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Obesity Disease and Surgery.

Obesity is a medical disease that is increasing significantly nowadays. Worldwide obesity prevalence doubled since 1980. Obese patients are at great risk for complications with physical and psychological burdens, thus affecting their quality of life. Obesity is well known to have higher risk for cardiovascular diseases, diabetes mellitus, musculoskeletal diseases and shorter life expectancy. In addition, obesity has a great impact on surgical diseases, and elective surgeries in comparison to general population. There is higher risk for wound infection, longer operative time, poorer outcome, an

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… present a frequent source of abdominal pain and anemia, incisional hernias which are common after open bariatric surgery and require subsequent surgical intervention, device-related complications with the gastric band which include malfunction of the band, tubing, or reservoir component, hypoglycemia steatorrhea …

Approach to the Patient With Bone Fracture: Making the First Fracture the Last.

The global burden of osteoporosis and osteoporotic fractures will increase significantly as we enter a rapidly aging population. Osteoporotic fractures lead to increased morbidity, mortality, and risk of subsequent fractures if left untreated. However, studies have shown that the majority of patients who suffer an osteoporotic fracture are not investigated or treated for osteoporosis, leading to an inexcusable "osteoporosis care gap." Systematic and coordinated models of care in secondary fracture prevention known as fracture liaison services (FLS) have been established to streamline and impro

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… On further questioning, he reports chronic steatorrhea, raising the possibility of pancreatic exocrine insufficiency secondary to alcohol excess. He consumes around one dietary serving of calcium daily and is not on calcium or cholecalciferol supplementation. There is no unintentional weight loss. …

Реальное воздействие NVX-CoV2373 COVID-19 вакцина для иммунокомпромиссных людей в Южной Корее.

BackgroundNVX-CoV2373 - наночастица, белковая COVID-19 вакцина. Лица, страдающие от иммунокомпрометированных заболеваний, подвергаются высокому риску инфицирования и серьезных заболеваний; однако в реальном мире NVX-CoV2373 Цель настоящего исследования состояла в том, чтобы оценить, являются ли данные о воздействии в МКС ограниченными. NVX-CoV2373 снижение риска SARS-CoV-2 :: инфекция и серьезные заболевания в ИМС по сравнению с лицами, не имеющими иммунокомпромиссных свойств (не связанными с ИС). Южнокорейский МКС в возрасте ≥12 лет, которые получили первичную серию, третью дозу или четвертую

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… 178,205 (56.0) Metabolic disorder | Type 1 diabetes mellitus (E10) Type 2 diabetes mellitus (E11) Malnutrition-related diabetes mellitus (E12) Other specified diabetes mellitus (E13) Intestinal malabsorption (K90) Celiac disease (K90.0) Tropical sprue (K90.1) Blind loop syndrome (K90.2) Pancreatic steatorrhea …

Педиатрическое ожирение - долгосрочные последствия и последствия потери веса.

Согласно ВОЗ, детский ожирение - это one наиболее серьезных проблем, с которыми сталкивается 21st Столетие. Более 100 million Сегодня у детей ожирение. Уже в детстве почти все органы подвергаются риску ожирения. В этом обзоре мы представляем текущие знания о болезнях, связанных с детским ожирением, и о том, как они влияют на потерю веса. One Основным побудительным фактором является вызванное ожирением низкосортное хроническое воспаление, которое уже наблюдается у детей дошкольного возраста. Это воспаление в сочетании с эндокринным, паракринным и метаболическим воздействием ожирения повышает до

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… a Limited experience 227 Digital support for lifestyle modification 4–18 years −0.30 None Limited experience 221 Liraglutide 12–18 years −0.22 Primarily gastrointestinal For adolescents with insufficient effect of lifestyle support 223 Orlistat 12–16 years −0.10 b Frequent steatorrheas …

2024 Clinical Practice Guidelines for the Diagnosis and Pharmacologic Treatment of Overweight and Obesity by the Korean Society for the Study of Obesity.

The Korean Society for the Study of Obesity has published the 9th edition of its Clinical Practice Guidelines to provide updated, evidence-based recommendations for the management of overweight and obesity. Developed through a structured process of systematic literature review and expert consensus, these guidelines incorporate recent clinical evidence for obesity management. Key clinical questions were formulated using the Population, Intervention, Comparison, and Outcome framework and addressed through comprehensive evaluations of randomized controlled trials, cohort studies, systematic revie

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… reduces dietary fat absorption by approximately 30% by inhibiting gastrointestinal lipases, resulting in weight loss primarily via decreased energy intake. 45 Unlike centrally acting agents, orlistat does not directly modulate appetite, and it is associated with gastrointestinal adverse effects such as steatorrhea …

Antiobesity Medications for Older Adults-the New, the Good, the Bad, and the Unknown.

OBJECTIVE: Obesity affects 42% of older adults, with rates continuing to rise. This a complex condition influenced by non-modifiable as well as modifiable risk factors. The disease can be treated through modifications to diet, physical activity, and behavior and more recently through antiobesity medications (AOMs) and surgery. Treatment must be tailored to individual needs due to age-related metabolic and physiological changes. This review aimed to identify the suitability of seven FDA-approved AOMs in the treatment of obesity in older adults. METHODS: A review of AOMs was performed, focusing

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… gastroparesis, family history of medullary thyroid cancer, Cr Cl < 30, eGFR < 30 | In patients with MEN2a and MEN2b, history of pancreatitis, T1DM, gastroparesis, family history of medullary thyroid cancer, Cr Cl < 30, eGFR < 30 Side effects of orlistat include abdominal discomfort, fecal incontinence, steatorrhea …

Pancreatitis: TIGAR-O Version 2 Risk/Etiology Checklist With Topic Reviews, Updates, and Use Primers.

The Toxic-metabolic, Idiopathic, Genetic, Autoimmune, Recurrent and severe acute pancreatitis and Obstructive (TIGAR-O) Pancreatitis Risk/Etiology Checklist (TIGAR-O_V1) is a broad classification system that lists the major risk factors and etiologies of recurrent acute pancreatitis, chronic pancreatitis, and overlapping pancreatic disorders with or without genetic, immunologic, metabolic, nutritional, neurologic, metaplastic, or other features. New discoveries and progressive concepts since the 2001 TIGAR-O list relevant to understanding and managing complex pancreatic disorders require an up

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… High prevalence of steatorrhea in 101 diabetic patients likely to suffer from exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations: A prospective multicenter study. Dig Dis Sci 2003;48:1688–92. 75. Chari ST, Leibson CL, Rabe KG, et al. …

Selected Abstracts from the 13th Annual Meeting of the Clinical Immunology Society: 2022 Annual Meeting: Immune Deficiency and Dysregulation North American Conference

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[Chinese experts consensus statement: diagnosis and treatment of cystic fibrosis (2023)].

Cystic fibrosis (CF) is one of the most common autosomal recessive genetic diseases in Caucasians, but CF patients in China are rare, and it … ion or meconium ileus; (3) pancreatic exocrine insufficiency, mainly characterized by long-standing steatorrhea and malnutrition; (4) recurrent lower respiratory tract infections of infantile onset, especially Pseudomonas aeruginosa (PA), Staphylococcus aureus infections of respiratory aetiology; (5) chronic sinusitis, especially when combined with juvenile p …

Innovative Peptide Therapeutics in the Pipeline: Transforming Cancer Detection and Treatment.

Cancer remains a leading global health burden, profoundly affecting patient survival and quality of life. Current treatments-including chemotherapy, radiotherapy, immunotherapy, and surgery-are often limited by toxicity or insufficient specificity. Conventional chemotherapy, for instance, indiscriminately attacks rapidly dividing cells, causing severe side effects. In contrast, peptide-based therapeutics offer a paradigm shift, combining high tumour-targeting precision with minimal off-target effects. Their low immunogenicity, multi-pathway modulation capabilities, and adaptability for diagnos

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… Common adverse effects include gastrointestinal disturbances (nausea, diarrhoea, steatorrhea), injection site reactions, glucose dysregulation, and cardiovascular effects (bradycardia and arrhythmia) [ 93 ]. Cholelithiasis occurs due to reduced gallbladder motility [ 93 ]. …

Obesity and Cancer: A Current Overview of Epidemiology, Pathogenesis, Outcomes, and Management.

BackgroundObesity or excess body fat is a major global health challenge that has not only been associated with diabetes mellitus and cardiovascular disease but is also a major risk factor for the development of and mortality related to a subgroup of cancer. This review focuses on epidemiology, the relationship between obesity and the risk associated with the development and recurrence of cancer and the management of obesity.MethodsA literature search using PubMed and Google Scholar was performed and the keywords 'obesity' and cancer' were used. The search was limited to research papers publish

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… 1.3% to 6.1% | headaches, hypertension, sleep disorders, nausea, constipation, vomiting, diarrhea, palpitation, dizziness, tremor, and others Orlistat | Pancreatic lipase inhibitor causing excretion of 30% of ingested trigylcerides in stool | 120 mg 3 times daily | 6.1% to 10.2% | nausea, diarrhea, steatorrhea …

Current Diagnosis and Management of Primary Chylomicronemia.

Primary chylomicronemia (PCM) is a rare and intractable disease characterized by marked accumulation of chylomicrons in plasma. The levels of plasma triglycerides (TGs) typically range from 1,000 - 15,000 mg/dL or higher.PCM is caused by defects in the lipoprotein lipase (LPL) pathway due to genetic mutations, autoantibodies, or unidentified causes. The monogenic type is typically inherited as an autosomal recessive trait with loss-of-function mutations in LPL pathway genes (LPL, LMF1, GPIHBP1, APOC2, and APOA5). Secondary/environmental factors (diabetes, alcohol intake, pregnancy, etc.) often

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… C) Management of Chronic Pancreatitis As acute pancreatitis can lead to chronic complications, patients with a history of it are better monitored for complications such as chronic pancreatitis, pancreatic pseudocysts, pancreatic insufficiency, steatorrhea, and insulin-dependent diabetes mellitus 4 , …

A year in pharmacology: new drugs approved by the US food and drug administration in 2025.

The US Food and Drug Administration approved 45 new drugs and 4 new cellular and gene therapy products in 2025, that is, a total of 49 new medical therapies. Oncology, hematology/immunotherapy, and cardiovascular/respiratory drugs remain most frequent. Among oncology drugs, there is a trend for targeting ever smaller subtypes of malignancies and/or rarer malignancies. Trends over the past 6 years include steady levels of first-in-indication (about 10%), first-in-class (about 38%), and next-in-class (about 51%) approvals. Along with a large share of approvals in orphan indications (> 50%), fast

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… Warnings and precautions include cholelithiasis, dysglycemia, cardiovascular effects, thyroid dysfunction, steatorrhea with fat malabsorption, and vitamin B12 deficiency. …

Molecular Inhibitors of Growth Signals

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62nd Annual Conference of the Indian Society of Gastroenterology, February 10th - 13th, 2022, Pune.

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61st Annual Conference of Indian Society of Gastroenterology, Virtual Diamond Jubilee ISGCON 2020, 19-20th December 2020.

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International Recommendations for Screening and Preventative Practices for Long-Term Survivors of Transplantation and Cellular Therapy: A 2023 Update.

As hematopoietic cell transplantation (HCT) and cellular therapy expand to new indications and international access improves, the number of HCTs performed annually continues to rise. Parallel improvements in HCT techniques and supportive care entails more patients surviving long term, creating further emphasis on survivorship needs. Survivors are at risk for developing late complications secondary to pretransplantation, peritransplantation, and post-transplantation exposures and other underlying risk factors. Guidelines for screening and preventive practices for HCT survivors were originally p

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… Pancreatic exocrine insufficiency occasionally presents with steatorrhea and weight loss despite adequate caloric intake. …

Secondary Osteoporosis and Metabolic Bone Diseases.

Fragility fracture is a worldwide problem and a main cause of disability and impaired quality of life. It is primarily caused by osteoporosis, characterized by impaired bone quantity and or quality. Proper diagnosis of osteoporosis is essential for prevention of fragility fractures. Osteoporosis can be primary in postmenopausal women because of estrogen deficiency. Secondary forms of osteoporosis are not uncommon in both men and women. Most systemic illnesses and organ dysfunction can lead to osteoporosis. The kidney plays a crucial role in maintaining physiological bone homeostasis by control

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… Furthermore, in cases of steatorrhea, calcium absorption may be hindered by binding to excess fatty acids in the gastrointestinal (GI) lumen [ 144 ]. In this section, we will discuss the most common causes of GI-related osteoporosis. 4.1. …

Obesity: pathophysiology and therapeutic interventions.

Over the past few decades, obesity has transitioned from a localized health concern to a pressing global public health crisis affecting over 650 million adults globally, as documented by WHO epidemiological surveys. As a chronic metabolic disorder characterized by pathological adipose tissue expansion, chronic inflammation, and neuroendocrine dysregulation that disrupts systemic homeostasis and impairs physiological functions, obesity is rarely an isolated condition; rather, it is frequently complicated by severe comorbidities that collectively elevate mortality risks. Despite advances in nutr

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… Orlistat, a lipase inhibitor, commonly induces gastrointestinal complications such as steatorrhea and constipation due to impaired fat absorption, with rare cases linked to fatal outcomes [ 303 ]. …

Biology and Diseases of Dogs

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… Consumption of fat in excess of an animal's ability to metabolize it results in steatorrhea and has been related to the development of acute pancreatitis, whereas lack of dietary fat may lead to a fatty acid/energy deficiency. …