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SFRP5 inhibits melanin synthesis of melanocytes in vitiligo by suppressing the Wnt/β-catenin signaling.

Secreted frizzled-related protein 5 (SFRP5) plays a pivotal role in regulating the development of many tissues and organs, however, as an inhibitor of Wnt signaling, the role of SFRP5 in vitiligo remains unknown. Hence, we speculated that SFRP5 might be associated with melanogenesis in melanocytes by regulating Wnt signaling in vitiligo. In this study, we found that SFRP5 was overexpressed in the skin lesions of patients with vitiligo. Compared with that in normal epidermal melanocytes (PIG1), the expression of SFRP5 was increased in vitiligo melanocytes (PIG3V). To investigate the effect of S

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… The secondary antibodies included Alexa Fluor 594 goat anti-mouse IgG (Zhongshan Golden Bridge, Beijing, China) and FITC goat anti-rabbit IgG (Zhongshan Golden Bridge, Beijing, China). 4′,6-Diamidino-2-phenylindole (DAPI; Beyotime, Beijing, China) was used as a nuclear counterstain. … The PVDF membranes were incubated with primary antibody overnight at 4 °C, followed by incubation with horseradish peroxidase-conjugated anti-rabbit antibody (Zhongshan Golden Bridge, Beijing, China) for 1 h at 37 °C. …

[Factors influencing hemorrhagic transformation after mechanical thrombectomy in patients with acute ischemic stroke patients].

OBJECTIVES: Patients with acute ischemic stroke remain at risk of hemorrhagic transformation after mechanical thrombectomy, which may lead t … al of 268 patients with AIS who underwent MT and had complete clinical data at the Stroke Center of Beijing Hospital between May 2020 and December 2024 were consecutively enrolled. All patients met the diagnostic criteria for AIS and the indications for vascular recanalization therapy. Patients were excluded if they had a pre-stroke Modified Rankin Scale …

Double-Blind, Randomized, Placebo-Controlled Phase III Clinical Trial to Evaluate the Efficacy and Safety of treating Healthcare Professionals with the Adsorbed COVID-19 (Inactivated) Vaccine Manufactured by Sinovac - PROFISCOV: A structured summary of a study protocol for a randomised controlled trial.

OBJECTIVES: To evaluate the efficacy of two doses of the adsorbed vaccine COVID-19 (inactivated) produced by Sinovac in symptomatic individu … N AND COMPARATOR: Experimental intervention: The vaccine was manufactured by Sinovac Life Sciences (Beijing, China) and contains 3 μg/0.5 mL (equivalent to 600 SU per dose) of inactivated SARS-CoV-2 virus, and aluminium hydroxide as adjuvant. Control comparator: The placebo contains aluminium hydroxide in a 0.5 mL solution The schedule of both, experiment …

Sacubitril/Valsartan Ameliorates Crizotinib-Induced Cardiotoxicity in Mice.

BackgroundLung cancer is one of the major cause of death globally. Crizotinib is a first-line drug used in treating non-small-cell lung cancer (NSCLC). However, the pathophysiological mechanisms underlying its cardiotoxicity are unknown. This study investigated the mechanisms of crizotinib-induced cardiotoxicity and explored whether this toxicity can be prevented by the angiotensin receptor/neprilysin inhibitor sacubitril/valsartan.MethodsMale C57BL/6 mice were randomly divided into three groups: control, crizotinib (40 mg ⋅ kg - 1 ⋅ d - 1 for four weeks), and crizotinib + sacubitril/valsartan

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… transcription kit (X0222, Tiangen, Beijing, China). … , China) and PMSF protease inhibitor (01392/06122, Cwbio, Beijing, China). …

Recommendations for influenza and Streptococcus pneumoniae vaccination in elderly people in China.

Influenza and pneumonia can be prevented by vaccination, but they remain major causes of morbidity and mortality in age-related diseases. In most areas of China, the rates of influenza and pneumococcal vaccination are relatively low and public awareness of vaccination remains insufficient. Thus, it is essential to recommend influenza and Streptococcus pneumoniae vaccination to elderly people in clinical practice. Based on recently published studies and related documents issued by several vaccination authorities, such as the World Health Organization, the National Health and Wellness Committee,

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… In 2003, the Beijing Municipal Center for Disease Control and Prevention analyzed the efficacy and cost‐benefit analysis of influenza vaccination in 665 people aged over 60 years in Beijing and found that the cost‐benefit ratio was 1.51, which is higher than that of the general population. 24 Approximately … Other cities, including Beijing, Karamay, Shenzhen, and Xinxiang, have implemented free vaccination policies for specific groups. 37 Based on data from the Beijing Municipal Center for Disease Control and Prevention, after the implementation of publicly funded vaccination, the influenza vaccination rate …

Iron deficiency in children at the time of initial neuroblastoma diagnosis.

ImportanceThere is a high incidence of iron deficiency in children worldwide. Notably, however, while iron deficiency is the most common cause of anemia, little is known about the prevalence and different types of iron deficiency in neuroblastoma patients.ObjectiveThe aim of the present study was to investigate the prevalence of iron deficiency in patients newly diagnosed with neuroblastoma.MethodsA total of 195 newly diagnosed neuroblastoma patients from November 2015 to January 2018 were analyzed retrospectively. The survival analysis was estimated by the Kaplan-Meier method.ResultsOf the 19

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… METHODS Ethical approval The study was approved by the Ethics Committee of Beijing Children’s Hospital and was conducted in accordance with the Helsinki Declaration. … NB patients All patients included in this study were newly diagnosed with NB at the Hematology Oncology Center of Beijing Children’s Hospital between November 2015 and January 2018. …

Характеристики мозга у пациентов с Mielin Oligendrocyte Glycoprotein Antibody-Associated 7.0 МРТ Тесла.

Гликопротеиновое заболевание, связанное с антителами (MOGAD), может с помощью радиографии имитировать множественный склероз (MS) и спектральное расстройство нейромиелита (NMOSD). В МОГАД пока еще не проведено всестороннего изучения признаков коркового повреждения, знака центральной вены (CVS) и повреждений парамагнитного обода, обнаруженных в MS. МЕТОДЫ: Мы описали 45 пациентов, использующих MOGAD 7.0 Тесла (Тесла)7 Т) МРТ two - научно-исследовательские больницы в Китае и Германии. 7 Были собраны МРТ, лабораторные и клинические данные. Были проанализированы классификация корковых повреждений,

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… Materials and Methods Participants From January 2018 to January 2024, imaging, laboratory, and clinical data of patients with MOGAD were collected from two academic research hospitals: Beijing Tiantan hospital (Beijing, China) and Charité Universitätsmedizin Berlin (Berlin, Germany). … BTH, Beijing Tiantan Hospital; CUB, Charité Universitätsmedizin Berlin. …

Rapid health transition in China, 1990-2010: findings from the Global Burden of Disease Study 2010.

BACKGROUND: China has undergone rapid demographic and epidemiological changes in the past few decades, including striking declines in fertility and child mortality and increases in life expectancy at birth. Popular discontent with the health system has led to major reforms. To help inform these reforms, we did a comprehensive assessment of disease burden in China, how it changed between 1990 and 2010, and how China's health burden compares with other nations. METHODS: We used results of the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) for 1990 and 2010 for China

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… Bayesian estimation methods. 23 For China, key sources included the 2002 China National Nutrition and Health Survey, the China Global Youth Tobacco Survey, the Second National Health Services Survey, the 1996 Global Youth Tobacco Survey, the 1996 National Prevalence Survey, the After-MONICA, the INTERSALT Beijing … , the INTERMAP Beijing, and the 2000 and 2005 national censuses. …

The Herba Patriniae (Caprifoliaceae): A review on traditional uses, phytochemistry, pharmacology and quality control.

ETHNOPHARMACOLOGICAL RELEVANCE: Herba Patriniae has been used for thousands of years in China as a traditional Chinese medicine with heat-clearing and detoxicating effects. It is applied widly for the treatment of rheumatoid arthritis, diarrhea, acute hepatitis, pelvic inflammatory disease and ulcerative colitis in clinic. Two species, namely Patrinia scabiosaefolia Fisch. (PS) and Patrinia villosa Juss. (PV) from the Caprifoliaceae family, are considered as Herba Patriniae in the pharmaceutical industry. AIM OF THE REVIEW: This paper aims to comprehensively outline the traditional uses, bota

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… Chinese Traditional Patent Medicine specification ⟪北京市中成药规范⟫ Volume 2 ( Beijing Municipal Bureau of Health, 1974 ) Lanweiyan Heji (阑尾炎合剂) Decoction Lonicerae Japonicae Flos, Taraxaci Herba, Herba Patriniae, Forsythiae Fructus, Rhei Radix et Rhizoma, Paeoniae Radix Rubra, Toosendan Fructus, Aucklandiae … Miltiorrhizae Radix et Rhizoma, Lycopi Herba, Paeoniae Radix Rubra, Persicae Semen, Carthami Flos, Olibanum, Myrrha, Vaccariae Semen, Citri Reticulatae Pericarpium, Toosendan Fructus, Foeniculi Fructus, Angelicae Dahuricae Radix, Herba Patriniae, Taraxaci Herba Surgery of Chinese medicine ⟪中医外科学⟫ ( Beijing …

Bortezomib-based therapy for transplant-ineligible East Asian patients with newly diagnosed mantle-cell lymphoma.

IntroductionThis subgroup analysis of the LYM-3002 Phase III study (NCT00722137) investigated whether substituting bortezomib for vincristine in frontline R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone) therapy could improve outcomes in East Asian patients with newly diagnosed mantle-cell lymphoma (MCL).Materials and methodsA total of 121 East Asian patients from China, Taiwan, Japan, and the Republic of Korea with stage II-IV MCL who were ineligible or not considered for stem-cell transplantation were enrolled to six to eight 21-day cycles of R-CHOP or VR-CA

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… Table S1 Institutional review boards (IRBs) and ethics committees (ECs) Country | Name and address | Chairperson(s) | Site China | NCC Ethics Committee/IRB, 17 Panjiayuan South Road, Beijing 100021 | Datong Chu | 086001 Received drug China | Beijing Cancer Hospital IEC, 52 Fucheng Road, Haidian, Beijing … Table S1 Institutional review boards (IRBs) and ethics committees (ECs) Country | Name and address | Chairperson(s) | Site China | NCC Ethics Committee/IRB, 17 Panjiayuan South Road, Beijing 100021 | Datong Chu | 086001 Received drug China | Beijing Cancer Hospital IEC, 52 Fucheng Road, Haidian, Beijing …

Поправка: взаимосвязь между моторными и когнитивными характеристиками и кортикальной активностью у пациентов с множественным склерозом: систематический обзор функциональных исследований вблизи инфракрасной спектроскопии.

[Это корректирует статью ДОИ: 10.3389/fresc.2026.1851559.]

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… Affiliation “Rehabilitation Hospital Affiliated to National Research Center for Rehabilitation Technical Aids, Beijing, China” was omitted for author Haonan Xing. This affiliation has now been added for author Haonan Xing. … Author Haonan Xing was erroneously assigned to affiliation “Department of Neurological Rehabilitation, China Rehabilitation Research Center, Beijing, China”. This affiliation has now been removed for author Haonan Xing. …

[Analysis on the incidence and perioperative outcomes of immune-related adverse events in preoperative immunotherapy for colorectal cancer based on multicenter real-world data].

Objective: To investigate the incidence of immune-related adverse events (irAEs) and corresponding perioperative outcomes among patients with colorectal cancer who received neoadjuvant immunotherapy and underwent curative radical resection. Methods: This was a retrospective, multicenter, real-world cohort study. A total of 452 patients with pathologically confirmed colorectal adenocarcinoma who completed neoadjuvant immunotherapy and curative radical surgery were enrolled from five tertiary hospitals between January 1, 2020 and December 31, 2024. The participating institutions included Beijing…

[Efficacy of a recombinant bovine basic fibroblast growth factor gel for the treatment of moderate dry eye: a multicenter randomized double-blind parallel controlled clinical trial].

Objective: To compare the clinical efficacy of a recombinant bovine basic fibroblast growth factor (rb-bFGF) gel and a gel matrix in the treatment of moderate dry eye. Methods: It was a prospective random double-blind controlled study. One hundred patients diagnosed as moderate dry eye in Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Beijing Tongren Hospital, Capital Medical University, Eye & ENT Hospital of Fudan University and Zhongshan Ophthalmic Center from August 20…

Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: a systematic analysis from the Global Burden of Disease Study 2016.

BACKGROUND: A key component of achieving universal health coverage is ensuring that all populations have access to quality health care. Exam … s with the highest and lowest scores in 2016. In China, performance ranged from 91·5 (89·1-93·6) in Beijing to 48·0 (43·4-53·2) in Tibet (a 43·5-point difference), while India saw a 30·8-point disparity, from 64·8 (59·6-68·8) in Goa to 34·0 (30·3-38·1) in Assam. Japan recorded the smallest range in subnational HAQ performance in 2016 (a 4·8-point differen …

Сосуществование Лактиплантацилла и Виккерхамомиц в верхнем слое сахарного тростника стимулирует потенциальное подавление патогенов и аэробную стабильность за счет увеличения производства лактической кислоты и уксусной кислоты.

Чтобы определить сосуществующие бактерии и дрожжи в верхнем слое сахарного тростника, которые определяют качество ферментации и повышают безопасность корма, мы манипулировали эпифитической микробиотой сверху сахарного тростника путем селективного подавления дрожжей (АФ) или бактерий с лактической кислотой (АБ) перед повторной цензурой, используя в качестве контроля неочищенные (КК) и стерилизованные стерилизованные силизы (НА). Результаты показывают, что высокоурожайное производство лактической кислоты и уксусной кислоты (p) < 0.05), лучшая аэробная стабильность и высокая плотность Лактипланта

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… Yeasts and molds were grown on potato dextrose agar (PDA, Beijing Land Bridge Technology, Beijing, China) at 25 °C for 72 h, and Enterobacteriaceae (EB) on violet red bile agar (Beijing Land Bridge Technology, Beijing, China) at 37 °C for 48 h. … Specifically, the isolated bacteria and yeast were passaged three times in MRS (Beijing Land Bridge Technology, Beijing, China) and PDB (Potato Dextrose Broth, Beijing Land Bridge Technology, Beijing, China) liquid media, respectively. …

Chinese expert consensus recommendations for the administration of immune checkpoint inhibitors to special cancer patient populations.

Immune checkpoint inhibitors (ICIs) targeting programmed cell death 1, programmed cell death ligand 1, and cytotoxic T lymphocyte-associated antigen-4 have shown significantly durable clinical benefits and tolerable toxicities and have improved the survival of patients with various types of cancer. Since 2018, the National Medical Products Administration of China has approved 17 ICIs as the standard treatment for certain advanced or metastatic solid tumors. As ICIs represent a broad-spectrum antitumor strategy, the populations eligible for cancer immunotherapy are rapidly expanding. However, t

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… Lu Si, Department of Melanoma, Cancer Hospital and Institute, Peking University, Beijing, China. Jianchun Duan, Department of Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. … Yutao Liu, Department of Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Haifeng Qin, Department of Oncology, Chinese People’s Liberation Army General Hospital, Beijing, China. …

Prices and Clinical Benefit of National Price-Negotiated Anticancer Medicines in China.

BackgroundHigh prices of anticancer medicines have increased the economic burden for both patients and health insurance systems. Since 2017, China has implemented national price negotiations for medicines, relying on evidence from health technology assessments. We aim to assess the relation between negotiated price and value of anticancer medicines listed in China's National Reimbursement Drug List (NRDL).MethodsFor all price-negotiated anticancer medicines and corresponding indications listed in the latest NRDL between 2017 and 2020, we collected their clinical outcomes data, including overal

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… As negotiated prices were mandated to be implemented nationwide since March 1, 2021, we collected negotiated prices of all authorized doses for each branded medicine from Beijing Medicine Sunshine Purchasing, the official hospital procurement website run by Beijing municipality, China [ 29 , 30 ]. … Beijing Medicine Sunshine Purchasing. https://yp.bjmbc.org.cn/view/index/guide.html . Accessed 1 Apr 2021. 30. Beijing Medical Insurance Public Service. https://fw.ybj.beijing.gov.cn/hallEnter/#/serviceGuidelines . Accessed 1 May 2022. 31. …

Arsenic trioxide and triptolide synergistically induce apoptosis in the SKM‑1 human myelodysplastic syndrome cell line.

Although certain combination therapies comprising arsenic trioxide (As2O3) with other agents exist for the treatment of several types of human cancer, few As2O3 combination therapies are clinically effective for myelodysplastic syndromes (MDS). Triptolide (TL) may be an effective therapeutic agent for the treatment of MDS. However, to date, there is no combination therapy for MDS with As2O3 and TL. Therefore, the aim of the present study was to investigate this combination therapy on the apoptosis of MDS SKM‑1 cells. The MDS SKM‑1 cells were treated with As2O3, TL or the two in combination at

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… As 2 O 3 powder (Beijing Double-Crane Pharmaceutical Co., Ltd., Beijing, China) was dissolved in phosphate-buffered saline (PBS). The MDS SKM-1 cell line was obtained from the Cell Bank of the Japanese Collection of Research Bioresources (Osaka, Japan). … RT-qPCR analysis was performed on an ABI 7900 sequence detection system (Applied Biosystems; Thermo Fisher Scientific, Inc.) using a qRT-PCR kit (Qiagen, Beijing, China), according to the manufacturer's protocol. The Abl gene was used as an internal control. …

Exploring The Role of TOP2A in the Intersection of Pathogenic Mechanisms Between Rheumatoid Arthritis and Idiopathic Pulmonary Fibrosis Based on Bioinformatics.

BackgroundRheumatoid arthritis (RA) and idiopathic pulmonary fibrosis (IPF) share a common pathogenic mechanism, but the underlying mechanisms remain ambiguous. Our study aims at exploring the genetic-level pathogenic mechanism of these two diseases.MethodsWe carried out bioinformatics analysis on the GSE55235 and GSE213001 datasets. Machine learning was employed to identify candidate genes, which were further verified using the GSE92592 and GSE89408 datasets, as well as quantitative real-time PCR (qRT-PCR). The expression levels of TOP2A in RA and IPF in vitro models were confirmed using West

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… RNA (1 µg) was reverse-transcribed to complementary DNA using All-in-One First-Strand cDNA Synthesis SuperMix (Trans Gen Biotech, Beijing, China). … The cells were incubated with 5% bovine serum albumin (BSA, Solarbio, Beijing, China) for 1 hour at 37 °C. The antibody was diluted at a ratio of 1:200 and incubated with the antibody overnight at 4 °C. …

Chidamide increases the sensitivity of Non-small Cell Lung Cancer to Crizotinib by decreasing c-MET mRNA methylation.

Introduction: Crizotinib is a kinase inhibitor targeting c-MET/ALK/ROS1 used as the first-line chemical for the treatment of non-small cell lung cancer (NSCLC) with ALK mutations. Although c-MET is frequently overexpressed in 35-72% of NSCLC, most NSCLCs are primarily resistant to crizotinib treatment. Method: A set of NSCLC cell lines were used to test the effect of chidamide on the primary crizotinib resistance in vitro and in vivo. Relationships between the synergistic effect of chidamide and c-MET expression and RNA methylation were systemically studied with a battery of molecular biologic

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… RNA extraction and quantitative RT-PCR (qRT-PCR) assay Total RNA was extracted using an Ultrapure RNA kit (Beijing Com Win Biotech Co., China) and reverse-transcribed into cDNA using the First-Strand cDNA Synthesis Kit (Transgen Co., Beijing, China). … Animal experiments HCC827 (3×10 6 ) cells suspended in 100 μL of PBS were injected into the left inguen of female Balb/c nude mice (body weight 18-20 g; age 6 weeks; Beijing Huafukang Bioscience Co., Inc.). …