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[Beta-thalassemia in Germany. Results of cooperative beta-thalassemia study].

At present, about 300 patients with thalassemia major are living in Germany. Starting in 1991, a multicenter study in Germany has concentrated on identifying all patients suffering from thalassemia as well as on establishing a uniform therapy protocol including follow-up diagnostic procedures. After six years of study, the data of 198 patients suffering from thalassaemia major were analysed. The majority of these patients originate from endemic regions around the Mediterranean Sea. The patient's median age is 13.8 years (range 1-37.5 yrs.). At present, about 20% of patients are older than 21 y…

[Fetal monitoring sub partu in West Germany. I. Basic data].

An inquiry was circulated among all Departments of Gynaecology and Obstetrics in West Germany and West-Berlin with regard to their procedure to effect foetal intensive-care management and monitoring, obstetrical management, and the results obtained. 58% of these Departments responded. With an average number of 55 beds, the annual birth rate is 628. A mean of 191 births are covered by one CTG unit, the scatter being 110-290 births per year and per unit (10th and 90th percentile). The mean incidence of Caesarean section is 11%, the mean incidence of forceps delivery 3.6%, and the mean incidence …

[Epidemiology of tick-borne encephalitis in Southern Germany (author's transl)].

A recently developed sensitive enzyme immunoassay for the detection of IgM antibodies to tick-borne encephalitis (TBE) virus was used to reinvestigate sera of patients with the clinical diagnosis of meningitis or encephalitis but without conclusive results in the complement fixation assay for TBE virus. 62 cases with sera positive for IgM antibodies to TBE virus collected from 1976 to 1980 were evaluated with regard to clinical and epidemiological aspects of the disease. Of the 62 cases, 37 had apparently been bitten by ticks. The mean age of the patients was 34 years. After a mean incubation

[Retinal artery occlusion in Germany: results from the oregis registry].

BACKGROUND: The oregis registry is Germany's first nationwide platform for real-world ophthalmological data. Launched as a multicenter, hypothesis-free registry by the German Society of Ophthalmology (DOG), oregis continuously collects treatment data from outpatient practices and clinics. With currently more than 2.5 million patients, oregis offers an unprecedented database for ophthalmological health research. Despite its clinical relevance, epidemiological and real-world data on the treatment of retinal artery occlusion (RAO) remain limited and based on small cohorts. This leads to uncertain…

LOCC-GER - A georeferenced local climate policy database for Germany.

Local climate action has increased massively worldwide. Germany is a noteworthy case in this respect, as local measures have been strongly promoted by the federal system over the past two decades. However, studying policies, their determinants, and consequences at this scale has been difficult so far due to a lack of centralized data. This article introduces LOCC-GER, the largest existing dataset of georeferenced local climate policy-making in Germany. The dataset currently covers 26,142 measures from 5,033 municipalities, including detailed descriptions of employed measures, funding sum, and …

Anaplastic thyroid cancer: Cases, incidence, prevalence and survival in Germany.

BACKGROUND: Because anaplastic thyroid cancer (ATC) is a rare diagnosis, detailed epidemiological data are difficult to find in publicly accessible platforms. The aim of this study was to report current incidence and survival estimates for ATC in Germany and to analyse their trends over time. METHODS: Data from the population-based cancer registries in Germany were pooled. ATC was classified according to the International Classification of Diseases, 10th edition (ICD-10). Age-standardised incidence rates (per 100,000) for the years 2011 to 2022 were calculated. The relative survival was estima…

[Thyroid surgery in Germany: where are complex surgical procedures performed?].

INTRODUCTION: Endocrine surgery has become an established subspecialty of general and visceral surgery in many countries, supported by curriculum-based advanced and continuing training. In Germany, comparable structures have not yet been fully implemented, although a robust body of evidence demonstrates an inverse relationship between the experience of the surgeon and complication rates, particularly for complex procedures. The aim of this study was to analyze the treatment situation for complex endocrine surgical procedures in Germany with respect to the number of interventions and distributi…

Управление терапией клеток CAR-T в Германии.

ВВЕДЕНИЕ: химическая антигенная рецепторная Т-клетка (CAR-T-клетка) стала стандартной терапией для рецидивов или рефрактальных гематологов, таких, как лимфома не Ходжкина и множественная миелома. Ввиду быстрого прогресса в области клеточной терапии CAR-T и отсутствия общепринятых руководящих принципов лечения мы гипотезуем значительные различия между центрами в профилактике, диагностике и лечении краткосрочных и долгосрочных осложнений.МЕТОДЫ: Для того чтобы отразить нынешнее управление ячейками ЦАР-Т в германских центрах в целях определения медицинских потребностей и конкретных областей для б

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… Along the same line, the duration of hospital stay is currently quite different depending on the CAR-T center in Germany. … GLA/DRST real-world outcome analysis of CAR-T cell therapies for large B-cell lymphoma in Germany. Blood. 2022;140(4):349–58. e-pub ahead of print 20220322. 4. Kamdar M, Solomon SR, Arnason J, Johnston PB, Glass B, Bachanova V, et al. …

Reemergence of Clade IIb-Associated Mpox, Germany, July-December 2023.

In July 2023, clade IIb-associated mpox reemerged in Germany at low levels, mainly affecting men who have sex with men. We report a representative case and phylogeny of available genome sequences. Our findings underscore the need for standardized surveillance and indication-based vaccination to limit transmission and help prevent endemicity.

Site-specific trends in gastroenteropancreatic neuroendocrine neoplasms in Bavaria, Germany.

INTRODUCTION: Neuroendocrine neoplasms (NEN) are rare and heterogeneous epithelial tumors, occurring throughout the body. For gastroenteropancreatic (GEP)-NEN, rising incidence rates were reported for the last decades, with underlying causes remaining largely unexplained. We evaluated NEN trends stratifying by their histologic subtypes. METHODS: Incident cases of GEP-NEN diagnosed between 2005 and 2019 were retrieved from the prospective, population-based Bavarian Cancer Registry. GEP-NEN were divided in their histologic subtypes, that is, neuroendocrine tumors (NET) G1, NET G2/G3, other NET

Newbornscreening SMA - From Pilot Project to Nationwide Screening in Germany.

Now that targeted therapies for spinal muscular atrophy are available, attempts are being made worldwide to include screening for spinal muscular atrophy in general newborn screening. In Germany, after pilot projects from 2018-2021, it was included in the general newborn screening from October 2021. To ensure a smooth transition, criteria for follow-up were developed together with key stakeholders. At the beginning of the transition to nationwide screening, false positive findings were reported in 3 patients. After optimization of the screening method in the laboratories concerned, all finding…

Responses Toward Injustice Shaped by Justice Sensitivity - Evidence From Germany.

Anger, indignation, guilt, rumination, victim compensation, and perpetrator punishment are considered primary responses associated with justice sensitivity (JS). However, injustice and high JS may predispose to further responses. We had N = 293 adults rate their JS, 17 potential responses toward 12 unjust scenarios from the victim's, observer's, beneficiary's, and perpetrator's perspectives, and several control variables. Unjust situations generally elicited many affective, cognitive, and behavioral responses. JS generally predisposed to strong affective responses toward injustice, including s

Who can take advantage of medically assisted reproduction in Germany?

Compared with other European societies, access to medically assisted reproduction (MAR) in Germany is rather restrictive. Surprisingly little is known about the actual utilization of MAR in Germany and its social selectivity, primarily due to a lack of appropriate data. This article studies the use of MAR by drawing on 11 waves of the German Family Panel (pairfam), an annual survey that collects data on partnership and family dynamics in Germany. In estimating pooled logistic regression models that take into account whether or not MAR has been used, the following treatments were included: (i) …

APExpose_DE, an air quality exposure dataset for Germany 2010-2019.

Exposure to poor air quality is considered a major influence on the occurrence of cardiovascular and respiratory diseases. Air pollution has also been linked to the severity of the effects of epidemics such as COVID-19 caused by the SARS-CoV-2 virus. Epidemiological studies require datasets of the long-term exposure to air pollution. We present the APExpose_DE dataset, a long-term (2010-2019) dataset providing ambient air pollution metrics at yearly time resolution for NO2, NO, O3, PM10 and PM2.5 at the NUTS-3 spatial resolution level for Germany (corresponding to the Landkreis or Kreisfreie S…

Child physical abuse: knowledge of dental students in Hamburg, Germany.

PURPOSE: This study was aimed at evaluating the levels of knowledge of child abuse among students attending the School of Dental and Oral Medicine at the University of Hamburg- Eppendorf, Germany. METHODS: This cross-sectional study utilized a self-administered and structured questionnaire, consisting of 23 multiple-choice questions; the questionnaire focused on rating the students' knowledge of and ability to diagnose child abuse. Each question was analysed with simple descriptive statistics. RESULTS: The students (181) were aware of their legal and ethical responsibilities towards the chil…

Retrospective Enhanced Bat Lyssavirus Surveillance in Germany between 2018-2020.

Lyssaviruses are the causative agents for rabies, a zoonotic and fatal disease. Bats are the ancestral reservoir host for lyssaviruses, and at least three different lyssaviruses have been found in bats from Germany. Across Europe, novel lyssaviruses were identified in bats recently and occasional spillover infections in other mammals and human cases highlight their public health relevance. Here, we report the results from an enhanced passive bat rabies surveillance that encompasses samples without human contact that would not be tested under routine conditions. To this end, 1236 bat brain samp…

Investigating the Campylobacter enteritis winter peak in Germany, 2018/2019.

Surveillance of notified Campylobacter enteritis in Germany revealed a recurrent annual increase of cases with disease onset several days after the Christmas and New Year holidays ("winter peak"). We suspected that handling and consumption of chicken meat during fondue and raclette grill meals on the holidays were associated with winter peak Campylobacter infections. The hypothesis was investigated in a case-control study with a case-case design where notified Campylobacter enteritis cases served as case-patients as well as control-patients, depending on their date of disease onset (case-patie…