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Gendered socioeconomic impacts of emerging infectious diseases: Insights from a mixed-methods study in Guinea.

This study examines the gendered socioeconomic impacts of infectious disease outbreaks, including both epidemics (e.g., yellow fever, Ebola, Marburg and Mpox) and pandemics (e.g., COVID-19), on populations in Guinea, using data from the Decentralize and Operationalize One Health Platforms (DOPERAUS) project. A mixed-methods approach combined quantitative survey data (N = 906) from participants aged 18 and over and qualitative data from an open-ended questionnaire answered by 508 respondents to capture both measurable outcomes and nuanced experiences. Sampling accounted for gender, age, and vul…

Antibodies elicited by a chimeric peritrophin antigen reduce Aedes aegypti survival after blood feeding.

Vector-borne diseases transmitted by Aedes aegypti, including dengue, Zika, chikungunya, and yellow fever, represent a persistent and expanding global health threat. Limitations of conventional vector control strategies, such as insecticide use and environmental source reduction, particularly in urban settings, underscore the need for novel and complementary tools. Anti-vector vaccination offers one such strategy by inducing host-derived antibodies that are ingested during vector feeding and interfere with vector physiology or survival. Although this concept has been successfully explored in s…

Энтомовирологическое исследование фрагментов городских лесов и внутридомиц во время вспышки денге в Салинасе, МГ, Бразилия.

КОЛИЧЕСТВО: Москито (Diptera: Culicidae) относятся к числу наиболее важных переносчиков болезней во всем мире. Несколько видов имеют высокий уровень антрополии и часто встречаются в жилищах людей и осколки лесов вблизи городских районов. ЦЕЛИ: В этом комплексном исследовании, сочетающем сбор комаров, обнаружение вирусов и экологический анализ, в ходе вспышки денге в городе Салинас, Минас-Жерайс, Бразилия, были исследованы дневные комары в трех различных средах - внутридомица и два отдельных осколки городских лесов.МЕТОДЫ: Пробы комаров были испытаны на наличие вирусов денге, зика и чикунгунья

Совпадение в аннотации оригинала
BACKGROUND: Mosquitoes (Diptera: Culicidae) are among the most important disease vectors worldwide. Several species exhibit high levels of a … s, and Coquillettidia venezuelensis, associated with the transmission of dengue, oropouche, mayaro, yellow fever, and Venezuelan equine encephalitis viruses. Entomological and virological investigations in urban and peri-urban environments are crucial, as these areas provide shelter and refuge for anthropophilic and opportunistic mosquito species. Our findings …

Vaccine-Induced Immunity in Children and Adolescents After Chemotherapy for Acute Lymphoblastic Leukemia: A Systematic Review.

BACKGROUND: Acute lymphoblastic leukemia is the most prevalent childhood cancer and the leading cause of cancer mortality before the age of … yelitis, Haemophilus influenzae type b, measles, mumps, rubella, influenza, varicella-zoster virus, yellow fever, pneumococcal, and meningococcal diseases in children and adolescents treated for acute lymphoblastic leukemia after completion of chemotherapy. RESULTS: A total of twenty-four studies published between 1981 and 2023 were included, comprising 1110 …

Novo plant-based mosquito repellent shows promise for exclusion of Aedes mosquitoes from "window" entry.

Mosquitoes threaten over half of the world's population through vectored diseases such as malaria, zika, yellow fever, dengue, and chikungunya. Mosquitoes have a highly developed olfactory system attuned to chemotaxis relating to host-seeking, mating, and oviposition behavior. In this study, we aimed to determine the spatial efficacy of 2 plant-based repellent blends (Blend3 and Blend4 that had previously been found to successfully repel Aedes, Anopheles and Culex mosquitoes in wind tunnel assays) in excluding Aedes aegypti from the window entry. A new cage system was developed for parallel "n…

Phytochemistry, Mode of Action Predictions, and Synergistic Potential of Hypenia irregularis Essential Oil Mixtures for Controlling Aedes aegypti.

Aedes aegypti, also known as the yellow fever mosquito, presents a major public health challenge, highlighting the need for effective biorational agents for mosquito control. Here, we investigated the synergistic effects of essential oil mixtures derived from Hypenia irregularis that is a mint-family shrub native to Brazil's Cerrado biome, known as "alecrim do Cerrado", in combination with essential oils from noni (Morinda citrifolia), Brazilian mint ("salva-do-Marajó", Hyptis crenata), and lemongrass (Cymbopogon citratus) against Ae. aegypti. We conducted phytochemical analyses and assessed l…

[Identification of Culex quinquefasciatus Highlights the Need for Strengthened Vector Mosquito Surveillance in the Republic of Korea].

OBJECTIVES: We investigated the presence of subtropical mosquito vectors that may become established in the Republic of Korea (ROK) owing to … quito-borne viruses, including the Japanese encephalitis, West Nile, Zika, Dengue, Chikungunya, and Yellow fever viruses. RESULTS: Cx. quinquefasciatus is morphologically very similar to the Cx. pipiens complex, making it difficult to distinguish based on external characteristics. In addition, the cytochrome c oxidase subunit I marker alone was insufficient f …

Characterisation of clinical response and transcriptional profiling of proliferating CD8 T cells in the blood of cancer patients after PD-1 monotherapy or combination therapy.

OBJECTIVE: Immune checkpoint inhibitors (ICI) that block the programmed cell death 1 (PD-1) pathway have shown promise with limited benefit. … nal analysis of CD8 T cells after the first treatment cycle with effector cells generated following yellow fever virus (YFV-17D) vaccine-induced infection was also compared. RESULTS: An early proliferative (Ki-67+) CD8 T-cell response was observed after cycle 1 in 60 patients (58.3%). Patients with early-and-sustained proliferative responses (cycle 1 and beyo …

Detection of anti-premembrane antibody as a specific marker of four flavivirus serocomplexes and its application to serosurveillance in endemic regions.

In the past few decades, several emerging/re-emerging mosquito-borne flaviviruses have resulted in disease outbreaks of public health concer … ith flaviviruses from four serocomplexes, including dengue (DENV), Zika (ZIKV), West Nile (WNV) and yellow fever (YFV) viruses, and explore its application for serosurveillance in flavivirus-endemic countries. We employed Western blot analysis including antigens of six flaviviruses (DENV1, 2 and 4, WNV, ZIKV and YFV) from four serocomplexes. We tested serum sa …

FEN1-aided recombinase polymerase amplification (FARPA) for one-pot and multiplex detection of nucleic acids with an ultra-high specificity and sensitivity.

Recombinase polymerase amplification (RPA) running at 37-42 °C is fast, efficient and less-implemented; however, the existing technologies o … , and the 4-plex assay for the screening of arboviruses (zika virus, tick-borne encephalitis virus, yellow fever virus, and chikungunya virus). We have validated multiplex FARPA with 103 nasopharyngeal swabs for SARS-CoV-2 detection. The results showed a 100% agreement with RT-qPCR assays. Moreover, a hand-held FARPA analyser was constructed for the visualized …

Larval Diet Abundance Influences Size and Composition of the Midgut Microbiota of Aedes aegypti Mosquitoes.

The midgut microbiota of the yellow fever mosquito Aedes aegypti impacts pathogen susceptibility and transmission by this important vector species. However, factors influencing the composition and size of the microbiome in mosquitoes are poorly understood. We investigated the impact of larval diet abundance during development on the composition and size of the larval and adult microbiota by rearing Aedes aegypti under four larval food regimens, ranging from nutrient deprivation to nutrient excess. We assessed the persistent impacts of larval diet availability on the microbiota of the larval br…

Impact of the COVID-19 pandemic on routine childhood immunisation in Colombia.

OBJECTIVE: To assess the impact of the COVID-19 pandemic on routine childhood vaccination coverage in Colombia by age group, rural/urban res … rence, 19.2%; 95% CI 14.8% to 23.7%). For children aged 12-23 months, the proportion vaccinated for yellow fever declined by 16.4% (12.4% to 20.9%) from 78.3% in 2019 to 61.8% in 2020. Among children 5 years of age, the biggest decrease occurred for the oral polio vaccine (second dose), with a difference of 11.4% (7.1% to 15.7%) between 2019 and 2020 (73.1% an …

Characterization of Symptoms after Radical Prostatectomy and Their Relation to Postoperative Complications.

PURPOSE: Many patients will experience symptoms in the initial days after radical prostatectomy (RP), but early patient-reported symptoms have not been well characterized. Our objective was to illustrate the pattern of symptoms experienced after RP and the relation of severe symptoms to postoperative complications. MATERIALS AND METHODS: In 2016, electronic patient-reported symptom monitoring began at our institution's ambulatory surgery center. We retrospectively reviewed patients treated with minimally invasive RP who were sent a daily questionnaire completed using a web interface until pos

The host range restriction of bat-associated no-known-vector flaviviruses occurs post-entry.

Most flaviviruses are transmitted horizontally between vertebrate hosts by haematophagous arthropods. Others exhibit host ranges restricted … eated by inserting the pre-membrane and envelope protein genes of RBV into the genetic backbones of yellow fever virus (YFV) and Zika virus (ZIKV), two mosquito-borne flaviviruses associated with human disease. The chimeric viruses infected both vertebrate and mosquito cells. In vertebrate cells, all viruses produced similar mean peak titres, but the chimeric …

Effects of methylmercury on mosquito oviposition behavior: Maladaptive response to non-toxic exposure.

Animals can modulate their own exposure to environmental contaminants through behavioral plasticity such as diet and habitat choice. However, it remains unclear if behavior also has cascading effects on contaminant exposure across multiple generations. In insects, oviposition site selection is an important behavior females can use to modify offspring contaminant exposure risk. In this study, we use the yellow fever mosquito, Aedes aegypti, to test how methylmercury (MeHg) affects oviposition site selection. We found that mosquito larval development rate and survival were negatively affected at…

Low Zika virus seroprevalence among pregnant women in North Central Nigeria, 2016.

BACKGROUND: Zika virus (ZIKV) has been known for decades in Africa but contemporary data is lacking at large. OBJECTIVES: To describe the s … revalence ratio 3.49; 95% confidence interval: 1.48-8.25; p = .004). No association with pregnancy, yellow fever vaccination or malaria was found for anti-ZIKV IgM or IgG positivity. ZIKV neutralizing antibodies were detected in 17/18 (94%) anti-ZIKV NS1 positive/borderline samples and in one sample without detectable ZIKV NS1 antibodies. Partial ZIKV E gene s …

Incomplete childhood immunization with new and old vaccines and associated factors: BRISA birth cohort, São Luís, Maranhão State, Northeast Brazil.

This study estimated the percentages of incomplete immunization with new vaccines and old vaccines and associated factors in children 13 to … B, human rotavirus, polio, tetravalent (diphtheria, tetanus, pertussis, Haemophilus influenzae b), yellow fever, and triple viral (measles, mumps, rubella). The study used hierarchical modeling and Poisson regression with robust variance. Prevalence ratios (PR) and 95% confidence intervals (95%CI) were calculated. Incomplete immunization was higher with new v …

Simultaneous isolation of Chryseobacterium gleum from bloodstream and respiratory tract: first case report from India.

Introduction. Species of the genus Chryseobacterium are emerging healthcare-associated pathogens, often colonizing the hospital environment. There are no clear guidelines available for antimicrobial susceptibility of this organism. In this report we present the first case, to our knowledge, of simultaneous central-line-associated bloodstream infection (CLABSI) and ventilator-associated pneumonia (VAP) due to Chryseobacterium gleum from India. Case presentation. A 62 years old man with a history of a road traffic accident 1 month previously was referred to our center for further management. He

Zika Virus Antagonizes Type I Interferon Responses during Infection of Human Dendritic Cells.

Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that is causally linked to severe neonatal birth defects, including microcephaly, and is associated with Guillain-Barre syndrome in adults. Dendritic cells (DCs) are an important cell type during infection by multiple mosquito-borne flaviviruses, including dengue virus, West Nile virus, Japanese encephalitis virus, and yellow fever virus. Despite this, the interplay between ZIKV and DCs remains poorly defined. Here, we found human DCs supported productive infection by a contemporary Puerto Rican isolate with considerable variability in…

The neurotranscriptome of the Aedes aegypti mosquito.

BACKGROUND: A complete genome sequence and the advent of genome editing open up non-traditional model organisms to mechanistic genetic studies. The mosquito Aedes aegypti is an important vector of infectious diseases such as dengue, chikungunya, and yellow fever and has a large and complex genome, which has slowed annotation efforts. We used comprehensive transcriptomic analysis of adult gene expression to improve the genome annotation and to provide a detailed tissue-specific catalogue of neural gene expression at different adult behavioral states. RESULTS: We carried out deep RNA sequencing…