Результаты поиска

Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors.

Infection-triggered perturbation of the immune system could induce psychopathology, and psychiatric sequelae were observed after previous coronavirus outbreaks. The spreading of the Severe Acute Respiratory Syndrome Coronavirus (COVID-19) pandemic could be associated with psychiatric implications. We investigated the psychopathological impact of COVID-19 in survivors, also considering the effect of clinical and inflammatory predictors. We screened for psychiatric symptoms 402 adults surviving COVID-19 (265 male, mean age 58), at one month follow-up after hospital treatment. A clinical intervie

Proactive Identification and Digital Mental Health Intervention for the Treatment of Depression Among Individuals With Likely Incurable Cancer: A Pilot Randomized Clinical Trial.

BackgroundAlthough depression is prevalent and has significant consequences among individuals living with likely incurable cancer (ILLIC), optimal methods of identifying and treating depression in this population remain unknown.AimsTo evaluate a paradigm of (1) proactive identification (ID) (i.e., remotely and asynchronously from clinical encounters) of depression among ILLIC and (2) digital mental health intervention (DMHI) for depression treatment.MethodsIn this decentralized randomized clinical trial, ILLIC with elevated depressive symptoms were proactively identified using electronic healt

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… Depression in this patient population is highly significant as it is associated with worse quality of life (QOL), reduced adherence to anti‐cancer therapies, suicidal ideation, and desire for hastened death [ 7 , 8 ]. … Patients were excluded if they had severe cognitive impairment precluding informed consent (self‐report or diagnosis of dementia or neurocognitive disorder) or if they had current suicidal ideation ( ≥ 2 on PHQ‐9 item 9). …

Suicide, other externally caused injuries and cardiovascular death following a cancer diagnosis: study protocol for a nationwide population-based study in Japan (J-SUPPORT 1902).

IntroductionA growing body of literature has demonstrated that cancer patients have a higher risk of suicide and cardiovascular mortality compared with the general population, especially immediately after a cancer diagnosis. Using data from the National Cancer Registry in Japan launched in January 2016, we will conduct the first nationwide population-based study in Japan to compare incidence of death by suicide, other externally caused injuries (ECIs) and cardiovascular disease following a cancer diagnosis with that of the general population in Japan. We will also aim to identify the patient s

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… Second, our study will explore mortality outcomes alone and we cannot capture nonfatal outcomes, such as suicidal ideation, attempted suicide and non-lethal cardiovascular events. Our findings will represent only a small portion of the psychological burden associated with a cancer diagnosis. …

Guselkumab, an inhibitor of the IL-23p19 subunit, provides sustained improvement in signs and symptoms of active psoriatic arthritis: 1 year results of a phase III randomised study of patients who were biologic-naïve or TNFα inhibitor-experienced.

OBJECTIVE: Evaluation of the efficacy and safety of guselkumab, a human monoclonal antibody targeting the interleukin-23p19 subunit, in patients with psoriatic arthritis (PsA) through 1 year. METHODS: Adults who met ClASsification criteria for Psoriatic ARthritis, with active disease (≥3 swollen and ≥3 tender joints; C reactive protein ≥0.3 mg/dL) despite standard treatment (31% previously received ≤2 tumour necrosis factor inhibitors (TNFi)), were randomised (1:1:1) to guselkumab 100 mg every 4 weeks (Q4W); guselkumab 100 mg at Week0, Week4, then Q8W; or placebo with cross-over to guselkumab

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… Suicidal ideation/behaviour or non-suicidal self-injurious behaviour was documented using electronic Columbia-Suicide Severity Rating Scale (eC-SSRS) Questionnaires, an instrument validated to assess these symptoms in clinical and research settings. 16 Adverse events (AEs) and routine clinical laboratory … ideation/behaviour (per eC-SSRS Questionnaire 16 or reported AEs) and laboratory abnormalities per National Cancer Institute Common Terminology Criteria for AEs (NCI-CTCAE). …

Internet-based guided self-help for glioma patients with depressive symptoms: a randomized controlled trial.

Depressive symptoms are common in glioma patients, and can negatively affect health-related quality of life (HRQOL). We performed a nation-wide randomized controlled trial to evaluate the effects of an online guided self-help intervention for depressive symptoms in adult glioma patients. Glioma patients with depressive symptoms were randomized to a 5-week online course based on problem-solving therapy, or a waiting list control group. After having received the intervention, the glioma patient groups combined were compared with patients with cancer outside the central nervous system (non-CNS ca

Glucagon-like Peptide-1 Receptor Agonists: Exciting Avenues Beyond Weight Loss.

The last two decades have proffered many remarkable choices in managing type 1 and type 2 diabetes mellitus. Leading the list are glucagon-like peptide-1 receptor agonists (GLP1RAs), the first of which, exenatide, was approved by the FDA in 2005. Two other major classes of drugs have also entered the market: dipeptidyl peptidase-4 (DPP-4) inhibitors, commonly known as gliptins and approved in 2006, and sodium-glucose cotransporter-2 (SGLT-2) inhibitors, with the first approval occurring in 2013. These drugs have revolutionized the treatment of diabetes. Additionally, on the horizon, the once-w

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… They studied reports of suicidal ideation, suicidal behavior, suicidal attempts, and completed suicide associated with GLP1A exposure reported to the FDA between 2005 and October 2023; data were obtained from the FDA Adverse Event Reporting System (FAERS). … They concluded that although there was a disproportionate reporting of suicidal ideation and the “depression/suicidal” category with semaglutide and liraglutide, there was no increased reporting of suicidal behavior, suicide attempts, and completed suicide of any of the FDA-approved GLP1As. …

Психиатрические результаты первого two спустя годы после октября 7 - нападения: систематический обзор последствий посттравматического стресса, беспокойства, депрессии и наркомании.

ЦЕЛИ: октябрь 7 :: нападения и последовавшая за ними война создали условия для устойчивой, многоплановой травмы. В настоящем систематическом обзоре обобщаются результаты исследований, проведенных в ходе первого обзора. two годы войны, чтобы прояснить раннее распространение симптомов посттравматического стресса (ПТСС), тревоги, депрессии и связанных с наркоманией последствий среди израильского населения. МЕТОДЫ: ПОСЛЕ ПРИСМА 2020 :: были проведены обыски по ПубМеду, Психиндо, Скопусу и веб-сайту науки с целью выявления исследований, опубликованных в период с октября 7, 2023 и октябрь 7, 2025 (з

Protocol for a randomised controlled feasibility trial of an integrated psychosexual intervention for sexual difficulties in people with Multiple Sclerosis: the PIMS trial.

BACKGROUND: Multiple Sclerosis (MS) is a long-term condition that significantly diminishes quality of life (QoL). Sexual difficulties (SDs) are common, but often overlooked symptom, affecting 50-80% of people with MS (PwMS). The emergence of SDs in MS results from the intricate interplay of disease processes, treatments, and psychosocial factors, contributing to a further decline in QoL and adverse effects on body image, relationships, and psychological well-being. Despite the limited treatment options, which mainly include medications and physiotherapy, there is promise in psychological inter

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… This will also be done if a participant reports suicidal ideation during intervention sessions. Level of risk will be assessed in line with the King’s Health Partners ‘Integrating Mental and Physical healthcare: research, training and services’ (IMPARTS) risk assessment protocol [ 81 ]. … This will include enquiring about degree of suicidal ideation, whether active plans are present, the patient’s history of suicide attempts, recent life stressors, protective factors, and current social support. The risk assessment will be carried out by a trained member of the research team. …

АКНП 60th Ежегодное совещание: выдержки из плакатов P276 - P550.

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… Correlations between altitude and self-reported diagnoses, suicidal ideation, suicide attempt, PHQ-9 score, and PHQ-9 item 9 (suicidal ideation) were estimated using a mixed model with repeated measures a spatial Gaussian covariance structure, with individual sociodemographic variables treated as fixed … Lifetime suicide attempt was significantly correlated with altitude ( p < .0001), although lifetime suicidal ideation was not. …

Понимание депрессии у людей, живущих с множественным склерозом: обзор последних событий в литературе.

Множественный склероз (MS) — хроническое нейродегенеративное и аутоиммунное заболевание, которое затрагивает примерно 1 миллион взрослых людей в США. Психологические расстройства являются типичными коморбидами у людей с MS (PwMS), причем наиболее распространенным явлением является депрессия. Клиническая депрессия в ПТМС может оказать существенное воздействие на качество жизни и фактор, в значительной степени влияющий на состояние лечения. Депрессия может вспыхнуть на ранних стадиях множества, что становится все более распространенным по мере развития болезни и усиления степени клинической инва

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… The global prevalence of suicidal ideation in the MS population has been estimated at 13% [ 69 ], although research on suicidal ideation (thoughts of suicide) in people with MS, may not reflect the true risk/rate of suicide in the MS population. …

Emerging B-Cell Therapies in Systemic Lupus Erythematosus.

Systemic lupus erythematosus (SLE) is a chronic, multisystem, autoimmune disease of unknown etiology, whose hallmark is the production of autoantibodies. B cells are promising targets for novel SLE therapies. In 2011, belimumab (Benlysta®), a fully humanized monoclonal antibody inhibiting B-cell activation and proliferation, was the first medication in 50 years to be approved by the US Food and Drug Administration to treat adult SLE. This review discusses the current experience with B-cell-targeted therapies, including those targeting B-cell-surface antigens (rituximab, ocrelizumab, ofatumumab

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… Up to 16% of the patients in the belimumab trials reported a psychiatric event while on treatment with belimumab. 58 , 59 Over 50% of these patients reported experiencing anxiety or insomnia; 0.1–0.4% of the patients reported suicidal ideation. … In addition, three patients developed severe neuropsychiatric side effects while on belimumab, including one with suicidal ideation and attempt and one with new-onset cerebral vasculitis as evidenced on imaging. …

Risk of Suicide After Cancer Diagnosis in England.

ImportanceA diagnosis of cancer carries a substantial risk of psychological distress. There has not yet been a national population-based study in England of the risk of suicide after cancer diagnosis.ObjectivesTo quantify suicide risk in patients with cancers in England and identify risk factors that may assist in needs-based psychological assessment.Design, setting, and participantsPopulation-based study using data from the National Cancer Registration and Analysis Service in England linked to death certification data of 4 722 099 individuals (22 million person-years at risk). Patients (aged

Навязчивое сексуальное поведение у депрессивных женщин

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… There were ideas of hopelessness, helplessness, and worthlessness, but there were no suicidal ideations with delusions or hallucinations. Her routine blood investigations, thyroid function tests, electroencephalogram, and magnetic resonance imaging brain were normal. …

Systemic Consequences of Inflammatory Bowel Disease Beyond Immune-Mediated Manifestations.

Inflammatory bowel disease (IBD) management traditionally focuses on intestinal inflammation, yet extraintestinal manifestations can substantially impair patient quality of life. In this perspective, we emphasize the broad systemic impact of IBD-from highly prevalent conditions such as anemia, metabolic dysfunction-associated steatotic liver disease, or fatigue to rare but severe complications like interstitial lung disease and drug-induced glomerulonephritis. We review underlying mechanisms linking gut inflammation to distant organs, including immune dysregulation, microbial translocation, an

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… Corticosteroids | Metabolic, Bone, Cardiovascular, Psychiatric, Ocular | Osteoporosis, weight gain, hyperglycaemia, hypertension, mood disturbance, cataracts, suicide ideation, depression and anxiety | Use lowest effective dose and shortest duration; consider bone protection; monitor BP, glucose, mood … Association of inflammatory bowel disease with suicidal ideation, suicide attempts, and suicide: A systematic review and meta-analysis. J. Can. Assoc. Gastroenterol. 2022;5:39–47. doi: 10.1093/jcag/gwab029. 37. Günther C., Rothhammer V., Karow M., Neurath M., Winner B. …

Связанные с сексом различия в болезни Хантингтона: обзор аналитического исследования.

Болезнь Хантингтона (HD) — это аутосомное и доминирующее нейродегенеративное расстройство, и новые данные свидетельствуют о различиях по признаку пола в проявлении и прогрессировании болезни. ЦЕЛЬ: Обобщение текущих данных о связанных с половой принадлежностью различиях в HD в генетических, клинических, биомаркетных и лечебных областях и выявление пробелов в знаниях. МЕТОДЫ: Поиск литературы был проведен в PubMed и Google Study (до 31.01.2026). В рамках соответствующих исследований были изучены гендерные или гендерные различия в отношении лиц с генетически подтвержденным врачом или лиц, подвер

Nicotine receptor partial agonists for smoking cessation.

BACKGROUND: Nicotine receptor partial agonists may help people to stop smoking by a combination of maintaining moderate levels of dopamine to counteract withdrawal symptoms (acting as an agonist) and reducing smoking satisfaction (acting as an antagonist). OBJECTIVES: The primary objective of this review is to assess the efficacy and tolerability of nicotine receptor partial agonists, including cytisine, dianicline and varenicline for smoking cessation. SEARCH METHODS: We searched the Cochrane Tobacco Addiction Group's specialised register for trials, using the terms ('cytisine' or 'Tabex' o

Protective Isolation for Patients with Haematological Malignancies: A Pilot Study Investigating Patients' Distress and Use of Time.

Background: Patients with haematological malignancies are often hospitalized in protective isolation until full neutrophil recovery in order to prevent infections. This descriptive pilot study evaluate the level of isolation-related distress and the use of free time in a sample of Italian onco-haematological patients who were hospitalized in protective isolation. Materials and Methods: Participants were 18 patients hospitalized in hematologic ward to receive induction therapy (n=12) or autologous stem cell transplant (n=6). They completed a self-report questionnaire before discharge. Results:

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… In some cases, patients can suffer from loneliness, depression, anxiety, confusion, feelings of esclusion, which in some case could lead to violence, escape behavior or suicidal ideation. …

Psychosocial distress in young adults surviving hematological malignancies: a pilot study.

PurposeSurvivors of cancer during young adulthood face multiple psychosocial challenges following treatment. This study explores psychosocial distress and unmet needs among young adult survivors treated of hematological malignancies.MethodsA total of 85 young adults aged between 18 and 39 years at time of diagnosis, were invited to join the survey after the completion of treatment with curative intent. Sociodemographic data and the need for advice were gathered with a self-report questionnaire. A set of standardized questionnaires for quality of life (EORTC QLQ-C30), psychosocial stressors (PH

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… Recently, Giberson et al. reported a higher rate of suicidal ideation by AYAs versus older adults (Giberson et al. 2021 ). In the present study, 26% of participants reported experiencing depressive symptoms and 15% moderate or severe anxiety symptoms. … Psychooncology 27:1802–1809. 10.1002/pon.4730 Giberson SA, Hall BC, Jester B, Short VM, Roaten K, de GarzaLaTrivediHowe-Marti NMHL (2021) Suicidal ideation and depression among adolescent and young adult cancer patients. …

Психометрическая оценка шкалы соответствия лекарствам ПРОМИСШ среди пациентов предписывала пероральное противораковое лекарство для множественных миелом.

Лекарства от оральных противораковых заболеваний являются стандартными средствами лечения рака. Соблюдение лекарств влияет на результаты медицинского обслуживания, однако действительные и надежные меры по оценке саморегистрируемого соответствия лекарствам ограничены. Психометрические свойства шкалы соблюдения лекарственных средств ПРОМИСС (PMAS) были оценены у пациентов, которым были предписаны пероральные противораковые препараты для множественных миелом. МЕТОДОЛОГИЯ: Это был вторичный анализ, проведенный в ходе продольного наблюдения, в ходе которого были исследованы соответствие лекарствам,

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… Any indication of suicidal ideation prompted immediate contact with the participant, where team members followed an IRB-protocol for differing scenarios based on suicidal ideation severity. … Average self-reported scale scores were symptom severity = 16.4; depression = 3.4 (no participants at any timepoint reported positive suicidal ideation); cognitive function = 84.7; and comorbidity burden = 5.4. …