Результаты поиска

Cross-Cultural Validation of the COmprehensive Score for Financial Toxicity (COST) Measure in an Australian Sample.

IntroductionThe COmprehensive Score for Financial Toxicity (COST) measure developed in the United States measures the financial impact resulting from cancer and its treatment. This paper reports on an Australian cross-cultural validation of the COST measure.MethodsParticipant eligibility criteria included individuals aged ≥ 18, undergoing or completed primary treatment for cancer. Immediate family members of patients were also eligible for Phase 1. Face and content validity were assessed through concurrent interviews and a brief survey (Phase 1). The subsequent revised version of COST was fiel

Использование схемы действий для адаптации с целью адаптации основанных на фактических данных мер по охране сексуального здоровья для молодых людей, пострадавших от травм.

Детей, сталкивающихся с проблемами в домашнем хозяйстве (т.е. потребление психоактивных веществ родителями, тюремное заключение и психические заболевания), относятся к группам, наиболее подверженным сексуальному риску в подростковом возрасте. Такое поведение связано с целым рядом негативных последствий на более позднем этапе жизни, включая злоупотребление наркотическими веществами, низкий уровень образования и тюремное заключение. Одной из стратегий удовлетворения потребностей этой группы населения является адаптация основанных на фактических данных мероприятий (ИВР).МЕТОДЫ: В настоящем исслед

The dual balance of the cytokine network: key messengers of immune activation and triggers of cytokine storm.

The cytokine network is the central regulatory system for intercellular communication within the immune system. Its proper function depends on the dynamic balance between pro-inflammatory and anti-inflammatory cytokines. Through complex positive and negative feedback loops, this balance precisely regulates the intensity and duration of immune responses, thereby playing a critical role in both physiological and pathological states. This review systematically summarizes the compositional features and classification framework of the cytokine network, as well as the mechanisms by which it maintain

The innate defenders: a review of natural killer cell immunotherapies in cancer.

Cancer is a condition that has been with us for centuries; however, the therapies that have been developed are often associated with significant toxicity and various side effects. Recent advances in immunology have revealed the potential of the immune system to fight cancer, leading to the emergence of immunotherapy. This review focuses on Natural Killer (NK) cells, innate immune effectors with a remarkable ability to directly kill cancer cells. We will explore the historical context of cancer treatment, the nature of NK cells, and the ways they have been developed to enhance their anti-tumor

Bispecific antibodies in the treatment of multiple myeloma.

The treatment paradigm in myeloma is constantly changing. Upfront use of monoclonal antibodies like daratumumab along with proteasome inhibitors (PI)s, and immune modulators (IMiD)s have significantly improved survival and outcomes, but also cause unique challenges at the time of relapse. Engaging immune T cells for tumour cell kill with chimeric antigenic T-cell (CAR T-cell) therapy and bispecific antibodies have become important therapeutic options in relapsed multiple myeloma. Bispecific antibodies are dual antigen targeting constructs that engage the T cells to plasma cells through various

Совпадение в полном тексте источника
… Davis RS Ehrhardt GR Leu CM Hirano M Cooper MD An extended family of Fc receptor relatives Eur J Immunol 2005 35 674 80 10.1002/eji.200425886 15688344 Davis RS, Ehrhardt GR, Leu CM, Hirano M, Cooper MD. An extended family of Fc receptor relatives. …

37th International Symposium on Intensive Care and Emergency Medicine (part 2 of 3) : Brussels, Belgium. 21-24 March 2017

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Tumour Cell Size Control and Its Impact on Tumour Cell Function.

Cell size is an important component of cell morphological characteristics. It reflects the characteristics of the cell type, nutritional status, growth stage and physiological function. The cell size of cells of the same type tends to be homogeneous and stable. However, in tumour cells, mutations in cell cycle genes and cytoskeletal genes and overexpression of the corresponding signalling pathways often lead to large variations in tumour cell size. Tumour cells regulate cell size and growth and proliferation through multiple signalling pathways, such as PI3K/Akt/mTOR, Myc and Hippo pathways, w

Implementation of Virtual Integrative Oncology Shared Medical Appointment Series (VIOSMAS) Within Mixed Diagnosis Population.

BackgroundIntegrative oncology [IO] is sought-after by patients, endorsed by clinical guidelines, and valued within National Cancer Institute Centers. Shared Medical Appointments [SMA] leverage health education and social connection to deliver enhanced patient experience, population health, cost-reduction, and clinician well-being. Integrative Oncology Shared Medical Appointments increase access to integrative medicine but delivering these services via telehealth have not been evaluated.ObjectiveWe created, and pilot tested a Virtual Integrative Oncology Shared Medical Appointment Series (VIOS

Clinical decision support in hematological malignancies using a case-grounded AI agent.

Multidisciplinary tumor boards integrate longitudinal treatment histories, molecular profiling and rapidly evolving evidence to guide decisions in hematological malignancies, yet access to this level of subspecialty deliberation is increasingly uneven. Here we develop HemaGuide, a locally deployable, modular large language model agent that converts unstructured clinical documents into structured case representations, autonomously routes cases to specialized decision modes ('guideline', 'advanced' and 'molecular') and grounds recommendations in disease-specific guideline flowcharts and a clinic

Recurrent plasmacytomas after allografting in a patient with multiple myeloma.

Extramedullary recurrence in multiple myeloma patients has been reported after both autologous and allogeneic hematopoietic cell transplantation and, more recently, after treatment with so-called new drugs with potent antimyeloma activity. Only a very few sizable reports focused on its clinical presentation and its incidence, which may be highly underestimated, and most observations are based on single patients reported from several institutions. Given the unusual sites of recurrence, diagnosis may be rather difficult and delayed treatment may play a relevant role in prognosis. Here we report

Сверхурочные проблемы с диагностикой и лечением у двух педиатрических пациентов с обширным церебральным церебральным церебральным стечением, иллюстрирующие множественный склероз типа Baló.

Концентрический склероз Бало выделяется как редкая форма множественного склероза, в котором имеются большие повреждения, подобные опухоли, которые напоминают опухоли мозга и создают значительные диагностические и терапевтические препятствия для педиатрических пациентов. КИСЛОТЫ: Мы представляем два тематических исследования педиатрических пациентов в возрасте 11 и 15 лет, у которых диагностирован обширный церебральный тюпфективный провокационный поражение, указывающий на множественный склероз (MS) типа Balo. В обоих случаях подчеркиваются уникальные проблемы, с которыми приходится сталкиваться

Clinical context and communication in shared decision-making about major surgery: Findings from a qualitative study with colorectal, orthopaedic and cardiac patients.

Increasing numbers of older people undergo major surgery in the United Kingdom (UK), with many at high risk of complications due to age, co-morbidities or frailty. This article reports on a study of such patients and their clinicians engaged in shared decision-making. Shared decision-making is a collaborative approach that seeks to value and centre patients' preferences, potentially addressing asymmetries of knowledge and power between clinicians and patients by countering medical authority with greater patient empowerment. We studied shared decision-making practices in the context of major su

A Clinical Genetics-Driven Dual Diagnosis of Prader-Willi Syndrome Due to Mosaic Maternal UPD(15) and NOTCH3-Related CADASIL.

Maternal uniparental disomy of chromosome 15 [UPD(15)mat] and imprinting defects account for about 30% of cases of Prader-Willi syndrome (PWS). Mosaic UPD(15)mat is rare and may escape routine testing. We describe a 45-year-old male patient in whom persistent clinical suspicion of PWS was not genetically confirmed by repeated methylation-based analyses. Clinical manifestations included neonatal hypotonia with low birth weight, early hyperphagia, severe obesity, short stature, growth hormone deficiency, type 2 diabetes mellitus, dyslipidemia, and MASLD/MASH with compensated cirrhosis. He presen

Abstracts from the ISSAID 2021 Periodic Congress : Virtual. May - Dec 2021

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Management of Potential Organ Donor: Indian Society of Critical Care Medicine-Position Statement.

This position statement is documented based on the input from all contributing coauthors from the Indian Society of Critical Care Medicine (ISCCM), following a comprehensive literature review and summary of current scientific evidence. Its objective is to provide the standard perspective for the management of potential organ/tissue donors after brain death (BD) in adults only, regardless of the availability of technology. This document should only be used for guidance only and is not a substitute for proper clinical decision making in particular circumstances of any case. Endorsement by the IS

Effects of Parkinson's disease on survival in cancer survivors: a retrospective, multicentre cohort study in Japan.

Aging populations and advances in medical care have contributed to an increase in the number of patients with Parkinson's disease and cancer survivors. However, the effects of Parkinson's disease on the survival of patients with cancer remain unclear. We aimed to investigate the effect of Parkinson's disease on the prognosis of patients with cancer. This retrospective multicentre cohort study used data from the Osaka Cancer Registry, which was linked to administrative data obtained between 2010 and 2015 in Japan. Patients with cancer who were followed up for 5 years after cancer diagnosis were

Modification of belantamab mafodotin dosing to balance efficacy and tolerability in the DREAMM-7 and DREAMM-8 trials.

AbstractBelantamab mafodotin (belamaf) combined with standard therapies demonstrated significant progression-free survival (PFS) and overall survival benefits in DREAMM-7 and PFS benefit in DREAMM-8 in relapsed/refractory multiple myeloma. Belamaf dose modifications managed adverse events, including belamaf-related ocular events. Ocular events included ocular adverse reactions (eg, dry eyes, photophobia, eye irritation) and protocol-mandated ophthalmic examination findings. Protocol-recommended dose modifications for ocular events were driven by ophthalmic examination findings and included bel

Биотипные антитела в гематологовых злодеях: атакуют фронтлайн.

С тех пор, как Блинатумомаб утвердился в качестве первого биконкретного антитела (BsAb) в лечении рака, эти иммунодуляторные агенты добились значительного успеха в лимфоидных малигнатах. Через десять лет после предварительного одобрения в рентгеновских условиях блинатумомаб стал частью первой линии индуктивной терапии для пациентов с острой лимфоболической лейкемией (B-ALL). Теперь, six Кроме того, БСАБ имеют разрешение УЛХ на обработку лимфомы В-клеток, не относящихся к Ходжкину, и множественной миеломы (ММ), что позволяет добиться высоких показателей ответов в других сценариях. В лимфоме, эп

Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers.

Cellular senescence, a stress-induced, irreversible cell cycle arrest coupled with a proinflammatory secretory phenotype, has emerged as both a central driver of aging and a tractable therapeutic target. Although acute senescence contributes beneficially to tumor suppression and wound healing, chronic accumulation of senescent cells sustains systemic inflammaging and accelerates organ dysfunction. This review synthesizes current progress in aging biology into a unified mechanistic and translational framework. We first examine how primary aging hallmarks, such as genomic instability and epigene

Потенциал для восстановления адамантских антивирусов COVID-19.

Несколько адамантанов приняли меры против коронавирусов. Амантадин, дивантадин, бананин и структурно связанные мемантины эффективны против человеческого дыхательного коронавируса HCoV-OC43Коронавирус говядины и острый острый респираторный синдром 1 (В тыс.SARS-CoV-1) и спиродановый амин эффективен против штамма коронавируса 229E. Исследования молекулярной стыковки показывают, что амантадин может блокировать вирусный канал белка Е, что приводит к нарушению распространения вируса. Кроме того, аналогии амантадина могут препятствовать проникновению вируса в камеру, повышая pH эндосомы и тем самым