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A case of a Japanese patient with neonatal diabetes mellitus caused by a novel mutation in the ABCC8 gene and successfully controlled with oral glibenclamide.

PURPOSE: To quantify the relationship between daily training load and a range of potential measures of fatigue in elite soccer players during an in-season competitive phase (17 d). METHODS: Total high-intensity-running (THIR) distance, perceived ratings of wellness (fatigue, muscle soreness, sleep quality), countermovement-jump height (CMJ), postexercise heart-rate recovery (HRR), and heart-rate variability (Ln rMSSD) were analyzed during an in-season competitive period (17 d). General linear models were used to evaluate the influence of daily fluctuation in THIR distance on potential fatigue…

Task Failure in Endurance Sports: A Review.

Task failure in endurance sports represents a complex and multifaceted phenomenon likely arising from the dynamic and intricate interaction between peripheral and central mechanisms. Traditional models of fatigue have long emphasized a gradual and inevitable decline in performance because of metabolic, neuromuscular, and cardiovascular limitations. Research has also highlighted that task failure may not only be a product of this progressive deterioration but could also result from acute and unpredictable disruptions at the central level (e.g., psychological factors such as perceived effort) th…

Apathy in Parkinson's Disease: Distinguishing Overlapping Symptoms Via Network Analysis.

BACKGROUND: Anxiety, fatigue, and excessive daytime sleepiness (EDS) frequently co-occur in Parkinson's disease (PD) and can influence the clinical determination of apathy. OBJECTIVE: To distinguish patient-reported apathy from other non-motor symptoms. METHODS: Individuals with PD meeting UK Brain Bank criteria underwent paired OFF- and ON- dopaminergic medication assessments, including the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Hamilton Anxiety and Depression Rating Scales (HAM-A, HAM-D), Symbol Digit Modalities Test, Stroop, and Scales for Outcomes…

Напряжение в течение жизни связано с невидимыми симптомами множественного склероза.

AIM: Детские стрессовые факторы могут усиливать восприятие стресса со стороны взрослых и накапливаться в течение всей жизни для воздействия на симптомы множественного склероза (MS). Растущие данные связывают детские стрессовые факторы (например, жестокое обращение, безнадзорность) с усталостью, болью и психическим заболеванием у взрослых с НР; тем не менее в литературе в этой области отсутствует всеобъемлющий подход к продолжительности жизни. Цель этого перекрестного исследования заключалась в изучении влияния детских и взрослых стрессовых характеристик (т.е. МЕТОДЫ: В рамках Национального общ

Совпадение в аннотации оригинала
AIM: Childhood stressors can increase adult stress perception and may accumulate over the lifespan to impact symptoms of multiple sclerosis (MS). Growing evidence links childhood stressors (e.g., abuse, neglect) to fatigue, pain, and psychiatric morbidity in adults with MS; yet literature in this area is lacking a comprehensive lifespan approach. The aim of …

The Effect of Combining Transcranial Direct Current Stimulation Treatment and an Exercise Program on Fragility in a Population with Multiple Sclerosis: Cross-Over Design Trial.

BACKGROUND: The relationship between fragility and neurological diseases is extensive and affects many patients with multiple sclerosis (MS), whose risk factors are related to fragility. OBJECTIVE: To study the effects of exercise and transcranial direct current stimulation (tDCS) in MS patients with fatigue from four dimensions: functional mobility, balance, fatigue, and depression. METHODS: A total of 12 patients who belonged to two associations of people with physical disabilities participated. Functional mobility, depression, balance, and fatigue were assessed before and after the interv…

Depression in myasthenia gravis: a heterogeneous and intriguing entity.

BACKGROUND: Depressive symptoms in myasthenia gravis (MG) are common, may mimic other disease features, and contribute to misdiagnosis and diagnostic delay. Nevertheless, the clinical determinants of depressive symptoms in MG remain poorly studied, in particular their overlap with fatigue. Moreover, studies in MG have rarely looked at distinct depression phenotypes. METHODS: In 68 consecutive MG patients, we ascertained cognitive-affective and somatic depression with the Beck Depression Inventory (BDI), and also assessed age at disease onset, education, marital state, work ability, sleepiness…

Effects of Physiological Load on Kinematic Variables Related to Tennis Serve Performance.

This study aimed to explore the effects of fatigue on the kinematic parameters and performance of the tennis serve, specifically speed and accuracy. Xsens inertial measurement units (IMUs) were used to obtain the kinematic parameters of the tennis serve. Seven professional tennis players participated in the study, performing multiple sets of serves along with tennis-specific fatigue-inducing drills. Key kinematic variables such as jump height, pelvis velocity, wrist height, wrist velocity, upper arm velocity, forearm velocity, and shoulder velocity were measured alongside serve speed and accur…

Size and structure of motor variability in young and old adults performing a rhythmic, repetitive tapping task.

The size of motor variability increases with fatigue in repetitive upper limb tasks, and the structure of variability differs with old age. However, the combined influences of old age and fatigue on the size and structure of movement-to-movement variability are unclear. Eighteen young and sixteen old adults performed a fatiguing repetitive tapping task while seated using their dominant arm. Optoelectronic motion capture served to measure upper body angles via forward kinematics. Movement-to-movement variability was measured by the size at joints (standard deviation: SD) and by the structure of…

External Anal Sphincter Fatigability: An Electromyographic and Manometric Study in Patients With Anorectal Disorders.

BACKGROUND/AIMS: External anal sphincter (EAS) plays an important role in fecal and gas voluntary continence. Like every muscle, it can be affected by repeated efforts due to fatigability (physiological response) and/or fatigue (pathological response). No standardized fatiguing protocol and measure method to assess EAS fatigability has existed. The aim is to test a simple, standardized protocol for fatiguing and measuring EAS fatigability and fatigue to understand better the part of EAS fatigability in the pathophysiology of fecal incontinence. METHODS: Patients with anorectal disorders evalu…

A comparison of the effects of exercises plus connective tissue massage to exercises alone in women with fibromyalgia syndrome: a randomized controlled trial.

This study aimed to compare the effectiveness of a 6-week combined exercise program with and without connective tissue massage (CTM) on pain, fatigue, sleep problem, health status, and quality of life in patients with fibromyalgia syndrome (FMS). Patients were randomly allocated into Exercise (n = 20) and Exercise + CTM (n = 20) groups. The exercise program with and without CTM was carried out 2 days a week for 6 weeks. Pain, fatigue, sleep problem with Visual Analog Scales, health status with Fibromyalgia Impact Questionnaire (FIQ), and quality of life with Short Form-36 were evaluated. After…

Effect of varying load magnitude on diaphragmatic glutathione metabolism during loaded breathing.

Some studies have suggested that protective mechanisms downregulate diaphragm activity during loaded breathing so as to prevent respiratory-muscle fatigue. Other work has indicated, however, that loading can sometimes elicit significant diaphragmatic fatigue, and that the development of fatigue may be related to alterations in diaphragmatic glutathione concentrations. One potential explanation for these discrepant observations is that the mechanism of respiratory failure may vary as a function of load magnitude, and that some loads evoke little fatigue whereas others produce substantial fatigu…

Systemic inflammation and symptomatology in patients with prostate cancer treated with androgen deprivation therapy: Preliminary findings.

BACKGROUND: Increases in fatigue, depressive symptomatology, and cognitive impairment are common after the initiation of androgen deprivation therapy (ADT) for prostate cancer. To date, no studies have examined the potential role of inflammation in the development of these symptoms in ADT recipients. The goal of the current study was to examine circulating markers of inflammation as potential mediators of change in fatigue, depressive symptomatology, and cognitive impairment related to the receipt of ADT. METHODS: Patients treated with ADT for prostate cancer (ADT+; n = 47) were assessed arou…

Central nervous system dysfunction in primary biliary cirrhosis and its relationship to symptoms.

BACKGROUND & AIMS: Primary biliary cirrhosis (PBC) is associated with fatigue, memory impairment, and sleep disturbances. These symptoms suggest the possibility of underlying central nervous system (CNS) dysfunction. During exercise, fatigue develops due to muscular processes (peripheral fatigue) and decreased neurological activation of the muscle (central fatigue). In this study we objectively quantify central and peripheral fatigue in PBC and investigate the integrity of cortical inhibitory and excitatory circuits. Finally, we determine the relationship of these indices to the symptoms of PB…

Investigation of Fatigability during Repetitive Robot-Mediated Arm Training in People with Multiple Sclerosis.

BACKGROUND: People with multiple sclerosis (MS) are encouraged to engage in exercise programs but an increased experience of fatigue may impede sustained participation in training sessions. A high number of movements is, however, needed for obtaining optimal improvements after rehabilitation. METHODS: This cross-sectional study investigated whether people with MS show abnormal fatigability during a robot-mediated upper limb movement trial. Sixteen people with MS and sixteen healthy controls performed five times three minutes of repetitive shoulder anteflexion movements. Movement performance, …

Изучение связей физических, умственных и эмоциональных симптомов и сыворотки биомаркеров ангиогенеза в множестве склерозов.

Множественный склероз (MS) связан с симптомами, которые могут быть затронуты ангиогенезом. В ранних периодах MS повышается коэффициент экспозелевого роста (VEGF) - мощная проангиогенная молекула, но его активность в более поздних болезнях недооценивается. [Met5]-enkephalin (ENK) имеет антиангиогенную активность и снижается у людей с MS (PwMS). ЦЕЛИ: Определение основных симптомов MS и оценка взаимосвязей между общими симптомами MS и биомаркерами, связанными с ангиогенезом. МЕТОДЫ: В рамках этого межсекторального исследования были определены участники ПwMS и не связанные с СУ контрольные органы

Совпадение в аннотации оригинала
BACKGROUND: Multiple sclerosis (MS) involves symptoms that may be impacted by angiogenesis. Vascular endothelial growth factor (VEGF), a pot … ontrol participants were identified for this cross-sectional study. Walking times and self-reported fatigue, anxiety, depression, and pain were measured. Serum VEGF and [Met5] ENK levels were measured in a subset of PwMS. RESULTS: PwMS (n = 66) had significantly greater fatigue than controls (n = 35). In PwMS, fatigue, anxiety, depression, and pain were …

Optimal design and biomechanical analysis of sandwich composite metal locking screws for far cortical locking constructs.

In the interests of more flexible and less stiff bridge constructs to stimulate bone healing, the technique of far cortical locking has been designed to improve locked plating constructs in terms of stress concentration, stress shielding, and inhibition of issues around fracture healing. However, far cortical locking screws currently lack objective designs and anti-fatigue designs. This study investigates an optimization algorithm to form a special locking screw composed of various metals, which can theoretically achieve the maintenance of the excellent mechanical properties of far cortical lo…

Relationship between Carnitine Deficiency and Tyrosine Kinase Inhibitor Use in Patients with Chronic Myeloid Leukemia.

BACKGROUND: Some chemotherapeutic agents cause carnitine deficiency, which causes general fatigue. However, there is no study on carnitine deficiency in patients with chronic myeloid leukemia (CML) during tyrosine kinase inhibitor (TKI) therapy. OBJECTIVE: In this study, we investigated carnitine concentrations in patients with CML receiving TKI therapy. METHOD: This study included patients with well-controlled CML. Total carnitine and free carnitine concentrations were evaluated using the enzyme cycling method. The brief fatigue inventory (BFI) and cancer fatigue scale (CFS) were used to as…

Identification of swallowing disorders: the perception of patients with neurodegenerative diseases.

PURPOSE: To verify the perception of patients with neurodegenerative diseases regarding swallowing changes and to know the perceptions of swallowing sensations that can promote the early identification of dysphagia. METHODS: It is a cross-sectional study with 44 patients with neurodegenerative diseases. All of them answered a questionnaire to know the sensation perceived during swallowing and its intensity. The Fatigue Severity Scale was applied to measure fatigue and the Swallowing Disturbance Questionnaire was applied to detect swallowing complaints. The Functional Oral Intake Scale was use…

The Effect of Whey Peptides and Micronutrients on Improving Exercise Performance in Mice.

Background: Durative exercise-induced fatigue influences muscle structure and exercise performance. Dietary supplements combining bioavailable proteins with essential vitamins and minerals may help reduce fatigue. Compared with proteins, whey peptides, as easily absorbed energy sources, are regarded as better promoting the utilization of vitamins and minerals. This study investigated whether the combination of whey peptides and micronutrients could synergistically improve exercise-induced fatigue and exercise performance. Methods: Four-week-old male C57BL/6J mice were forced to exercise using …