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Caregiver's quality of life in advanced cancer: validation of the construct in a real-life setting of early palliative care.

IntroductionEarly palliative care (EPC) improves the quality of life (QoL) of advanced cancer patients and their caregivers. The increasingly widespread use of this care model requires the development of measures supporting its interventions. Although the construct of patient's QoL has been extensively investigated and several QoL measures have been further validated, there is a paucity of data concerning the QoL of the caregiver. In 2018, McDonald and colleagues addressed this issue by interviewing 23 primary caregivers of advanced cancer patients who participated in an EPC randomized clinica

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… While, historically, late PC focuses on oncologists or hematologists relieving physical pain at the end of life, EPC also addresses the emotional, social, and spiritual needs of patients over the whole course of the illness through a multidisciplinary team-based approach. … Before, when I didn’t have the opportunity to talk to the oncologists, I felt anxious and full of fear. To me, knowing the truth was fundamental to being able to accept the idea of ​​death. While before I believe that the illusion prevailed. …

Burden of Disease and Cost of Illness of Triple-Negative Breast Cancer in Portugal.

BackgroundTriple-negative breast cancer accounts for 15% of all breast cancer cases, and it has a lower survival rate and higher incidence of early recurrence, particularly during the first 10 years after diagnosis.ObjectiveThis study aimed to estimate the cost and burden of triple-negative breast cancer among the female population in 2019 in Portugal from a societal perspective.MethodsThe prevalence of triple-negative breast cancer was calculated using a cumulative incidence model on the basis of national epidemiological data. The burden of disease was expressed as disability-adjusted life ye

Myeloma Spine and Bone Damage Score (MSBDS) on Whole-Body Computed Tomography (WBCT): Multiple Reader Agreement in a Multicenter Reliability Study.

Objective: To assess the reliability of the myeloma spine and bone damage score (MSBDS) across multiple readers with different levels of expertise and from different institutions. Methods: A reliability exercise, including 104 data sets of static images and complete CT examinations of patients affected by multiple myeloma (MM), was performed. A complementary imaging atlas provided detailed examples of the MSBDS scores, including low-risk and high-risk lesions. A total of 15 readers testing the MSBDS were evaluated. ICC estimates and their 95% confidence intervals were calculated based on mean

Cost analysis of skeletal-related events in Spanish patients with bone metastases from solid tumours.

PurposeTo estimate the cost per skeletal-related event (SRE) in patients with bone metastases secondary to solid tumours in the Spanish healthcare setting.MethodsPatients diagnosed with bone metastases secondary to breast, prostate or lung cancer were included in this multicentre, observational study. SREs are defined as pathologic fracture (vertebral and non-vertebral fracture), radiation to bone, spinal cord compression or surgery to bone. Health resource utilisation associated with these events (inpatient stays, outpatient, emergency room and home health visits, nursing home stays and proce

Darbepoetin alpha in the treatment of cancer chemotherapy-induced anemia.

Anemia is a common, but underestimated and undertreated, complication of patients with cancer receiving chemo- or radiotherapy, and negatively affects their quality of life (QoL). Erythropoietic proteins (EPS) offer an effective treatment of cancer anemia and ameliorate QoL, although their use requires the correct targeting of hemoglobin increase to avoid thromboembolic complications. Currently the effort is focused on offering patients this effective treatment with reduced frequency of administration. Higher weekly single doses of recombinant human Epo (rHuEpo) either alpha or beta, instead o

Building a comprehensive cancer survivorship program.

There is a significant increase in the number of people surviving cancer as a result of improved detection and better treatments. In the United States (US) alone, these numbers are estimated to reach 20 million by 2026 [Miller et al (2016) CA Cancer J Clin 66(4) 271-289)]; [Bluethmann et al (2016) Cancer Epidemiol Biomarkers Prev 25(7) 1029-1036]. Living through cancer treatment represents a life-changing event, often including residual and long-term emotional, physical, psychological and spiritual sequelae. Survivorship programming must encompass the clinical management of medical issues, loc

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… If community oncologists are connected to a larger cancer centre network, such as a satellite or affiliate site, survivorship care can be incorporated within the network, moving towards patient-centred and personalised survivorship care. … PCPs often do not have a complete treatment summary from oncologists, which also limits their ability to monitor side effects from treatment. Table 2 summarises the most common side effects of cancer treatment. …

Patient-reported preferences for oral versus intravenous administration for the treatment of cancer: a review of the literature.

ObjectiveThe emergence of various modes of administration for cancer treatment, including oral administration, brings into focus the importance of patient preference for administration. The purpose of this research was to evaluate the administration preferences of cancer patients, specifically between oral and intravenous (IV) treatment, as well as the factors contributing to preference.MethodsA literature search was conducted in OvidSP to identify research in which the preferences of cancer patients for oral or IV treatment have been evaluated. Data were analyzed in two stages: 1) those artic

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… A survey of 400 oncologists found that while the most commonly reported recommendation for a first-line, single-agent therapy for the treatment of metastatic colorectal was oral therapy (42%), twice as many oncologists reported that their patients would prefer this mode of administration. … Oncologist. 2014;19(2):127–134. doi: 10.1634/theoncologist.2013-0359. 15. Fallowfield L, Stebbing J, Braybrooke J, Langridge C, Jenkins V. The preferences and experiences of different bisphosphonate treatments in women with breast cancer. …

Kidney care in patients with cancer: perspectives from the onconephrology committee of the Brazilian Society of Nephrology.

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… As a result, regular screenings to detect cancer at an early, treatable stage and vigilant monitoring for post-transplant lymphoproliferative disorder (PTLD) and other hematologic malignancies are part of the interplay between nephrologists and oncologists 16 . … The working team includes nephrologists, hematologists, oncologists, a dedicated data manager, and a nursing care coordinator with specialized training in onconephrology. …

Implementing guidelines to prevent cancer associated thrombosis: how can we do better?

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… Martin et al. [ 7 ] reported that none of the high-risk patients received an anticoagulant prescription for prophylaxis and over 90% of surveyed oncologists reported rarely or never performing VTE risk assessment. … Update on guidelines for the management of cancer-associated thrombosis Oncologist 26 2021 e24 e40 33275332 10.1002/onco.13596 PMC7794170 2 Khorana A.A. Mackman N. Falanga A. Pabinger I. Noble S. Ageno W. …

Glioma drug development benefits from emerging phase 0 and window-of-opportunity trial paradigm.

Clinical drug development is fundamentally difficult for rare and difficult-to-treat solid tumors, for example, glioma. Glioblastoma (GBM), an invariably fatal primary brain tumor, poses a significant challenge in the realm of effective treatments, necessitating an accelerated approach to innovative drug discovery. Investigators keep requiring a process toward obtaining more reliable early-stage signals related to drug activity and a process toward translating those signals into clinical benefits efficiently in late-stage drug development. Besides, these processes could increase the likelihood

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… Notably, the neurological oncologist plays a pivotal role in the study design, patient accrual, and surgical phases [ 98 ]. … Furthermore, the neurosurgical oncologists should envisage the impact of data biases and tumor heterogeneity. …

Advancing Palliative Care Integration in Hematology: Building Upon Existing Evidence.

Opinion statementPatients with hematologic malignancies and their families are among the most distressed of all those with cancer. Despite high palliative care-related needs, the integration of palliative care in hematology is underdeveloped. The evidence is clear that the way forward includes standard-of-care PC integration into routine hematologic malignancy care to improve patient and caregiver outcomes. As the PC needs for patients with blood cancer vary significantly by disease, a disease-specific PC integration strategy is needed, allowing for serious illness care interventions to be ind

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… While PC is sometimes provided by oncologists or other members of the cancer care team, referred to as “primary PC,” our use of the term refers to specialty PC services, or those provided by specialized clinicians on an interdisciplinary team. … Hematologic malignancy specialists are less likely than solid tumor oncologists to request specialty PC consultation [ 4 , 41 – 43 ]. Many also equate PC to end-of-life care and may not recognize the demonstrated benefits of early PC [ 44 – 46 ]. …

Cancer Patients' Experiences with Telehealth before and during the COVID-19 Pandemic in British Columbia.

BackgroundPatients have had their cancer care either postponed or changed to telehealth visits to reduce exposure to COVID-19. However, it is unclear how these changes may have affected their experiences. We aim to identify patient characteristics that affect telehealth experiences and evaluate their preferences for using telehealth in the future.MethodsPatients who completed the Outpatient Cancer Care (OCC) Patient Experience Survey were invited to participate. They comepleted the modified OCC Survey, which focused on telehealth during the pandemic. Linear and logistic regression analyses wer

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… Patients reported having video visits with their regular oncologists ( n = 90, 41%) or another oncologist ( n = 36, 17%) before the pandemic ( Supplementary Figure S1b ). … First, the higher proportion of virtual oncology visits may be a result of a BC pilot project launched in 2018 to deliver follow-up cancer care virtually by oncologists [ 35 ]. …

Diagnosis and Management of Oncologic Emergencies.

Oncologic emergencies may be seen in any emergency department and will become more frequent as our population ages and more patients receive chemotherapy. Life-saving interventions are available for certain oncologic emergencies if the diagnosis is made in a timely fashion. In this article we will cover neutropenic fever, tumor lysis syndrome, hypercalcemia of malignancy, and hyperviscosity syndrome. After reading this article the reader should be much more confident in the diagnosis, evaluation, and management of these oncologic emergencies.

Important learning points for setting up a dental-oncology service in Ireland.

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… Establishment of secured, structured pathways to ensure preventative dental care access has been shown to satisfy not only patients but oncologists, and community dental services [ 53 ]. … Oncologist 20(5):523–31 41. Rajbhoj AN, Rajbhoj AA (2025) Dental Oncology: A Pressing Necessity for Comprehensive Cancer Care. Asian Pac J Cancer Prev 26(9):3125–6 42. …

Burnout and job satisfaction among hematologists: A cross-sectional study.

Burnout and job satisfaction represent significant challenges among healthcare professionals, especially within high-stress specialties such as hematology. Despite the demanding nature of the field, burnout and job satisfaction among hematologists remain underexplored. This study aimed to evaluate the levels of burnout and job satisfaction in this population and to investigate their associations with sociodemographic variables. This cross-sectional study included 139 hematologists practicing in Turkey. Participants completed a sociodemographic questionnaire, Maslach Burnout Inventory and Job S

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… Burnout in US hematologists and oncologists: impact of compensation models and advanced practice provider support. Blood Adv. 2023;7:3058–68. [2] Nitzsche A, Neumann M, Groß SE, et al. … Recovery opportunities, work-home conflict and emotional exhaustion among hematologists and oncologists in private practice. Psychol Health Med. 2017;22:462–73. [3] Petruzzelli D, Vignetti M, Trasarti S, et al. …

Family caregiver roles and challenges in assisting patients with cancer treatment decision-making: Analysis of data from a national survey.

BackgroundWe aimed to describe the roles and challenges of family caregivers involved in patients' cancer treatment decision-making.MethodsFamily caregiver-reported data were analyzed from a national survey conducted in the United States by CancerCare® (2/2021-7/2021). Four select-all-that-apply caregiver roles were explored: (1) observer (patient as primary decision-maker); (2) primary decision-maker; (3) shared decision-maker with patient and (4) decision delegated to healthcare team. Roles were compared across five treatment decisions: where to get treatment, the treatment plan, second opin

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… End‐of‐Life care and advanced directives in Hispanic/Latinx patients: challenges and solutions for the practicing oncologist . Oncologist . 2022 ; 27 ( 12 ): 1074 ‐ 1080 . 10.1093/oncolo/oyac211 36288534 PMC10259759 20 Molokwu JC , Penaranda E , Shokar N . … Triadic treatment decision‐making in advanced cancer: a pilot study of the roles and perceptions of patients, caregivers, and oncologists . Supp Care Cancer . 2018 ; 26 ( 4 ): 1197 ‐ 1205 . 10.1007/s00520-017-3942-y 29101469 …

Assessment of Bone Health Awareness and Education in Breast Cancer Patients with Bone Metastasis in the USA.

Bone metastases are common in advanced breast cancer (BC) patients and increase the risk for skeletal-related events (SREs), which present a significant health and economic burden. Bone targeting agents (BTAs) can improve health-related quality of life by delaying or preventing SREs; nevertheless, a significant portion of eligible BC patients are not receiving this therapy. A bone health education needs assessment survey was conducted to examine cancer-related bone health awareness and to identify opportunities to improve bone health education. Direct-to-patient outreach was used to recruit ad

Silent Conversations: Goals of Care and End-of-Life Quality in Relapsed High-Risk Leukemia.

BackgroundAdvanced practice providers (APPs) affect high-quality health care through leadership, evidence-based practice implementation, and quality improvement projects. When planning solutions to clinical problems, leadership must solicit APP input to promote success. Hematology patients are more likely to receive poor-quality end-of-life (EOL) care than those with solid tumors. Regardless of disease, aggressive EOL care is increasing despite evidence that it is often inconsistent with patients' goals of care (GOC). Data regarding this phenomenon in hematology specifically is lacking. The di

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… Kitta and colleagues (2021) similarly note the “silent” transition from curative to palliative treatment with their qualitative findings surrounding patients’ perceptions of EOL discussions with medical oncologists. … Impact of oncologists’ attitudes toward end-of-life care on patients’ access to palliative care. The Oncologist, 21(9), 1149–1155. 10.1634/theoncologist.2016-0090 Hui, D., Didwaniya, N., Vidal, M., Shin, S. H., Chisholm, G., Roquemore, J., & Bruera, E. (2014). …

Oral Side Effects in Patients with Metastatic Renal Cell Carcinoma Receiving the Antiangiogenic Agent Pazopanib-Report of Three Cases.

Pazopanib is a potent multi-kinase inhibitor that hinders angiogenesis and blocks tumor growth. It has been approved for the treatment of metastatic renal cell carcinoma (mRCC) and advanced soft tissue sarcoma. There is emerging evidence that bleeding is a common adverse effect of pazopanib and other targeted therapies in patients with mRCC. In addition, jaw osteonecrosis related to pazopanib was recently described in the literature. We report three cases of patients with mRCC who developed adverse oral events related to pazopanib. The first patient, treated with pazopanib as monotherapy, pres

Decoding the Role of Companions in Supporting the Health Communication of Older African-American Men With Cancer.

The objective of this study was to systematically characterize the content and patterning of companion's communicative behavior during oncology consultations for older African-American male patients. Companions and family members often play an important role in patient-centered communication for patients with cancer. Despite their disproportionate cancer burden, little is known about how companions facilitate patient-provider communication for older African-American men with cancer. This study represents a secondary qualitative analysis of 14 video-recorded doctor patient-companion medical vis

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… This study also included global ratings of the oncologists’ behavior and the medical visit dynamics as captured by trained observers ( 5 ). … These clarifying statements also co-occurred 16 times when companions were responding to the oncologist’s questions (even when directed primarily at the patient). …