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[Analysis of related factors of carbapenem resistant Klebsiella pneumoniae infection in patients with artificial airway].

OBJECTIVE: To analyze the clinical characteristics and related influencing factors of carbapenem resistant Klebsiella pneumoniae (CRKP) in patients with artificial airway and mechanical ventilation in intensive care unit (ICU), and provide theoretical basis for clinical prevention of Klebsiella pneumoniae infection. METHODS: The clinical data of patients with pulmonary infection of Klebsiella pneumoniae in ICU of Beijing Shijitan Hospital Affiliated to Capital Medical University from January 2016 to December 2019 were collected. Compared CRKP pneumonia patients (study group) with carbapenem a…

Preoperative Wilms tumor rupture in children.

PURPOSE: According to the guidelines of International Society of Pediatric Oncology (SIOP) and National Wilms Tumor Study (NWTS), Wilms tumor with preoperative rupture should be classified as at least stage III. Few clinical reports can be found about preoperative Wilms tumor rupture. The purpose of this study was to investigate our experience on the diagnosis, treatment and prognosis of preoperative Wilms tumor rupture. METHODS: Patients with Wilms tumor who underwent treatment according to the NWTS or SIOP protocol from January 2008 to September 2017 in Beijing Children's Hospital were revi…

[Comparison of different bone age assessment methods in 5 573 children aged 3-18 years].

Objective: To compare the differences among Tanner-Whitehouse 3 (TW3), the standards of skeletal maturity of hand and wrist for Chinese-China 05 (China 05), and the standards of skeletal maturity of hand and wrist for Chinese-CHN (CHN) in the practical application of bone age (BA) assessment. Methods: A cross-sectional study was conducted to investigate 6 013 children aged 3-18 years in Tongzhou District, Beijing, from September 2022 to July 2023. Basic information was collected via self-designed questionnaires; physical development indicators such as height and weight were measured on-site; a…

Development and validation of a deep learning model to predict visual and anatomical prognosis of anti-VEGF therapy for neovascular age-related macular degeneration (KongMing Study): a prospective, nationwide, multicentre study.

BACKGROUND: The financial burden and the uncertain response of the anti-vascular endothelial growth factor (anti-VEGF) treatment often cause … Universities, Peking Union Medical College, National High-Level Hospital Clinical Research Funding, Beijing Students' Funding for Innovation and Entrepreneurship Training Program, Guangdong Basic and Applied Basic Research Foundation, Guangdong Provincial Key Laboratory.

Effects of Bifidobacterium bifidum tetragonum tablets and Jin Gui Ren Qi Pill on intestinal flora and metabolism in patients with diabetic kidney disease.

OBJECTIVE: To investigate the effects of Bifidobacterium bifidum tetragonum tablets and Jin Gui Ren Qi Pill on intestinal flora and metaboli … values of tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), and interleukin-6 (IL-6) using the Beijing Biolite ELISA kit. This study was conducted with the approval of the Ethics Committee of Changzhi Medical College. RESULTS: 1. The 2hPBG, total cholesterol and LDL levels were observed among patients with diabetic kidney disease (DKD) across all gr …

Evaluation of proximod, a selective agonist of sphingosine-1-phosphate receptor-1, in healthy volunteers and patients with rheumatoid arthritis: a phase 1, double-blind, randomised, placebo-controlled, ascending dose trial.

BACKGROUND: Proximod is a selective agonist of sphingosine-1-phosphate receptor-1 (S1PR1). It acts by redirecting lymphocytes from the circu … oid arthritis treatment, warranting further investigation in subsequent clinical studies. FUNDING: Beijing Union Pharmaceutical Factory and Jian Kuan (Suzhou) Biotechnology.

[Timing of permanent tooth emergence and its association with physical growth among children aged from four to seven years in nine cities of China].

Objective: To investigate the timing of permanent tooth emergence and its association with physical growth among children aged 4-7 years in 9 cities of China, and to analyze the trend of permanent teeth development. Methods: According to a stratified cluster sampling design, a cross-sectional survey on the timing of permanent tooth emergence children aged 4-7 years was carried out in 9 cities (Beijing, Harbin and Xi'an in northern China; Shanghai, Nanjing and Wuhan in central China; Guangzhou, Fuzhou and Kunming in southern China) from June to October in 2015. A total of 37 973 children (19 03…

Role of Sirt3 in mitochondrial biogenesis and developmental competence of human in vitro matured oocytes.

STUDY QUESTION: Does Sirt3 dysfunction result in poor developmental outcomes for human oocytes after in vitro maturation (IVM)? SUMMARY ANS … 2014CB943203), the National Natural Science Foundation of General Program (31371521 and 81571400), Beijing Nova Program (xxjh2015011), and Specialized Research Fund for the Doctoral Program of Higher Education (20120001130008) and the National Natural Science Foundation of Young Scholar (31501201). The authors have declared that no conflict of interest e …

Initial CT features and dynamic evolution of early-stage patients with COVID-19.

OBJECTIVE: To explore the initial CT features and dynamic evolution of early-stage patients with Coronavirus disease 2019 (COVID-19). METHODS: A total of 126 COVID-19 patients in the early stage were enrolled. The initial CT features and dynamic evolution characteristics of the progression and absorption process from the stage of admission to discharge were retrospectively analyzed in this study. RESULTS: The main initial CT features were as follows: bilateral distribution (112/126, 88.9%), diffuse distribution (106/126, 84.1%), multiple lesions (117/126, 92.9%), nodular shapes (84/126, 66.7

Clinical and imaging features of COVID-19.

Since December 2019, multiple cases of 2019 coronavirus disease (COVID-19) have been reported in Wuhan in China's Hubei Province, a disease which has subsequently spread rapidly across the entire country. Highly infectious, COVID-19 has numerous transmission channels and humans are highly susceptible to infection. The main clinical symptoms of COVID-19 are fever, fatigue, and a dry cough. Laboratory examination in the early stage of the disease shows a normal or decreased white blood cell count, and a decreased lymphocyte count. While CT examination serves as the screening and diagnostic basis

Imaging manifestations and pathological analysis of severe pneumonia caused by human infected avian influenza (H7N9).

OBJECTIVE: To investigate the imaging and pathological findings of severe pneumonia caused by human infected avian influenza (H7N9), and therefore to further understand and improve diagnostic accuracy of severe pneumonia caused by human infected avian influenza (H7N9). METHODS: The relevant clinical and imaging data of 19 cases, including 10 males and 9 females, with pneumonia caused by human infected avian influenza (H7N9) was retrospectively analyzed. One of the cases had received percutaneous lung biopsy, with the clinical, imaging and pathological changes possible to be analyzed. RESULTS

Chest imaging of H7N9 subtype of human avian influenza.

BACKGROUND: Human infection with avian influenza A H7N9 virus is an acute respiratory infectious disease, which usually causes severe pneumonia with a high mortality. Chest radiographs and Computed Tomography (CT) are principal radiological modalities to assess the lung abnormalities. OBJECTIVES: The goal of this study was to investigate the chest images characteristic of H7N9 subtype of human avian influenza. MATERIALS AND METHODS: The clinical and imaging data of 11 cases diagnosed as H7N9 subtype of human avian influenza were collected from 4 cities in the southern region of the Yangtze R

[Epidemiological investigation of 169 inpatients with high-voltage electrical burns on the wrist].

Objective: To analyze the epidemiological characteristics of inpatients with high-voltage electrical burns on the wrist in Beijing Jishuitan Hospital (hereinafter referred to as the author's unit), so as to provide reference for the prevention and treatment of high-voltage electrical burns on the wrist. Methods: The medical records of inpatients suffered from high-voltage electrical burns on the wrist in the author's unit from January 2008 to December 2019 were collected. The patients' gender, age, population category, injury situation, injury season, total burn area, electrical burn type on t…

Performance and label efficiency of traditional deep-learning models and a retina-specific foundation model for ocular and systemic disease detection: a retrospective comparative study.

BACKGROUND: RETFound, a self-supervised retina-specific foundation model, has shown potential in downstream tasks, but its performance in co … Each model was also evaluated on external datasets, comprising population-based datasets (from the Beijing Eye Study, the Central India Eye and Medical Study, the Singapore Prospective Study, and the UK Biobank) and open-source datasets (Ocular Disease Recognition-5K [ODIR-5K], PAPILA, Glaucoma Grading from Multi-Modality Images [GAMMA], Indian Diabetic …

Safety and immunogenicity of an inactivated COVID-19 vaccine, BBIBP-CorV, in people younger than 18 years: a randomised, double-blind, controlled, phase 1/2 trial.

BACKGROUND: Although SARS-CoV-2 infection often causes milder symptoms in children and adolescents, young people might still play a key part … of China for Major Infectious Diseases, National Mega Projects of China for New Drug Creation, and Beijing Science and Technology Plan. TRANSLATION: For the Chinese translation of the abstract see Supplementary Materials section.

[A twenty-year review of clinical liver transplantation].

OBJECTIVE: To review the development of adult and pediatric liver transplantation in Tianjin First Center Hospital, and to enhance academic … was performed in May 2018. During the 20 years, the team has performed or assisted other centers in Beijing, Shanghai, Guangzhou and Shenzhen to carry out more than 10 000 cases of liver transplantations. A total of 7 043 cases of various types of liver transplantation were performed in the single center of the hospital (6 005 adult liver transplantations …

[Clinical characteristics of bone disease in multiple myeloma and clinical significance of monitoring bone metabolic markers].

OBJECTIVE: To observe the clinical characteristics of bone disease in patients with multiple myeloma (MM) and the clinical significance of monitoring bone metabolic markers. METHODS: The data of 178 MM cases newly diagnosed in Beijing Ji Shui Tan Hospital from January 2009 to June 2014 were reviewed to analysis the types and classification of bone disease and to observe the clinical characteristics of patients with different grades of bone disease. The levels of bone metabolic markers total procollagen type Ⅰ N-terminal peptide (tPINP) and β C-terminal telopeptide of type Ⅰ collagen (β-CTX) w…

Патогенная адаптация HLA Alleles и его корреляция с аутоиммунными заболеваниями на китайском языке.

Гены антигена лейкоцита человека (HLA) играют решающую роль в адаптации населения к динамичной патогенной среде. Несмотря на их важное значение, изучение патогенной эволюции ВПП и ее последствий для аутоиммунных заболеваний сопряжено с серьезными проблемами. Вот, мы генотипировали 20 Гены HLA 3-field разрешение 8278 лиц, принадлежащих к различным этническим группам, включая 4013 Не связанные с Ханом китайские личности. Мы сосредоточили внимание на адаптации ХЛА среди населения Китая, анализируя их связь с различными патогенами, и изучили потенциальную корреляцию между патогенной адаптацией и а

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… of Sciences, Beijing 100049, China. … Yiwei Niu, State Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049 …

[Determination of atmospheric organochlorine pesticides using isotope dilution high-resolution gas chromatography/high-resolution mass spectrometry].

A method for the determination of 25 organochlorine pesticides (OCPs) in the atmosphere using isotope dilution high-resolution gas chromatog … s study were reduced to at least 2% of the current monitoring standards. Analysis of air samples in Beijing showed that all the target compounds except for trans-heptachlor epoxide, endrin, cis-nonachlor and 4,4'-DDD were 100% detected in the air samples. The concentrations of HCB (in volumes of 15-30 m3) ranged from 514 to 563 pg/m3, while those of the o …

Epidemiology and management of osteoporosis in the People's Republic of China: current perspectives.

With the progressive aging of the population, osteoporosis has gradually grown into a global health problem for men and women aged 50 years and older because of its consequences in terms of disabilities and fragility fractures. This is especially true in the People's Republic of China, which has the largest population and an increasing proportion of elderly people, as osteoporosis has become a serious challenge to the Chinese government, society, and family. Apart from the fact that all osteoporotic fractures can increase the patient's morbidity, they can also result in fractures of the hip an

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… Research conducted in Beijing validated the OP Self-assessment Tool for Asians (OSTA) as a simple and effective tool for identifying primary OP in postmenopausal Han Chinese women. … Very low rates of hip fracture in Beijing, People’s Republic of China the Beijing Osteoporosis Project. Am J Epidemiol. 1996;144(9):901–907. doi: 10.1093/oxfordjournals.aje.a009024. 56. Yan L, Zhou B, Prentice A, Wang X, Golden MH. …