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A national portfolio of bone oncology trials-The Canadian experience in 2012.

BackgroundThe impact of both cancer and its treatment on bone is an essential component of oncological practice. Bone oncology not only affects patients with both early stage and metastatic disease but also covers the entire spectrum of tumour types. We therefore decided to review and summarise bone oncology-related trials that are currently being conducted in Canada.MethodWe assessed ongoing and recently completed trials in Canada. We used available North American and Canadian cancer trial websites and also contacted known investigators in this field for their input.ResultsTwenty seven clinic

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… These can include such diverse groups as; medical oncologists, radiation oncologists, surgical oncologists, palliative care specialists, endocrinologists, nursing, orthopaedics, basic scientists, imaging and primary care providers, to name but a few. … BONUS 5: 5th Annual Bone and The Oncologist New Updates. Current Oncology. 2010;17(4):113–118. 41. Hilton J.F., Amir E., Hopkins S., Nabavi M., DiPrimio G., Sheikh A. Acquisition of metastatic tissue from patients with bone metastases from breast cancer. …

Disparities in care of older adults of color with cancer: A narrative review.

This review describes the barriers and challenges faced by older adults of color with cancer and highlights methods to improve their overall care. In the next decade, cancer incidence rates are expected to increase in the United States for people aged ≥65 years. A large proportion will be older adults of color who often have worse outcomes than older White patients. Many issues contribute to racial disparities in older adults, including biological factors and social determinants of health (SDOH) related to healthcare access, socioeconomic concerns, systemic racism, mistrust, and the neighborho

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… How does older age influence oncologists' cancer management? Oncologist. 2010;15(6):584‐592. 23. Klepin HD, Estey E, Kadia T. More versus less therapy for older adults with acute myeloid leukemia: new perspectives on an old debate. Am Soc Clin Oncol Educ Book. 2019;39:421‐432. 24. … The use of validated geriatric assessment instruments among U.S. community oncologists. J Clin Oncol. 2020;38(29_suppl):129. 117. Mohile SG, Magnuson A, Pandya C, et al. Community oncologists' decision‐making for treatment of older patients with cancer. …

Fertility Preservation in Female Patients with Cancer. Part I: Challenges and Future Prospects in Developing Countries; A Narrative Review Study.

While international guidelines on oncofertility practice have been published in developed countries, there is limited information available on oncofertility practice in developing countries, which often face limitations in their cancer health support networks. As survival rates improve in the field of cancer and other diseases, there is a growing need for stronger oncofertility services in developing countries. Given that 50% of cancer patients are under the age of 65, many of these patients are of reproductive age and preserving their fertility health prior to starting treatment is valuable.

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… Furthermore, it is strongly recommended to conduct multidisciplinary meetings involving gynecologic oncologists, infertility specialists, and other relevant services ( 8 ). Chemotherapy Chemotherapy is effective in treating cancer and improving survival rates. … Given the intricacy of FP for female patients, oncologists and hematologists should devote extra time to address fertility matters with women who are still menstruating. …

Building Trust in a Newly Established Physician-Patient Relationship: A Scoping Review.

BackgroundTrust is a fundamental component of the physician-patient relationship, influencing cooperation, adherence, and patient outcomes. While much research has focused on long-term relationships, little is known about the factors that shape trust during the very first physician-patient encounter.ObjectiveThe aim of this study was to assess the factors contributing to the development of patients' trust in a newly established physician-patient relationship.Search strategyWe conducted a scoping review and applied thematic analysis to synthesise findings from identified studies. PubMed databas

Use of Complementary Traditional Chinese Medicines by Adult Cancer Patients in Taiwan: A Nationwide Population-Based Study.

BACKGROUND: Many patients with cancer seek complementary and alternative medicine treatments. We investigated the use of traditional Chinese medicine (TCM) by adult cancer patients in Taiwan. METHODS: We reviewed the Registry for Catastrophic Illness Patients Database of Taiwan, and included all adult patients diagnosed cancer, based on the International Classification of Diseases (ninth revision), from 2001 to 2009 and followed until 2011. This database allowed categorization of patients as TCM users (n = 74 620) or non-TCM users (n = 508 179). All demographic and clinical claims data were a

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… A previous study reported that 70% of oncologists from the United States agreed to combine CAM with conventional treatments for curable disease, but only 48% of oncologists from China and Taiwan agreed. 47 Although cancer patients in China and Taiwan have used CAM therapies, such as TCM, for centuries … , there is limited communication about TCM usage among patients, TCM practitioners, and oncologists. …

Patient perspectives on considerations, tradeoffs, and experiences with multiple myeloma treatment selection: a qualitative descriptive study.

BACKGROUND: Advances in multiple myeloma treatment and a proliferation of treatment options have resulted in improved survival rates and periods of symptom-free remission for many multiple myeloma patients. As a result, health-related quality of life (HRQoL) concerns related to myeloma treatments have become increasingly salient for this patient population and represent an important consideration guiding patients' treatment choices. To gain an understanding of patients' experiences with choosing myeloma therapies and explore the HRQoL concerns that are most important to them, we interviewed a

How we manage medication-related osteonecrosis of the jaw.

Bone-modifying agents (BMAs) are integral to managing patients with advanced cancer. They improve quality of survival by reducing skeletal-related events, treating hypercalcaemia and chemotherapy-induced bone loss (Coleman in Clin Cancer Res 12: 6243s-6249s, 2006), (Coleman in Ann Oncol 31: 1650-1663, 2020). Two decades ago, medication-related osteonecrosis of the jaw (MRONJ) was first reported following BMA therapy (Marx in J Oral Maxillofac Surg 61: 1115-1117, 2003). The risk of MRONJ extends over a decade following BMA treatment with bisphosphonates, complicating dental care such as extract

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… The purpose of this review is to provide practical guidance for oncologists prescribing BMAs, and to emphasise the need for further integration of dental oncology into cancer care. … This document was produced by an expert panel of oncologist based on 10 randomised control trials. …

Balancing Quality, Cost, and Access During Delivery of Newer Cellular and Immunotherapy Treatments.

Purpose of reviewThe chimeric antigen receptor (CAR) T-cell therapy is currently changing the landscape of hematologic malignancies with multiple FDA-approved cell therapy products in the USA. The current administration process of the CAR T-cell therapy is complicated, labor-intensive, and expensive.Recent findingsThe chimeric antigen receptor (CAR) T-cell therapy is currently changing the landscape of hematologic malignancies with multiple FDA-approved cell therapy products in the USA. The current administration process of the CAR T-cell therapy is complicated, labor-intensive, and expensive.

Participation of older newly-diagnosed cancer patients in an observational prospective pilot study: an example of recruitment and retention.

BackgroundThere have been few prospective observational studies which recruited older newly-diagnosed cancer patients, and of these only some have reported information on the number needed to screen to recruit their study sample, and the number and reasons for refusal and drop-out. This paper reports on strategies to recruit older newly-diagnosed cancer patients prior to treatment into an observational prospective pilot study and to retain them during a six-month period.MethodsMedical charts of all patients in the Segal Cancer Centre aged 65 and over were screened and evaluated for inclusion.

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… The Segal Cancer Centre includes surgeons, medical oncologists, haematologists, radiation oncologists and pulmonary oncologists involved in patient's cancer treatments. … Barriers to clinical trial participation as perceived by oncologists and patients. J Natl Compr Canc Netw. 2007;5:655–664. doi: 10.6004/jnccn.2007.0067. Kemeny MM, Peterson BL, Kornblith AB, Muss HB, Wheeler J, Levine E. et al. …

Time's up: the urgency to investigate time toxicity in patients with genitourinary malignancies.

Patients with genitourinary (GU) malignancies have seen the development of multiple life-prolonging treatments in the past decade. As patients and clinicians consider their treatment options along the cancer journey, time spent with healthcare contact, or "time toxicity," has emerged as a new outcome measure that comprehensively considers time receiving cancer care, including planned visits for evaluation and treatment as well as unplanned urgent care addressing complications. Despite its rising study across cancer populations, there has been a surprising lack of work evaluating time toxicity

Comparing the Influence of Surgical and Conservative Therapy on Quality of Life in Patients with Early-Stage Medication-Related Osteonecrosis of the Jaw-A Prospective Longitudinal Study.

Background and Objectives: The purpose of this study was to evaluate the impact of surgical and conservative, non-surgical treatment on general health-related (QoL) and oral health-related quality of life (OHRQoL) in patients suffering from AAOMS stage I MRONJ. Materials and Methods: In the course of this prospective clinical study, QoL and OHRQoL using QLQ-C30 and QHIP G14 questionnaire were longitudinally assessed in N = 174 prospectively enrolled patients with indication of treatment of MRONJ stage I over a period of 12 months. Patients received conservative or surgical treatment. The measu

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… The decisions on this were always made by the treating oncologists. It must be emphasized that we therefore had no influence on this. 2.4. … In all cases, it had previously been initialized by the attending oncologist or osteologist. Consequently, we were not involved in the decision. …

Integration of Chronic Oncology Services in Noncommunicable Disease Clinic in Rural Rwanda.

BackgroundIn rural sub-Saharan Africa, access to care for severe non-communicable diseases (NCDs) is limited due to myriad delivery challenges. We describe the implementation, patient characteristics, and retention rate of an integrated NCD clinic inclusive of cancer services at a district hospital in rural Rwanda.MethodsIn 2006, the Rwandan Ministry of Health at Rwinkwavu District Hospital (RDH) and Partners In Health established an integrated NCD clinic focused on nurse-led care of severe NCDs, within a single delivery platform. Implementation modifications were made in 2011 to include cance

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… Regarding mentorship, the limited availability of oncologists in-country does create a need for ongoing clinical guidance from oncologists outside of Rwanda. … Access to technical support on a near daily basis is critical to provide quality care in a task-shifted approach that largely depends on non-oncologists. …

Discharge or admit? Emergency department management of incidental pulmonary embolism in patients with cancer: a retrospective study.

BackgroundHospitalization and early anticoagulation therapy remain standard care for patients who present to the emergency department (ED) with pulmonary embolism (PE). For PEs discovered incidentally, however, optimal therapeutic strategies are less clear-and all the more so when the patient has cancer, which is associated with a hypercoagulable state that exacerbates the threat of PE.MethodsWe conducted a retrospective review of a historical cohort of patients with cancer and incidental PE who were referred for assessment to the ED in an institution whose standard of care is outpatient treat

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… In most cases, ED physicians function independently of oncologists regarding initial management, treatment, and disposition of patients with incidental PE, although the oncologists and other specialists are available for consultation. … Discharged patients were given an outpatient appointment with internal medicine or their oncologist for follow-up, typically within 1 week. Email communication about the patient’s ED visit was sent to his or her oncologist. …

Conference report: Introducing oncology to undergraduate medical and allied health sciences students: reflections from 2nd ecancer TMC Oncology Congress 2023 at Kolkata, India.

Despite the high cancer burden in low-middle-income-countries, medical students often have inadequate exposure to oncology. This may contribute to reduced interest in pursuing training in the field. The second ecancer TMC Oncology Congress at Kolkata on 30th September and 1st October 2023 was planned primarily to introduce undergraduate medical and allied health science students to oncology. There were separate sessions on breast cancer, thyroid cancer, myeloma and research methods so that students get exposure to a wide range of topics. Multi-disciplinary case-based discussions on common clin

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… Various nuances of management of these patients were discussed with panelists consisting of breast surgeons, medical oncologists, radiologists, radiation oncologists and palliative care experts. … The faculty felt the interaction was meaningful as relayed by senior oncologists of the country ( Video 2 and 3 ). …

Complex Regional Pain Syndrome in Cancer Cases: Current Knowledge and Perspectives.

BACKGROUND: Complex regional pain syndrome (CRPS) is a disabling painful disorder caused by many different and poorly understood mechanisms. It often affects the distal limbs and usually happens as consequence of a trauma. Its severity can remarkably affect patients' quality of life. When this painful complication happens in a cancer patient, the impact may be exponential. To date, there is limited knowledge of the surrounding circumstances of CRPS cases in this population. METHODS: We present two clinical cases of patients diagnosed with cancer-related pain presenting with symptoms and signs

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… CRPS is typically diagnosed by non-oncologists (eg, orthopedists, rheumatologists, physiatrists, pain physicians). … How well do medical oncologists manage chronic cancer pain? A national survey. Oncologist . 2015;20(2):202–209. doi: 10.1634/theoncologist.2014-0276 38. Iolascon G, Moretti A. Pharmacotherapeutic options for complex regional pain syndrome. …

Current and future roles of biosimilars in oncology practice.

Biologics have been used increasingly in the treatment and supportive care of cancer; however, their high cost places a significant burden on healthcare systems. The expiration of patents for biologics has led to the development of biosimilars, with the aim of reducing cost and increasing accessibility to novel treatments, which are affordable for a greater number of patients. Biosimilars are highly similar but not identical to the reference products; therefore, strict regulatory requirements have been formed for their approval. This ensures that there are no clinically meaningful differences

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… As reported by Cook et al ( 12 ) only 26% of oncologists can explain what a biosimilar is, whereas another study demonstrated that only 21% of prescribers are familiar with the concept of biosimilars ( 13 ). … Oncologist. 2018;23:1261–1265. doi: 10.1634/theoncologist.2018-0066. 28. Greenwald M, Tesser J, Sewell KL. Biosimilars have arrived: Rituximab. Arthritis. 2018;2018:3762864. doi: 10.1155/2018/3762864. 29. European Generic medicines Association, corp-author. …

Psychological care of caregivers, nurses and physicians: a study of a new approach.

There is much evidence demonstrating that psychosocial interventions in caregivers and oncological staff produce an improvement in their patients' quality of life. The aim of this explorative study was to evaluate the effect of a new approach in promoting more functional ways to face stressful situations in the constellation of people around patients: caregivers, physicians and nurses. Thirty-four subjects were divided into three groups: 10 caregivers, 11 physicians, and 13 nurses. A "Balint Group" method modified according to a mindfulness technique was used as the intervention. Three assessm

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… Oncologists and nurses deal with existential questions of life and death daily, which are always difficult issues to face and manage. … It has been demonstrated that medical oncologists are more prone to experience symptoms of depression than other internal medicine physicians and this phenomenon can be observed even during their training 15 – 17 . …

Clinical Posters From JADPRO Live 2024

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Quality of Life Evaluation in Patients with Follicular Cell Lymphoma: A Real-World Study in Europe and the United States.

INTRODUCTION: Follicular lymphoma (FL) is an indolent subtype of non-Hodgkin's lymphoma (NHL), characterized by a long natural course of remissions/relapses. We aimed to evaluate real-world quality of life (QoL) in patients with FL, by line of therapy (LOT), and across countries. METHODS: Data were drawn from the Adelphi FL Disease Specific Programme™, a cross-sectional survey of physicians and their patients in Europe [France, Germany, Italy, Spain, the United Kingdom (UK)], and the United States (US) from June 2021 to January 2022. Patients provided demographics and patient-reported outcome

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… Physicians were eligible to participate in this survey if they were medical oncologists, hematologists, or hem-oncologists. … Physician and Patient Sample Populations A total of 251 oncologists/hematologists/hem-oncologists completed PRFs for 1478 eligible patients. A total of 401 patients completed a PSC and were included in the analyses. …

2019 ASCO Annual Meeting: Takeaways for Advanced Practitioners.

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… Also notable at the Annual Meeting was the research presented by community oncologists, which highlights the critical contributions of those individuals. As you know, over half of our patients are cared for in the community setting. … Community oncologists presented over 60 studies, demonstrating the growing role of these individuals in clinical research across multiple cancer types. …