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Musculoskeletal infections in patients with human immunodeficiency virus infection.

Musculoskeletal infections constitute an unusual clinical manifestation in patients with human immunodeficiency virus (HIV) infection. Available information about patients' characteristics and their clinical course has been obtained mainly from case reports and small retrospective studies. Our retrospective study is the largest in the literature providing detailed information about the clinical and laboratory characteristics of HIV-infected patients with different musculoskeletal infections. We identified 30 patients with various infections of the musculoskeletal system during a 5-year period …

Pathological findings in harbour seals (Phoca vitulina): 1996-2005.

Between 1996 and 2005 the carcasses of 355 harbour seals originating from the coast of Schleswig-Holstein, Germany, were investigated for pathological changes. The animals were collected before (n=280) and after (n=75) the second phocine distemper virus (PDV) epizootic in 2002. The seals were either found dead or were killed due to severe illness. Necropsy was performed in each case, in addition to histopathological, immunohistochemical, microbiological and parasitological examinations. Throughout the period of study, the respiratory and alimentary tracts were the organ systems most consistent

Occupational risks and musculoskeletal complaints among industrial workers: a cross-sectional study.

INTRODUCTION: Work-related musculoskeletal disorders result from the overuse of the musculoskeletal system and insufficient time for the structures to recover. They are generally characterized by chronic pain, paresthesia, feeling of heaviness and fatigue, especially in the upper extremities, concomitantly or not, with an insidious onset. OBJECTIVES: To characterize musculoskeletal complaints and occupational risks in workers with work-related musculoskeletal disorders. METHODS: A cross-sectional observational study of 60 participants in a Workers' Health Reference Center with clinical and i…

Maintaining and restoring mobility in middle and old age: the importance of the soft tissues.

For many older individuals, impairment of musculoskeletal function, especially weakness, stiffness, and pain, cause progressive disability, thereby limiting mobility and decreasing the quality of life. With advancing age, musculoskeletal soft tissue function declines, susceptibility to degenerative diseases and injuries increases, and the ability to recover from disease or injury declines; these changes increase the probability of impairment (Fig. 1). However, the function of individual cells, tissues, or organ systems may remain stable or even improve temporarily with age, and a number of int

Temporomandibular Disorders: Current and Future Concepts in Diagnosis and Management.

Temporomandibular disorders (TMD) are musculoskeletal and/or neuromuscular conditions relating to muscles, joints, and the associated structures of the stomatognathic system [...].

Musculoskeletal Chronic Graft versus Host Disease-A Rare Complication to Allogeneic Hematopoietic Stem Cell Transplant: A Case-Based Report and Review of the Literature.

Musculoskeletal graft versus host disease (GVHD) is a rare manifestation of chronic GVHD (cGVHD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Left untreated, the disease can cause extensive damage to muscle tissue and joints. We describe a 62-year-old male with musculoskeletal GVHD and generalized muscle pain and stiffness. In addition, we performed a systemic literature review based on published cases of musculoskeletal GVHD between 1983 and 2019. We identified 85 cases, 62% male and 38% female with an age of 4-69 years and median age of 39 years at diagnosis. The

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… The majority of the 85 patients showed signs of GVHD in other organs outside of the musculoskeletal system. Most (61, 72%) of the 85 individuals had diseases in at least one other system. From these 61 patients, 18 (21%) had disease in a single organ, while 43 (51%) had disease in multiple organs. …

The orthopaedic manifestation and outcomes of methicillin-sensitive Staphylococcus aureus septicaemia.

AIMS: The aim of this paper was to present the clinical features of patients with musculoskeletal sources of methicillin-sensitive Staphyloc … ion occurred in six of these patients (25%). In five patients, the infection originated outside the musculoskeletal system. Three patients (6%) with MSSA septicaemia from a musculoskeletal sources died. CONCLUSION: Amongst the musculoskeletal sources of MSSA septicaemia, the spine was the most commonly involved. We recommend an MRI scan of the whole spine and pelvis in …

Orthopedic Manifestations and Post-COVID-19 Infection.

BACKGROUND: It's been widely reported that the new coronavirus has adverse effects on the musculoskeletal system. The primary goal of this study is to establish the frequency of musculoskeletal complaintswith extended COVID syndrome. This retrospective cohort research examined the occurrence of musculoskeletal problems in patients with chronic COVID-19 syndrome. MATERIAL AND METHODS: About 100 COVID-19patients tested positive, of which 27 (27.0%) had a minimum of one orthopedic impairment. RESULTS: Patients with orthopedic conditions were significantly younger than those without (53.7 years …

Musculoskeletal perturbations of deep space radiation: Assessment using a Gateway MRI.

Human space exploration expansion from Low-Earth Orbit to deep space is accelerating the need to monitor and address the known health concerns related to deep space radiation. The human musculoskeletal system is vulnerable to these risks (alongside microgravity) and its health reflects the well-being of other body systems. Multiparametric magnetic resonance imaging (MRI) is an important approach for assessing temporal physiological changes in the musculoskeletal system. We propose that ultra-low-field MRI provides an optimal low Size Weight and Power (SwaP) solution for non-invasively monitori…

Advanced silk materials for musculoskeletal tissue regeneration.

Musculoskeletal diseases are the leading causes of chronic pain and physical disability, affecting millions of individuals worldwide. Over t … sign of cell niches. Silk proteins also offer active sites for chemical modifications to facilitate musculoskeletal system regeneration. With the emergence of genetic engineering techniques, silk proteins have been further optimized from the molecular level with other functional motifs to introduce new advantageous biological properties. In this review, we highlight the …

Musculoskeletal Conditions and Secondary Cardiovascular Morbidity Increase Veterans' Rehabilitation and Orthopaedic Service Utilization.

Background Musculoskeletal conditions often affect patients' mobility and ability to participate in health behaviors such as exercise, potentially affecting their systemic health. The purpose of this research is to determine how frequently cardiac-related comorbidities present in a veteran population with musculoskeletal service-connected disability and how this affects musculoskeletal health care utilization.  Methodology A retrospective cohort of Iraq and Afghanistan Veterans who received a Veterans Affairs (VA) disability determination for service-connected musculoskeletal disability were c

Использование услуг здравоохранения 2-3 За десять лет до первого события, связанного с множественным склерозом.

ЦЕЛЬ: визиты в больницу, врачебную службу и отделение скорой помощи (ЭД) с помощью диагностики и специализации 29 :: годы, предшествующие многообразному склерозу (MS), по сравнению с совпадающей популяцией без MS. Мы идентифицировали людей с MS (PwMS) с использованием демографических административных данных из Онтарио (Канада)1991-2020). В первом диагностическом коде MS/Demilelining определяется начало MS (дата индекса). Ежегодные показатели использования медицинских услуг (больницы, врач, медицинский персонал) в разбивке по первичной диагностике (уровень главы) и врачебной специализации были

Neuromuscular Control Deficits and the Risk of Subsequent Injury after a Concussion: A Scoping Review.

An emerging area of research has identified that an increased risk of musculoskeletal injury may exist upon returning to sports after a sport-related concussion. The mechanisms underlying this recently discovered phenomenon, however, remain unknown. One theorized reason for this increased injury risk includes residual neuromuscular control deficits that remain impaired despite clinical recovery. Thus, the objectives of this review were: (1) to summarize the literature examining the relationship between concussion and risk of subsequent injury and (2) to summarize the literature for one mechani

Musculoskeletal diagnosis in adolescents.

Musculoskeletal complaints are a common reason for adolescents to seek medical attention. It is estimated that musculoskeletal problems account for up to 20% of visits to primary care practitioners. Many studies have shown the inadequacies of training of medical students and primary care residents in musculoskeletal medicine. Also, many practitioners do not feel comfortable in the management of common problems in this area. A general outline for approaching adolescents with musculoskeletal complaints is presented in this article and is not unlike the approach to other clinical problems. This o

Vaccine-associated lupus and related organ involvements: A pharmacovigilance analysis of VAERS database 1990-2025.

OBJECTIVES: The relationships between vaccines and the development of systemic lupus erythematosus (SLE) and related organ involvements remain unclear. METHODS: We analyzed data from the Vaccine Adverse Event Reporting System (VAERS) during the period of 1990 to 2025 to determine the incidence of vaccine-associated SLE over time. The relationships between vaccines and the development of SLE and organ involvements were assessed by disproportionality and case-control analyses. RESULTS: 1976 (0.017%) cases of vaccine-associated lupus were identified amongst 11,301,263 adverse events (AEs) repor

Combat musculoskeletal wounds in a US Army Brigade Combat Team during operation Iraqi Freedom.

BACKGROUND: A prospective, longitudinal analysis of musculoskeletal combat injuries sustained by a large combat-deployed maneuver unit has not previously been performed. METHODS: A detailed description of the musculoskeletal combat casualty care statistics, distribution of wounds, and mechanisms of injury incurred by a US Army Brigade Combat Team during "The Surge" phase of Operation Iraqi Freedom was performed using a centralized casualty database and an electronic medical record system. RESULTS: Among the 4,122 soldiers deployed, there were 242 musculoskeletal combat wounds in 176 combat c

The Musculoskeletal Involvement After Mild to Moderate COVID-19 Infection.

COVID-19, a disease caused by the novel coronavirus SARS-CoV-2, has been drastically affecting the daily lives of millions of people. COVID-19 is described as a multiorgan disease that affects not only the respiratory tract of infected individuals, but it has considerable effects on the musculoskeletal system, causing excessive fatigue, myalgia, arthralgia, muscle weakness and skeletal muscle damage. These symptoms can persist for months, decreasing the quality of life of numerous individuals. Curiously, most studies in the scientific literature focus on patients who were hospitalized due to S…

Shear-Wave Elastography: Basic Physics and Musculoskeletal Applications.

In the past 2 decades, sonoelastography has been progressively used as a tool to help evaluate soft-tissue elasticity and add to information obtained with conventional gray-scale and Doppler ultrasonographic techniques. Recently introduced on clinical scanners, shear-wave elastography (SWE) is considered to be more objective, quantitative, and reproducible than compression sonoelastography with increasing applications to the musculoskeletal system. SWE uses an acoustic radiation force pulse sequence to generate shear waves, which propagate perpendicular to the ultrasound beam, causing transien…

The efficacy of bedside chest ultrasound: from accuracy to outcomes.

For many respiratory physicians, point-of-care chest ultrasound is now an integral part of clinical practice. The diagnostic accuracy of ultrasound to detect abnormalities of the pleura, the lung parenchyma and the thoracic musculoskeletal system is well described. However, the efficacy of a test extends beyond just diagnostic accuracy. The true value of a test depends on the degree to which diagnostic accuracy efficacy influences decision-making efficacy, and the subsequent extent to which this impacts health outcome efficacy. We therefore reviewed the demonstrable levels of test efficacy for…

Cirrhosis-related musculoskeletal disease: radiological review.

Musculoskeletal problems in patients with liver disease are common; however, they are not so well described in the literature. Therefore, there is a need to collate information on these disorders, as their incidence is on a constant rise and some of these pathologies can severely debilitate the patient's quality of life. These disorders are parietal wall varices with or without bleeding, spontaneous intramuscular haematoma (e.g. rectus sheath), abdominal wall hernia, anasarca, hepatic osteodystrophy, septic arthritis, osteomyelitis, necrotizing fasciitis, osseous metastases from hepatocellular