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The German Twin Registry (GERTRUD): Towards Harmonized, Multisource Twin Research.

Twin registries worldwide increasingly function as large-scale Исследование infrastructures, enabling standardized phenotyping across the lifespan, integration of biological and environmental data streams, and international cross-cohort collaborative Исследование and replications. This development is also taking place in Germany. The GERman Twin Registry Under Development (GERTRUD; www.gertrud.info) was established in 2022 as the first nationwide Исследование platform for recruiting twins and higher order multiples of all ages within Germany to support the large-scale genetically informative psychological…

[Research on auditory neurofeedback technology and its multi-disciplinary applications].

Auditory neurofeedback (ANF) utilizes sound to map brain activity in real-time, guiding individuals to self-regulate neural states via operant conditioning. Compared to visual neurofeedback, ANF offers distinct advantages in millisecond-level response speed and non-visual dependency, significantly enhancing ecological validity and reducing visual fatigue. This paper reviews the physiological basis, signal processing workflows, and three typical experimental paradigms of ANF: threshold regulation, parameter modulation, and state-dependent triggering. Furthermore, it discusses current applicatio

Self-citation in nursing Исследование: Patterns, outliers, and empirical thresholds.

BACKGROUND: Self-citation plays a dual role in scientific communication: it may reflect legitimate scholarly continuity, but excessive self-referencing can distort citation-based metrics used in Исследование evaluation. As citation indicators increasingly influence faculty promotion, institutional benchmarking, and the global visibility of nursing schools, understanding typical self-citation patterns within nursing has become important. PURPOSE: To examine the distribution of self-citation among highly cited nursing Исследованиеers and to establish empirical thresholds for identifying unusually high …

Incorporating context and co-occurring internal processes into psychophysiological Исследование.

The field of psychophysiology is characterized by its use of rigorous methodological approaches to understand exchanges between the human body and its surrounding environment. However, a majority of the Исследование to date has focused on the use of single psychophysiological measures for processes of interest within lab-based settings. We present a conceptual paper where we draw expertise from two complementary disciplines, psychology and anthropology, to discuss key opportunities and challenges. We argue for the consideration of context and co-occurring internal processes into psychophysiologica…

Research progress and application prospect of engineered small extracellular vesicles.

Extracellular vesicles (Evs) act as a natural intercellular message transmitter, Evs can carry proteins, ribonucleic acid (RNA) and other bioactive substances, and have rich biological regulatory functions. Because of its low immunogenicity and high biocompatibility, it has become a popular Исследование object in drug delivery. These remarkable properties also create new opportunities for modern therapy. However, due to the complex preparation process, there are challenges in terms of targeting accuracy, load release controllability, and pharmacokinetic optimization, and many problems may be encou…

Grounding psychosis Исследование: why observable signs should anchor biological investigations.

Biological psychiatry faces a significant epistemic challenge in identifying valid objects for mechanistic Исследование. Both diagnostic constructs and individual symptoms are abstract symbols defined circularly within a closed hermeneutic system, creating a symbol grounding problem that hinders the discovery of biophysical substrates (biomarkers). I argue that progress requires an epistemological separation between the ungrounded symptoms such as delusions and hallucinations, which are co-constructed through personal and clinical interpretation from grounded signs that are directly observable fea…

Disinfection and sterilization: Current issues, new Исследование, and new technology.

BACKGROUND: Disinfection and sterilization play a pivotal role in protecting patients from health care-associated infections. Numerous studies have highlighted the significant role of environmental surfaces and reusable medical devices (eg, endoscopes) in the transmission of health care pathogens. METHODS: We searched published literature for articles that will appreciably improve the disinfection and sterilization knowledge base and practices. RESULTS: The increased emphasis on infection from environmental surfaces and reusable medical devices has driven Исследование and innovations in disinfec…

Framing social policy preferences: A scoping review and Исследование agenda.

This article reviews over 160 studies that use survey experiments to analyze how framing affects citizens' social policy preferences. In doi … depend on characteristics of the frames, receivers, senders, and context. However, because existing Исследование has predominantly focused on the characteristics of frame receivers, significant gaps remain in our understanding of how framing effects are shaped by other contingency factors. Most importantly, few studies have examined how these factors interact …

Research on Tin Bath Bottom Bricks for Float Glass Furnaces.

The bottom brick is a critical component of float glass furnace tin baths, serving under harsh conditions including high temperature, tin penetration, hydrogen diffusion and alkali attack. Traditional flint clay-based bottom bricks suffer from high porosity and insufficient service performance. In this study, a high-performance low-cement castable was developed by introducing mullite aggregates to partially replace flint clay. The effects of mullite particle size and addition content on sintering behavior, mechanical properties, thermal shock resistance, refractoriness under load and hydrogen

Global Trends in Phenylketonuria Treatment Research, 2000-2025: Bibliometric Analysis.

BACKGROUND: Phenylketonuria (PKU) is the most common inborn error of amino acid metabolism, and if untreated, leads to severe neurocognitive impairment. Over the past 2 decades, treatment strategies have evolved from strict dietary phenylalanine restriction to include pharmacological therapies such as tetrahydrobiopterin and, more recently, enzyme substitution with pegvaliase. Despite these advances, significant heterogeneity exists in global Исследование priorities, collaboration patterns, and the translation of emerging therapies into clinical practice. A systematic overview of the field's devel…

[Research progress in inducible expression regulation systems in photosynthetic cyanobacteria].

Cyanobacteria, as a group of prokaryotic photosynthetic microorganisms, have recently garnered widespread attention in the fields of synthetic biology and green biomanufacturing due to their ability to utilize light energy and carbon dioxide for autotrophic growth. The development of efficient and controllable gene expression regulation systems is a crucial step for achieving precise control over cyanobacterial metabolic engineering and efficient production of heterologous compounds. This review summarizes recent advances in inducible gene expression regulation systems developed for cyanobacte

Focus on DnaJ protein Исследование from Arabidopsis to crop improvement.

DnaJ proteins (Hsp40s) are essential components of the cellular proteostasis network, functioning as molecular co-chaperones that regulate protein folding, stability, and stress-responsive homeostasis in plants. Beyond their classical role as Hsp70 partners, accumulating evidence demonstrates that DnaJ proteins participate in diverse biological processes by integrating proteostasis with hormonal, developmental, and defense signaling pathways. This review synthesizes recent advances in the structural diversity, evolutionary distribution, and functional specialization of DnaJ proteins across mod

Chloroflexota in agricultural soils: current knowledge and future Исследование directions.

The review organizes current knowledge on the biofunctions, life-history strategies, and environmental responses of Chloroflexota in agricul … However, most Chloroflexota remain uncultured, and available genomic data are still limited. Future Исследование integrating high-resolution taxonomic profiling, metagenomics, and cultivation-based approaches is needed to clarify the ecological roles and life-history strategies of Chloroflexota members. Such advances may ultimately establish this phylum as an …

Emerging therapeutic pipelines on kidney fibrosis: challenges in translational Исследование.

BACKGROUND: Chronic kidney disease (CKD) is estimated that by 2040, it will be the 5th highest cause of years of life lost globally due to t … rogression and improving patient outcomes. CONCLUSIONS: Despite the encouraging results, additional Исследование is necessary to fully assess the protective roles of these treatments in various clinical contexts. This review aims to synthesize the available data and current insights into this important issue.

Cancer treatment-related cardiotoxicity, molecular mechanism, challenges, and Исследование trends.

Cancer treatment-related cardiotoxicity (CTRC) encompasses a spectrum of cardiovascular complications associated with chemotherapy, targeted therapy, and radiotherapy. This review synthesizes recent mechanistic insights to delineate distinct pathological pathways: anthracyclines provoke oxidative mitochondrial damage and disrupt cardiomyocyte iron homeostasis; HER2-targeted therapies inhibit the PI3K-Akt survival pathway, compromising contractile function and calcium regulation; tyrosine kinase inhibitors impair VEGF and PDGF signaling, inducing endothelial dysfunction and microvascular rarefa

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… Collectively, these features offer clinicians and Исследованиеers an updated, mechanism-based, and clinically actionable roadmap that complements—rather than overlaps with—existing publications. … Future trends and Исследование prospects The evolving landscape of cancer therapy demands equally advanced strategies to manage cardiotoxicity. …

Bundibugyo virus disease evidence map: a rapid Исследование needs appraisal.

BACKGROUND: The 2026 Bundibugyo virus disease (BVD) outbreak in DRC and Uganda underscores that filoviruses remain an unpredictable global health threat, particularly in resource-limited settings. The sporadic occurrence of outbreaks has constrained evidence-generation. We implemented a Rapid Research Needs Appraisal (RRNA) to rapidly and systematically synthesise published Исследование evidence and identify gaps in the evidence base to support management and Исследование strategies. METHODS: We searched Ovid Medline, Embase and Scopus for primary Исследование studies published between Jan 1, 1999, and F…

SUDEP update 2026: recent advances in experimental and clinical Исследование.

PURPOSE OF REVIEW: This review summarizes experimental and clinical Исследование advances in the field of sudden unexpected death in epilepsy (SUDEP) over the past 3 years. RECENT FINDINGS: Novel animal models of SUDEP have been developed, highlighting the prevalence of peri-ictal respiratory dysfunction.The circumstances of SUDEP in genetic developmental and epileptic encephalopathies were found similar to those reported in more common epilepsies. Accordingly, most caregivers of patients with Dravet syndrome report using nocturnal monitoring devices and having averted critical incidents through …