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Whole Brain Amide Proton Transfer Weighted Imaging in Children With Obstructive Sleep Apnea.

PURPOSE: To investigate alteration of brain amide proton transfer weighted (APTw) signals in children with obstructive sleep apnea (OSA) and … the supramarginal gyrus, the gray matter of the lingual gyrus, the corona radiata, and the genu of corpus callosum in children with moderate-severe OSA were significantly lower than that of volunteers. The APTw signals of the frontal-parietal-temporal regions, hippocampus, and corona radiata were significantly associated with cognitive assessment scores. CONCLU …

Dl-3-n-Butylphthalide Promotes Neurogenesis in Ischemic Stroke Mice Through Wnt/β-Catenin Signaling Activation and Neurotrophic Factor Production.

Synchronized neurogenesis and angiogenesis after stroke have been well documented, and inducing neurovascular remodeling may provide a promi … after stroke. NBP promoted the proliferation of NSCs in the SVZ, migration of neuroblasts along the corpus callosum, and differentiation of neuroblasts toward neurons in the peri-infarct zone, resulting in restored neural function. Moreover, we revealed that NBP-induced neurogenesis was associated with the activation of the Wnt/β-catenin pathway, which was revers …

Evidence for cognitive compensation mechanism in the postoperative delirium: a prospective multi-modal neuroimaging cohort study.

To explore the effect of brain cognitive compensation on the pathogenesis of postoperative delirium (POD) in the frontal glioma patients. Ei … vely correlated with POD incidence and severity (all P < 0.05); and the FA value of the genu of the corpus callosum was significantly positively correlated with the GMV in the contralateral DLPFC and preoperative cognition, while was negative correlated with the incidence and severity of POD (all P < 0.05). Our findings showed that compensation of contralateral D …

RAB24 Missense Variant in Dogs with Cerebellar Ataxia.

Hereditary ataxias are a highly heterogenous group of diseases characterized by loss of coordination. In this study, we investigated a family of random-bred dogs, in which two siblings were affected by a slowly progressive ataxia. They presented with clinical signs of progressive cerebellar ataxia, hypermetria, and absent menace response. The MRI revealed generalized brain atrophy, reduced cortical demarcation, hypoplastic corpus callosum, and cerebellar folia thinning, highly suggestive of a neurodegenerative disorder. We sequenced the genomes of the two affected dogs and their unaffected par…

Astrocytic Interleukin-33 Deficiency Reduces Glial Fibrillary Acidic Protein Expression and Exacerbates Microglial Activation and Neuronal Damage in a Chemically Induced Inflamed Frontal Cortex.

Astrocytes, the most abundant glial cells in the CNS, play a crucial role in supporting neurons and respond to injury or disease through ast … gliotoxin cuprizone (CPZ), IL-33 was previously shown to be reduced in oligodendrocytes within the corpus callosum. In this study, we found that lipopolysaccharide (LPS) stimulation enhanced nuclear IL-33 expression and GFAP production in cortical astrocytes. Using lentiviral-mediated IL-33 knockdown (IL33KD) and overexpression (IL33oe), we demonstrated that IL- …

Sleep profile in patients with septo-optic-pituitary dysplasia: protocol for a prospective cohort study.

INTRODUCTION: Children with septo-optic-pituitary dysplasia (SOD) may experience a range of visual impairments and hormonal dysfunctions bey … ose of children with isolated bilateral visual impairment, as well as patients with agenesis of the corpus callosum. METHODS AND ANALYSIS: Participants aged between 3 and 18 years previously diagnosed with SOD will be recruited prospectively. Each participant will be assessed at baseline and at each follow-up visit scheduled to evaluate the clinical course. Slee …

Congenital external hydrocephalus: A rare presentation of lobar holoprosencephaly in a neonate.

External hydrocephalus is a rare condition characterized by abnormal cerebrospinal fluid (CSF) accumulation in the subarachnoid space, often … e imaging (MRI) revealed fused frontal horns of the lateral ventricles, hypoplasia of the posterior corpus callosum, and extensive extra-axial CSF accumulation compressing the brain parenchyma. The CSF collection showed complete suppression on FLAIR imaging, confirming its nature, and a cortical vein sign indicated an enlarged subarachnoid space rather than a sub …

Epileptic Spasms in Septo-Optic-Pituitary Dysplasia: A Retrospective Cohort Study.

BACKGROUND: To assess the prevalence, clinical characteristics, and outcomes of epileptic spasms (ES) in patients with septo-optic-pituitary … tic nerve hypoplasia, an absent septum pellucidum, and schizencephaly in all patients. A dysplastic corpus callosum and a small pituitary gland size were noted in one (14.3%) patient. Two (28.6%) patients had comorbid diabetes insipidus. All patients experienced severe developmental delays and were nonverbal and nonambulatory. EEG analysis showed a hypsarrhythmia …

Successful Endoscopic Resection of a Chronic Expanding Hematoma Following Gamma Knife Surgery for Cerebral Arteriovenous Malformation: A Case Report.

Gamma knife surgery is useful for treating cerebral arteriovenous malformations. However, some radiation-induced long-term complications have been reported. One of these is a chronic expanding hematoma. We present a case of chronic expanding hematoma, successfully treated with endoscopic resection. The patient, a woman in her 30s, experienced a cerebral hemorrhage 17 years ago associated with an arteriovenous malformation in the corpus callosum. The lesion was completely embolized with n-butyl-2-cyanoacrylate embolization twice, followed 2 years later by gamma knife surgery. The patient presen…

Propranolol Effective in Suppressing Paroxysmal Sympathetic Hyperactivity Attacks Occurring in the Acute Phase of Diffuse Axonal Injury: A Case Report.

Paroxysmal sympathetic hyperactivity occurs primarily after severe traumatic brain injury and is characterized by abnormal paroxysmal surges … resonance imaging revealed cerebral contusion in bilateral frontal lobes, genu, and splenium of the corpus callosum, and diffuse axonal injury was diagnosed. Pharmacological therapy with medication to reduce cerebral edema, analgesics, sedatives, and antiepileptic drugs was initiated. On the 7th day, the sedatives were temporarily discontinued, the patient's limb …

Transcript Imbalance from TENM4 Exon Skipping: Effects on Epilepsy and Genetic Pleiotropy.

TENM4 is a transmembrane protein belonging to the teneurin family. It is localized in neurons and oligodendrocytes, where it regulates oligo … y increased susceptibility to pentylenetetrazole-induced seizures. Their brains exhibited a smaller corpus callosum compared to the wildtype, and culture experiments showed impaired oligodendrocyte differentiation. Remarkably, the ΔE10 transcript exhibited natural alternative splicing, even in wildtype cells. During the differentiation of oligodendrocyte progenit …

Successful Pregnancy Management of a Woman With Severe Methylmalonic Acidemia.

Isolated methylmalonic acidemia (MMA) is a rare, genetically heterogeneous group of metabolic disorders resulting from a deficiency of the e … d retrognathia, a soft palate cleft, mild hypospadias, mild ventriculomegaly, and hypoplasia of the corpus callosum and cerebellum without the need for immediate intervention. The mother experienced a mild metabolic decompensation on the fifth postpartum day, which was promptly managed by additional renal replacement therapy. At 3 months postpartum, both mother a …

Multiple Cerebral Infarctions and Clinically Mild Encephalitis/Encephalopathy with a Reversible Splenial Lesion Associated with Streptococcal Toxic Shock Syndrome: A Case Report.

INTRODUCTION: Streptococcal toxic shock syndrome (STSS) is a rapidly progressing, fatal disease. Sepsis can be complicated by multiple cereb … for intensive care. At the time of transfer, high signal intensity observed in the splenium of the corpus callosum on MRI was thought to be MERS. Blood tests revealed septic coagulopathy. He received intensive care and was discharged home on day 32. Head MRI performed during outpatient follow-up on the 15th day after discharge, we made a definitive diagnosis of …

Дигит Спан тесты более чувствительны, чем SDMT для обнаружения рабочего нарушения памяти и корреляции с метаболическими изменениями в белой материи и глубоко серой материи Nucley в многоразовом склерозе: исследование GABA-Edited Magnetic Resonance Spectropy.

В этом документе мы ставили цель оценить эффективность и полезность трех кратких, легко управляемых и повторяемых тестов, а именно: SDMT, Digit Span Forth (DSF) и Digit Span Backward (DSB) в случае пациентов с MS (MSp), и сравнить результаты с результатами здоровых добровольцев (CON). Мы надеялись определить наиболее чувствительный тест, который мог бы регулярно использоваться в клинической практике. Кроме того, мы попытались определить метаболический фон когнитивной настройки с использованием усовершенствованного радиологического метода Mescher-Garwood (MEGA) с использованием 1H магнитной спе

Совпадение в аннотации оригинала
In this paper, we aimed to evaluate the efficacy and usefulness of three brief, easy-to-administer, and repeatable tests, namely SDMT, Digit … in MSp correlated with inflammatory and degenerative metabolites in the thalamus, hippocampus, and corpus callosum. A correlation between increased Glx- and GABA-ratios and SDMT was found. Unlike the SDMT, the DSF and DSB showed correlations with inflammatory metabolites in the caudate nucleus and hypothalamus. DSF correlated with GABA ratios in the hippocampus. …

Functional connectivity in autism spectrum disorder evaluated using rs-fMRI and DKI.

We evaluated functional connectivity (FC) in patients with adult autism spectrum disorder (ASD) using resting-state functional MRI (rs-fMRI) … ant negative correlation between MK and FC between the cerebellar vermis and the right OFusG in the corpus callosum, FM, right SLF and right ACR. Increased DKI metrics might represent neuroinflammation, increased complexity, or disrupted WM tissue integrity that alters long-distance connectivity. Nonetheless, protective or compensating adaptations of inflammation …

Quantitative reliability assessment of brain MRI volumetric measurements in type II GM1 gangliosidosis patients.

PURPOSE: GM1-gangliosidosis (GM1) leads to extensive neurodegenerative changes and atrophy that precludes the use of automated MRI segmentat … teams on a slice-by-slice basis: whole brain, ventricles, cerebellum, lentiform nucleus, thalamus, corpus callosum, and caudate nucleus. The inter- and intra-rater reliability of the segmentation method was assessed with an intraclass correlation coefficient as well as Sorensen-Dice and Jaccard coefficients. RESULTS: Based on the Sorensen-Dice and Jaccard coeff …

The Relationship between White Matter Architecture and Language Lateralization in the Healthy Brain.

Interhemispheric anatomical differences have long been thought to be related to language lateralization. Previous studies have explored whet … nal lateralization. Connectometry revealed a significant negative correlation between LQs and QA of corpus callosum tracts, indicating that higher QA in these regions is associated with bilateral and right hemisphere language representation in frontal and temporal regions. Left language laterality in the temporal lobe was significantly associated with longer righ …

Under recognized yet a clinically relevant impact of aneurysm location in Distal Anterior Cerebral Artery (DACA) aneurysms: insights from a contemporary surgical experience.

Aneurysms of the distal anterior cerebral artery (DACA) are rare but surgically challenging. Despite a known therapeutic implication of the aneurysm location on the DACA territory, the literature is unclear about its clinical and prognostic significance. Our surgical experience over the last 5 years was reviewed to compare the clinical, operative, and outcome characteristics between aneurysms located below the mid portion of the genu of the corpus callosum (called proximal aneurysms) to those distal to this point (called distal aneurysms). A prognostic factor analysis was done using uni and mu…

A Mouse Model of Temporal Lobe Contusion.

Trauma to the brain can induce a contusion characterized by a discrete intracerebral or diffuse interstitial hemorrhage. In humans, "compute … and evidence of interhemispheric connectional diaschisis involving the fiber bundle in the ventral corpus callosum that connects temporal lobe structures. This model may be useful to advance our understanding of the unique features of tlCont in humans.

Effect of gestational age on cerebral lesions in neonatal encephalopathy.

OBJECTIVE: To determine the risk on brain lesions according to gestational age (GA) in neonates with neonatal encephalopathy. DESIGN: Secon … ain regions: basal ganglia and thalami, white matter (WM), cortex, posterior limb internal capsule, corpus callosum, brainstem and cerebellum. A given infant could have several brain structures affected. Risk of brain lesion according to GA was estimated by crude and adjusted ORs (aOR). RESULTS: MRI was available for 626 (78.8%) of the 794 included infants with …