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A Review of Clinical Practice Guidelines and Treatment Recommendations for Cancer Care in the COVID-19 Pandemic.

The COVID-19 pandemic has inevitably caused those involved in cancer care to change clinical practice in order to minimize the risk of infection while maintaining cancer treatment as a priority. General advice during the pandemic suggests that most patients continue with ongoing therapies or planned surgeries, while follow-up visits may instead be delayed until the resolution of the outbreak. We conducted a literature search using PubMed to identify articles published in English language that reported on care recommendations for cancer patients during the COVID-19 pandemic from its inception u

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… In conclusion, we believe that oncologists, surgeons, and radiation oncologists should refer to the indications of their proper, national, scientific societies. The rapid evolution of epidemiology of pandemic, however, makes a continuous update of clinical practice guidelines, a necessity. … Oncologist. 2020 doi: 10.1634/theoncologist.2020-0316. 84. …

Early integration of palliative care for patients with haematological malignancies.

Early palliative care (EPC) significantly improves quality of life, symptoms, and satisfaction with care for patients with advanced cancer. International organizations have recognized and promoted the role of palliative care as a distinct specialty, advocating its involvement throughout the cancer trajectory. Although patients with haematologic malignancies (HMs) have a comparable symptom burden to patients with solid tumours, they face multiple barriers to EPC integration. In this review, we discuss these barriers, present updated evidence from clinical trials of EPC in HMs and propose models

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… Attitudinal barriers Haemato‐oncologists are more likely than oncologists to prescribe systemic therapy with moderate toxicity and no survival benefit for patients with a severely impaired performance status and an expected survival of 1 month. 57 PC providers may see this as resistance of haemato‐oncologists … Referral initiated on clinical judgement by oncologists or haemato‐oncologists is currently the most popular method and remains synonymous with usual care, both in practice and for clinical trials. 20 , 92 Oncologists are increasingly making early referrals to PC services at their centres for patients …

Inside the Black Box: A Narrative Review on Comprehensive Geriatric Assessment-Driven Interventions in Older Adults with Cancer.

There is a consensus that the use of comprehensive geriatric assessment (CGA) is good clinical practice for older patients with solid tumors or hematological malignancies. To be complete, a CGA must include a geriatric assessment and an intervention plan. According to the SIOG consensus, a CGA should assess several domains: functional status, comorbidity, cognition, mental health status, fatigue, social status and support, nutrition, and the presence of geriatric syndromes. Progress has been made in the definition of the best way to detect problems, but the benefits are mostly based on prognos

Perspectives of patients, partners, primary and hospital-based health care professionals on living with advanced cancer and systemic treatment.

PurposeAn emerging group of patients lives longer with advanced cancer while receiving systemic treatment. This study aimed to investigate psychosocial aspects of living longer with advanced cancer, and experiences with psychosocial care, from the perspectives of patients, partners, and health care professionals (HCPs).MethodsFrom May to December 2020, participants were purposively selected. In-depth, semi-structured interviews were conducted by video or phone call, containing open questions regarding psychosocial aspects and psychosocial care in oncology. The data was analysed following thema

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… (Oncologist, female, 40) Similar to oncologists, psychologists and social workers are confronted with the guidance of an emerging group of patients and their partners for extended periods of time, and consequently build up a close relationship. … These instruments could be used by oncologists or CNSs to monitor patients during a longer-term disease trajectory, aimed at timely providing tailored psychosocial support. …

A qualitative evidence synthesis of healthcare professionals' experiences and views of palliative care for patients with a haematological malignancy.

IntroductionPatients with haematological malignancies may not be receiving appropriate referrals to palliative care and continuing to have treatments in the end stages of their disease. This systematic review of qualitative research aimed to synthesise healthcare professionals' (HCPs) views and experiences of palliative care for adult patients with a haematologic malignancy.MethodsA systematic search strategy was undertaken across eight databases. Thomas and Harden's approach to thematic analysis guided synthesis on the seventeen included studies. GRADE-GRADEQual guided assessment of confidenc

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… Practicing oncologists from three sites. ( n = 43 solid tumour oncologists and n = 23 haematologic oncologists* (*data extracted from haematologic oncologists only) 6 | Mc Caughan et al. | 2018a | UK | Qualitative descriptive/semi‐structured in‐depth interviews | Purposive and snowball sampling | Inductive … End‐of‐life care for blood cancers: A series of focus groups with hematologic oncologists . …

Evaluation of psychosocial distress in patients treated in a community-based oncology group practice in Germany.

BackgroundSystematic evaluation of psychosocial distress in oncology outpatients is an important issue. We assessed feasibility and benefit of standardized routine screening using the Distress Thermometer (DT) and Problem List (PL) in all patients of our community-based hematooncology group practice.Patients and methodsOne thousand four hundred forty-six patients were screened between July 2008 and September 2008. Five hundred randomly selected patients were sent a feedback form.ResultsThe average distress level was 4.7, with 37% indicating a distress level >5. Patients with nonmalignant disea

Treatment of cancer with oral drugs: a position statement by the Spanish Society of Medical Oncology (SEOM).

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… Several solid reasons support our warning that the administration of oral anticancer drugs outside the scope of trained oncologists should be considered unsuitable and potentially dangerous. It is not true that oral anticancer drugs are less toxic. … At the heart of a multidisciplinary team that includes a medical oncologist, many treatment options are available. Oral therapy is usually one among several possibilities. …

Facilitators and barriers to implementing patient-reported outcomes in clinical oncology practice: a systematic review based on the consolidated framework for implementation research.

BackgroundIn clinical oncology practice, patient-reported outcomes (PROs) are essential for assessing the symptom burden, quality of life, and psychological status of patients. However, there remains a gap between the use of PROs in an oncologic setting and its implementation. Furthermore, numerous reviews in PRO implementation are often based on one particular technology, setting, or health condition, making it difficult to obtain a comprehensive and coherent summary of available evidence to help plan and undertake implementation. This systematic review aims to identify and integrate enablers

A Qualitative Study of the Initial Diagnosis and Treatment Experience of Black Patients with Newly Diagnosed Acute Myeloid Leukemia.

PURPOSE: Black patients with acute myeloid leukemia (AML) experience disparate outcomes, and factors such as structural racism and differential treatment access have been implicated. We sought to understand the experience of Black patients with newly diagnosed AML to gain insight into their unique experience. METHODS: We interviewed Black patients ≥18 years of age with newly diagnosed AML (diagnosed from 7/1/2021 to 7/31/2022) over Zoom. Interviews were conducted by the same interviewer, with concordance in race between the interviewer and interviewees. A rapid qualitative content analysis wa

PD-1 Inhibitors in Elderly and Immunocompromised Patients with Advanced or Metastatic Cutaneous Squamous Cell Carcinoma.

Cutaneous squamous cell carcinoma (cSCC) of the skin is the second most common form of skin cancer, with aging and prolonged exposure to ultraviolet rays being the main causes of the disease. Cemiplimab and pembrolizumab recently gained regulatory approval for the treatment of locally advanced and metastatic cSCC-conditions that are not treatable by surgical resection and/or radiotherapy. Although the results from the clinical trials have been promising, these studies have not included immunosuppressed, elderly patients. In this study, we included all immunocompromised and immunocompetent pati

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… Each study patient, on admission to the Oncology Center at Soroka Medical Center, was presented to a multidisciplinary medical team that included a medical oncologist, radiation oncologist, dermatologist, plastic surgeon, pathologist, and radiologist. … All of our patients were treated in an academic facility by experienced medical oncologists and radiotherapists, along with other relevant specialists as part of the disease management team. …

Strategies to Increase Vaccinations in Adult Cancer Patients: A Systematic Review.

BACKGROUND/OBJECTIVES: Although vaccinations are a priority for patients with cancer, achieving high coverage remains challenging. Evidence on effective strategies in oncology settings is still limited. This systematic review aimed to identify interventions to improve vaccination uptake or reduce hesitancy among cancer patients. METHODS: A systematic search was conducted in PubMed, Embase, and Scopus, including studies published up to the end of 2023. The protocol was registered in PROSPERO (CRD42024511008). RESULTS: Out of 10,927 non-duplicate records, 15 studies describing unique intervent

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… Counselling is especially important for cancer patients, as previous studies have shown that oncologist recommendations strongly influence vaccine acceptance [ 21 , 60 ]. … Pharmacists are accessible, knowledgeable about medication, and capable of reinforcing provider recommendations without adding to oncologists’ workload. This approach may be particularly valuable in settings where oncologists have limited time or competing priorities. …

Patterns and perceptions of supplement use among patients with plasma cell disorders.

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… More concerningly, inadequate supplement knowledge among oncologists may compromise patient outcomes. … n = 563 Yes 327 58 No 34 6 N/A 202 36 What advice did your hematologist/oncologist give you about supplement use? …

Multidisciplinary Care for the Prevention and Treatment of Venous Thromboembolism in Patients with Cancer-Associated Thrombosis (CAT): Impact of Educational Interventions on CAT-Related Events and on Patients' and Clinicians' Awareness.

Cancer is a leading cause of death. Venous thromboembolism (VTE) is an often-overlooked cause of morbidity and mortality in cancer patients that can be readily prevented and treated. Actions are needed to reduce the morbidity and mortality of patients with cancer-associated thrombosis (CAT). There is a need to increase awareness of the impact of CAT on cancer patients' morbidity and mortality, on their quality of life and to understand the importance of more effective preventions and treatments of VTE in cancer patients. Moreover, it is of great importance to systematically assess the risk of

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… Therefore, while waiting for information on the impact of cancer drugs on the efficacy and safety of DOACs, the collaboration between oncologists and vascular physicians/angiologist is important. … In fact, there are even knowledge deficits regarding CAT among healthcare providers (physicians, oncology nurses, oncologists) [ 31 ]. …

Early Palliative Care in Acute Myeloid Leukemia.

BackgroundSeveral novel targeted therapies seem to improve the outcome of acute myeloid leukemia (AML) patients. Nonetheless, the 5-year survival rate remains below 40%, and the trajectory of the disease remains physically and emotionally challenging, with little time to make relevant decisions. For patients with advanced solid tumors, the integration of early palliative care (EPC) with standard oncologic care a few weeks after diagnosis has demonstrated several benefits. However, this model is underutilized in patients with hematologic malignancies.MethodsIn this article, we analyze the palli

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… Hematologic oncologists report that this impacts their ability to accurately determine when a patient is at the end of life (EOL) and reduces the possibility of discussing prognostic information with their patients [ 27 ]. … Recommendations for Palliative and Hospice Care in NCCN Guidelines for Treatment of Cancer Oncologist 2021 26 77 83 10.1002/ONCO.13515 32915490 PMC7794182 76. Bramati P. Hui D. Bruera E. …

Remaining Systemic Treatment Options: A Valuable Predictor of Survival and Functional Outcomes after Surgical Treatment for Spinal Metastasis.

ObjectivesTo evaluate survival and functional outcomes in surgically-treated spinal metastasis patients and to identify the prognostic value of the remaining options for systemic treatment.MethodsThe current study reviewed 100 consecutive patients who received surgery for spinal metastasis in a single center from March 2012 to June 2016. The decision for surgery had been made in a weekly multidisciplinary tumor board after considering multiple factors. Among these factors, those associated with the functional outcome were identified using crosstab and logistic regression analyses. Survival ana

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… The Decision for Surgical Treatment The decision to perform surgery was made using a multidisciplinary approach through a weekly tumor board consisting of a medical oncologist, a radiation oncologist, a radiologist, a pathologist, an orthopaedic oncologist, and an orthopaedic spine surgeon. … Information on the estimated life expectancy and availability of remaining systemic treatment or radiotherapy was provided by the medical oncologists or the radiation oncologists who had been treating the particular patient. …

Практическое руководство по клиническому управлению окулистическими неблагоприятными событиями, связанными с Belantamab Mafodotin для пациентов с повторной/редактированной миеломой: рекомендации Группы экспертов стран Латинской Америки.

Множественная миелома является значительной причиной смертности во всем мире, и, хотя изменения в области лечения в целом улучшили результаты, многие пациенты становятся небрежными к стандартной терапии. В Латинской Америке результаты являются особенно неблагоприятными, что еще больше усугубляется препятствиями на пути доступа и равенства. Belantamab mafodotin — новый антитело-наркоманный матрос, направленный против анти-B-клеток антигена. Two недавно фазы 3 - судебные разбирательства, DREAMM-7 и DREAMM-8, продемонстрировали заметную эффективность комбинаций белантамб мафодотина у пациентов с

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… As hematologists/oncologists may be unfamiliar with OAEs, clear guidance is needed to ensure appropriate care by healthcare teams. … Treatment decisions should be guided by the hematologist/oncologist, and ophthalmologist, and by informed patient decision. …

Knowledge, feelings, and willingness to use palliative care in cancer patients with hematologic malignancies and solid tumors: a prospective, cross-sectional study in a comprehensive cancer center in Germany.

PurposePatients with hematologic malignancies (HM) receive palliative care (PC) less often and later than patients with solid tumors (ST). Patients' lack of knowledge about PC and negative feelings about PC are barriers to their willingness to use PC. Is there a difference between patients with HM and ST in their knowledge and willingness to use PC?MethodsTwo hundred ten patients (85 HM, 125 ST) from an oncology day clinic at a university hospital participated in this cross-sectional, questionnaire-based survey.ResultsPatients with HM and ST had high knowledge and mainly positive feelings abou

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… Differences are about the conversation with oncologists. There are major differences between HM and ST. While 8.3% of patients with HM had a conversation about PC with the oncologist, 19.5% of patients with ST had such a conversation. … On the one hand, it might be useful to educate oncologists about patients’ expectations and how to address relevant PC topics communicatively. …

Case Report: AL Amyloidosis Severe Restrictive Cardiomyopathy Associated With Multiple Myeloma-Diagnostic Difficulties.

BackgroundCardiac AL amyloidosis as a complication of multiple myeloma (MM) is a formidable life-threatening condition. The first-line therapy for both MM and systemic AL amyloidosis is proteasome inhibitors (PIs). Unfortunately, the use of PIs may lead to cardiovascular toxicity development, which requires specific cardio-oncology supervision.Case reportA 57-year-old woman was admitted to a university hospital with clinical manifestation of progressive chronic heart failure. The patient had hypertension and no history of diabetes mellitus, myocardial infarction (MI), stroke, and arrhythmias.

The role of social networks in prognostic understanding of older adults with advanced cancer.

ObjectivesExplore how older patients utilize their social networks to inform prognostic understanding.MethodsIn a pilot study of adults (≥65 years old) with advanced cancer, 16 patients completed surveys, social network maps, and semi-structured interviews exploring with whom they preferred to communicate about their illness. Interviews were analyzed using open-coding, and codes were categorized into emergent themes. Social network maps and themes were analyzed via mixed-methods social network analysis (MMSNA). Three case examples with diverse network characteristics and communication patterns

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… Patients’ connection with their oncologist is a crucial aspect of their care,[ 28 ] especially to ensure that patients have clear prognostic communication with their oncologists. … This suggests that patients report a desire to spend time with oncologists who listen and talk to their patients.[ 31 ]. …

Palliative Care in Patients with Hematological Malignancies.

Palliative care is an attempt to improve the quality of life of patients and their relatives who have lost the chance of a cure. Interventions to improve the quality of life of patients include physical, mental, and psychosocial problems. It is known that symptoms such as pain, fatigue, loss of appetite, and feeling unwell, which often cause deterioration in quality of life, are improved with palliative care support. It is seen that palliative care support, which is mostly recommended in the end-of-life period of patients with solid tumors, is not recommended for patients with hematological ma

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… In the same survey, 84% of both oncologists and transplant physicians stated that palliative patient care is required at all stages of the disease, including end-of-life care (El-Jawahri et al., 2018). … However, in another study, it was shown that unrealistic expectations of oncologists caring for patients with hematological malignancies hinder good planning of end-of-life care ( Odejide et al., 2016 ). …