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Biliary atresia associated with prenatal infection by Listeria monocytogenes.

Recent disorganization of extrahepatic bile ducts was shown in a premature infant dying at 3 hours of age of an intrauterine pneumonia associated with an amniotic infection by Listeria monocytogenes. The alimentary canal was heavily infected with Listeria and listerial abscesses were located in the periportal zones of the liver. An ascending listerial cholangitis was considered to have caused both the abscesses and the disruptive changes in the biliary tract. Heavy infection of the alimentary tract from the amniotic cavity is usual in prenatal listeriosis, and the infection may resolve postnat…

Outcome Analysis of Palliative Endoscopic Biliary Stenting (EBS) for Frail Elderly Patients Aged 80 Years and Above With Choledocholithiasis.

OBJECTIVES: This study aims to retrospectively analyse the outcome of palliative endoscopic biliary stenting (EBS) in very elderly patients … RESULTS: Out of the 11 patients included in the study, six patients (54.44%) experienced recurrent cholangitis, with a median interval of 534 days from the date of index ERCP to the onset of the first recurrence. Two of the six patients (33.33%) who experienced recurrence were able to achieve stone clearance after undergoing repeat ERCP. Among the five patie …

Unveiling the hidden risks of nanomedicine-based drug delivery: a comparative evaluation of drug safety profiles of liposomal irinotecan and conventional irinotecan.

Liposomal irinotecan(Nal-IRI) plays a crucial role as a nanomedicine in cancer treatment. Although it has clinically beneficial properties, … strated stronger signals in the hepatobiliary disorders. We identified new specific AEs of Nal-IRI, cholangitis (ROR = 56.45), enterocolitis (ROR = 41.89), hematotoxicity (ROR = 18.47) and 302 off-label use reports. Meanwhile, Nal-IRI exhibited delayed toxicity, with a prolonged median AE onset time (35 days vs. 27 days for IRI) and fewer early reactions (≤7 …

Bile duct dilatation as a key determinant of technical success and access-related challenges in percutaneous transhepatic biliary drainage: a comprehensive single-center study.

OBJECTIVES: To compare technical success, procedural metrics, and complication patterns of percutaneous transhepatic biliary drainage (PTBD) … however, bleeding complications were more frequent in nondilated ducts (6.6% vs. 1.3%, p = 0.005). Cholangitis predominantly occurred in dilated ducts (6.0% vs. 0.8%, p = 0.019). CONCLUSION: Nondilated ducts pose greater technical difficulty and procedural burden during PTBD, reflected by lower success rates and increased bleeding risk, whereas dilated duct …

Optimal Stenting Strategy During Chemotherapy: Impact of Time to First Reintervention on Survival in Malignant Hilar Biliary Obstruction.

OBJECTIVES: Advances in chemotherapy have increased survival in biliary tract cancer patients, and reports of the effectiveness of neoadjuva … related with overall survival (r = 0.60, p < 0.01). Univariable analyses identified prechemotherapy cholangitis and stenting above the sphincter of Oddi (SO) as factors associated with shorter TTFR, whereas multivariable analysis revealed stenting above the SO as the only independent factor (hazard ratio [HR] 0.44, p = 0.01). Among 52 non-endoscopic sphincter …

Quality of Life in Patients With Variant Syndromes of Autoimmune Liver Diseases-A Cross-Sectional Multicentre Study.

BACKGROUND & AIMS: Primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) go along with reduced health-related quality of life (HRQOL). Variant syndromes, that is, conditions with features of both PBC/PSC and AIH, are associated with higher clinical complexity and worse prognosis. Studies on HRQOL in patients with variant syndromes are lacking. We aimed to provide large-scale evidence addressing this gap. METHODS: We included adult patients with clinical diagnoses of autoimmune liver diseases across nine countries in a cross-sectional study. We …

Continuous vs. interrupted suturing in hepaticojejunostomy: a comprehensive systematic review and meta-analysis.

BACKGROUND: Hepaticojejunostomy (HJ) is a crucial reconstructive step in upper gastrointestinal (UGI), pancreaticoduodenectomy (PD), and Hep … c time and costs, while secondary outcomes included bile leakage, anastomotic stricture, morbidity, cholangitis, hospital stay, and re-exploration rates. A random or fixed-effects model was applied based on heterogeneity. We included randomized controlled trials and non-randomized cohort studies. The risk of bias was assessed using the Cochrane ROB 2 tool, Ne …

Clinical Characteristics of Patients With Ulcerative Colitis and Small Intestinal Malignancy.

BACKGROUND: Prior studies have examined small intestinal dysplasia and cancer in Crohn's disease; however, there is limited information on u … ion and location of disease, prior UC medical treatment or surgery, diagnosis of primary sclerosing cholangitis (PSC), PSC-related complications, and details of cancer or dysplasia. Descriptive statistics were performed. RESULTS: Thirty-five patients (60% male, mean age of diagnosis 39.3 ± 21.5 years old) were identified with UC and subsequent small intestin …

Causal effects of immune cell phenotypes on the risk of autoimmune liver diseases: a bidirectional two-sample Mendelian randomization study.

BACKGROUND: Currently, the relationship between immune cell phenotypes and susceptibility to autoimmune liver diseases (AILDs) remains underexplored. This study aims to investigate potential causal associations between immune cell phenotypes and AILDs using a bioinformatics approach. METHODS: We utilized a two-sample Mendelian randomization (MR) analysis to explore the potential causal relationship between immune cell phenotypes and susceptibility to AILDs, including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC). The data of 731 immune…

Improved Outcomes Following Resection of Perihilar Cholangiocarcinoma: A 27-Year Experience.

BACKGROUND: Resection of perihilar cholangiocarcinoma (pCCA) is associated with significant perioperative morbidity and mortality. We sought … tween cohorts in age, sex, or Bismuth-Corlette classification between the two cohorts. Preoperative cholangitis was less common in the recent cohort (31% vs. 53%, p = 0.03). The proportions of right and left hepatectomies were similar in both cohorts. However, for patients with Bismuth-Corlette types I, II, and IV tumors (n = 35), left hepatectomy was more fr …

Association of bile acid composition with synthetic pathways and efficacy of bezafibrate in cholestatic liver disease.

BACKGROUND/AIMS: Bezafibrate (BZF), a dual peroxisome proliferator-activated receptor/pregnane X receptor agonist, has demonstrated efficacy in combination with ursodeoxycholic acid (UDCA) for primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). Although one of the therapeutic effects of BZF is suppression of bile acid synthesis, its specific impact on bile acid synthesis pathways has not been thoroughly explored. This study investigated bile acid profiles, synthesis intermediates, and their associations with liver biochemistries in patients with PBC and PSC, and evaluat…

Preoperative classification based on intrahepatic bile duct morphology for predicting postoperative complications in congenital biliary dilatation.

BACKGROUND: Late postoperative complications of congenital biliary dilatation include intrahepatic bile duct stones, cholangitis, and cholangiocarcinoma. This study aimed to establish a preoperative classification system using intrahepatic bile duct morphology and evaluate its effectiveness in predicting postoperative complications. METHODS: This retrospective study reviewed 196 patients who underwent radical congenital biliary dilatation surgery between 2003 and 2022. Patients were classified into 3 risk groups based on preoperative cholangiopancreatography findings of intrahepatic bile duct…

Understanding Alcohol Abuse in Deceased Donors: Effects on Liver Transplant Results.

Background/Objectives: Liver transplantation is a life-saving procedure for patients with end-stage liver disease. In recent years, the dema … ease coexisting with HCV, cryptogenic cirrhosis, chronic cholestatic liver disease, primary biliary cholangitis, primary sclerosing cholangitis, metabolic liver disease, hepatocellular carcinoma, and alcoholic hepatitis. We compared the 1-year, 5-year, and 9-year survival rates with those of liver recipients from non-alcohol-consuming donors. Results: In tota …

Причинно-следственная связь метформинового лечения с различными имунизированными подстрекательскими заболеваниями: менделийский анализ случайности.

Метформин, как было установлено, обладает иммуномодилизующим и антивоспалительным воздействием в различных исследованиях животных и клинических исследованиях. Считается, что он является эффективным средством лечения некоторых иммунизированных подстрекательских заболеваний (ИМИД). Вместе с тем продолжается обсуждение вопроса о том, в какой степени метформин может снизить риск разработки ИМНИ. Мы использовали данные, полученные в результате исследований, посвященных общегеномной ассоциации, для изучения причинно-следственной связи между метформином и некоторыми IMID с помощью менделианского анал

Совпадение в аннотации оригинала
Metformin has been shown to possess immune-modulating and anti-inflammatory effects in various animal and clinical studies. It is believed t … = .002), multiple sclerosis (MS) (OR = 0.966, 95% CI: 0.936-0.997, P = .030) and primary sclerosing cholangitis (PSC) (OR = 6.82 × 10-4, 95% CI: 7.83 × 10-6-5.93 × 10-2, P = .001). But metformin treatment is not significantly associated with the risk of Crohn disease (OR = 0.994, 95% CI: 0.979-1.009, P = .431), ulcerative colitis (UC) (OR = 0.987, 95% CI: 0.9 …

Increased Morbidity and One-Year Post-Discharge Mortality in Patients with Bacteremia Undergoing Emergent Cholecystectomy: An Exploratory Retrospective Observational Study.

Background: Gallbladder disease, one of the most common diseases in the United States, ranges from symptomatic gallstones to severe systemic infections from cholangitis. Little research is available on how often patients undergoing emergent cholecystectomy also have bacteremia. We hypothesized that blood cultures would be performed rarely in patients undergoing emergent cholecystectomy, and that positive cultures would be associated with worse outcomes. Methods: Exploratory retrospective observational cohort study of patients admitted to a single institution from January 17, 2011, to December …

Increasing Prevalence and High Survival Rate of Liver Transplanted Patients with NASH and PSC Cirrhosis.

BACKGROUND: Epidemiological studies on liver transplant (LT) patients can provide valuable information about the etiology and trends of cirr … cal records between 2001 and 2018. RESULTS: The MELD scores of LT patients with primary sclerosing cholangitis (PSC), hepatitis B virus (HBV), and non-alcoholic steatohepatitis (NASH) cirrhosis significantly decreased over the study period (P<0.001). Among the LT patients, HBV infection had the highest frequency (21.09%), followed by cryptogenic (17.33%) and …

Obstructive sleep apnea and 19 gastrointestinal diseases: a Mendelian randomization study.

BACKGROUND: Alterations gastrointestinal diseases (GDs) were reported in individuals with obstructive sleep apnea (OSA), however, the genetic background between OSA and GDs is still unclear. METHODS: This investigation employed Mendelian randomization (MR) analyses to evaluate the causal effect between OSA and 19 types of GDs (gastroesophageal reflux disease (GERD), ulcerative colitis, celiac disease, Crohn's disease, chronic gastritis, irritable bowel syndrome, primary biliary cholangitis, diverticular disease, gastroduodenal ulcer, acute pancreatitis, non-alcoholic fatty liver disease, prim…

Natural History and Predictors of Clinical Outcomes in Autoimmune Liver Diseases: A Multicenter Study.

BACKGROUND AND AIM: Prognosis in autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) has historically been poor. This multicenter retrospective cohort study investigated the natural history and assessed the predictors of outcomes in patients with AIH, PBC, and PSC. METHODS: AIH, PBC, and PSC patients were identified from the state-wide Hepascore and Clinical Outcome cohort. Overall death or transplant, liver-related mortality (liver-related death or transplant), and liver-related decompensation were determined using a population-based data l…

Technical success and adverse event rates after endoscopic retrograde cholangiopancreatography using deep sedation with propofol.

BACKGROUND: With the increasing complexity and prolonged duration of endoscopic retrograde cholangiopancreatography (ERCP) procedures, sedat … more often in the propofol group (77 [20%] vs. 38 [11%], P=0.002), due to higher rates of post-ERCP cholangitis (21 [5%] vs. 8 [2%], P=0.039), and post-ERCP pancreatitis (29 [7%] vs. 11 [3%], P=0.014). After adjustment, propofol-based sedation remained significantly associated with technical success and adverse events, with odds ratios of 1.53 (95% confidence …

Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease.

Autoimmune liver diseases are associated with an increased risk of diabetes, yet the underlying mechanisms remain unknown. In this cross-sectional study, we investigated the glucose-regulatory disturbances in patients with autoimmune hepatitis (AIH, n = 19), primary biliary cholangitis (PBC, n = 15), and primary sclerosing cholangitis (PSC, n = 6). Healthy individuals (n = 24) and patients with metabolic dysfunction-associated steatotic liver disease (MASLD, n = 18) were included as controls. Blood samples were collected during a 120-min oral glucose tolerance test. We measured the concentrati…