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Suicide, other externally caused injuries, and cardiovascular disease within 2 years after cancer diagnosis: A nationwide population-based study in Japan (J-SUPPORT 1902).

BackgroundThis study aimed to investigate the risk of death by suicide, other externally caused injuries (ECIs), or cardiovascular disease for patients with cancer.MethodsWe used data from the National Cancer Registry, which include the entire population in Japan. Patients diagnosed with cancer from January 1 to December 31, 2016 were included, and their follow-up period was set to 2 years. The standardized mortality ratio (SMR) of death by suicide, other ECIs, and cardiovascular disease was calculated compared with the general population. Multivariate Poisson or negative binomial regression a

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… Patient‐oncologist alliance as protection against suicidal ideation in young adults with advanced cancer. Cancer. 2014;120:2272‐2281. 20. Fujimori M, Shirai Y, Asai M, Kubota K, Katsumata N, Uchitomi Y. … Ketamine for the acute treatment of severe suicidal ideation: double blind, randomised placebo controlled trial. BMJ. 2022;376:e067194. 27. Gascon B, Leung Y, Espin‐Garcia O, Rodin G, Chu D, Li M. Suicide risk screening and suicide prevention in patients with cancer. …

Treatment of paediatric narcolepsy with sodium oxybate: a double-blind, placebo-controlled, randomised-withdrawal multicentre study and open-label investigation.

BACKGROUND: Narcolepsy is a lifelong neurological disorder with onset commonly in childhood or adolescence. No drugs are indicated for catap … 1 [3%]). Two serious adverse events (one event of severe acute psychosis and one event of moderate suicidal ideation) were reported, and both were considered to be related to the study drug. There were no reported deaths. INTERPRETATION: These results support the clinical efficacy of sodium oxybate for the treatment of both excessive daytime sleepiness and catapl …

Internet-based guided self-help for glioma patients with depressive symptoms: design of a randomized controlled trial.

BackgroundAmong glioma patients, depression is estimated to be more prevalent than in both the general population and the cancer patient population. This can have negative consequences for both patients and their primary informal caregivers (e.g., a spouse, family member or close friend). At present, there is no evidence from randomized controlled trials for the effectiveness of psychological treatment for depression in glioma patients. Furthermore, the possibility of delivering mental health care through the internet has not yet been explored in this population. Therefore, a randomized contro

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… Suicidal intent is screened for with the Beck Scale for Suicide Ideation (BSS) [ 38 ]. If patients have a score higher than 0 on the BSS, a board certified psychologist (MK) conducts an interview through telephone to assess the severity of symptoms. … To minimize this possible effect we keep track of the patients’ suicidal ideation and depressive symptoms throughout follow-up and we will contact both the participant and their general practitioner in case symptoms worsen significantly. …

Major depression.

Major depression is a common, disabling condition seen frequently in primary care practices. Non-psychiatrist ambulatory providers are increasingly responsible for diagnosing, and primarily managing patients suffering from major depressive disorder (MDD). The goal of this review is to help primary care providers to understand the natural history of MDD, identify practical tools for screening, and a thoughtful approach to management. Clinically challenging topics like co-morbid conditions, treatment resistant depression and pharmacotherapy selection with consideration to side effects and medica

Assessment of Psychiatric Disorders in Consultation-Liaison Setting.

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… Apart from MSE, there can be application of standardized tools to determine chance of recurrence of suicide attempt based on the current severity of intent Beck’s scale for suicidal ideation (SSI)[ 17 ] – most commonly applied tool particularly in research – but the tool is not available for free use … Assessment of suicidal intention:The Scale for Suicide Ideation. J Consult Clin Psychol. 1979;47:343–52. doi: 10.1037//0022-006x.47.2.343. 18. Posner K, Brown GK, Stanley B, Brent DA, Yershova KV, Oquendo MA, et al. …

2024 Clinical Practice Guidelines for the Diagnosis and Pharmacologic Treatment of Overweight and Obesity by the Korean Society for the Study of Obesity.

The Korean Society for the Study of Obesity has published the 9th edition of its Clinical Practice Guidelines to provide updated, evidence-based recommendations for the management of overweight and obesity. Developed through a structured process of systematic literature review and expert consensus, these guidelines incorporate recent clinical evidence for obesity management. Key clinical questions were formulated using the Population, Intervention, Comparison, and Outcome framework and addressed through comprehensive evaluations of randomized controlled trials, cohort studies, systematic revie

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… ideation. 99 Although regulatory reviews have not established a causal relationship between GLP-1 receptor agonists and suicidal or self-injurious thoughts, 100 some pharmacovigilance analyses suggest a higher rate of suicidal ideation, particularly among individuals concurrently using antidepressants … Association of semaglutide with risk of suicidal ideation in a real-world cohort. Nat Med. 2024;30:168–76. doi: 10.1038/s41591-023-02672-2. 103. Popkin B, Monteiro C, Swinburn B. …

Serving Vietnam Veterans Hospitalized Outside the VA System: A Scoping Review of Presumptive Service-Related Illnesses and Presentations.

BackgroundRecent legislation, the MISSION Act and the PACT Act, expanded access to and utilization of non-Department of Veterans Affairs (VA) health care; more Veterans now receive care from non-VA healthcare providers. Hospitalists outside the VA may be less familiar with Veterans' service-related exposures and presumptive service-related conditions. We aimed to summarize research findings on service-related exposures and conditions among Vietnam War Veterans.MethodsUsing Arksey and O'Malley's methodological framework for scoping reviews, we searched PubMed, EMBASE, and Web of Science databas

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… in Veterans Study and had a history of combat exposure and exposure to events during military service that violated their moral beliefs • Transgressions by self were associated with current mental disorders and suicidal ideation. … Killing in combat may be independently associated with suicidal ideation. Depress Anxiety. 2012;29(11):918-23. 10.1002/da.21954. 42. Smith BN, Spiro A, Frayne SM, et al. …

Abstracts from the 11th International Conference for Healthcare and Medical Students (ICHAMS) : Virtual. 10-12 February 2022.

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… Previous studies have shown that addressing insomnia in patients with MDD decreases suicidal ideation. However, the relationship between insomnia and suicidal ideation has not yet been examined as a predictive measure of treatment response. … In the aripiprazole group, those who remitted at week 16 demonstrated significantly lower suicidal ideation scores at week 8 than non-remitters (p=0.015), indicating level of suicidal ideation prior to initiating aripiprazole treatment is correlated to remission. …

Correlation of affective temperament and psychiatric symptoms in palliative care cancer patients.

BackgroundPsychiatric symptoms are common in terminally ill patients. Studies linking temperamental traits and psychiatric disorders in patients suffering from advanced disease are rare. This study investigated the influence of temperament on depression and anxiety in palliative care cancer patients.MethodsA total of 53 patients at the palliative care unit (PCU) of the Medical University of Vienna were enrolled in the study. Patients filled out the TEMPS-M and the brief PHQ-9 questionnaires to examine associations between temperament, psychiatric symptoms and sociodemographic parameters.Result

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… Gender Gender differences were not significant for self-reported psychiatric and somatic symptoms, PHQ-9, suicidal ideation and temperament (all p < 0.05), with the exception of the cyclothymic temperament, which was significantly more frequent among males (Z = −2.416, p = 0.016). … The patients also frequently reported suicidal ideations within the past month (23.6%, n = 13) and within the past 12-months (29.1%; N = 16). …

#Bias: The Opportunities and Challenges of Surveys That Recruit and Collect Data of Autistic Adults Online.

UNLABELLED: Internet-based online surveys are a crucial tool for researchers to learn about the understudied and often overlooked population … quantify and define the population of interest. We use a case example of an online survey study of suicidal ideation in autistic adults and describe how issues in selection bias and sample identifiability arise and may lead to challenges unique to studying autistic adults. We conclude with recommendations to improve the quality and utility of online survey researc …

Диагностика множественных склерозов: из материалов Конференции Национального общества по проблемам множественных склерозов.

28-летняя чернокожая женщина имела как типичные, так и нетипичные особенности множественного склероза в условиях многоженства, включая психиатрическую историю, осложняющие диагностику и лечение. Этот случай иллюстрирует важность дифференциального диагноза и продольного контроля, прежде чем брать на себя обязательство по профилактике заболеваний. Особое внимание уделяется принятию решений в отношении индивидуального лечения.

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… With the second induction dose, she received methylprednisolone 125 mg, in addition to diphenhydramine and acetaminophen, and noted worsening of her mood with pervasive suicidal ideation in the subsequent month. … Corticosteroids may result in various neuropsychiatric alterations including depressed mood, anxiety, mania, psychosis, delirium, and suicidality. 17 This patient experienced a decline in her mood and increase in suicidal ideation in the context of 125-mg methylprednisolone use, which required tailoring …

Investigating the therapeutic efficacy of psilocybin in advanced cancer patients: A comprehensive review and meta-analysis.

BackgroundPsilocybin, a naturally occurring psychedelic compound found in certain species of mushrooms, is known for its effects on anxiety and depression. It has recently gained increasing interest for its potential therapeutic effects, particularly in patients with advanced cancer. This systematic review and meta-analysis aim to evaluate the effects of psilocybin on adult patients with advanced cancer.AimTo investigate the therapeutic effect of psilocybin in patients with advanced cancer.MethodsA comprehensive search of electronic databases was conducted in PubMed, Cochrane Central Register

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… Table 2 Study descriptor table SI: Suicidal ideation; PAP: Psilocybin-assisted psychotherapy. … Acute and Sustained Reductions in Loss of Meaning and Suicidal Ideation Following Psilocybin-Assisted Psychotherapy for Psychiatric and Existential Distress in Life-Threatening Cancer. ACS Pharmacol Transl Sci. 2021;4:553–562. doi: 10.1021/acsptsci.1c00020. 25. …

Suicides among Danish cancer patients 1971-1999.

Compared to the general population, the suicide risk among Danish cancer patients diagnosed in 1971-1986 was increased by 50% for men and 30% for women. We updated the earlier study to evaluate both long-term and recent trends in the suicide risk. Cancer patients with a first cancer diagnosed between 1971 and 1999 in Denmark were followed-up for completed suicide through 1999. Excluding nonmelanoma skin cancer, 564 508 cancer patients were included and 1241 suicides observed. Both the standardised mortality ratio (SMR) of suicide relative to the general population and the suicide rates were an

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… In clinical practice, it is important to be aware that depression and suicidal ideation in cancer patients are common and that cancer patients are at an increased risk of suicide. … References Akechi T, Okamura H, Kugaya A, Nakano T, Nakanishi T, Akizuki N, Yamawaki S, Uchitomi Y (2000) Suicidal ideation in cancer patients with major depression. Jpn J Clin Oncol 30: 221–224 Allebeck P, Bolund C, Ringbäck G (1989) Increased suicide rate in cancer patients. …

Telephone interventions, delivered by healthcare professionals, for providing education and psychosocial support for informal caregivers of adults with diagnosed illnesses.

BACKGROUND: Maintaining care for ill persons in the community is heavily dependent on support from unpaid caregivers. Many caregivers, however, find themselves in a caring role for which they are ill prepared and may require professional support. The telephone is an easily accessible method of providing support irrespective of geographical location. OBJECTIVES: The objective of this review was to evaluate the effectiveness of telephone support interventions, delivered by healthcare professionals, when compared to usual care or non-telephone-based support interventions for providing education

Suicide after a Diagnosis of Cancer: Follow-Up of 1.4 Million Individuals, 2009-2019.

Background: The study explores whether Polish cancer patients face elevated suicide risk, emphasizing the vital need to comprehend and mitigate their unique mental health struggles. Methods: We conducted a cohort study based on Polish National Cancer Registry data (diagnosis in 2009-2019). Age-, sex-, and year-standardized mortality ratios (SMR) are presented with 95% confidence intervals (CIs) overall and by sex. Results: The study included 1.43 million individuals diagnosed with cancer. There were 830 suicide cases in this group. The overall SMR for suicide was 1.34 (95% CI 1.25-1.43). The h

Suicide Risk Among Patients With Cancer by Sex in Japan: A Population-based Study.

BackgroundIn Japan, few studies have examined suicide risk for 5-year relative survival rates for cancer sites. Since 5-year relative survival rates differ by sex, we aim to examine suicide risk for patients with cancer separately for men and women.MethodsWe estimated the risk of suicide among patients with cancer by sex in Japan compared to the general population, using standardized mortality ratios (SMRs). Patients with cancer diagnosed between January 1, 1985-December 31, 2013 and registered in the Osaka Cancer Registry were followed for up to 10 years. The outcome was suicide death. In add

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… However, previous studies of suicidal ideation in patients with advanced-stage cancer have reported associations with depressive disorder 42 and pain. 42 , 43 Therefore, increased patient symptoms (pain, depression) may increase suicide risk regardless of sex and anatomical site, which may explain the … Predictive factors for suicidal ideation in patients with unresectable lung carcinoma. Cancer. 2002;95:1085–1093. 10.1002/cncr.10769 43. Park SA, Chung SH, Lee Y. Factors associated with suicide risk in advanced cancer patients: a cross-sectional study. …

Severe hyperammonemia from intense skeletal muscle activity: A rare case report and literature review.

RATIONALE: Adult hyperammonemia is most often the result of hepatic dysfunction. Hyperammonemia in the setting of normal hepatic function is a much less common phenomenon and has usually been associated with medications and certain disease states. Here, we present an unusual case of severe hyperammonemia caused physiologically by intense muscle activity in a patient lacking any evidence of liver disease. PATIENT CONCERNS: A 36-year-old woman was brought to the emergency department for a suicide attempt after being found covered in Lysol and Clorox germicidal bleach. She was noted to be in a s

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… There is prior evidence of proportionate lactic acidosis with hyperammonemia associated with exercise. [ 33 ] The choice of ketamine was likely influenced by its safety [ 34 ] and its potential role in the treatment of suicidal ideation in subanesthetic doses. [ 35 ] There have been reports of late … Ketamine for rapid reduction of suicidal ideation: a randomized controlled trial. Psychol Med 2015;45:3571–80. [36] Summar ML, Barr F, Dawling S, et al. Unmasked adult-onset urea cycle disorders in the critical care setting. Crit Care Clin 2005;21: 4 Suppl: S1–8. …

Пищевая зависимость от поведенческих пристрастий: сетевой подход.

СПРАВОЧНАЯ ИНФОРМАЦИЯ/AIMS: Сопоставимость психических расстройств является хорошо задокументированным явлением. Вместе с тем не было проведено никакого расследования по вопросу о соучастии и механизмах, лежащих в основе пищевой зависимости и поведенческих пристрастий. Таким образом, цели этого исследования заключались в следующем: a) проведение сетевого анализа для изучения взаимосвязей между клиническим профилем пациентов, нуждающихся в лечении от игорного расстройства, навязчивым расстройством, связанным с покупкой и покупкой (CBSD), навязанным расстройством сексуального поведения, и сопутс

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… For example, studies of suicidal behavior have shown that these tendencies are frequent among patients with BAs, with gambling disorder showing the highest percentage of suicidal ideation, followed by CBSD, compulsive sexual behavior disorder, and gaming disorder, while the highest prevalence of suicidal …

Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials.

BACKGROUND: Post-partum depression is associated with substantial morbidity, and improved pharmacological treatment options are urgently nee … cebo group for study 2). In study 1, one patient in the BRX60 group had two serious adverse events (suicidal ideation and intentional overdose attempt during follow-up). In study 2, one patient in the BRX90 group had two serious adverse events (altered state of consciousness and syncope), which were considered to be treatment related. INTERPRETATION: Administratio …

Neuropsychiatric Disorders and Frailty in Older Adults over the Spectrum of Cancer: A Narrative Review.

BackgroundThe interplay between different neuropsychiatric conditions, beyond dementia, in the presence of a diagnosis of cancer in older adults may mediate patients' fitness and cancer-related outcomes. Here, we aimed to investigate the presence of depression, sleep disturbances, anxiety, attitude, motivation, and support in older adults receiving a diagnosis of cancer and the dimension of frailty in order to understand the magnitude of the problem.MethodsThis review provides an update of the state of the art based on references from searches of PubMed between 2000 and June 2021.ResultsThe ev

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… Depressive Disorders and Suicidal Ideation in Older Adults with Cancer Older adults receiving a diagnosis of cancer need to be considered at higher risk of developing depressive disorders and death from suicide. … Similarly, 8.6% of cancer patients in a Japanese old-age cohort manifested suicidal ideation, which is widely considered to be a reliable predictor of suicidal behavior [ 92 ]. …