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A profile of travelers--an analysis from a large swiss travel clinic.

BACKGROUND: Globally, the Swiss have one of the highest proportions of the population traveling to tropical and subtropical countries. Large … s abroad; 272 (24.9%) stayed longer than 6 months. VFR travelers received the highest percentage of yellow fever vaccinations (523, 30.5%); in contrast, rabies (269, 24.2%) and typhoid vaccinations (279, 25.1%) were given more often to the "other travel reasons" group. CONCLUSIONS: New insights into the characteristics of a selected and large population of Sw …

Canine rangeliosis due to Rangelia vitalii: from first report in Brazil in 1910 to current day - a review.

Canine rangeliosis (popular names: "nambi-uvú", i.e. ``bleeding ears''; "peste de sangue", i.e. ``bleeding plague''; and "febre amarela dos cães", i.e. ``yellow fever of dogs'') is a tick-borne haemolytic and haemorrhagic disease caused by the protozoan parasite Rangelia vitalii which infects erythrocytes, leukocytes, and endothelial cells of blood capillaries. Rangelia vitalii was first reported as a novel piroplasm of dogs in 1910 in Brazil, a discovery that was met with skepticism at that time. Canine rangeliosis has been diagnosed in domestic dogs not only in Brazil but also in other South…

A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.

[7-[3-(1,3-Benzodioxol-5-yl)propyl]-2-(2-furyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] (LZ37) was identified as a selective inhibitor of in vitro bovine viral diarrhea virus (BVDV) replication. The EC(50) values for inhibition of BVDV-induced cytopathic effect (CPE) formation, viral RNA synthesis and production of infectious virus were 4.3+/-0.7microM, 12.9+/-1microM and 5.8+/-0.6microM, respectively. LZ37 proved inactive against the hepatitis C virus and the flavivirus yellow fever. LZ37 inhibits BVDV replication at a time point that coincides with the onset of intracellul…

How do we manage vaccinations in patients with inflammatory bowel disease?

The mortality in inflammatory bowel disease (IBD) has been reported similar or slightly increased as compared to that of the general populat … ressive. The same consideration should be kept in mind for patients travelling to endemic areas for yellow fever. Finally, IBD patients on immunosuppressive may have an altered response to vaccine immunization. Decreased response has been reported for hepatitis B and pneumoccocal vaccination. In those cases, testing for serological responses to vaccine should …

A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase.

We report on the highly potent and selective antipestivirus activity of 5-[(4-bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine (BPIP). … IP was approximately 2,000. BPIP was inactive against the hepatitis C virus subgenomic replicon and yellow fever virus but demonstrated weak activity against GB virus. Drug-resistant mutants were at least 300-fold less susceptible to BPIP than wild-type virus; showed cross-resistance to N-propyl-N-[2-(2H-1,2,4-triazino[5,6-b]indol-3-ylthio)ethyl]-1-propanamine …

Melanogenesis and associated cytotoxic reactions: applications to insect innate immunity.

Insects transmit the causative agents for such debilitating diseases as malaria, lymphatic filariases, sleeping sickness, Chagas' disease, leishmaniasis, river blindness, Dengue, and yellow fever. The persistence of these diseases provides testimony to the genetic capacity of parasites to evolve strategies that ensure their successful development in two genetically diverse host species: insects and mammals. Current efforts to address the problems posed by insect-borne diseases benefit from a growing understanding of insect and mammalian immunity. Of considerable interest are recent genomic inv…

[The geopolitics of tropical diseases: a geo-epidemiological perspective].

The objective of my article is to investigate how the West had strong interest in tropical diseases and developed tropical medicine and hygi … hey failed to occupy the canal because of their inability to control high prevalence of malaria and yellow fever. Taking advantage of 'tropical medicine,' the United States succeeded in taking up the canal by eradicating tropical diseases in the canal. It was owing to the scientific development of tropical hygiene and medicine that the West transformed its pes …

Leptospirosis disease burden estimation and surveillance networking in India.

Although leptospirosis is known to have occurred in India since the early years of the 20th century, no accurate data on disease burden exist. During the past two decades, leptospirosis cases have been reported with increasing frequency from different parts of the country. Several large outbreaks have occurred. In the year 2000, the Indian Council of Medical Research set up a Task Force on Leptospirosis. The Task Force conducted a multicentric study on disease burden due to leptospirosis. As part of the study, 3,682 patients with acute febrile illness, from 13 different centers in India, were

Membrane conductances of principal cells in Malpighian tubules of Aedes aegypti.

Two-electrode voltage clamp (TEVC) methods were used to explore conductive transport pathways in principal cells, the dominant cell type in Malpighian tubules of the yellow fever mosquito. The basolateral membrane of principal cells had a voltage (V(bl)) of -85.1 mV in 49 principal cells under control conditions. Measures of the input resistance R(pc) together with membrane fractional resistance yielded estimates of the conductance of the basolateral membrane (g(bl) = 1.48 &mgr;S) and the apical membrane (g(a) = 3.13 &mgr;S). K(+) channels blocked by barium accounted for 0.94 &mgr;S of g(bl). …

Предварительное использование лекарств и состояние здоровья в качестве факторов риска для лимфомы, не связанной с Ходжкином: предварительные результаты исследования по вопросам контроля в графстве Лос-Анджелес.

Для определения того, связана ли ли ли лимфома не Ходжкина (НХЛ) с ранее использованными лекарствами или с историей состояния здоровья, было проведено тематическое исследование по контролю за состоянием здоровья населения. В общей сложности 619 мужчин и женщин, проживающих в округе Лос-Анджелес, которым был поставлен диагноз НХЛ в период с 1 января 1979 года по 30 июня 1982 года, были сопоставлены с индивидуальными возрастной, расовой и половой принадлежностью мерами контроля в районе в отношении применения 49 различных лекарств, 47 хронических и инфекционных заболеваний или других заболеваний

Совпадение в аннотации оригинала
To determine whether non-Hodgkin's lymphoma (NHL) is related to prior medication use or health history, a population-based case-control stud … nization and allergy to nuts and berries were significantly protective. Subjects who had received a yellow fever immunization also had lower NHL risk. Further analyses of these data will attempt to establish the relative importance of these potential risk factors and to determine whether any are markers of early symptoms of NHL.

Sequence and secondary structure analysis of the 5'-terminal region of flavivirus genome RNA.

The 5'-terminal noncoding region sequences were determined for the genome RNAs of seven strains of St. Louis encephalitis virus (SLEV) and one strain of West Nile virus (WNV) using a single synthetic cDNA primer complementary to the 5'-terminus of the coding region of a strain of WNV RNA. The 5'-terminal sequences obtained for the SLEV and WNV RNAs were compared with published sequences for yellow fever virus (YFV), Murray Valley encephalitis virus (MVEV), and dengue virus. While only short regions within the 5'-noncoding sequence were conserved among different flavivirus RNAs, significant hom…

A deoxyribonucleic acid-replication intermediate in the growing mosquito.

In previous experiments on growth and aging in the yellow-fever mosquito, Aedes aegypti, a low mol. wt. (500000) DNA species was found in the supernatant fraction after ultracentrifugation of homogenates of rapidly-growing larvae. This DNA species, "sDNA", constituted 30-40% of total DNA in 2-4-day-old larvae, but was less than 5% in older larvae, pupae and adults. We have now isolated and characterized sDNA and initiated experiments to determine its metabolic role. Isolated sDNA has the same physical and chemical characteristics as bulk DNA, "pDNA", and differs only in size. In CsCl isopycnic

Mosquito-Borne Arboviruses Occurrence and Distribution in the Last Three Decades in Central Africa: A Systematic Literature Review.

Arboviruses represent a real public health problem globally and in the Central African subregion in particular, which represents a high-risk … led our selection criteria. Of the six arboviruses (dengue virus (DENV), chikungunya virus (CHIKV), yellow fever virus (YFV), Zika virus (ZIKV), Rift Valley fever virus (RVFV), and West Nile virus (WNV)) of public health concern studied, the most frequently reported were chikungunya and dengue. The entomological records showed >248 species of mosquitoes regrou …

An economic evaluation of vector control in the age of a dengue vaccine.

INTRODUCTION: Dengue is a rapidly emerging vector-borne Neglected Tropical Disease, with a 30-fold increase in the number of cases reported … health. If additional benefits for the control of other Aedes borne diseases, such as Chikungunya, yellow fever and Zika fever are taken into account, the investment case is even stronger. High-burden endemic countries should proceed to map populations to be covered by sustained vector control.

Isolation and Genetic Characterization of Mangshi Virus: A Newly Discovered Seadornavirus of the Reoviridae Family Found in Yunnan Province, China.

BACKGROUND: Seadornavirus is a genus of viruses in the family Reoviridae, which consists of Banna virus, Kadipiro virus, and Liao ning virus. Banna virus is considered a potential pathogen for zoonotic diseases. Here, we describe a newly discovered Seadornavirus isolated from mosquitos (Culex tritaeniorhynchus) in Yunnan Province, China, which is related to Banna virus, and referred to as Mangshi virus. METHODS AND RESULTS: The Mangshi virus was isolated by cell culture in Aedes albopictus C6/36 cells, in which it replicated and caused cytopathic effects, but not in mammalian BHK-21 or Vero c

Replication or inactivation of different viruses by human lymphocyte preparations.

Cultures of phytohemagglutinin-stimulated, unstimulated, and frozen and thawed mononuclear (as controls) cells from normal human donors were infected with different viruses. A variable pattern of virus infectivity was noted, and influenza and Coxsackie virus were rapidly inactivated even by stimulated lymphocytes. Direct inactivation by lymphocytes may be one form of host defense in infection by some viruses.

Neurological Manifestations of Zika Virus Infection: An Updated Review of the Existing Literature.

Zika virus (ZIKV) is a neurotropic virus closely linked to other flaviviruses like dengue virus, West Nile virus, yellow fever, and Japanese encephalitis virus. Though initially considered a mild virus, ZIKV gained everybody's attention when the World Health Organization (WHO) declared it a global public health emergency in February 2016. Being considered an important cause of innumerable neurological manifestations and pediatric modality, we aimed to present a comprehensive overview of the neurological details of ZIKV infection. This study reviews the neurological manifestations of ZIKV infec…

Highly specific detection of antibodies to tick-borne encephalitis (TBE) virus in humans using a domain III antigen and a sensitive immune complex (IC) ELISA.

BACKGROUND: In contrast to most antibodies directed to the envelope glycoprotein of flaviviruses, those to the domain III (ED3) show serotyp … the commercial TCV ELISA varied between 30% with samples of people with acute dengue fever or with yellow fever vaccination and 100% with samples of students from Hamburg without any previous contact to TBE. CONCLUSION: Obviously, the IC ELISA is able to detect human antibodies to small antigens with only few serotype-specific epitopes with high specificity …

Ларвалская экология эдеса, комаров и арбовирусных трансмиссий в четырех средних городах на юге Камеруна.

Векторное наблюдение имеет решающее значение для мониторинга таких заболеваний, как денге, чикунгунья, желтая лихорадка и зика. В Камеруне данные о распределении и биономике видов < < Аедес > > в средних городах экваториального лесного региона ограничены. В ходе этого исследования была проведена оценка распределения, местообитаний личинок и биономики незрелых эдесов в четырех средних городах Южного Камеруна. В период с марта 2022 года по март 2023 года в Бертуа, Криби, Сангмелиме и Абонг-Мбанге в сезонах дождей и засухи проводились обследования в Ларвале. Контейнеры для хранения во

Совпадение в аннотации оригинала
Vector-based surveillance is crucial for monitoring arboviral diseases such as dengue, chikungunya, yellow fever, and Zika. In Cameroon, data on the distribution and bionomics of Aedes species in medium-sized cities within the equatorial forest region are limited. This study assessed the distribution, larval habitats, and bionomics of immature Aedes spp. sta…