechanisms and candidate therapeutics.

Jansen's metaphyseal chondrodysplasia (JMC) is a rare disorder caused by activating mutations in the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor (PTH1R). Patients exhibit short stature, dysmorphic bones, and severe growth plate abnormalities, as well as hypercalcemia, hypercalciuria, hypophosphatemia, and reduced plasma PTH levels. Humanized PTH1R (hPTH1R) mice expressing the H223R-hPTH1R JMC mutation die early without breeding. We therefore generated and characterized a stable mouse line expressing the T410R-hPTH1R allele, which confers a milder disease phenotype in patient…

Post-transplantation management of hyperparathyroidism and its association with kidney graft survival and fibrosis.

BACKGROUND: Hyperparathyroidism (HPT) is a potential risk factor for graft loss after kidney transplantation (KTx). However, the effects of … p did not show an increased risk of graft loss (fully adjusted HR = 0.28, P = 0.239). Additionally, hypercalcemia during the first year after KTx was significantly associated with IFTA progression (fully adjusted odds ratio = 1.91, P = 0.038). CONCLUSION: Hypercalcemic HPT was associated with inferior graft survival and IFTA progression. Proactive management o …

Validation and implementation of the Dutch PHPQoL for primary hyperparathyroidism.

BACKGROUND: Patients with primary hyperparathyroidism (PHPT) often present with nonspecific neuropsychological symptoms, which remain challe … on medical requirement and patient preference. Clinicians classified patients as asymptomatic if no hypercalcemia-related complaints were present. HRQoL questionnaires were assessed using the PHPQoL, SF-36, and EQ-5D questionnaires at inclusion and 3 months after treatment. Statistical significance was set at P < 0.001. RESULTS: Of the 100 patients included (m …